PPI-network.ipynb

{
 "cells": [
  {
   "cell_type": "code",
   "execution_count": 1,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "import numpy as np\n",
    "import pandas as pd\n",
    "import csv\n",
    "from collections import defaultdict"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# String data"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Build PPI network"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "nodes = []\n",
    "node1=[]\n",
    "node2=[]\n",
    "weights=[]\n",
    "with open('STRING-scores.txt','r') as f:\n",
    "    next(f)\n",
    "    reader=csv.reader(f,delimiter='\\t')\n",
    "    for n1, n2, w in reader:\n",
    "        node1.append(n1)\n",
    "        node2.append(n2)\n",
    "        weights.append(1/float(w)) # inverse confidence: shorter \"distance\" when more confident\n",
    "        \n",
    "        if n1 not in nodes:\n",
    "            nodes.append(n1)\n",
    "        if n2 not in nodes:\n",
    "            nodes.append(n2)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "class Edge:\n",
    "    def __init__(self, dest, weight):\n",
    "        self.dest = dest\n",
    "        self.weight = weight\n",
    "    def __repr__(self):\n",
    "        return self.dest + \": \" + str(self.weight)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "net = defaultdict(list)\n",
    "for i in range(len(node1)):\n",
    "    # add corresponding edge for both nodes\n",
    "    e1 = Edge(node2[i], weights[i])\n",
    "    net[node1[i]].append(e1)\n",
    "        \n",
    "    e2 = Edge(node1[i], weights[i])\n",
    "    net[node2[i]].append(e2)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "def printEdges(node):\n",
    "    for e in node:\n",
    "        print(e.dest + ': ' + str(e.weight))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "ATR: 1.2150668286755772\n",
      "CMPK1: 1.0775862068965516\n"
     ]
    }
   ],
   "source": [
    "printEdges(net['RRM1'])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "ATR\n",
      "CMPK1\n"
     ]
    }
   ],
   "source": [
    "for edge in net['RRM1']:\n",
    "    dest = edge.dest\n",
    "    print(dest)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Path search for interaction scores"
   ]
  },
  {
   "cell_type": "raw",
   "metadata": {},
   "source": [
    " 1 function Dijkstra(Graph, source):\n",
    " 2\n",
    " 3      create vertex set Q\n",
    " 4\n",
    " 5      for each vertex v in Graph:             // Initialization\n",
    " 6          dist[v] ← INFINITY                  // Unknown distance from source to v\n",
    " 7          prev[v] ← UNDEFINED                 // Previous node in optimal path from source\n",
    " 8          add v to Q                          // All nodes initially in Q (unvisited nodes)\n",
    " 9\n",
    "10      dist[source] ← 0                        // Distance from source to source\n",
    "11      \n",
    "12      while Q is not empty:\n",
    "13          u ← vertex in Q with min dist[u]    // Source node will be selected first\n",
    "14          remove u from Q \n",
    "15          \n",
    "16          for each neighbor v of u:           // where v is still in Q.\n",
    "17              alt ← dist[u] + length(u, v)\n",
    "18              if alt < dist[v]:               // A shorter path to v has been found\n",
    "19                  dist[v] ← alt \n",
    "20                  prev[v] ← u \n",
    "21\n",
    "22      return dist[], prev[]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 8,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "def dijkstra(graph, source):\n",
    "    Q = []                # unvisited nodes\n",
    "    dist = {}\n",
    "    prev = {}             # only necessary for tracking paths - not used so far\n",
    "    \n",
    "    for node in graph:\n",
    "        dist[node] = float('inf')\n",
    "        prev[node] = None\n",
    "        Q.append(node)\n",
    "        \n",
    "    dist[source] = 0      # distance from source to itself is 0\n",
    "    \n",
    "    while len(Q) > 0:\n",
    "        current = Q[0]\n",
    "        for node in Q:\n",
    "            if dist[node] < dist[current]:\n",
    "                current = node                # select node with shortest distance; source will be first\n",
    "        Q.remove(current)\n",
    "        \n",
    "        for edge in graph[current]:\n",
    "            dest = edge.dest\n",
    "            \n",
    "            alt = dist[current] + edge.weight  # new weight: total so far + edge weight\n",
    "            if alt < dist[dest]:               # if new weight < old weight to this neighbor\n",
    "                dist[dest] = alt\n",
    "                prev[dest] = current\n",
    "                \n",
    "    return dist"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "{'ATM': 1.001001001001001, 'WNT1': 3.3360230758465317, 'IGF1R': 2.147789991826689, 'AR': 2.330665896905453, 'MAP2': 3.3630150822917035, 'AKT3': 2.443967836321961, 'CSNK2A1': 2.192896114231037, 'SGK1': 3.0535305936544406, 'CHEK1': 1.001001001001001, 'BIRC5': 3.060014031173013, 'CHUK': 2.284698048497792, 'EGFR': 3.018262164603628, 'TUBB': 3.4897005069187115, 'PIM1': 3.1760097151669378, 'WEE1': 1.2836970474967908, 'XIAP': 2.370864014699631, 'PIP5K1A': 3.4607894730179183, 'PDGFRA': 3.426900970708982, 'FASN': 3.1713913650801575, 'BRAF': 3.1271390770321497, 'PARP1': 2.056967210082311, 'FLT1': 1.3605442176870748, 'FLT4': 2.3355739870266685, 'ATR': 0, 'ADAM17': 3.603159421175263, 'SRC': 2.3202622147213177, 'BIRC3': 3.1892502938301757, 'KIF11': 1.3315579227696406, 'PTK2': 2.374743000648535, 'MAP2K1': 3.2625911760559267, 'HDAC3': 2.35836106260776, 'TNFSF10': 3.3764011052663507, 'MET': 3.312597951167394, 'ALK': 3.474967769826384, 'TYMS': 3.771670187562222, 'RET': 3.3586838138905803, 'PIK3CD': 2.523453035999676, 'DNMT1': 2.173333943556687, 'MAPT': 3.1002626286329176, 'CMPK1': 2.292653035572129, 'UBA3': 3.415872791420804, 'TNF': 2.457684048895767, 'BIRC2': 3.1749166129050796, 'JAK2': 3.0676813316698537, 'HDAC1': 1.3123359580052494, 'IKBKB': 3.0397560511281894, 'TOP2A': 2.4846689005609353, 'BCL2': 2.4134303795320746, 'PAWR': 3.260100470182705, 'RRM1': 1.2150668286755772, 'PIK3CB': 2.424374004921117, 'MTOR': 2.262035048920295, 'FGFR2': 3.48462862548837, 'FNTA': inf, 'SYK': 3.334460997682778, 'JAK1': 3.133332592174056, 'AKT1': 2.0891402828290753, 'PRKDC': 2.0060261266291417, 'FNTB': inf, 'VEGFC': 2.332558923770642, 'FGFR4': 3.5625712238936433, 'TEK': 3.4326689347717423, 'HSP90AA1': 2.017261163602627, 'IGF2R': 3.294410176740543, 'CD19': 3.169053889740522, 'MAP4': 4.581343790700235, 'ESR1': 2.3133369590062505, 'FGFR1': 3.48462862548837, 'PIK3CA': 2.3808758661064715, 'FGFR3': 3.0765831975009323, 'RAF1': 3.018262164603628, 'AKT2': 2.3167904746852117, 'KDR': 1.3315579227696406, 'MAP2K2': 3.34704839764518, 'TOP1': 2.204370435417367, 'NAE1': 4.416873792421805}\n"
     ]
    }
   ],
   "source": [
    "print(dijkstra(net, 'ATR'))"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Building interaction matrix"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "ppi_mat = pd.DataFrame(columns=nodes, index=nodes)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "metadata": {
    "collapsed": false,
    "scrolled": true
   },
   "outputs": [],
   "source": [
    "for node in nodes:\n",
    "    dist = dijkstra(net, node)\n",
    "    for prot, score in dist.items():\n",
    "        if score == 0:\n",
    "            score = 1\n",
    "        ppi_mat.set_value(prot, node, 1/score)     # inverse score: the higher confidence/fewer steps it takes to get\n",
    "                                                   # from target A to target B, the higher the score"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 12,
   "metadata": {
    "collapsed": false,
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>ATR</th>\n",
       "      <th>RRM1</th>\n",
       "      <th>BCL2</th>\n",
       "      <th>ATM</th>\n",
       "      <th>SRC</th>\n",
       "      <th>PIK3CB</th>\n",
       "      <th>AKT2</th>\n",
       "      <th>HSP90AA1</th>\n",
       "      <th>ALK</th>\n",
       "      <th>JAK2</th>\n",
       "      <th>...</th>\n",
       "      <th>FGFR4</th>\n",
       "      <th>BRAF</th>\n",
       "      <th>PAWR</th>\n",
       "      <th>PIM1</th>\n",
       "      <th>FNTA</th>\n",
       "      <th>FNTB</th>\n",
       "      <th>TYMS</th>\n",
       "      <th>MAP2</th>\n",
       "      <th>ADAM17</th>\n",
       "      <th>CMPK1</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>ATR</th>\n",
       "      <td>1</td>\n",
       "      <td>0.823</td>\n",
       "      <td>0.414348</td>\n",
       "      <td>0.999</td>\n",
       "      <td>0.4309858</td>\n",
