diff --git a/setup.py b/setup.py
index 119ccb0af..abed852a8 100644
--- a/setup.py
+++ b/setup.py
@@ -45,7 +45,7 @@
     "protobuf>=3.19.5,<5.0.0dev,!=3.20.0,!=3.20.1,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",  # For the legacy proto-based types.
     "python-dateutil >= 2.7.2, <3.0dev",
     "pyarrow >= 3.0.0, < 10.0dev",
-    "requests >= 2.18.0, < 3.0.0dev",
+    "requests >= 2.21.0, < 3.0.0dev",
 ]
 extras = {
     # Keep the no-op bqstorage extra for backward compatibility.
diff --git a/testing/constraints-3.7.txt b/testing/constraints-3.7.txt
index ecce2c7cd..57928714f 100644
--- a/testing/constraints-3.7.txt
+++ b/testing/constraints-3.7.txt
@@ -22,7 +22,7 @@ proto-plus==1.22.0
 protobuf==3.19.5
 pyarrow==3.0.0
 python-dateutil==2.7.3
-requests==2.18.0
+requests==2.21.0
 Shapely==1.6.4.post2
 six==1.13.0
 tqdm==4.7.4