diff --git a/packages/google-cloud-apigee-registry/setup.py b/packages/google-cloud-apigee-registry/setup.py
index 8cafa37397d8..d3a0e67c695f 100644
--- a/packages/google-cloud-apigee-registry/setup.py
+++ b/packages/google-cloud-apigee-registry/setup.py
@@ -24,9 +24,9 @@
 version = "0.3.1"
 release_status = "Development Status :: 4 - Beta"
 dependencies = [
-    "google-api-core[grpc] >= 1.33.1, <3.0.0dev,!=2.0.*,!=2.1.*,!=2.2.*,!=2.3.*,!=2.4.*,!=2.5.*,!=2.6.*,!=2.7.*",
+    "google-api-core[grpc] >= 1.33.2, <3.0.0dev,!=2.0.*,!=2.1.*,!=2.2.*,!=2.3.*,!=2.4.*,!=2.5.*,!=2.6.*,!=2.7.*",
     "proto-plus >= 1.22.0, <2.0.0dev",
-    "protobuf >= 3.20.2, <5.0.0dev",
+    "protobuf>=3.19.5,<5.0.0dev,!=3.20.0,!=3.20.1,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
     "grpc-google-iam-v1 >=0.12.4, <1.0.0dev",
 ]
 url = "https://github.com/googleapis/python-apigee-registry"
diff --git a/packages/google-cloud-apigee-registry/testing/constraints-3.7.txt b/packages/google-cloud-apigee-registry/testing/constraints-3.7.txt
index ea9ee0d44fa9..883a87aefd06 100644
--- a/packages/google-cloud-apigee-registry/testing/constraints-3.7.txt
+++ b/packages/google-cloud-apigee-registry/testing/constraints-3.7.txt
@@ -4,7 +4,7 @@
 # Pin the version to the lower bound.
 # e.g., if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0dev",
 # Then this file should have google-cloud-foo==1.14.0
-google-api-core==1.33.1
+google-api-core==1.33.2
 proto-plus==1.22.0
-protobuf==3.20.2
+protobuf==3.19.5
 grpc-google-iam-v1==0.12.4