       "      <td>0.4124776</td>\n",
       "      <td>0.4316316</td>\n",
       "      <td>0.4957216</td>\n",
       "      <td>0.2877725</td>\n",
       "      <td>0.3259791</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2806961</td>\n",
       "      <td>0.3197811</td>\n",
       "      <td>0.306739</td>\n",
       "      <td>0.3148605</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2651345</td>\n",
       "      <td>0.2973522</td>\n",
       "      <td>0.2775342</td>\n",
       "      <td>0.4361759</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>RRM1</th>\n",
       "      <td>0.823</td>\n",
       "      <td>1</td>\n",
       "      <td>0.2755962</td>\n",
       "      <td>0.4512497</td>\n",
       "      <td>0.2828591</td>\n",
       "      <td>0.2747675</td>\n",
       "      <td>0.2831371</td>\n",
       "      <td>0.3093745</td>\n",
       "      <td>0.213218</td>\n",
       "      <td>0.2334949</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2093084</td>\n",
       "      <td>0.2302977</td>\n",
       "      <td>0.2234553</td>\n",
       "      <td>0.2277346</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2005319</td>\n",
       "      <td>0.2184321</td>\n",
       "      <td>0.2075453</td>\n",
       "      <td>0.928</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BCL2</th>\n",
       "      <td>0.414348</td>\n",
       "      <td>0.2755962</td>\n",
       "      <td>1</td>\n",
       "      <td>0.708</td>\n",
       "      <td>0.765</td>\n",
       "      <td>0.4972438</td>\n",
       "      <td>0.917</td>\n",
       "      <td>0.986</td>\n",
       "      <td>0.322883</td>\n",
       "      <td>0.93</td>\n",
       "      <td>...</td>\n",
       "      <td>0.4167356</td>\n",
       "      <td>0.4995</td>\n",
       "      <td>0.4602009</td>\n",
       "      <td>0.4602044</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2603794</td>\n",
       "      <td>0.4255423</td>\n",
       "      <td>0.4549369</td>\n",
       "      <td>0.2124909</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ATM</th>\n",
       "      <td>0.999</td>\n",
       "      <td>0.4512497</td>\n",
       "      <td>0.708</td>\n",
       "      <td>1</td>\n",
       "      <td>0.758</td>\n",
       "      <td>0.453747</td>\n",
       "      <td>0.4659539</td>\n",
       "      <td>0.4957216</td>\n",
       "      <td>0.3070177</td>\n",
       "      <td>0.4253052</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2934506</td>\n",
       "      <td>0.3197811</td>\n",
       "      <td>0.306739</td>\n",
       "      <td>0.3148605</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2863381</td>\n",
       "      <td>0.4233675</td>\n",
       "      <td>0.3184437</td>\n",
       "      <td>0.3036142</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SRC</th>\n",
       "      <td>0.4309858</td>\n",
       "      <td>0.2828591</td>\n",
       "      <td>0.765</td>\n",
       "      <td>0.758</td>\n",
       "      <td>1</td>\n",
       "      <td>0.963</td>\n",
       "      <td>0.4967398</td>\n",
       "      <td>0.998</td>\n",
       "      <td>0.4743179</td>\n",
       "      <td>0.969</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3093086</td>\n",
       "      <td>0.4873687</td>\n",
       "      <td>0.4587068</td>\n",
       "      <td>0.4628017</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2679605</td>\n",
       "      <td>0.959</td>\n",
       "      <td>0.4982469</td>\n",
       "      <td>0.2167827</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PIK3CB</th>\n",
       "      <td>0.4124776</td>\n",
       "      <td>0.2747675</td>\n",
       "      <td>0.4972438</td>\n",
       "      <td>0.453747</td>\n",
       "      <td>0.963</td>\n",
       "      <td>1</td>\n",
       "      <td>0.981</td>\n",
       "      <td>0.497492</td>\n",
       "      <td>0.836</td>\n",
       "      <td>0.908</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3025751</td>\n",
       "      <td>0.4873687</td>\n",
       "      <td>0.4587068</td>\n",
       "      <td>0.3155738</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2223511</td>\n",
       "      <td>0.4804979</td>\n",
       "      <td>0.491694</td>\n",
       "      <td>0.2119979</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>AKT2</th>\n",
       "      <td>0.4316316</td>\n",
       "      <td>0.2831371</td>\n",
       "      <td>0.917</td>\n",
       "      <td>0.4659539</td>\n",
       "      <td>0.4967398</td>\n",
       "      <td>0.981</td>\n",
       "      <td>1</td>\n",
       "      <td>0.989</td>\n",
       "      <td>0.4752416</td>\n",
       "      <td>0.4884135</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3002439</td>\n",
       "      <td>0.4784979</td>\n",
       "      <td>0.4508402</td>\n",
       "      <td>0.4608569</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.230385</td>\n",
       "      <td>0.3272381</td>\n",
       "      <td>0.3900285</td>\n",
       "      <td>0.2169459</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>HSP90AA1</th>\n",
       "      <td>0.4957216</td>\n",
       "      <td>0.3093745</td>\n",
       "      <td>0.986</td>\n",
       "      <td>0.4957216</td>\n",
       "      <td>0.998</td>\n",
       "      <td>0.497492</td>\n",
       "      <td>0.989</td>\n",
       "      <td>1</td>\n",
       "      <td>0.3229876</td>\n",
       "      <td>0.952</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3090198</td>\n",
       "      <td>0.901</td>\n",
       "      <td>0.4604134</td>\n",
       "      <td>0.863</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3003509</td>\n",
       "      <td>0.4890557</td>\n",
       "      <td>0.4982469</td>\n",
       "      <td>0.2320232</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ALK</th>\n",
       "      <td>0.2877725</td>\n",
       "      <td>0.213218</td>\n",
       "      <td>0.322883</td>\n",
       "      <td>0.3070177</td>\n",
       "      <td>0.4743179</td>\n",
       "      <td>0.836</td>\n",
       "      <td>0.4752416</td>\n",
       "      <td>0.3229876</td>\n",
       "      <td>1</td>\n",
       "      <td>0.4691672</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2928586</td>\n",
       "      <td>0.3201127</td>\n",
       "      <td>0.30618</td>\n",
       "      <td>0.2958294</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.1797098</td>\n",
       "      <td>0.3173552</td>\n",
       "      <td>0.3213085</td>\n",
       "      <td>0.1733817</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>JAK2</th>\n",
       "      <td>0.3259791</td>\n",
       "      <td>0.2334949</td>\n",
       "      <td>0.93</td>\n",
       "      <td>0.4253052</td>\n",
       "      <td>0.969</td>\n",
       "      <td>0.908</td>\n",
       "      <td>0.4884135</td>\n",
       "      <td>0.952</td>\n",
       "      <td>0.4691672</td>\n",
       "      <td>1</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2978079</td>\n",
       "      <td>0.4664488</td>\n",
       "      <td>0.3115939</td>\n",
       "      <td>0.452659</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2283178</td>\n",
       "      <td>0.481987</td>\n",
       "      <td>0.4734331</td>\n",
       "      <td>0.1865555</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PIK3CD</th>\n",
       "      <td>0.3962824</td>\n",
       "      <td>0.2674855</td>\n",
       "      <td>0.4954753</td>\n",
       "      <td>0.4528247</td>\n",
       "      <td>0.965</td>\n",
       "      <td>0.4937438</td>\n",
       "      <td>0.977</td>\n",
       "      <td>0.4957216</td>\n",
       "      <td>0.822</td>\n",
       "      <td>0.912</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3009772</td>\n",
       "      <td>0.4856696</td>\n",
       "      <td>0.4572013</td>\n",
       "      <td>0.3148605</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2194619</td>\n",
       "      <td>0.4809953</td>\n",
       "      <td>0.4777847</td>\n",
       "      <td>0.2076366</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>CHEK1</th>\n",
       "      <td>0.999</td>\n",
       "      <td>0.4512497</td>\n",
       "      <td>0.4924995</td>\n",
       "      <td>0.999</td>\n",
       "      <td>0.4954753</td>\n",
       "      <td>0.4768215</td>\n",
       "      <td>0.76</td>\n",
       "      <td>0.984</td>\n",
       "      <td>0.3141461</td>\n",
       "      <td>0.4838678</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2351669</td>\n",
       "      <td>0.4703363</td>\n",
       "      <td>0.4426543</td>\n",
       "      <td>0.4597683</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2843075</td>\n",
       "      <td>0.3266888</td>\n",
       "      <td>0.3307647</td>\n",
