diff --git a/packages/react-dom-bindings/src/client/ReactDOMComponent.js b/packages/react-dom-bindings/src/client/ReactDOMComponent.js
index 037d787197c85..57689ca6145c7 100644
--- a/packages/react-dom-bindings/src/client/ReactDOMComponent.js
+++ b/packages/react-dom-bindings/src/client/ReactDOMComponent.js
@@ -74,6 +74,7 @@ import {
   enableCustomElementPropertySupport,
   enableClientRenderFallbackOnTextMismatch,
   enableHostSingletons,
+  disableIEWorkarounds,
 } from 'shared/ReactFeatureFlags';
 import {
   mediaEventTypes,
@@ -116,7 +117,8 @@ if (__DEV__) {
   // normalized. Since it only affects IE, we're skipping style warnings
   // in that browser completely in favor of doing all that work.
   // See https://github.com/facebook/react/issues/11807
-  canDiffStyleForHydrationWarning = canUseDOM && !document.documentMode;
+  canDiffStyleForHydrationWarning =
+    disableIEWorkarounds || (canUseDOM && !document.documentMode);
 }
 
 function validatePropertiesInDevelopment(type: string, props: any) {
@@ -308,7 +310,11 @@ function setInitialDOMProperties(
     } else if (propKey === DANGEROUSLY_SET_INNER_HTML) {
       const nextHtml = nextProp ? nextProp[HTML] : undefined;
       if (nextHtml != null) {
-        setInnerHTML(domElement, nextHtml);
+        if (disableIEWorkarounds) {
+          domElement.innerHTML = nextHtml;
+        } else {
+          setInnerHTML(domElement, nextHtml);
+        }
       }
     } else if (propKey === CHILDREN) {
       if (typeof nextProp === 'string') {
@@ -366,7 +372,11 @@ function updateDOMProperties(
     if (propKey === STYLE) {
       setValueForStyles(domElement, propValue);
     } else if (propKey === DANGEROUSLY_SET_INNER_HTML) {
-      setInnerHTML(domElement, propValue);
+      if (disableIEWorkarounds) {
+        domElement.innerHTML = propValue;
+      } else {
+        setInnerHTML(domElement, propValue);
+      }
     } else if (propKey === CHILDREN) {
       setTextContent(domElement, propValue);
     } else {
diff --git a/packages/react-dom/src/client/__tests__/dangerouslySetInnerHTML-test.js b/packages/react-dom/src/client/__tests__/dangerouslySetInnerHTML-test.js
index 25aece64a0734..71f9249a1e823 100644
--- a/packages/react-dom/src/client/__tests__/dangerouslySetInnerHTML-test.js
+++ b/packages/react-dom/src/client/__tests__/dangerouslySetInnerHTML-test.js
@@ -55,6 +55,7 @@ describe('dangerouslySetInnerHTML', () => {
       );
     });
 
+    // @gate !disableIEWorkarounds
     it('sets innerHTML on it', () => {
       const html = '<circle></circle>';
       const container = document.createElementNS(
@@ -69,6 +70,7 @@ describe('dangerouslySetInnerHTML', () => {
       expect(circle.tagName).toBe('circle');
     });
 
+    // @gate !disableIEWorkarounds
     it('clears previous children', () => {
       const firstHtml = '<rect></rect>';
       const secondHtml = '<circle></circle>';
diff --git a/packages/react-dom/src/client/__tests__/trustedTypes-test.internal.js b/packages/react-dom/src/client/__tests__/trustedTypes-test.internal.js
index 7483d15e7fcce..777ef41756ce4 100644
--- a/packages/react-dom/src/client/__tests__/trustedTypes-test.internal.js
+++ b/packages/react-dom/src/client/__tests__/trustedTypes-test.internal.js
@@ -208,6 +208,7 @@ describe('when Trusted Types are available in global object', () => {
       );
     });
 
+    // @gate !disableIEWorkarounds
     it('should log a warning', () => {
       class Component extends React.Component {
         render() {
diff --git a/packages/shared/ReactFeatureFlags.js b/packages/shared/ReactFeatureFlags.js
index 1bba854339b98..c0e3c2eac0ad9 100644
--- a/packages/shared/ReactFeatureFlags.js
+++ b/packages/shared/ReactFeatureFlags.js
@@ -169,6 +169,9 @@ export const enableTrustedTypesIntegration = false;
 // DOM properties
 export const disableInputAttributeSyncing = false;
 
