diff --git a/packages/react-native/Libraries/AppDelegate/RCTAppDelegate.mm b/packages/react-native/Libraries/AppDelegate/RCTAppDelegate.mm
index 6e8e018b254c1a..d666fe31c1005d 100644
--- a/packages/react-native/Libraries/AppDelegate/RCTAppDelegate.mm
+++ b/packages/react-native/Libraries/AppDelegate/RCTAppDelegate.mm
@@ -89,6 +89,11 @@ - (BOOL)application:(UIApplication *)application didFinishLaunchingWithOptions:(
 #if RCT_NEW_ARCH_ENABLED
     // Enable native view config interop only if both bridgeless mode and Fabric is enabled.
     RCTSetUseNativeViewConfigsInBridgelessMode([self fabricEnabled]);
+
+    // Enable TurboModule interop by default in Bridgeless mode
+    RCTEnableTurboModuleInterop(YES);
+    RCTEnableTurboModuleInteropBridgeProxy(YES);
+
     [self createReactHost];
     [self unstable_registerLegacyComponents];
     [RCTComponentViewFactory currentComponentViewFactory].thirdPartyFabricComponentsProvider = self;
diff --git a/packages/react-native/ReactAndroid/src/main/java/com/facebook/react/defaults/DefaultNewArchitectureEntryPoint.kt b/packages/react-native/ReactAndroid/src/main/java/com/facebook/react/defaults/DefaultNewArchitectureEntryPoint.kt
index c0d5e90e41b47f..fa6ff875dda211 100644
--- a/packages/react-native/ReactAndroid/src/main/java/com/facebook/react/defaults/DefaultNewArchitectureEntryPoint.kt
+++ b/packages/react-native/ReactAndroid/src/main/java/com/facebook/react/defaults/DefaultNewArchitectureEntryPoint.kt
@@ -35,6 +35,7 @@ object DefaultNewArchitectureEntryPoint {
     ReactFeatureFlags.unstable_useFabricInterop = fabricEnabled
     ReactFeatureFlags.enableBridgelessArchitecture = bridgelessEnabled
     ReactFeatureFlags.useNativeViewConfigsInBridgelessMode = fabricEnabled && bridgelessEnabled
+    ReactFeatureFlags.unstable_useTurboModuleInterop = bridgelessEnabled
 
     this.privateFabricEnabled = fabricEnabled
     this.privateTurboModulesEnabled = turboModulesEnabled