diff --git a/Libraries/Components/AccessibilityInfo/AccessibilityInfo.js b/Libraries/Components/AccessibilityInfo/AccessibilityInfo.js
index 3933de41bc9d95..ed2c4a3644e1d2 100644
--- a/Libraries/Components/AccessibilityInfo/AccessibilityInfo.js
+++ b/Libraries/Components/AccessibilityInfo/AccessibilityInfo.js
@@ -19,6 +19,11 @@ import NativeAccessibilityManagerIOS from './NativeAccessibilityManager';
 import legacySendAccessibilityEvent from './legacySendAccessibilityEvent';
 import type {ElementRef} from 'react';
 
+// Events that are only supported on Android.
+type AccessibilityEventDefinitionsAndroid = {
+  accessibilityServiceChanged: [boolean],
+};
+
 // Events that are only supported on iOS.
 type AccessibilityEventDefinitionsIOS = {
   announcementFinished: [{announcement: string, success: boolean}],
@@ -29,6 +34,7 @@ type AccessibilityEventDefinitionsIOS = {
 };
 
 type AccessibilityEventDefinitions = {
+  ...AccessibilityEventDefinitionsAndroid,
   ...AccessibilityEventDefinitionsIOS,
   change: [boolean], // screenReaderChanged
   reduceMotionChanged: [boolean],
@@ -44,6 +50,7 @@ const EventNames: Map<$Keys<AccessibilityEventDefinitions>, string> =
         ['change', 'touchExplorationDidChange'],
         ['reduceMotionChanged', 'reduceMotionDidChange'],
         ['screenReaderChanged', 'touchExplorationDidChange'],
+        ['accessibilityServiceChanged', 'accessibilityServiceDidChange'],
       ])
     : new Map([
         ['announcementFinished', 'announcementFinished'],
@@ -224,6 +231,33 @@ const AccessibilityInfo = {
     });
   },
 
+  /**
+   * Query whether Accessibility Service is currently enabled.
+   *
+   * Returns a promise which resolves to a boolean.
+   * The result is `true` when any service is enabled and `false` otherwise.
+   *
+   * @platform android
+   *
+   * See https://reactnative.dev/docs/accessibilityinfo/#isaccessibilityserviceenabled-android
+   */
+  isAccessibilityServiceEnabled(): Promise<boolean> {
+    return new Promise((resolve, reject) => {
+      if (Platform.OS === 'android') {
+        if (
+          NativeAccessibilityInfoAndroid != null &&
+          NativeAccessibilityInfoAndroid.isAccessibilityServiceEnabled != null
+        ) {
+          NativeAccessibilityInfoAndroid.isAccessibilityServiceEnabled(resolve);
+        } else {
+          reject(null);
+        }
+      } else {
+        reject(null);
+      }
+    });
+  },
+
   /**
    * Add an event handler. Supported events:
    *
diff --git a/Libraries/Components/AccessibilityInfo/NativeAccessibilityInfo.js b/Libraries/Components/AccessibilityInfo/NativeAccessibilityInfo.js
index 916667aa5c2c0a..c9eecfde41ce53 100644
--- a/Libraries/Components/AccessibilityInfo/NativeAccessibilityInfo.js
+++ b/Libraries/Components/AccessibilityInfo/NativeAccessibilityInfo.js
@@ -18,6 +18,9 @@ export interface Spec extends TurboModule {
   +isTouchExplorationEnabled: (
     onSuccess: (isScreenReaderEnabled: boolean) => void,
   ) => void;
+  +isAccessibilityServiceEnabled?: ?(
+    onSuccess: (isAccessibilityServiceEnabled: boolean) => void,
+  ) => void;
   +setAccessibilityFocus: (reactTag: number) => void;
   +announceForAccessibility: (announcement: string) => void;
   +getRecommendedTimeoutMillis?: (
diff --git a/ReactAndroid/src/main/java/com/facebook/react/modules/accessibilityinfo/AccessibilityInfoModule.java b/ReactAndroid/src/main/java/com/facebook/react/modules/accessibilityinfo/AccessibilityInfoModule.java
index ad148228cd9bc0..b68412bcef7271 100644
--- a/ReactAndroid/src/main/java/com/facebook/react/modules/accessibilityinfo/AccessibilityInfoModule.java
+++ b/ReactAndroid/src/main/java/com/facebook/react/modules/accessibilityinfo/AccessibilityInfoModule.java
@@ -46,6 +46,19 @@ public void onTouchExplorationStateChanged(boolean enabled) {
     }
   }
 
