diff --git a/packages/react-native/ReactCommon/hermes/inspector-modern/chrome/HermesRuntimeAgentDelegateNew.cpp b/packages/react-native/ReactCommon/hermes/inspector-modern/chrome/HermesRuntimeAgentDelegateNew.cpp
index 1ca7fdd2001499..79139846bc1d87 100644
--- a/packages/react-native/ReactCommon/hermes/inspector-modern/chrome/HermesRuntimeAgentDelegateNew.cpp
+++ b/packages/react-native/ReactCommon/hermes/inspector-modern/chrome/HermesRuntimeAgentDelegateNew.cpp
@@ -74,6 +74,12 @@ class HermesRuntimeAgentDelegateNew::Impl final : public RuntimeAgentDelegate {
     if (sessionState.isLogDomainEnabled) {
       sendHermesIntegrationDescription();
     }
+    if (sessionState.isRuntimeDomainEnabled) {
+      hermes_->enableRuntimeDomain();
+    }
+    if (sessionState.isDebuggerDomainEnabled) {
+      hermes_->enableDebuggerDomain();
+    }
   }
 
   bool handleRequest(const cdp::PreparsedRequest& req) override {
diff --git a/packages/react-native/ReactCommon/jsinspector-modern/HostAgent.cpp b/packages/react-native/ReactCommon/jsinspector-modern/HostAgent.cpp
index 2415586f099a07..e8171ec625e52a 100644
--- a/packages/react-native/ReactCommon/jsinspector-modern/HostAgent.cpp
+++ b/packages/react-native/ReactCommon/jsinspector-modern/HostAgent.cpp
@@ -74,6 +74,16 @@ void HostAgent::handleRequest(const cdp::PreparsedRequest& req) {
   } else if (req.method == "Runtime.disable") {
     sessionState_.isRuntimeDomainEnabled = false;
 
+    shouldSendOKResponse = true;
+    isFinishedHandlingRequest = false;
+  } else if (req.method == "Debugger.enable") {
+    sessionState_.isDebuggerDomainEnabled = true;
+
+    shouldSendOKResponse = true;
+    isFinishedHandlingRequest = false;
+  } else if (req.method == "Debugger.disable") {
+    sessionState_.isDebuggerDomainEnabled = false;
+
     shouldSendOKResponse = true;
     isFinishedHandlingRequest = false;
   }
diff --git a/packages/react-native/ReactCommon/jsinspector-modern/SessionState.h b/packages/react-native/ReactCommon/jsinspector-modern/SessionState.h
index a0329cc2db7b41..6a61ff5468524e 100644
--- a/packages/react-native/ReactCommon/jsinspector-modern/SessionState.h
+++ b/packages/react-native/ReactCommon/jsinspector-modern/SessionState.h
@@ -20,6 +20,7 @@ namespace facebook::react::jsinspector_modern {
 struct SessionState {
  public:
   // TODO: Generalise this to arbitrary domains
+  bool isDebuggerDomainEnabled{false};
   bool isLogDomainEnabled{false};
   bool isRuntimeDomainEnabled{false};