       "      <td>0.3036142</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>CHUK</th>\n",
       "      <td>0.4376946</td>\n",
       "      <td>0.2857335</td>\n",
       "      <td>0.788</td>\n",
       "      <td>0.4376946</td>\n",
       "      <td>0.832</td>\n",
       "      <td>0.497492</td>\n",
       "      <td>0.973</td>\n",
       "      <td>0.986</td>\n",
       "      <td>0.3229876</td>\n",
       "      <td>0.4843509</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2725807</td>\n",
       "      <td>0.4892957</td>\n",
       "      <td>0.4604134</td>\n",
       "      <td>0.4602044</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2302218</td>\n",
       "      <td>0.4454986</td>\n",
       "      <td>0.3894156</td>\n",
       "      <td>0.218467</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PTK2</th>\n",
       "      <td>0.4210982</td>\n",
       "      <td>0.2785663</td>\n",
       "      <td>0.91</td>\n",
       "      <td>0.452362</td>\n",
       "      <td>0.999</td>\n",
       "      <td>0.853</td>\n",
       "      <td>0.4904587</td>\n",
       "      <td>0.4992499</td>\n",
       "      <td>0.4710541</td>\n",
       "      <td>0.872</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3071882</td>\n",
       "      <td>0.3275643</td>\n",
       "      <td>0.3143623</td>\n",
       "      <td>0.3162802</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2225074</td>\n",
       "      <td>0.4892957</td>\n",
       "      <td>0.4924589</td>\n",
       "      <td>0.2142522</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PDGFRA</th>\n",
       "      <td>0.2918088</td>\n",
       "      <td>0.2154259</td>\n",
       "      <td>0.4792436</td>\n",
       "      <td>0.3979975</td>\n",
       "      <td>0.838</td>\n",
       "      <td>0.85</td>\n",
       "      <td>0.4863515</td>\n",
       "      <td>0.4639139</td>\n",
       "      <td>0.4672642</td>\n",
       "      <td>0.4799917</td>\n",
       "      <td>...</td>\n",
       "      <td>0.4119266</td>\n",
       "      <td>0.3251152</td>\n",
       "      <td>0.3107533</td>\n",
       "      <td>0.3017209</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2055776</td>\n",
       "      <td>0.4472131</td>\n",
       "      <td>0.4165389</td>\n",
       "      <td>0.1748388</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>HDAC3</th>\n",
       "      <td>0.4240233</td>\n",
       "      <td>0.2798433</td>\n",
       "      <td>0.4559337</td>\n",
       "      <td>0.4390679</td>\n",
       "      <td>0.881</td>\n",
       "      <td>0.4600884</td>\n",
       "      <td>0.4359192</td>\n",
       "      <td>0.761</td>\n",
       "      <td>0.3083218</td>\n",
       "      <td>0.4614535</td>\n",
       "      <td>...</td>\n",
       "      <td>0.228933</td>\n",
       "      <td>0.4367507</td>\n",
       "      <td>0.4135918</td>\n",
       "      <td>0.4149849</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2983189</td>\n",
       "      <td>0.4591734</td>\n",
       "      <td>0.3182574</td>\n",
       "      <td>0.2150069</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>WEE1</th>\n",
       "      <td>0.779</td>\n",
       "      <td>0.4001979</td>\n",
       "      <td>0.4959819</td>\n",
       "      <td>0.753</td>\n",
       "      <td>0.499</td>\n",
       "      <td>0.4813576</td>\n",
       "      <td>0.4967398</td>\n",
       "      <td>0.998</td>\n",
       "      <td>0.3161087</td>\n",
       "      <td>0.4872287</td>\n",
       "      <td>...</td>\n",
       "      <td>0.235958</td>\n",
       "      <td>0.4736802</td>\n",
       "      <td>0.4465609</td>\n",
       "      <td>0.4628017</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2881099</td>\n",
       "      <td>0.3282174</td>\n",
       "      <td>0.3323318</td>\n",
       "      <td>0.2796147</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>KIF11</th>\n",
       "      <td>0.751</td>\n",
       "      <td>0.3926766</td>\n",
       "      <td>0.3025844</td>\n",
       "      <td>0.4287137</td>\n",
       "      <td>0.3037051</td>\n",
       "      <td>0.2970782</td>\n",
       "      <td>0.3028664</td>\n",
       "      <td>0.4365547</td>\n",
       "      <td>0.2246117</td>\n",
       "      <td>0.2993041</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2043264</td>\n",
       "      <td>0.2941359</td>\n",
       "      <td>0.283447</td>\n",
       "      <td>0.2899045</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2101035</td>\n",
       "      <td>0.2306581</td>\n",
       "      <td>0.2326825</td>\n",
       "      <td>0.2759221</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>AKT1</th>\n",
       "      <td>0.4786658</td>\n",
       "      <td>0.3026445</td>\n",
       "      <td>0.998</td>\n",
       "      <td>0.4786658</td>\n",
       "      <td>0.991</td>\n",
       "      <td>0.991</td>\n",
       "      <td>0.955</td>\n",
       "      <td>0.999</td>\n",
       "      <td>0.4773058</td>\n",
       "      <td>0.490594</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3010665</td>\n",
       "      <td>0.959</td>\n",
       "      <td>0.854</td>\n",
       "      <td>0.4630166</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2309234</td>\n",
       "      <td>0.4873687</td>\n",
       "      <td>0.4512352</td>\n",
       "      <td>0.2282171</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ESR1</th>\n",
       "      <td>0.432276</td>\n",
       "      <td>0.2834143</td>\n",
       "      <td>0.757</td>\n",
       "      <td>0.4655949</td>\n",
       "      <td>0.999</td>\n",
       "      <td>0.4972438</td>\n",
       "      <td>0.899</td>\n",
       "      <td>0.999</td>\n",
       "      <td>0.4752416</td>\n",
       "      <td>0.4918857</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3065659</td>\n",
       "      <td>0.4890557</td>\n",
       "      <td>0.4602009</td>\n",
       "      <td>0.4630166</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2889893</td>\n",
       "      <td>0.4892957</td>\n",
       "      <td>0.4977489</td>\n",
       "      <td>0.2171086</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PIK3CA</th>\n",
       "      <td>0.4200135</td>\n",
       "      <td>0.2780912</td>\n",
       "      <td>0.4992499</td>\n",
       "      <td>0.4623103</td>\n",
       "      <td>0.986</td>\n",
       "      <td>0.909</td>\n",
       "      <td>0.99</td>\n",
       "      <td>0.4995</td>\n",
       "      <td>0.914</td>\n",
       "      <td>0.964</td>\n",
       "      <td>...</td>\n",
       "      <td>0.430937</td>\n",
       "      <td>0.4926575</td>\n",
       "      <td>0.4604134</td>\n",
       "      <td>0.4374003</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2236918</td>\n",
       "      <td>0.4861563</td>\n",
       "      <td>0.4954955</td>\n",
       "      <td>0.2139711</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGFR</th>\n",
       "      <td>0.3313165</td>\n",
       "      <td>0.2362207</td>\n",
       "      <td>0.827</td>\n",
       "      <td>0.4685517</td>\n",
       "      <td>0.999</td>\n",
       "      <td>0.973</td>\n",
       "      <td>0.4969874</td>\n",
       "      <td>0.999</td>\n",
       "      <td>0.4747802</td>\n",
       "      <td>0.904</td>\n",
       "      <td>...</td>\n",
       "      <td>0.4246516</td>\n",
       "      <td>0.4737363</td>\n",
       "      <td>0.3151629</td>\n",
       "      <td>0.4630166</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2882141</td>\n",
       "      <td>0.4892957</td>\n",
       "      <td>0.994</td>\n",
       "      <td>0.1882915</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>IGF2R</th>\n",
       "      <td>0.3035445</td>\n",
       "      <td>0.2217552</td>\n",
       "      <td>0.31489</td>\n",
       "      <td>0.415587</td>\n",
       "      <td>0.4357977</td>\n",
       "      <td>0.4316805</td>\n",
       "      <td>0.3104791</td>\n",
       "      <td>0.4364073</td>\n",
       "      <td>0.2967537</td>\n",
       "      <td>0.3018366</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2840598</td>\n",
       "      <td>0.3109007</td>\n",
       "      <td>0.2989833</td>\n",
       "      <td>0.2898394</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2182733</td>\n",
       "      <td>0.2996349</td>\n",
       "      <td>0.2944031</td>\n",
       "      <td>0.1789849</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>IGF1R</th>\n",
       "      <td>0.4655949</td>\n",
       "      <td>0.2973662</td>\n",
       "      <td>0.488713</td>\n",
       "      <td>0.872</td>\n",
       "      <td>0.966</td>\n",
       "      <td>0.946</td>\n",
       "      <td>0.4934954</td>\n",
       "      <td>0.969</td>\n",
       "      <td>0.4738546</td>\n",
       "      <td>0.4869487</td>\n",