+  // Android can listen for accessibility service enable with `accessibilityStateChange`, but
+  // `accessibilityState` conflicts with React Native props and confuses developers. Therefore, the
+  // name `accessibilityServiceChange` is used here instead.
+  @TargetApi(Build.VERSION_CODES.LOLLIPOP)
+  private class ReactAccessibilityServiceChangeListener
+      implements AccessibilityManager.AccessibilityStateChangeListener {
+
+    @Override
+    public void onAccessibilityStateChanged(boolean enabled) {
+      updateAndSendAccessibilityServiceChangeEvent(enabled);
+    }
+  }
+
   // Listener that is notified when the global TRANSITION_ANIMATION_SCALE.
   private final ContentObserver animationScaleObserver =
       new ContentObserver(new Handler(Looper.getMainLooper())) {
@@ -64,13 +77,16 @@ public void onChange(boolean selfChange, Uri uri) {
 
   private @Nullable AccessibilityManager mAccessibilityManager;
   private @Nullable ReactTouchExplorationStateChangeListener mTouchExplorationStateChangeListener;
+  private @Nullable ReactAccessibilityServiceChangeListener mAccessibilityServiceChangeListener;
   private final ContentResolver mContentResolver;
   private boolean mReduceMotionEnabled = false;
   private boolean mTouchExplorationEnabled = false;
+  private boolean mAccessibilityServiceEnabled = false;
   private int mRecommendedTimeout;
 
   private static final String REDUCE_MOTION_EVENT_NAME = "reduceMotionDidChange";
   private static final String TOUCH_EXPLORATION_EVENT_NAME = "touchExplorationDidChange";
+  private static final String ACCESSIBILITY_SERVICE_EVENT_NAME = "accessibilityServiceDidChange";
 
   public AccessibilityInfoModule(ReactApplicationContext context) {
     super(context);
@@ -79,8 +95,10 @@ public AccessibilityInfoModule(ReactApplicationContext context) {
         (AccessibilityManager) appContext.getSystemService(Context.ACCESSIBILITY_SERVICE);
     mContentResolver = getReactApplicationContext().getContentResolver();
     mTouchExplorationEnabled = mAccessibilityManager.isTouchExplorationEnabled();
+    mAccessibilityServiceEnabled = mAccessibilityManager.isEnabled();
     mReduceMotionEnabled = this.getIsReduceMotionEnabledValue();
     mTouchExplorationStateChangeListener = new ReactTouchExplorationStateChangeListener();
+    mAccessibilityServiceChangeListener = new ReactAccessibilityServiceChangeListener();
   }
 
   @Override
@@ -106,6 +124,11 @@ public void isTouchExplorationEnabled(Callback successCallback) {
     successCallback.invoke(mTouchExplorationEnabled);
   }
 
+  @Override
+  public void isAccessibilityServiceEnabled(Callback successCallback) {
+    successCallback.invoke(mAccessibilityServiceEnabled);
+  }
+
   private void updateAndSendReduceMotionChangeEvent() {
     boolean isReduceMotionEnabled = this.getIsReduceMotionEnabledValue();
 
@@ -134,16 +157,31 @@ private void updateAndSendTouchExplorationChangeEvent(boolean enabled) {
     }
   }
 
+  private void updateAndSendAccessibilityServiceChangeEvent(boolean enabled) {
+    if (mAccessibilityServiceEnabled != enabled) {
+      mAccessibilityServiceEnabled = enabled;
+
+      ReactApplicationContext reactApplicationContext = getReactApplicationContextIfActiveOrWarn();
+      if (reactApplicationContext != null) {
+        getReactApplicationContext()
+            .getJSModule(DeviceEventManagerModule.RCTDeviceEventEmitter.class)
+            .emit(ACCESSIBILITY_SERVICE_EVENT_NAME, mAccessibilityServiceEnabled);
+      }
+    }
+  }
+
   @Override
   @TargetApi(Build.VERSION_CODES.LOLLIPOP)
   public void onHostResume() {
     mAccessibilityManager.addTouchExplorationStateChangeListener(
         mTouchExplorationStateChangeListener);
+    mAccessibilityManager.addAccessibilityStateChangeListener(mAccessibilityServiceChangeListener);
 
