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Multi-omics analysis of developing Rett Syndrome brain organoids

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Multi-Omics Characterization of Developing Forebrain Organoids Unravels the Dynamic Molecular Events of Rett Syndrome Pathogenesis

Background . Our Study · Software · Contact

This repository contains the scripts of the project "Multi-Omics Characterization of Developing Forebrain Organoids Unravels the Dynamic Molecular Events of Rett Syndrome Pathogenesis".


Background

Although MECP2 mutations are a well-known cause of Rett Syndrome (RTT), the molecular events contributing to its pathogenesis are still not fully elucidated.

Our Study

We analyzed the spatiotemporal gene and protein expression patterns in MeCP2-mutant (RTT) and isogenic control (IC) forebrain organoids. HiPSC-derived dorsal and ventral forebrain organoids were cultured and transcriptomics and proteomics profiles were characterized at days 0, 13, 40, and 75.

Software

  • R version 4.3.1.
  • RStudio version 2024.04.0+735

Contact

Feel free to contact us via email: jarno.koetsier@maastrichtuniversity.nl

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Multi-omics analysis of developing Rett Syndrome brain organoids

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