       "      <td>...</td>\n",
       "      <td>0.4422939</td>\n",
       "      <td>0.4797487</td>\n",
       "      <td>0.3150633</td>\n",
       "      <td>0.4564667</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2292826</td>\n",
       "      <td>0.4812436</td>\n",
       "      <td>0.4678892</td>\n",
       "      <td>0.2252028</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>IKBKB</th>\n",
       "      <td>0.3289738</td>\n",
       "      <td>0.2350274</td>\n",
       "      <td>0.79</td>\n",
       "      <td>0.4202199</td>\n",
       "      <td>0.943</td>\n",
       "      <td>0.4967469</td>\n",
       "      <td>0.816</td>\n",
       "      <td>0.978</td>\n",
       "      <td>0.3226734</td>\n",
       "      <td>0.4824124</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2728196</td>\n",
       "      <td>0.4885749</td>\n",
       "      <td>0.4597751</td>\n",
       "      <td>0.4584541</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2297829</td>\n",
       "      <td>0.4754664</td>\n",
       "      <td>0.397264</td>\n",
       "      <td>0.1875325</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>RAF1</th>\n",
       "      <td>0.3313165</td>\n",
       "      <td>0.2362207</td>\n",
       "      <td>0.999</td>\n",
       "      <td>0.4483877</td>\n",
       "      <td>0.913</td>\n",
       "      <td>0.886</td>\n",
       "      <td>0.86</td>\n",
       "      <td>0.999</td>\n",
       "      <td>0.4607195</td>\n",
       "      <td>0.875</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2990105</td>\n",
       "      <td>0.999</td>\n",
       "      <td>0.4602009</td>\n",
       "      <td>0.4630166</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2309234</td>\n",
       "      <td>0.4677174</td>\n",
       "      <td>0.4241984</td>\n",
       "      <td>0.1882915</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PRKDC</th>\n",
       "      <td>0.498498</td>\n",
       "      <td>0.3104536</td>\n",
       "      <td>0.4992499</td>\n",
       "      <td>0.909</td>\n",
       "      <td>0.887</td>\n",
       "      <td>0.497492</td>\n",
       "      <td>0.956</td>\n",
       "      <td>0.949</td>\n",
       "      <td>0.3229876</td>\n",
       "      <td>0.4752488</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2950725</td>\n",
       "      <td>0.4892957</td>\n",
       "      <td>0.4604134</td>\n",
       "      <td>0.4519796</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2862193</td>\n",
       "      <td>0.4607979</td>\n",
       "      <td>0.4901571</td>\n",
       "      <td>0.2326296</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SYK</th>\n",
       "      <td>0.2998985</td>\n",
       "      <td>0.219803</td>\n",
       "      <td>0.4794917</td>\n",
       "      <td>0.4285482</td>\n",
       "      <td>0.986</td>\n",
       "      <td>0.917</td>\n",
       "      <td>0.4798495</td>\n",
       "      <td>0.4959819</td>\n",
       "      <td>0.4599804</td>\n",
       "      <td>0.488713</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2940797</td>\n",
       "      <td>0.3261543</td>\n",
       "      <td>0.3130634</td>\n",
       "      <td>0.3149655</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2106997</td>\n",
       "      <td>0.4861563</td>\n",
       "      <td>0.3309904</td>\n",
       "      <td>0.177711</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FGFR1</th>\n",
       "      <td>0.2869746</td>\n",
       "      <td>0.2127797</td>\n",
       "      <td>0.4275</td>\n",
       "      <td>0.3061098</td>\n",
       "      <td>0.4721543</td>\n",
       "      <td>0.858</td>\n",
       "      <td>0.4730696</td>\n",
       "      <td>0.3219829</td>\n",
       "      <td>0.4549912</td>\n",
       "      <td>0.4670503</td>\n",
       "      <td>...</td>\n",
       "      <td>0.4167356</td>\n",
       "      <td>0.3191258</td>\n",
       "      <td>0.305277</td>\n",
       "      <td>0.2949863</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.1793983</td>\n",
       "      <td>0.3163852</td>\n",
       "      <td>0.3203142</td>\n",
       "      <td>0.1730918</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MET</th>\n",
       "      <td>0.3018779</td>\n",
       "      <td>0.2208644</td>\n",
       "      <td>0.4468282</td>\n",
       "      <td>0.4298652</td>\n",
       "      <td>0.993</td>\n",
       "      <td>0.857</td>\n",
       "      <td>0.4863515</td>\n",
       "      <td>0.772</td>\n",
       "      <td>0.4672642</td>\n",
       "      <td>0.4904266</td>\n",
       "      <td>...</td>\n",
       "      <td>0.4193317</td>\n",
       "      <td>0.4157633</td>\n",
       "      <td>0.3137657</td>\n",
       "      <td>0.4267408</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2222988</td>\n",
       "      <td>0.4878519</td>\n",
       "      <td>0.4914385</td>\n",
       "      <td>0.1784041</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TUBB</th>\n",
       "      <td>0.2865575</td>\n",
       "      <td>0.2125504</td>\n",
       "      <td>0.416222</td>\n",
       "      <td>0.2865575</td>\n",
       "      <td>0.4149994</td>\n",
       "      <td>0.4149994</td>\n",
       "      <td>0.40855</td>\n",
       "      <td>0.4163958</td>\n",
       "      <td>0.2860696</td>\n",
       "      <td>0.2907902</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2117708</td>\n",
       "      <td>0.4092803</td>\n",
       "      <td>0.388875</td>\n",
       "      <td>0.2808744</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.1744896</td>\n",
       "      <td>0.289654</td>\n",
       "      <td>0.2764952</td>\n",
       "      <td>0.17294</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SGK1</th>\n",
       "      <td>0.3274898</td>\n",
       "      <td>0.234269</td>\n",
       "      <td>0.4957216</td>\n",
       "      <td>0.4164043</td>\n",
       "      <td>0.924</td>\n",
       "      <td>0.736</td>\n",
       "      <td>0.4982489</td>\n",
       "      <td>0.965</td>\n",
       "      <td>0.4597336</td>\n",
       "      <td>0.479228</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2939788</td>\n",
       "      <td>0.4957216</td>\n",
       "      <td>0.3150633</td>\n",
       "      <td>0.4555771</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2290579</td>\n",
       "      <td>0.4705874</td>\n",
       "      <td>0.3308805</td>\n",
       "      <td>0.1870493</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>XIAP</th>\n",
       "      <td>0.4217872</td>\n",
       "      <td>0.2788676</td>\n",
       "      <td>0.901</td>\n",
       "      <td>0.4217872</td>\n",
       "      <td>0.4952499</td>\n",
       "      <td>0.4952499</td>\n",
       "      <td>0.756</td>\n",
       "      <td>0.4972398</td>\n",
       "      <td>0.3220411</td>\n",
       "      <td>0.4640365</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2849424</td>\n",
       "      <td>0.4967348</td>\n",
       "      <td>0.4584924</td>\n",
       "      <td>0.3154723</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2107074</td>\n",
       "      <td>0.3265908</td>\n",
       "      <td>0.4105431</td>\n",
       "      <td>0.2144304</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FGFR2</th>\n",
       "      <td>0.2869746</td>\n",
       "      <td>0.2127797</td>\n",
       "      <td>0.4221847</td>\n",
       "      <td>0.3061098</td>\n",
       "      <td>0.4721543</td>\n",
       "      <td>0.845</td>\n",
       "      <td>0.4730696</td>\n",
       "      <td>0.3219829</td>\n",
       "      <td>0.4549912</td>\n",
       "      <td>0.4670503</td>\n",
       "      <td>...</td>\n",
       "      <td>0.4116831</td>\n",
       "      <td>0.3191258</td>\n",
       "      <td>0.305277</td>\n",
       "      <td>0.2949863</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.1793983</td>\n",
       "      <td>0.3163852</td>\n",
       "      <td>0.3203142</td>\n",
       "      <td>0.1730918</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>CD19</th>\n",
       "      <td>0.3155516</td>\n",
       "      <td>0.2280959</td>\n",
       "      <td>0.4803264</td>\n",
       "      <td>0.3155516</td>\n",
       "      <td>0.4947438</td>\n",
       "      <td>0.8</td>\n",
       "      <td>0.4768586</td>\n",
       "      <td>0.4805579</td>\n",
       "      <td>0.4584951</td>\n",
       "      <td>0.4707431</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2934719</td>\n",
       "      <td>0.4711056</td>\n",
       "      <td>0.4442719</td>\n",
       "      <td>0.3086741</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.1848308</td>\n",
       "      <td>0.3263707</td>\n",
       "      <td>0.3220468</td>\n",
       "      <td>0.1830929</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FLT4</th>\n",