     Uri transitionUri = Settings.Global.getUriFor(Settings.Global.TRANSITION_ANIMATION_SCALE);
     mContentResolver.registerContentObserver(transitionUri, false, animationScaleObserver);
 
     updateAndSendTouchExplorationChangeEvent(mAccessibilityManager.isTouchExplorationEnabled());
+    updateAndSendAccessibilityServiceChangeEvent(mAccessibilityManager.isEnabled());
     updateAndSendReduceMotionChangeEvent();
   }
 
@@ -152,6 +190,8 @@ public void onHostResume() {
   public void onHostPause() {
     mAccessibilityManager.removeTouchExplorationStateChangeListener(
         mTouchExplorationStateChangeListener);
+    mAccessibilityManager.removeAccessibilityStateChangeListener(
+        mAccessibilityServiceChangeListener);
 
     mContentResolver.unregisterContentObserver(animationScaleObserver);
   }
@@ -160,6 +200,7 @@ public void onHostPause() {
   public void initialize() {
     getReactApplicationContext().addLifecycleEventListener(this);
     updateAndSendTouchExplorationChangeEvent(mAccessibilityManager.isTouchExplorationEnabled());
+    updateAndSendAccessibilityServiceChangeEvent(mAccessibilityManager.isEnabled());
     updateAndSendReduceMotionChangeEvent();
   }
 
diff --git a/jest/setup.js b/jest/setup.js
index 778778859da0ce..8aed65f3b82feb 100644
--- a/jest/setup.js
+++ b/jest/setup.js
@@ -123,6 +123,7 @@ jest
     default: {
       addEventListener: jest.fn(),
       announceForAccessibility: jest.fn(),
+      isAccessibilityServiceEnabled: jest.fn(),
       isBoldTextEnabled: jest.fn(),
       isGrayscaleEnabled: jest.fn(),
       isInvertColorsEnabled: jest.fn(),
diff --git a/packages/rn-tester/js/examples/Accessibility/AccessibilityExample.js b/packages/rn-tester/js/examples/Accessibility/AccessibilityExample.js
index 6133080a4adfd0..95734b01d612a2 100644
--- a/packages/rn-tester/js/examples/Accessibility/AccessibilityExample.js
+++ b/packages/rn-tester/js/examples/Accessibility/AccessibilityExample.js
@@ -942,6 +942,19 @@ class EnabledExamples extends React.Component<{}> {
           </>
         ) : null}
 
+        {Platform.OS === 'android' ? (
+          <RNTesterBlock
+            title="isAccessibilityServiceEnabled()"
+            description={
+              'Event emitted whenever an accessibility service is enabled. This includes TalkBack as well as assistive technologies such as "Select to Speak".'
+            }>
+            <EnabledExample
+              test="any accessibility service"
+              eventListener="accessibilityServiceChanged"
+            />
+          </RNTesterBlock>
+        ) : null}
+
         <RNTesterBlock title="isReduceMotionEnabled()">
           <EnabledExample
             test="reduce motion"
@@ -969,7 +982,8 @@ class EnabledExample extends React.Component<
       | 'invertColorsChanged'
       | 'reduceTransparencyChanged'
       | 'reduceMotionChanged'
-      | 'screenReaderChanged',
+      | 'screenReaderChanged'
+      | 'accessibilityServiceChanged',
     test: string,
   },
   {
@@ -991,6 +1005,10 @@ class EnabledExample extends React.Component<
         return AccessibilityInfo.isReduceMotionEnabled().then(state => {
           this.setState({isEnabled: state});
         });
+      case 'accessibilityServiceChanged':
+        return AccessibilityInfo.isAccessibilityServiceEnabled().then(state => {
+          this.setState({isEnabled: state});
+        });
       default:
         return null;
     }