diff --git a/CMakeLists.txt b/CMakeLists.txt
index 98ceb7e3ab2a3..6814b5ff5907b 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -38,6 +38,7 @@ list(APPEND CMAKE_MODULE_PATH ${PROJECT_SOURCE_DIR}/cmake/module)
 # Configurable options.
 # When adding a new option, end the <help_text> with a full stop for consistency.
 include(CMakeDependentOption)
+option(ASM "Use assembly routines." ON)
 cmake_dependent_option(CXX20 "Enable compilation in C++20 mode." OFF "NOT MSVC" ON)
 
 if(CXX20)
@@ -110,6 +111,7 @@ else()
   message(" - LDFLAGS for executables ............ ${CMAKE_EXE_LINKER_FLAGS_RELEASE}")
   message(" - LDFLAGS for shared libraries ....... ${CMAKE_SHARED_LINKER_FLAGS_RELEASE}")
 endif()
+message("Use assembly routines ................. ${ASM}")
 message("\n")
 if(configure_warnings)
     message("  ******\n")
diff --git a/src/CMakeLists.txt b/src/CMakeLists.txt
index 72b989682b06d..8a77ed465e110 100644
--- a/src/CMakeLists.txt
+++ b/src/CMakeLists.txt
@@ -6,6 +6,7 @@ configure_file(${CMAKE_SOURCE_DIR}/cmake/bitcoin-config.h.in config/bitcoin-conf
 add_compile_definitions(HAVE_CONFIG_H)
 include_directories(${CMAKE_CURRENT_BINARY_DIR} ${CMAKE_CURRENT_SOURCE_DIR})
 
+add_subdirectory(crypto)
 add_subdirectory(univalue)
 
 
diff --git a/src/crypto/CMakeLists.txt b/src/crypto/CMakeLists.txt
new file mode 100644
index 0000000000000..dd4ed01c24e4a
--- /dev/null
+++ b/src/crypto/CMakeLists.txt
@@ -0,0 +1,107 @@
+# Copyright (c) 2023 The Bitcoin Core developers
+# Distributed under the MIT software license, see the accompanying
+# file COPYING or http://www.opensource.org/licenses/mit-license.php.
+
+if(ASM AND NOT MSVC)
+  # Check for SSE4.1 intrinsics.
+  set(SSE41_CXXFLAGS -msse4.1)
+  string(REPLACE ";" " " CMAKE_REQUIRED_FLAGS "${SSE41_CXXFLAGS}")
+  check_cxx_source_compiles("
+    #include <immintrin.h>
+
+    int main()
+    {
+      __m128i l = _mm_set1_epi32(0);
+      return _mm_extract_epi32(l, 3);
+    }
+    " HAVE_SSE41
+  )
+
+  # Check for AVX2 intrinsics.
+  set(AVX2_CXXFLAGS -mavx -mavx2)
+  string(REPLACE ";" " " CMAKE_REQUIRED_FLAGS "${AVX2_CXXFLAGS}")
+  check_cxx_source_compiles("
+    #include <immintrin.h>
+
+    int main()
+    {
+      __m256i l = _mm256_set1_epi32(0);
+      return _mm256_extract_epi32(l, 7);
+    }
+    " HAVE_AVX2
+  )
+
+  # Check for x86 SHA-NI intrinsics.
+  set(X86_SHANI_CXXFLAGS -msse4 -msha)
+  string(REPLACE ";" " " CMAKE_REQUIRED_FLAGS "${X86_SHANI_CXXFLAGS}")
+  check_cxx_source_compiles("
+    #include <immintrin.h>
+
+    int main()
+    {
+      __m128i i = _mm_set1_epi32(0);
+      __m128i j = _mm_set1_epi32(1);
+      __m128i k = _mm_set1_epi32(2);
+      return _mm_extract_epi32(_mm_sha256rnds2_epu32(i, i, k), 0);
+    }
+    " HAVE_X86_SHANI
+  )
+
+  # Check for ARMv8 SHA-NI intrinsics.
+  set(ARM_SHANI_CXXFLAGS -march=armv8-a+crypto)
+  string(REPLACE ";" " " CMAKE_REQUIRED_FLAGS "${ARM_SHANI_CXXFLAGS}")
+  check_cxx_source_compiles("
+    #include <arm_neon.h>
+
+    int main()
+    {
+      uint32x4_t a, b, c;
+      vsha256h2q_u32(a, b, c);
+      vsha256hq_u32(a, b, c);
+      vsha256su0q_u32(a, b);
+      vsha256su1q_u32(a, b, c);
+    }
+    " HAVE_ARM_SHANI
+  )
+
+  set(CMAKE_REQUIRED_FLAGS)
+endif()
+
+# The `bitcoin_crypto` must be of an `OBJECT` type to include
+# its object files into the output static library archives.
+add_library(bitcoin_crypto OBJECT EXCLUDE_FROM_ALL
+  $<$<BOOL:${ASM}>:sha256_sse4.cpp>
+  $<$<BOOL:${HAVE_SSE41}>:sha256_sse41.cpp>
+  $<$<BOOL:${HAVE_AVX2}>:sha256_avx2.cpp>
+  $<$<BOOL:${HAVE_X86_SHANI}>:sha256_x86_shani.cpp>
+  $<$<BOOL:${HAVE_ARM_SHANI}>:sha256_arm_shani.cpp>
+  aes.cpp
+  chacha_poly_aead.cpp
+  chacha20.cpp
+  hkdf_sha256_32.cpp
+  hmac_sha256.cpp
+  hmac_sha512.cpp
+  poly1305.cpp
+  muhash.cpp
+  ripemd160.cpp
+  sha1.cpp
+  sha256.cpp
+  sha3.cpp
+  sha512.cpp
+  siphash.cpp
+)
+target_compile_definitions(bitcoin_crypto
+  PRIVATE
+    $<$<BOOL:${ASM}>:USE_ASM>
+    $<$<BOOL:${HAVE_SSE41}>:ENABLE_SSE41>
+    $<$<BOOL:${HAVE_AVX2}>:ENABLE_AVX2>
+    $<$<BOOL:${HAVE_X86_SHANI}>:ENABLE_X86_SHANI>
+    $<$<BOOL:${HAVE_ARM_SHANI}>:ENABLE_ARM_SHANI>
+)
+target_compile_options(bitcoin_crypto
+  PRIVATE
+    $<$<BOOL:${HAVE_SSE41}>:${SSE41_CXXFLAGS}>
+    $<$<BOOL:${HAVE_AVX2}>:${AVX2_CXXFLAGS}>
+    $<$<BOOL:${HAVE_X86_SHANI}>:${X86_SHANI_CXXFLAGS}>
+    $<$<BOOL:${HAVE_ARM_SHANI}>:${ARM_SHANI_CXXFLAGS}>
+)