diff --git a/Libraries/Core/Timers/queueMicrotask.js b/Libraries/Core/Timers/queueMicrotask.js
new file mode 100644
index 00000000000000..a131696dcf64af
--- /dev/null
+++ b/Libraries/Core/Timers/queueMicrotask.js
@@ -0,0 +1,41 @@
+/**
+ * Copyright (c) Facebook, Inc. and its affiliates.
+ *
+ * This source code is licensed under the MIT license found in the
+ * LICENSE file in the root directory of this source tree.
+ *
+ * @format
+ * @flow
+ */
+
+'use strict';
+
+let resolvedPromise;
+
+/**
+ * Polyfill for the microtask queuening API defined by WHATWG HTMP spec.
+ * https://html.spec.whatwg.org/multipage/timers-and-user-prompts.html#dom-queuemicrotask
+ *
+ * The method must queue a microtask to invoke @param {function} callback, and
+ * if the callback throws an exception, report the exception.
+ */
+export default function queueMicrotask(callback: Function) {
+  if (arguments.length < 1) {
+    throw new TypeError(
+      'queueMicrotask must be called with at least one argument (a function to call)',
+    );
+  }
+  if (typeof callback !== 'function') {
+    throw new TypeError('The argument to queueMicrotask must be a function.');
+  }
+
+  // Try to reuse a lazily allocated resolved promise from closure.
+  (resolvedPromise || (resolvedPromise = Promise.resolve()))
+    .then(callback)
+    .catch(error =>
+      // Report the exception until the next tick.
+      setTimeout(() => {
+        throw error;
+      }, 0),
+    );
+}
diff --git a/Libraries/Core/setUpTimers.js b/Libraries/Core/setUpTimers.js
index ffca65d3798be6..8629872a3963c1 100644
--- a/Libraries/Core/setUpTimers.js
+++ b/Libraries/Core/setUpTimers.js
@@ -10,10 +10,21 @@
 
 'use strict';
 
+const {polyfillGlobal} = require('../Utilities/PolyfillFunctions');
+
+if (__DEV__) {
+  if (typeof global.Promise !== 'function') {
+    console.error('Promise should exist before setting up timers.');
+  }
+}
+
+// Currently, Hermes `Promise` is implemented via Internal Bytecode.
+const hasHermesPromiseQueuedToJSVM =
+  global?.HermesInternal?.hasPromise?.() &&
+  global?.HermesInternal?.useEngineQueue?.();
+
 // In bridgeless mode, timers are host functions installed from cpp.
 if (!global.RN$Bridgeless) {
-  const {polyfillGlobal} = require('../Utilities/PolyfillFunctions');
-
   /**
    * Set up timers.
    * You can use this module directly, or just require InitializeCore.
@@ -42,3 +53,18 @@ if (!global.RN$Bridgeless) {
     () => require('./Timers/JSTimers').clearReactNativeMicrotask,
   );
 }
+
+/**
+ * Set up the microtask queueing API, which is required to use the same
+ * microtask queue as the Promise.
+ */
+if (hasHermesPromiseQueuedToJSVM) {
+  // Fast path for Hermes.
+  polyfillGlobal('queueMicrotask', () => global.HermesInternal.enqueueJob);
+} else {
+  // Polyfill it with promise (regardless it's polyfiled or native) otherwise.
+  polyfillGlobal(
+    'queueMicrotask',
+    () => require('./Timers/queueMicrotask.js').default,
+  );
+}