+// Remove IE and MsApp specific workarounds for innerHTML
+export const disableIEWorkarounds = __EXPERIMENTAL__;
+
 // Filter certain DOM attributes (e.g. src, href) if their values are empty
 // strings. This prevents e.g. <img src=""> from making an unnecessary HTTP
 // request for certain browsers.
diff --git a/packages/shared/forks/ReactFeatureFlags.native-fb.js b/packages/shared/forks/ReactFeatureFlags.native-fb.js
index 7482b84e7cf96..19ec4fc39750a 100644
--- a/packages/shared/forks/ReactFeatureFlags.native-fb.js
+++ b/packages/shared/forks/ReactFeatureFlags.native-fb.js
@@ -36,6 +36,7 @@ export const debugRenderPhaseSideEffectsForStrictMode = true;
 export const disableJavaScriptURLs = false;
 export const disableCommentsAsDOMContainers = true;
 export const disableInputAttributeSyncing = false;
+export const disableIEWorkarounds = true;
 export const replayFailedUnitOfWorkWithInvokeGuardedCallback = __DEV__;
 export const enableScopeAPI = false;
 export const enableCreateEventHandleAPI = false;
diff --git a/packages/shared/forks/ReactFeatureFlags.native-oss.js b/packages/shared/forks/ReactFeatureFlags.native-oss.js
index 29259deed6ecc..2c4b7993a6c37 100644
--- a/packages/shared/forks/ReactFeatureFlags.native-oss.js
+++ b/packages/shared/forks/ReactFeatureFlags.native-oss.js
@@ -26,6 +26,7 @@ export const enableFetchInstrumentation = false;
 export const disableJavaScriptURLs = false;
 export const disableCommentsAsDOMContainers = true;
 export const disableInputAttributeSyncing = false;
+export const disableIEWorkarounds = true;
 export const enableSchedulerDebugging = false;
 export const enableScopeAPI = false;
 export const enableCreateEventHandleAPI = false;
diff --git a/packages/shared/forks/ReactFeatureFlags.test-renderer.js b/packages/shared/forks/ReactFeatureFlags.test-renderer.js
index 2e0079d5eccf8..1a1549a7d98e0 100644
--- a/packages/shared/forks/ReactFeatureFlags.test-renderer.js
+++ b/packages/shared/forks/ReactFeatureFlags.test-renderer.js
@@ -26,6 +26,7 @@ export const enableFetchInstrumentation = true;
 export const disableJavaScriptURLs = false;
 export const disableCommentsAsDOMContainers = true;
 export const disableInputAttributeSyncing = false;
+export const disableIEWorkarounds = true;
 export const enableSchedulerDebugging = false;
 export const enableScopeAPI = false;
 export const enableCreateEventHandleAPI = false;
diff --git a/packages/shared/forks/ReactFeatureFlags.test-renderer.native.js b/packages/shared/forks/ReactFeatureFlags.test-renderer.native.js
index 92f5a8ed4eda1..e6dabd338bb2b 100644
--- a/packages/shared/forks/ReactFeatureFlags.test-renderer.native.js
+++ b/packages/shared/forks/ReactFeatureFlags.test-renderer.native.js
@@ -26,6 +26,7 @@ export const enableFetchInstrumentation = false;
 export const disableJavaScriptURLs = false;
 export const disableCommentsAsDOMContainers = true;
 export const disableInputAttributeSyncing = false;
+export const disableIEWorkarounds = true;
 export const enableSchedulerDebugging = false;
 export const enableScopeAPI = false;
 export const enableCreateEventHandleAPI = false;
diff --git a/packages/shared/forks/ReactFeatureFlags.test-renderer.www.js b/packages/shared/forks/ReactFeatureFlags.test-renderer.www.js
index c3ccf711f766f..dbd8b2ff69f3a 100644
--- a/packages/shared/forks/ReactFeatureFlags.test-renderer.www.js
+++ b/packages/shared/forks/ReactFeatureFlags.test-renderer.www.js
@@ -27,6 +27,7 @@ export const enableSchedulerDebugging = false;
 export const disableJavaScriptURLs = false;
 export const disableCommentsAsDOMContainers = true;
 export const disableInputAttributeSyncing = false;
+export const disableIEWorkarounds = true;
 export const enableScopeAPI = true;
 export const enableCreateEventHandleAPI = false;
 export const enableSuspenseCallback = true;
diff --git a/packages/shared/forks/ReactFeatureFlags.www-dynamic.js b/packages/shared/forks/ReactFeatureFlags.www-dynamic.js
index c754e18430701..53a293dab56f4 100644
--- a/packages/shared/forks/ReactFeatureFlags.www-dynamic.js
+++ b/packages/shared/forks/ReactFeatureFlags.www-dynamic.js
@@ -14,6 +14,7 @@
 // with the __VARIANT__ set to `true`, and once set to `false`.
 
 export const disableInputAttributeSyncing = __VARIANT__;
+export const disableIEWorkarounds = __VARIANT__;
 export const enableFilterEmptyStringAttributesDOM = __VARIANT__;
 export const enableLegacyFBSupport = __VARIANT__;
 export const skipUnmountedBoundaries = __VARIANT__;
diff --git a/packages/shared/forks/ReactFeatureFlags.www.js b/packages/shared/forks/ReactFeatureFlags.www.js
index aa247e2c23b53..4150dc9c8e904 100644
--- a/packages/shared/forks/ReactFeatureFlags.www.js
+++ b/packages/shared/forks/ReactFeatureFlags.www.js
@@ -16,6 +16,7 @@ const dynamicFeatureFlags: DynamicFeatureFlags = require('ReactFeatureFlags');
 
 export const {
   disableInputAttributeSyncing,
+  disableIEWorkarounds,
   enableTrustedTypesIntegration,
   disableSchedulerTimeoutBasedOnReactExpirationTime,
   replayFailedUnitOfWorkWithInvokeGuardedCallback,