       "      <td>0.4281603</td>\n",
       "      <td>0.2816393</td>\n",
       "      <td>0.4698491</td>\n",
       "      <td>0.4182224</td>\n",
       "      <td>0.933</td>\n",
       "      <td>0.831</td>\n",
       "      <td>0.4795312</td>\n",
       "      <td>0.4977499</td>\n",
       "      <td>0.4609653</td>\n",
       "      <td>0.4753297</td>\n",
       "      <td>...</td>\n",
       "      <td>0.4482268</td>\n",
       "      <td>0.3220533</td>\n",
       "      <td>0.3079548</td>\n",
       "      <td>0.3156775</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2081727</td>\n",
       "      <td>0.4729107</td>\n",
       "      <td>0.4034196</td>\n",
       "      <td>0.2160655</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MAPT</th>\n",
       "      <td>0.3225533</td>\n",
       "      <td>0.231732</td>\n",
       "      <td>0.4967398</td>\n",
       "      <td>0.3856319</td>\n",
       "      <td>0.785</td>\n",
       "      <td>0.4949995</td>\n",
       "      <td>0.4858513</td>\n",
       "      <td>0.4969874</td>\n",
       "      <td>0.3219352</td>\n",
       "      <td>0.4336745</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2308057</td>\n",
       "      <td>0.4868845</td>\n",
       "      <td>0.4582778</td>\n",
       "      <td>0.3153707</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2166815</td>\n",
       "      <td>0.43166</td>\n",
       "      <td>0.3160776</td>\n",
       "      <td>0.1854285</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>HDAC1</th>\n",
       "      <td>0.762</td>\n",
       "      <td>0.3956631</td>\n",
       "      <td>0.724</td>\n",
       "      <td>0.812</td>\n",
       "      <td>0.4995</td>\n",
       "      <td>0.3319958</td>\n",
       "      <td>0.4731828</td>\n",
       "      <td>0.781</td>\n",
       "      <td>0.3220411</td>\n",
       "      <td>0.4290317</td>\n",
       "      <td>...</td>\n",
       "      <td>0.264493</td>\n",
       "      <td>0.4183597</td>\n",
       "      <td>0.3150633</td>\n",
       "      <td>0.4483398</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.4066141</td>\n",
       "      <td>0.3284337</td>\n",
       "      <td>0.3322208</td>\n",
       "      <td>0.2773934</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MAP2K2</th>\n",
       "      <td>0.2987707</td>\n",
       "      <td>0.2191966</td>\n",
       "      <td>0.4995</td>\n",
       "      <td>0.3118285</td>\n",
       "      <td>0.4858992</td>\n",
       "      <td>0.4695565</td>\n",
       "      <td>0.4868686</td>\n",
       "      <td>0.752</td>\n",
       "      <td>0.4677415</td>\n",
       "      <td>0.4804953</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2972328</td>\n",
       "      <td>0.999</td>\n",
       "      <td>0.3150633</td>\n",
       "      <td>0.4018427</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2146279</td>\n",
       "      <td>0.3224981</td>\n",
       "      <td>0.3265814</td>\n",
       "      <td>0.1773144</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FLT1</th>\n",
       "      <td>0.735</td>\n",
       "      <td>0.3882574</td>\n",
       "      <td>0.4732384</td>\n",
       "      <td>0.4234516</td>\n",
       "      <td>0.926</td>\n",
       "      <td>0.94</td>\n",
       "      <td>0.4840114</td>\n",
       "      <td>0.4944818</td>\n",
       "      <td>0.4651037</td>\n",
       "      <td>0.4777122</td>\n",
       "      <td>...</td>\n",
       "      <td>0.4462026</td>\n",
       "      <td>0.3240678</td>\n",
       "      <td>0.3097963</td>\n",
       "      <td>0.4227394</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.215933</td>\n",
       "      <td>0.4711056</td>\n",
       "      <td>0.4057229</td>\n",
       "      <td>0.2737328</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>WNT1</th>\n",
       "      <td>0.2997581</td>\n",
       "      <td>0.2197276</td>\n",
       "      <td>0.4446644</td>\n",
       "      <td>0.2997581</td>\n",
       "      <td>0.4490796</td>\n",
       "      <td>0.4432694</td>\n",
       "      <td>0.4359192</td>\n",
       "      <td>0.4547889</td>\n",
       "      <td>0.2992242</td>\n",
       "      <td>0.307764</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2188946</td>\n",
       "      <td>0.4367507</td>\n",
       "      <td>0.4135918</td>\n",
       "      <td>0.2978344</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2250316</td>\n",
       "      <td>0.3058544</td>\n",
       "      <td>0.3100963</td>\n",
       "      <td>0.1776617</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>CSNK2A1</th>\n",
       "      <td>0.456018</td>\n",
       "      <td>0.2934304</td>\n",
       "      <td>0.4954874</td>\n",
       "      <td>0.456018</td>\n",
       "      <td>0.711</td>\n",
       "      <td>0.4090161</td>\n",
       "      <td>0.4962438</td>\n",
       "      <td>0.996</td>\n",
       "      <td>0.2845144</td>\n",
       "      <td>0.4867515</td>\n",
       "      <td>...</td>\n",
       "      <td>0.235846</td>\n",
       "      <td>0.4730606</td>\n",
       "      <td>0.3148637</td>\n",
       "      <td>0.4623712</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.4300293</td>\n",
       "      <td>0.4082928</td>\n",
       "      <td>0.3321097</td>\n",
       "      <td>0.2229381</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>AKT3</th>\n",
       "      <td>0.4091707</td>\n",
       "      <td>0.2732961</td>\n",
       "      <td>0.905</td>\n",
       "      <td>0.4206543</td>\n",
       "      <td>0.4932499</td>\n",
       "      <td>0.979</td>\n",
       "      <td>0.4962469</td>\n",
       "      <td>0.972</td>\n",
       "      <td>0.4745492</td>\n",
       "      <td>0.4876822</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3007918</td>\n",
       "      <td>0.4675771</td>\n",
       "      <td>0.3142616</td>\n",
       "      <td>0.4571313</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2294501</td>\n",
       "      <td>0.3257199</td>\n",
       "      <td>0.3299964</td>\n",
       "      <td>0.211121</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MAP4</th>\n",
       "      <td>0.2182766</td>\n",
       "      <td>0.1725206</td>\n",
       "      <td>0.3000818</td>\n",
       "      <td>0.2793029</td>\n",
       "      <td>0.4422662</td>\n",
       "      <td>0.4278266</td>\n",
       "      <td>0.3002219</td>\n",
       "      <td>0.3064584</td>\n",
       "      <td>0.2923217</td>\n",
       "      <td>0.3036677</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2151777</td>\n",
       "      <td>0.2318617</td>\n",
       "      <td>0.2251682</td>\n",
       "      <td>0.2261505</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.1668621</td>\n",
       "      <td>0.3026786</td>\n",
       "      <td>0.2342953</td>\n",
       "      <td>0.1454758</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TOP2A</th>\n",
       "      <td>0.4024681</td>\n",
       "      <td>0.2702896</td>\n",
       "      <td>0.3916119</td>\n",
       "      <td>0.4534379</td>\n",
       "      <td>0.4090161</td>\n",
       "      <td>0.3114886</td>\n",
       "      <td>0.3274866</td>\n",
       "      <td>0.489611</td>\n",
       "      <td>0.2337799</td>\n",
       "      <td>0.3233256</td>\n",
       "      <td>...</td>\n",
       "      <td>0.220385</td>\n",
       "      <td>0.3172271</td>\n",
       "      <td>0.2372818</td>\n",
       "      <td>0.3123842</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.777</td>\n",
       "      <td>0.2867265</td>\n",
       "      <td>0.3136096</td>\n",
       "      <td>0.2093223</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TEK</th>\n",
       "      <td>0.2913185</td>\n",
       "      <td>0.2151585</td>\n",
       "      <td>0.4405867</td>\n",
       "      <td>0.3084708</td>\n",
       "      <td>0.4777951</td>\n",
       "      <td>0.929</td>\n",
       "      <td>0.4787324</td>\n",
       "      <td>0.3245962</td>\n",
       "      <td>0.4602271</td>\n",
       "      <td>0.472569</td>\n",
       "      <td>...</td>\n",
       "      <td>0.429162</td>\n",
       "      <td>0.3216927</td>\n",
       "      <td>0.3076251</td>\n",
       "      <td>0.2971783</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.1802066</td>\n",
       "      <td>0.318908</td>\n",
       "      <td>0.3229004</td>\n",
       "      <td>0.1746627</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PIP5K1A</th>\n",
       "      <td>0.2889514</td>\n",
       "      <td>0.2138646</td>\n",
       "      <td>0.324368</td>\n",
       "      <td>0.30836</td>\n",
       "      <td>0.4775293</td>\n",
       "      <td>0.929</td>\n",
       "      <td>0.4784656</td>\n",
       "      <td>0.3244735</td>\n",
       "      <td>0.4599804</td>\n",
