diff --git a/setup_LRGASP.sh b/setup_LRGASP.sh
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+++ b/setup_LRGASP.sh
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+# cd to your working directory, then:
+
+mkdir fastqs
+mkdir genomes
+cd genomes
+#download genomes
+cd genomes
+synapse get syn25683364  
+synapse get syn25683365
+zcat lrgasp_grch38_sirvs.fasta.gz >hg38.fa
+zcat lrgasp_grcm39_sirvs.fasta.gz > mm10.fa
+cd ..
+
+cd fastqs 
+# name fastqs according to sample_name values in sample_annotations_LRGASP.tsv
+
+cd ..
+
+# follow further instructions in https://github.com/julienlag/LyRic to install and execute LyRic
+