diff --git a/tests/integration/01-scriptdebugger.ts b/tests/integration/01-scriptdebugger.ts
new file mode 100644
index 000000000..1051af390
--- /dev/null
+++ b/tests/integration/01-scriptdebugger.ts
@@ -0,0 +1,107 @@
+/*
+ * Copyright 2018-2022 Elyra Authors
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ * http://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+const TESTFILE = 'helloworld.py';
+const TIMEOUT = 50000;
+
+describe('Script debugger tests', () => {
+  before(() => {
+    cy.resetJupyterLab();
+    cy.bootstrapFile(TESTFILE);
+  });
+
+  afterEach(() => {
+    cy.closeTab(-1);
+  });
+
+  after(() => {
+    cy.deleteFile(TESTFILE);
+  });
+
+  it(
+    'test for debugger button to be enabled for default Python kernel',
+    { defaultCommandTimeout: TIMEOUT },
+    () => {
+      openFile(TESTFILE);
+      checkDefaultKernelSelection();
+      checkDebuggerButtonEnabled(true);
+    }
+  );
+
+  it(
+    'test for debugger button state persistence on page reload',
+    { defaultCommandTimeout: TIMEOUT },
+    () => {
+      openFile(TESTFILE);
+      checkDefaultKernelSelection();
+      checkDebuggerButtonEnabled(true);
+      cy.reload();
+      checkDebuggerButtonEnabled(true);
+    }
+  );
+
+  it(
+    'test for debugger button state persistence on reopening editor tab',
+    { defaultCommandTimeout: TIMEOUT },
+    () => {
+      openFile(TESTFILE);
+      checkDefaultKernelSelection();
+      checkDebuggerButtonEnabled(true);
+      cy.closeTab(-1);
+      // Reopen editor
+      openFile(TESTFILE);
+      checkDebuggerButtonEnabled(true);
+    }
+  );
+
+  it(
+    'test for debugger button disabled for default kernel without debug support',
+    { defaultCommandTimeout: TIMEOUT },
+    () => {
+      cy.createNewScriptEditor('R');
+      cy.get(
+        '.elyra-ScriptEditor .jp-Toolbar select > option[value*=python]'
+      ).should('not.exist');
+      checkDebuggerButtonEnabled(false);
+      cy.deleteFile('untitled.r');
+    }
+  );
+});
+
+// ------------------------------
+// ----- Utility Functions
+// ------------------------------
+
+const checkDefaultKernelSelection = (): void => {
+  cy.get('.elyra-ScriptEditor .jp-Toolbar select > option[value=python3]');
+};
+
+const checkDebuggerButtonEnabled = (enabled: boolean): void => {
+  const buttonElem = cy.get(
+    'button.jp-DebuggerBugButton[title="Enable Debugger"]'
+  );
+
+  enabled
+    ? buttonElem.should('not.be.disabled')
+    : buttonElem.should('not.exist');
+};
+
+const openFile = (fileName: string): void => {
+  cy.findByRole('menuitem', { name: /file/i }).click();
+  cy.findByText(/^open from path$/i).click({ force: true });
+  cy.get('input#jp-dialog-input-id').type(`/${fileName}`);
+  cy.get('.p-Panel .jp-mod-accept').click();
+};