diff --git a/evm/src/executor/inspector/cheatcodes/env.rs b/evm/src/executor/inspector/cheatcodes/env.rs
index 058e4a63d18b..7c70f2910cbf 100644
--- a/evm/src/executor/inspector/cheatcodes/env.rs
+++ b/evm/src/executor/inspector/cheatcodes/env.rs
@@ -52,6 +52,33 @@ pub struct Prank {
     pub depth: u64,
     /// Whether the prank stops by itself after the next call
     pub single_call: bool,
+    /// Whether the prank has been used yet (false if unused)
+    pub used: bool,
+}
+
+impl Prank {
+    pub fn new(
+        prank_caller: Address,
+        prank_origin: Address,
+        new_caller: Address,
+        new_origin: Option<Address>,
+        depth: u64,
+        single_call: bool,
+    ) -> Prank {
+        Prank { prank_caller, prank_origin, new_caller, new_origin, depth, single_call, used: false }
+    }
+
+    /// Apply the prank by setting `used` to true iff it is false
+    pub fn apply(&self) -> Self {
+        if self.used {
+            self.clone()
+        } else {
+            Prank {
+                used: true,
+                ..self.clone()
+            }
+        }
+    }
 }
 
 /// Sets up broadcasting from a script using `origin` as the sender
@@ -118,7 +145,13 @@ fn prank(
     depth: u64,
     single_call: bool,
 ) -> Result<Bytes, Bytes> {
-    let prank = Prank { prank_caller, prank_origin, new_caller, new_origin, depth, single_call };
+    let prank = Prank::new(prank_caller, prank_origin, new_caller, new_origin, depth, single_call);
+
+    if let Some(Prank { used, ..}) = state.prank {
+        if !used {
+            return Err("You cannot overwrite `prank` until it is applied at least once".encode().into());
+        }
+    }
 
     if state.broadcast.is_some() {
         return Err("You cannot `prank` for a broadcasted transaction. Pass the desired tx.origin into the broadcast cheatcode call".encode().into());
diff --git a/evm/src/executor/inspector/cheatcodes/mod.rs b/evm/src/executor/inspector/cheatcodes/mod.rs
index 7d1d7d3158d0..ffbf0f2b519c 100644
--- a/evm/src/executor/inspector/cheatcodes/mod.rs
+++ b/evm/src/executor/inspector/cheatcodes/mod.rs
@@ -583,15 +583,22 @@ where
                 if data.journaled_state.depth() >= prank.depth &&
                     call.context.caller == prank.prank_caller
                 {
+                    let mut prank_applied = false;
                     // At the target depth we set `msg.sender`
                     if data.journaled_state.depth() == prank.depth {
                         call.context.caller = prank.new_caller;
                         call.transfer.source = prank.new_caller;
+                        prank_applied = true;
                     }
 
                     // At the target depth, or deeper, we set `tx.origin`
                     if let Some(new_origin) = prank.new_origin {
                         data.env.tx.caller = new_origin;
+                        prank_applied = true;
+                    }
+                    // If prank applied, then update the prank state accordingly
+                    if prank_applied {
+                        self.prank = Some(prank.apply());
                     }
                 }
             }