diff --git a/.changelog/unreleased/improvements/ibc-relayer-cli/3745-compat-0.50.md b/.changelog/unreleased/improvements/ibc-relayer-cli/3745-compat-0.50.md
new file mode 100644
index 0000000000..bc891fd71b
--- /dev/null
+++ b/.changelog/unreleased/improvements/ibc-relayer-cli/3745-compat-0.50.md
@@ -0,0 +1,2 @@
+- Update compatibility check to allow IBC-Go 4.1.1 to 8.x and SDK 0.45.x to 0.50.x.
+  ([\#3745](https://github.com/informalsystems/hermes/issues/3745))
diff --git a/crates/relayer/src/chain/cosmos/compatibility.rs b/crates/relayer/src/chain/cosmos/compatibility.rs
index f98b38865a..990fc0b60a 100644
--- a/crates/relayer/src/chain/cosmos/compatibility.rs
+++ b/crates/relayer/src/chain/cosmos/compatibility.rs
@@ -10,7 +10,7 @@ use super::version;
 /// # Note: Should be consistent with [features] guide page.
 ///
 /// [features]: https://hermes.informal.systems/advanced/features.html
-const SDK_MODULE_VERSION_REQ: &str = ">=0.44, <0.48";
+const SDK_MODULE_VERSION_REQ: &str = ">=0.45, <0.51";
 
 /// Specifies the IBC-go module version requirement.
 /// At the moment, we support both chains with and without
@@ -20,7 +20,7 @@ const SDK_MODULE_VERSION_REQ: &str = ">=0.44, <0.48";
 /// # Note: Should be consistent with [features] guide page.
 ///
 /// [features]: https://hermes.informal.systems/advanced/features.html
-const IBC_GO_MODULE_VERSION_REQ: &str = ">=1.1, <=7";
+const IBC_GO_MODULE_VERSION_REQ: &str = ">=4.1.1, <9";
 
 #[derive(Error, Debug)]
 pub enum Diagnostic {
diff --git a/guide/src/advanced/features.md b/guide/src/advanced/features.md
index 2f37930e9b..6af3001987 100644
--- a/guide/src/advanced/features.md
+++ b/guide/src/advanced/features.md
@@ -4,8 +4,8 @@ This section includes a summary of the supported and planned features. It also i
 
 > **Cosmos SDK & IBC compatibility:**
 > Hermes supports Cosmos SDK chains implementing the [IBC protocol v1][ibcv1-proto] protocol specification.
-> Cosmos SDK versions `0.44.0` through `0.47.x` are officially supported.
-> IBC-go versions `1.1.*` thorough `7.*` are officially supported.
+> Cosmos SDK versions `0.45.0` through `0.50.x` are officially supported.
+> IBC-go versions `4.1.1` through `8.x` are officially supported.
 > In case Hermes finds an incompatible SDK or IBC-go version, it will output a log warning upon initialization as part of the `start` command or upon `health-check` command.
 
 ---