diff --git a/ibis/expr/operations/generic.py b/ibis/expr/operations/generic.py
index 19c96cbd44f8..fe4cb8afa64f 100644
--- a/ibis/expr/operations/generic.py
+++ b/ibis/expr/operations/generic.py
@@ -2,6 +2,7 @@
 import enum
 import functools
 import itertools
+import uuid
 
 import numpy as np
 import pandas as pd
@@ -247,6 +248,7 @@ class Literal(ValueOp):
                         str,
                         tuple,
                         type(None),
+                        uuid.UUID,
                     )
                 ),
                 rlz.is_computable_input,
diff --git a/ibis/tests/expr/test_value_exprs.py b/ibis/tests/expr/test_value_exprs.py
index de292e2da2dc..12ba8907bf80 100644
--- a/ibis/tests/expr/test_value_exprs.py
+++ b/ibis/tests/expr/test_value_exprs.py
@@ -1,6 +1,7 @@
 import functools
 import operator
 import os
+import uuid
 from collections import OrderedDict
 from datetime import date, datetime, time
 from operator import methodcaller
@@ -118,6 +119,8 @@ def test_literal_with_implicit_type(value, expected_type):
         (tuple(multipoint), 'multipoint'),
         (list(multipolygon1), 'multipolygon'),
         (tuple(multipolygon1), 'multipolygon'),
+        (uuid.uuid4(), 'uuid'),
+        (str(uuid.uuid4()), 'uuid'),
     ],
 )
 def test_literal_with_explicit_type(value, expected_type):