       "      <td>0.472309</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2940797</td>\n",
       "      <td>0.3215722</td>\n",
       "      <td>0.3075149</td>\n",
       "      <td>0.2970754</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.1801688</td>\n",
       "      <td>0.3187896</td>\n",
       "      <td>0.3227789</td>\n",
       "      <td>0.173809</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>RET</th>\n",
       "      <td>0.2977357</td>\n",
       "      <td>0.2186389</td>\n",
       "      <td>0.4628618</td>\n",
       "      <td>0.4241453</td>\n",
       "      <td>0.963</td>\n",
       "      <td>0.4815</td>\n",
       "      <td>0.4866102</td>\n",
       "      <td>0.4900938</td>\n",
       "      <td>0.4675029</td>\n",
       "      <td>0.4829953</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2971365</td>\n",
       "      <td>0.3252308</td>\n",
       "      <td>0.3108589</td>\n",
       "      <td>0.3125807</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2096298</td>\n",
       "      <td>0.4804979</td>\n",
       "      <td>0.3283577</td>\n",
       "      <td>0.1769493</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PARP1</th>\n",
       "      <td>0.4861526</td>\n",
       "      <td>0.3056203</td>\n",
       "      <td>0.824</td>\n",
       "      <td>0.947</td>\n",
       "      <td>0.4741153</td>\n",
       "      <td>0.4741153</td>\n",
       "      <td>0.4851417</td>\n",
       "      <td>0.4833325</td>\n",
       "      <td>0.3129692</td>\n",
       "      <td>0.4368985</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2767633</td>\n",
       "      <td>0.4666654</td>\n",
       "      <td>0.440321</td>\n",
       "      <td>0.3098164</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2954825</td>\n",
       "      <td>0.3172645</td>\n",
       "      <td>0.3272904</td>\n",
       "      <td>0.2299051</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TOP1</th>\n",
       "      <td>0.4536443</td>\n",
       "      <td>0.2924458</td>\n",
       "      <td>0.43311</td>\n",
       "      <td>0.831</td>\n",
       "      <td>0.4583711</td>\n",
       "      <td>0.4528192</td>\n",
       "      <td>0.4442777</td>\n",
       "      <td>0.4583711</td>\n",
       "      <td>0.3042403</td>\n",
       "      <td>0.4372861</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2828447</td>\n",
       "      <td>0.308818</td>\n",
       "      <td>0.2970567</td>\n",
       "      <td>0.2993665</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.436871</td>\n",
       "      <td>0.310136</td>\n",
       "      <td>0.4573156</td>\n",
       "      <td>0.2223693</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FGFR4</th>\n",
       "      <td>0.2806961</td>\n",
       "      <td>0.2093084</td>\n",
       "      <td>0.4167356</td>\n",
       "      <td>0.2934506</td>\n",
       "      <td>0.3093086</td>\n",
       "      <td>0.3025751</td>\n",
       "      <td>0.3002439</td>\n",
       "      <td>0.3090198</td>\n",
       "      <td>0.2928586</td>\n",
       "      <td>0.2978079</td>\n",
       "      <td>...</td>\n",
       "      <td>1</td>\n",
       "      <td>0.2301303</td>\n",
       "      <td>0.2225939</td>\n",
       "      <td>0.2275423</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.1716881</td>\n",
       "      <td>0.233876</td>\n",
       "      <td>0.2975386</td>\n",
       "      <td>0.1707877</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BRAF</th>\n",
       "      <td>0.3197811</td>\n",
       "      <td>0.2302977</td>\n",
       "      <td>0.4995</td>\n",
       "      <td>0.3197811</td>\n",
       "      <td>0.4873687</td>\n",
       "      <td>0.4873687</td>\n",
       "      <td>0.4784979</td>\n",
       "      <td>0.901</td>\n",
       "      <td>0.3201127</td>\n",
       "      <td>0.4664488</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2301303</td>\n",
       "      <td>1</td>\n",
       "      <td>0.4517297</td>\n",
       "      <td>0.4407954</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2252599</td>\n",
       "      <td>0.3231448</td>\n",
       "      <td>0.32083</td>\n",
       "      <td>0.1845089</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PAWR</th>\n",
       "      <td>0.306739</td>\n",
       "      <td>0.2234553</td>\n",
       "      <td>0.4602009</td>\n",
       "      <td>0.306739</td>\n",
       "      <td>0.4587068</td>\n",
       "      <td>0.4587068</td>\n",
       "      <td>0.4508402</td>\n",
       "      <td>0.4604134</td>\n",
       "      <td>0.30618</td>\n",
       "      <td>0.3115939</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2225939</td>\n",
       "      <td>0.4517297</td>\n",
       "      <td>1</td>\n",
       "      <td>0.3002363</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.1817719</td>\n",
       "      <td>0.3102897</td>\n",
       "      <td>0.2952379</td>\n",
       "      <td>0.1800908</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PIM1</th>\n",
       "      <td>0.3148605</td>\n",
       "      <td>0.2277346</td>\n",
       "      <td>0.4602044</td>\n",
       "      <td>0.3148605</td>\n",
       "      <td>0.4628017</td>\n",
       "      <td>0.3155738</td>\n",
       "      <td>0.4608569</td>\n",
       "      <td>0.863</td>\n",
       "      <td>0.2958294</td>\n",
       "      <td>0.452659</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2275423</td>\n",
       "      <td>0.4407954</td>\n",
       "      <td>0.3002363</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2228071</td>\n",
       "      <td>0.312158</td>\n",
       "      <td>0.3158773</td>\n",
       "      <td>0.1828601</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FNTA</th>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0.999</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FNTB</th>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.999</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TYMS</th>\n",
       "      <td>0.2651345</td>\n",
       "      <td>0.2005319</td>\n",
       "      <td>0.2603794</td>\n",
       "      <td>0.2863381</td>\n",
       "      <td>0.2679605</td>\n",
       "      <td>0.2223511</td>\n",
       "      <td>0.230385</td>\n",
       "      <td>0.3003509</td>\n",
       "      <td>0.1797098</td>\n",
       "      <td>0.2283178</td>\n",
       "      <td>...</td>\n",
       "      <td>0.1716881</td>\n",
       "      <td>0.2252599</td>\n",
       "      <td>0.1817719</td>\n",
       "      <td>0.2228071</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0.2094396</td>\n",
       "      <td>0.2234298</td>\n",
       "      <td>0.1648989</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MAP2</th>\n",
       "      <td>0.2973522</td>\n",
       "      <td>0.2184321</td>\n",
       "      <td>0.4255423</td>\n",
       "      <td>0.4233675</td>\n",
       "      <td>0.959</td>\n",
       "      <td>0.4804979</td>\n",
       "      <td>0.3272381</td>\n",
       "      <td>0.4890557</td>\n",
       "      <td>0.3173552</td>\n",
       "      <td>0.481987</td>\n",
       "      <td>...</td>\n",
       "      <td>0.233876</td>\n",
       "      <td>0.3231448</td>\n",
       "      <td>0.3102897</td>\n",
       "      <td>0.312158</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2094396</td>\n",
       "      <td>1</td>\n",
       "      <td>0.3278914</td>\n",
       "      <td>0.1768138</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ADAM17</th>\n",
       "      <td>0.2775342</td>\n",
       "      <td>0.2075453</td>\n",
       "      <td>0.4549369</td>\n",
       "      <td>0.3184437</td>\n",
       "      <td>0.4982469</td>\n",
       "      <td>0.491694</td>\n",
       "      <td>0.3900285</td>\n",
       "      <td>0.4982469</td>\n",
       "      <td>0.3213085</td>\n",
       "      <td>0.4734331</td>\n",
       "      <td>...</td>\n",
       "      <td>0.2975386</td>\n",
       "      <td>0.32083</td>\n",
       "      <td>0.2952379</td>\n",
       "      <td>0.3158773</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2234298</td>\n",
       "      <td>0.3278914</td>\n",
       "      <td>1</td>\n",
       "      <td>0.1696119</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>CMPK1</th>\n",
       "      <td>0.4361759</td>\n",
       "      <td>0.928</td>\n",
       "      <td>0.2124909</td>\n",
       "      <td>0.3036142</td>\n",
       "      <td>0.2167827</td>\n",
       "      <td>0.2119979</td>\n",
       "      <td>0.2169459</td>\n",
       "      <td>0.2320232</td>\n",
       "      <td>0.1733817</td>\n",
       "      <td>0.1865555</td>\n",
       "      <td>...</td>\n",
       "      <td>0.1707877</td>\n",
       "      <td>0.1845089</td>\n",
       "      <td>0.1800908</td>\n",
