diff --git a/google/cloud/bigquery/_helpers.py b/google/cloud/bigquery/_helpers.py
index 4cf6dddac..905d4aee1 100644
--- a/google/cloud/bigquery/_helpers.py
+++ b/google/cloud/bigquery/_helpers.py
@@ -55,6 +55,9 @@
 _DEFAULT_HOST = "https://bigquery.googleapis.com"
 """Default host for JSON API."""
 
+_DEFAULT_UNIVERSE = "googleapis.com"
+"""Default universe for the JSON API."""
+
 
 def _get_bigquery_host():
     return os.environ.get(BIGQUERY_EMULATOR_HOST, _DEFAULT_HOST)
diff --git a/google/cloud/bigquery/client.py b/google/cloud/bigquery/client.py
index 182319646..b2ea130c4 100644
--- a/google/cloud/bigquery/client.py
+++ b/google/cloud/bigquery/client.py
@@ -78,6 +78,7 @@
 from google.cloud.bigquery._helpers import _verify_job_config_type
 from google.cloud.bigquery._helpers import _get_bigquery_host
 from google.cloud.bigquery._helpers import _DEFAULT_HOST
+from google.cloud.bigquery._helpers import _DEFAULT_UNIVERSE
 from google.cloud.bigquery._job_helpers import make_job_id as _make_job_id
 from google.cloud.bigquery.dataset import Dataset
 from google.cloud.bigquery.dataset import DatasetListItem
@@ -252,6 +253,14 @@ def __init__(
             if client_options.api_endpoint:
                 api_endpoint = client_options.api_endpoint
                 kw_args["api_endpoint"] = api_endpoint
+            elif (
+                hasattr(client_options, "universe_domain")
+                and client_options.universe_domain
+                and client_options.universe_domain is not _DEFAULT_UNIVERSE
+            ):
+                kw_args["api_endpoint"] = _DEFAULT_HOST.replace(
+                    _DEFAULT_UNIVERSE, client_options.universe_domain
+                )
 
         self._connection = Connection(self, **kw_args)
         self._location = location
diff --git a/tests/unit/test_client.py b/tests/unit/test_client.py
index ad22e0ddb..56bdbad5e 100644
--- a/tests/unit/test_client.py
+++ b/tests/unit/test_client.py
@@ -201,6 +201,23 @@ def test_ctor_w_client_options_object(self):
             client._connection.API_BASE_URL, "https://www.foo-googleapis.com"
         )
 
+    @pytest.mark.skipif(
+        packaging.version.parse(getattr(google.api_core, "__version__", "0.0.0"))
+        < packaging.version.Version("2.15.0"),
+        reason="universe_domain not supported with google-api-core < 2.15.0",
+    )
+    def test_ctor_w_client_options_universe(self):
+        creds = _make_credentials()
+        http = object()
+        client_options = {"universe_domain": "foo.com"}
+        client = self._make_one(
+            project=self.PROJECT,
+            credentials=creds,
+            _http=http,
+            client_options=client_options,
+        )
+        self.assertEqual(client._connection.API_BASE_URL, "https://bigquery.foo.com")
+
     def test_ctor_w_location(self):
         from google.cloud.bigquery._http import Connection