diff --git a/extensions/netty/runtime/src/main/java/io/quarkus/netty/runtime/graal/NettySubstitutions.java b/extensions/netty/runtime/src/main/java/io/quarkus/netty/runtime/graal/NettySubstitutions.java
index 37a79003cd594..ce7cd265223b3 100644
--- a/extensions/netty/runtime/src/main/java/io/quarkus/netty/runtime/graal/NettySubstitutions.java
+++ b/extensions/netty/runtime/src/main/java/io/quarkus/netty/runtime/graal/NettySubstitutions.java
@@ -1,5 +1,6 @@
 package io.quarkus.netty.runtime.graal;
 
+import static io.netty.handler.codec.http.HttpHeaderValues.BR;
 import static io.netty.handler.codec.http.HttpHeaderValues.DEFLATE;
 import static io.netty.handler.codec.http.HttpHeaderValues.GZIP;
 import static io.netty.handler.codec.http.HttpHeaderValues.X_DEFLATE;
@@ -43,13 +44,13 @@
 import io.netty.buffer.ByteBufAllocator;
 import io.netty.channel.Channel;
 import io.netty.channel.ChannelFuture;
-import io.netty.channel.ChannelHandler;
 import io.netty.channel.ChannelHandlerContext;
 import io.netty.channel.DefaultChannelPromise;
 import io.netty.channel.embedded.EmbeddedChannel;
+import io.netty.handler.codec.compression.Brotli;
+import io.netty.handler.codec.compression.BrotliDecoder;
 import io.netty.handler.codec.compression.ZlibCodecFactory;
 import io.netty.handler.codec.compression.ZlibWrapper;
-import io.netty.handler.codec.http.HttpHeaderValues;
 import io.netty.handler.codec.http2.Http2Exception;
 import io.netty.handler.ssl.ApplicationProtocolConfig;
 import io.netty.handler.ssl.ApplicationProtocolConfig.SelectorFailureBehavior;
@@ -518,6 +519,10 @@ protected EmbeddedChannel newContentDecoder(String contentEncoding) throws Excep
             return new EmbeddedChannel(ctx.channel().id(), ctx.channel().metadata().hasDisconnect(),
                     ctx.channel().config(), ZlibCodecFactory.newZlibDecoder(wrapper));
         }
+        if (Brotli.isAvailable() && BR.contentEqualsIgnoreCase(contentEncoding)) {
+            return new EmbeddedChannel(ctx.channel().id(), ctx.channel().metadata().hasDisconnect(),
+                    ctx.channel().config(), new BrotliDecoder());
+        }
 
         // 'identity' or unsupported
         return null;
@@ -533,21 +538,23 @@ final class Target_io_netty_handler_codec_http2_DelegatingDecompressorFrameListe
     @Substitute
     protected EmbeddedChannel newContentDecompressor(ChannelHandlerContext ctx, CharSequence contentEncoding)
             throws Http2Exception {
-        if (!HttpHeaderValues.GZIP.contentEqualsIgnoreCase(contentEncoding)
-                && !HttpHeaderValues.X_GZIP.contentEqualsIgnoreCase(contentEncoding)) {
-            if (!HttpHeaderValues.DEFLATE.contentEqualsIgnoreCase(contentEncoding)
-                    && !HttpHeaderValues.X_DEFLATE.contentEqualsIgnoreCase(contentEncoding)) {
-                return null;
-            } else {
-                ZlibWrapper wrapper = this.strict ? ZlibWrapper.ZLIB : ZlibWrapper.ZLIB_OR_NONE;
-                return new EmbeddedChannel(ctx.channel().id(), ctx.channel().metadata().hasDisconnect(),
-                        ctx.channel().config(),
-                        new ChannelHandler[] { ZlibCodecFactory.newZlibDecoder(wrapper) });
-            }
-        } else {
-            return new EmbeddedChannel(ctx.channel().id(), ctx.channel().metadata().hasDisconnect(), ctx.channel().config(),
-                    new ChannelHandler[] { ZlibCodecFactory.newZlibDecoder(ZlibWrapper.GZIP) });
+        if (GZIP.contentEqualsIgnoreCase(contentEncoding) || X_GZIP.contentEqualsIgnoreCase(contentEncoding)) {
+            return new EmbeddedChannel(ctx.channel().id(), ctx.channel().metadata().hasDisconnect(),
+                    ctx.channel().config(), ZlibCodecFactory.newZlibDecoder(ZlibWrapper.GZIP));
         }
+        if (DEFLATE.contentEqualsIgnoreCase(contentEncoding) || X_DEFLATE.contentEqualsIgnoreCase(contentEncoding)) {
+            final ZlibWrapper wrapper = strict ? ZlibWrapper.ZLIB : ZlibWrapper.ZLIB_OR_NONE;
+            // To be strict, 'deflate' means ZLIB, but some servers were not implemented correctly.
+            return new EmbeddedChannel(ctx.channel().id(), ctx.channel().metadata().hasDisconnect(),
+                    ctx.channel().config(), ZlibCodecFactory.newZlibDecoder(wrapper));
+        }
+        if (Brotli.isAvailable() && BR.contentEqualsIgnoreCase(contentEncoding)) {
+            return new EmbeddedChannel(ctx.channel().id(), ctx.channel().metadata().hasDisconnect(),
+                    ctx.channel().config(), new BrotliDecoder());
+        }
+
+        // 'identity' or unsupported
+        return null;
     }
 }