diff --git a/packages/node/src/sdk/index.ts b/packages/node/src/sdk/index.ts
index 746136c03022..4c30ba2bd2cf 100644
--- a/packages/node/src/sdk/index.ts
+++ b/packages/node/src/sdk/index.ts
@@ -130,7 +130,7 @@ function _init(
     }
   }
 
-  if (!isCjs()) {
+  if (!isCjs() && options.registerEsmLoaderHooks !== false) {
     maybeInitializeEsmLoader();
   }
 
diff --git a/packages/node/src/types.ts b/packages/node/src/types.ts
index 2c00302e2e64..882114a013f9 100644
--- a/packages/node/src/types.ts
+++ b/packages/node/src/types.ts
@@ -85,6 +85,16 @@ export interface BaseNodeOptions {
    */
   maxSpanWaitDuration?: number;
 
+  /**
+   * Whether to register ESM loader hooks to automatically instrument libraries.
+   * This is necessary to auto instrument libraries that are loaded via ESM imports, but might it can cause issues
+   * with certain libraries. If you run into problems running your app with this enabled,
+   * please raise an issue in https://github.com/getsentry/sentry-javascript.
+   *
+   * Defaults to `true`.
+   */
+  registerEsmLoaderHooks?: boolean;
+
   /** Callback that is executed when a fatal global error occurs. */
   onFatalError?(this: void, error: Error): void;
 }