       "      <td>0.1828601</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.1648989</td>\n",
       "      <td>0.1768138</td>\n",
       "      <td>0.1696119</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>76 rows × 76 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                ATR       RRM1       BCL2        ATM        SRC     PIK3CB  \\\n",
       "ATR               1      0.823   0.414348      0.999  0.4309858  0.4124776   \n",
       "RRM1          0.823          1  0.2755962  0.4512497  0.2828591  0.2747675   \n",
       "BCL2       0.414348  0.2755962          1      0.708      0.765  0.4972438   \n",
       "ATM           0.999  0.4512497      0.708          1      0.758   0.453747   \n",
       "SRC       0.4309858  0.2828591      0.765      0.758          1      0.963   \n",
       "PIK3CB    0.4124776  0.2747675  0.4972438   0.453747      0.963          1   \n",
       "AKT2      0.4316316  0.2831371      0.917  0.4659539  0.4967398      0.981   \n",
       "HSP90AA1  0.4957216  0.3093745      0.986  0.4957216      0.998   0.497492   \n",
       "ALK       0.2877725   0.213218   0.322883  0.3070177  0.4743179      0.836   \n",
       "JAK2      0.3259791  0.2334949       0.93  0.4253052      0.969      0.908   \n",
       "PIK3CD    0.3962824  0.2674855  0.4954753  0.4528247      0.965  0.4937438   \n",
       "CHEK1         0.999  0.4512497  0.4924995      0.999  0.4954753  0.4768215   \n",
       "CHUK      0.4376946  0.2857335      0.788  0.4376946      0.832   0.497492   \n",
       "PTK2      0.4210982  0.2785663       0.91   0.452362      0.999      0.853   \n",
       "PDGFRA    0.2918088  0.2154259  0.4792436  0.3979975      0.838       0.85   \n",
       "HDAC3     0.4240233  0.2798433  0.4559337  0.4390679      0.881  0.4600884   \n",
       "WEE1          0.779  0.4001979  0.4959819      0.753      0.499  0.4813576   \n",
       "KIF11         0.751  0.3926766  0.3025844  0.4287137  0.3037051  0.2970782   \n",
       "AKT1      0.4786658  0.3026445      0.998  0.4786658      0.991      0.991   \n",
       "ESR1       0.432276  0.2834143      0.757  0.4655949      0.999  0.4972438   \n",
       "PIK3CA    0.4200135  0.2780912  0.4992499  0.4623103      0.986      0.909   \n",
       "EGFR      0.3313165  0.2362207      0.827  0.4685517      0.999      0.973   \n",
       "IGF2R     0.3035445  0.2217552    0.31489   0.415587  0.4357977  0.4316805   \n",
       "IGF1R     0.4655949  0.2973662   0.488713      0.872      0.966      0.946   \n",
       "IKBKB     0.3289738  0.2350274       0.79  0.4202199      0.943  0.4967469   \n",
       "RAF1      0.3313165  0.2362207      0.999  0.4483877      0.913      0.886   \n",
       "PRKDC      0.498498  0.3104536  0.4992499      0.909      0.887   0.497492   \n",
       "SYK       0.2998985   0.219803  0.4794917  0.4285482      0.986      0.917   \n",
       "FGFR1     0.2869746  0.2127797     0.4275  0.3061098  0.4721543      0.858   \n",
       "MET       0.3018779  0.2208644  0.4468282  0.4298652      0.993      0.857   \n",
       "...             ...        ...        ...        ...        ...        ...   \n",
       "TUBB      0.2865575  0.2125504   0.416222  0.2865575  0.4149994  0.4149994   \n",
       "SGK1      0.3274898   0.234269  0.4957216  0.4164043      0.924      0.736   \n",
       "XIAP      0.4217872  0.2788676      0.901  0.4217872  0.4952499  0.4952499   \n",
       "FGFR2     0.2869746  0.2127797  0.4221847  0.3061098  0.4721543      0.845   \n",
       "CD19      0.3155516  0.2280959  0.4803264  0.3155516  0.4947438        0.8   \n",
       "FLT4      0.4281603  0.2816393  0.4698491  0.4182224      0.933      0.831   \n",
       "MAPT      0.3225533   0.231732  0.4967398  0.3856319      0.785  0.4949995   \n",
       "HDAC1         0.762  0.3956631      0.724      0.812     0.4995  0.3319958   \n",
       "MAP2K2    0.2987707  0.2191966     0.4995  0.3118285  0.4858992  0.4695565   \n",
       "FLT1          0.735  0.3882574  0.4732384  0.4234516      0.926       0.94   \n",
       "WNT1      0.2997581  0.2197276  0.4446644  0.2997581  0.4490796  0.4432694   \n",
       "CSNK2A1    0.456018  0.2934304  0.4954874   0.456018      0.711  0.4090161   \n",
       "AKT3      0.4091707  0.2732961      0.905  0.4206543  0.4932499      0.979   \n",
       "MAP4      0.2182766  0.1725206  0.3000818  0.2793029  0.4422662  0.4278266   \n",
       "TOP2A     0.4024681  0.2702896  0.3916119  0.4534379  0.4090161  0.3114886   \n",
       "TEK       0.2913185  0.2151585  0.4405867  0.3084708  0.4777951      0.929   \n",
       "PIP5K1A   0.2889514  0.2138646   0.324368    0.30836  0.4775293      0.929   \n",
       "RET       0.2977357  0.2186389  0.4628618  0.4241453      0.963     0.4815   \n",
       "PARP1     0.4861526  0.3056203      0.824      0.947  0.4741153  0.4741153   \n",
       "TOP1      0.4536443  0.2924458    0.43311      0.831  0.4583711  0.4528192   \n",
       "FGFR4     0.2806961  0.2093084  0.4167356  0.2934506  0.3093086  0.3025751   \n",
       "BRAF      0.3197811  0.2302977     0.4995  0.3197811  0.4873687  0.4873687   \n",
       "PAWR       0.306739  0.2234553  0.4602009   0.306739  0.4587068  0.4587068   \n",
       "PIM1      0.3148605  0.2277346  0.4602044  0.3148605  0.4628017  0.3155738   \n",
       "FNTA              0          0          0          0          0          0   \n",
       "FNTB              0          0          0          0          0          0   \n",
       "TYMS      0.2651345  0.2005319  0.2603794  0.2863381  0.2679605  0.2223511   \n",
       "MAP2      0.2973522  0.2184321  0.4255423  0.4233675      0.959  0.4804979   \n",
       "ADAM17    0.2775342  0.2075453  0.4549369  0.3184437  0.4982469   0.491694   \n",
       "CMPK1     0.4361759      0.928  0.2124909  0.3036142  0.2167827  0.2119979   \n",
       "\n",
       "               AKT2   HSP90AA1        ALK       JAK2    ...          FGFR4  \\\n",
       "ATR       0.4316316  0.4957216  0.2877725  0.3259791    ...      0.2806961   \n",
       "RRM1      0.2831371  0.3093745   0.213218  0.2334949    ...      0.2093084   \n",
       "BCL2          0.917      0.986   0.322883       0.93    ...      0.4167356   \n",
       "ATM       0.4659539  0.4957216  0.3070177  0.4253052    ...      0.2934506   \n",
       "SRC       0.4967398      0.998  0.4743179      0.969    ...      0.3093086   \n",
       "PIK3CB        0.981   0.497492      0.836      0.908    ...      0.3025751   \n",
       "AKT2              1      0.989  0.4752416  0.4884135    ...      0.3002439   \n",
       "HSP90AA1      0.989          1  0.3229876      0.952    ...      0.3090198   \n",
       "ALK       0.4752416  0.3229876          1  0.4691672    ...      0.2928586   \n",
       "JAK2      0.4884135      0.952  0.4691672          1    ...      0.2978079   \n",
       "PIK3CD        0.977  0.4957216      0.822      0.912    ...      0.3009772   \n",
       "CHEK1          0.76      0.984  0.3141461  0.4838678    ...      0.2351669   \n",
       "CHUK          0.973      0.986  0.3229876  0.4843509    ...      0.2725807   \n",
       "PTK2      0.4904587  0.4992499  0.4710541      0.872    ...      0.3071882   \n",
       "PDGFRA    0.4863515  0.4639139  0.4672642  0.4799917    ...      0.4119266   \n",
       "HDAC3     0.4359192      0.761  0.3083218  0.4614535    ...       0.228933   \n",
       "WEE1      0.4967398      0.998  0.3161087  0.4872287    ...       0.235958   \n",
       "KIF11     0.3028664  0.4365547  0.2246117  0.2993041    ...      0.2043264   \n",
       "AKT1          0.955      0.999  0.4773058   0.490594    ...      0.3010665   \n",
       "ESR1          0.899      0.999  0.4752416  0.4918857    ...      0.3065659   \n",
       "PIK3CA         0.99     0.4995      0.914      0.964    ...       0.430937   \n",
       "EGFR      0.4969874      0.999  0.4747802      0.904    ...      0.4246516   \n",
       "IGF2R     0.3104791  0.4364073  0.2967537  0.3018366    ...      0.2840598   \n",
       "IGF1R     0.4934954      0.969  0.4738546  0.4869487    ...      0.4422939   \n",
       "IKBKB         0.816      0.978  0.3226734  0.4824124    ...      0.2728196   \n",
       "RAF1           0.86      0.999  0.4607195      0.875    ...      0.2990105   \n",
       "PRKDC         0.956      0.949  0.3229876  0.4752488    ...      0.2950725   \n",
       "SYK       0.4798495  0.4959819  0.4599804   0.488713    ...      0.2940797   \n",
       "FGFR1     0.4730696  0.3219829  0.4549912  0.4670503    ...      0.4167356   \n",
       "MET       0.4863515      0.772  0.4672642  0.4904266    ...      0.4193317   \n",
       "...             ...        ...        ...        ...    ...            ...   \n",
       "TUBB        0.40855  0.4163958  0.2860696  0.2907902    ...      0.2117708   \n",
