diff --git a/plugins/database/mysql/mysql.go b/plugins/database/mysql/mysql.go
index 297941c94b7c..87289274e0ee 100644
--- a/plugins/database/mysql/mysql.go
+++ b/plugins/database/mysql/mysql.go
@@ -5,7 +5,7 @@ import (
 	"strings"
 	"time"
 
-	_ "github.com/go-sql-driver/mysql"
+	stdmysql "github.com/go-sql-driver/mysql"
 	"github.com/hashicorp/vault/api"
 	"github.com/hashicorp/vault/builtin/logical/database/dbplugin"
 	"github.com/hashicorp/vault/helper/strutil"
@@ -140,13 +140,28 @@ func (m *MySQL) CreateUser(statements dbplugin.Statements, usernameConfig dbplug
 		if len(query) == 0 {
 			continue
 		}
-
-		stmt, err := tx.Prepare(dbutil.QueryHelper(query, map[string]string{
+		query = dbutil.QueryHelper(query, map[string]string{
 			"name":       username,
 			"password":   password,
 			"expiration": expirationStr,
-		}))
+		})
+
+		stmt, err := tx.Prepare(query)
 		if err != nil {
+			// If the error code we get back is Error 1295: This command is not
+			// supported in the prepared statement protocol yet, we will execute
+			// the statement without preparing it. This allows the caller to
+			// manually prepare statements, as well as run other not yet
+			// prepare supported commands. If there is no error when running we
+			// will continue to the next statement.
+			if e, ok := err.(*stdmysql.MySQLError); ok && e.Number == 1295 {
+				_, err = tx.Exec(query)
+				if err != nil {
+					return "", "", err
+				}
+				continue
+			}
+
 			return "", "", err
 		}
 		defer stmt.Close()
diff --git a/plugins/database/mysql/mysql_test.go b/plugins/database/mysql/mysql_test.go
index 851bd02da17c..203158b461a1 100644
--- a/plugins/database/mysql/mysql_test.go
+++ b/plugins/database/mysql/mysql_test.go
@@ -184,6 +184,19 @@ func TestMySQL_CreateUser(t *testing.T) {
 	if err := testCredsExist(t, connURL, username, password); err != nil {
 		t.Fatalf("Could not connect with new credentials: %s", err)
 	}
+
+	// Test with a manualy prepare statement
+	statements.CreationStatements = testMySQLRolePreparedStmt
+
+	username, password, err = db.CreateUser(statements, usernameConfig, time.Now().Add(time.Minute))
+	if err != nil {
+		t.Fatalf("err: %s", err)
+	}
+
+	if err := testCredsExist(t, connURL, username, password); err != nil {
+		t.Fatalf("Could not connect with new credentials: %s", err)
+	}
+
 }
 
 func TestMySQL_CreateUser_Legacy(t *testing.T) {
@@ -316,6 +329,13 @@ func testCredsExist(t testing.TB, connURL, username, password string) error {
 	return db.Ping()
 }
 
+const testMySQLRolePreparedStmt = `
+CREATE USER '{{name}}'@'%' IDENTIFIED BY '{{password}}';
+set @grants=CONCAT("GRANT SELECT ON ", "*", ".* TO '{{name}}'@'%'");
+PREPARE grantStmt from @grants;
+EXECUTE grantStmt;
+DEALLOCATE PREPARE grantStmt;
+`
 const testMySQLRoleWildCard = `
 CREATE USER '{{name}}'@'%' IDENTIFIED BY '{{password}}';
 GRANT SELECT ON *.* TO '{{name}}'@'%';