       "SGK1      0.4982489      0.965  0.4597336   0.479228    ...      0.2939788   \n",
       "XIAP          0.756  0.4972398  0.3220411  0.4640365    ...      0.2849424   \n",
       "FGFR2     0.4730696  0.3219829  0.4549912  0.4670503    ...      0.4116831   \n",
       "CD19      0.4768586  0.4805579  0.4584951  0.4707431    ...      0.2934719   \n",
       "FLT4      0.4795312  0.4977499  0.4609653  0.4753297    ...      0.4482268   \n",
       "MAPT      0.4858513  0.4969874  0.3219352  0.4336745    ...      0.2308057   \n",
       "HDAC1     0.4731828      0.781  0.3220411  0.4290317    ...       0.264493   \n",
       "MAP2K2    0.4868686      0.752  0.4677415  0.4804953    ...      0.2972328   \n",
       "FLT1      0.4840114  0.4944818  0.4651037  0.4777122    ...      0.4462026   \n",
       "WNT1      0.4359192  0.4547889  0.2992242   0.307764    ...      0.2188946   \n",
       "CSNK2A1   0.4962438      0.996  0.2845144  0.4867515    ...       0.235846   \n",
       "AKT3      0.4962469      0.972  0.4745492  0.4876822    ...      0.3007918   \n",
       "MAP4      0.3002219  0.3064584  0.2923217  0.3036677    ...      0.2151777   \n",
       "TOP2A     0.3274866   0.489611  0.2337799  0.3233256    ...       0.220385   \n",
       "TEK       0.4787324  0.3245962  0.4602271   0.472569    ...       0.429162   \n",
       "PIP5K1A   0.4784656  0.3244735  0.4599804   0.472309    ...      0.2940797   \n",
       "RET       0.4866102  0.4900938  0.4675029  0.4829953    ...      0.2971365   \n",
       "PARP1     0.4851417  0.4833325  0.3129692  0.4368985    ...      0.2767633   \n",
       "TOP1      0.4442777  0.4583711  0.3042403  0.4372861    ...      0.2828447   \n",
       "FGFR4     0.3002439  0.3090198  0.2928586  0.2978079    ...              1   \n",
       "BRAF      0.4784979      0.901  0.3201127  0.4664488    ...      0.2301303   \n",
       "PAWR      0.4508402  0.4604134    0.30618  0.3115939    ...      0.2225939   \n",
       "PIM1      0.4608569      0.863  0.2958294   0.452659    ...      0.2275423   \n",
       "FNTA              0          0          0          0    ...              0   \n",
       "FNTB              0          0          0          0    ...              0   \n",
       "TYMS       0.230385  0.3003509  0.1797098  0.2283178    ...      0.1716881   \n",
       "MAP2      0.3272381  0.4890557  0.3173552   0.481987    ...       0.233876   \n",
       "ADAM17    0.3900285  0.4982469  0.3213085  0.4734331    ...      0.2975386   \n",
       "CMPK1     0.2169459  0.2320232  0.1733817  0.1865555    ...      0.1707877   \n",
       "\n",
       "               BRAF       PAWR       PIM1   FNTA   FNTB       TYMS       MAP2  \\\n",
       "ATR       0.3197811   0.306739  0.3148605      0      0  0.2651345  0.2973522   \n",
       "RRM1      0.2302977  0.2234553  0.2277346      0      0  0.2005319  0.2184321   \n",
       "BCL2         0.4995  0.4602009  0.4602044      0      0  0.2603794  0.4255423   \n",
       "ATM       0.3197811   0.306739  0.3148605      0      0  0.2863381  0.4233675   \n",
       "SRC       0.4873687  0.4587068  0.4628017      0      0  0.2679605      0.959   \n",
       "PIK3CB    0.4873687  0.4587068  0.3155738      0      0  0.2223511  0.4804979   \n",
       "AKT2      0.4784979  0.4508402  0.4608569      0      0   0.230385  0.3272381   \n",
       "HSP90AA1      0.901  0.4604134      0.863      0      0  0.3003509  0.4890557   \n",
       "ALK       0.3201127    0.30618  0.2958294      0      0  0.1797098  0.3173552   \n",
       "JAK2      0.4664488  0.3115939   0.452659      0      0  0.2283178   0.481987   \n",
       "PIK3CD    0.4856696  0.4572013  0.3148605      0      0  0.2194619  0.4809953   \n",
       "CHEK1     0.4703363  0.4426543  0.4597683      0      0  0.2843075  0.3266888   \n",
       "CHUK      0.4892957  0.4604134  0.4602044      0      0  0.2302218  0.4454986   \n",
       "PTK2      0.3275643  0.3143623  0.3162802      0      0  0.2225074  0.4892957   \n",
       "PDGFRA    0.3251152  0.3107533  0.3017209      0      0  0.2055776  0.4472131   \n",
       "HDAC3     0.4367507  0.4135918  0.4149849      0      0  0.2983189  0.4591734   \n",
       "WEE1      0.4736802  0.4465609  0.4628017      0      0  0.2881099  0.3282174   \n",
       "KIF11     0.2941359   0.283447  0.2899045      0      0  0.2101035  0.2306581   \n",
       "AKT1          0.959      0.854  0.4630166      0      0  0.2309234  0.4873687   \n",
       "ESR1      0.4890557  0.4602009  0.4630166      0      0  0.2889893  0.4892957   \n",
       "PIK3CA    0.4926575  0.4604134  0.4374003      0      0  0.2236918  0.4861563   \n",
       "EGFR      0.4737363  0.3151629  0.4630166      0      0  0.2882141  0.4892957   \n",
       "IGF2R     0.3109007  0.2989833  0.2898394      0      0  0.2182733  0.2996349   \n",
       "IGF1R     0.4797487  0.3150633  0.4564667      0      0  0.2292826  0.4812436   \n",
       "IKBKB     0.4885749  0.4597751  0.4584541      0      0  0.2297829  0.4754664   \n",
       "RAF1          0.999  0.4602009  0.4630166      0      0  0.2309234  0.4677174   \n",
       "PRKDC     0.4892957  0.4604134  0.4519796      0      0  0.2862193  0.4607979   \n",
       "SYK       0.3261543  0.3130634  0.3149655      0      0  0.2106997  0.4861563   \n",
       "FGFR1     0.3191258   0.305277  0.2949863      0      0  0.1793983  0.3163852   \n",
       "MET       0.4157633  0.3137657  0.4267408      0      0  0.2222988  0.4878519   \n",
       "...             ...        ...        ...    ...    ...        ...        ...   \n",
       "TUBB      0.4092803   0.388875  0.2808744      0      0  0.1744896   0.289654   \n",
       "SGK1      0.4957216  0.3150633  0.4555771      0      0  0.2290579  0.4705874   \n",
       "XIAP      0.4967348  0.4584924  0.3154723      0      0  0.2107074  0.3265908   \n",
       "FGFR2     0.3191258   0.305277  0.2949863      0      0  0.1793983  0.3163852   \n",
       "CD19      0.4711056  0.4442719  0.3086741      0      0  0.1848308  0.3263707   \n",
       "FLT4      0.3220533  0.3079548  0.3156775      0      0  0.2081727  0.4729107   \n",
       "MAPT      0.4868845  0.4582778  0.3153707      0      0  0.2166815    0.43166   \n",
       "HDAC1     0.4183597  0.3150633  0.4483398      0      0  0.4066141  0.3284337   \n",
       "MAP2K2        0.999  0.3150633  0.4018427      0      0  0.2146279  0.3224981   \n",
       "FLT1      0.3240678  0.3097963  0.4227394      0      0   0.215933  0.4711056   \n",
       "WNT1      0.4367507  0.4135918  0.2978344      0      0  0.2250316  0.3058544   \n",
       "CSNK2A1   0.4730606  0.3148637  0.4623712      0      0  0.4300293  0.4082928   \n",
       "AKT3      0.4675771  0.3142616  0.4571313      0      0  0.2294501  0.3257199   \n",
       "MAP4      0.2318617  0.2251682  0.2261505      0      0  0.1668621  0.3026786   \n",
       "TOP2A     0.3172271  0.2372818  0.3123842      0      0      0.777  0.2867265   \n",
       "TEK       0.3216927  0.3076251  0.2971783      0      0  0.1802066   0.318908   \n",
       "PIP5K1A   0.3215722  0.3075149  0.2970754      0      0  0.1801688  0.3187896   \n",
       "RET       0.3252308  0.3108589  0.3125807      0      0  0.2096298  0.4804979   \n",
       "PARP1     0.4666654   0.440321  0.3098164      0      0  0.2954825  0.3172645   \n",
       "TOP1       0.308818  0.2970567  0.2993665      0      0   0.436871   0.310136   \n",
       "FGFR4     0.2301303  0.2225939  0.2275423      0      0  0.1716881   0.233876   \n",
       "BRAF              1  0.4517297  0.4407954      0      0  0.2252599  0.3231448   \n",
       "PAWR      0.4517297          1  0.3002363      0      0  0.1817719  0.3102897   \n",
       "PIM1      0.4407954  0.3002363          1      0      0  0.2228071   0.312158   \n",
       "FNTA              0          0          0      1  0.999          0          0   \n",
       "FNTB              0          0          0  0.999      1          0          0   \n",
       "TYMS      0.2252599  0.1817719  0.2228071      0      0          1  0.2094396   \n",
       "MAP2      0.3231448  0.3102897   0.312158      0      0  0.2094396          1   \n",
       "ADAM17      0.32083  0.2952379  0.3158773      0      0  0.2234298  0.3278914   \n",
       "CMPK1     0.1845089  0.1800908  0.1828601      0      0  0.1648989  0.1768138   \n",
       "\n",
       "             ADAM17      CMPK1  \n",
       "ATR       0.2775342  0.4361759  \n",
       "RRM1      0.2075453      0.928  \n",
       "BCL2      0.4549369  0.2124909  \n",
       "ATM       0.3184437  0.3036142  \n",
       "SRC       0.4982469  0.2167827  \n",
       "PIK3CB     0.491694  0.2119979  \n",
       "AKT2      0.3900285  0.2169459  \n",
       "HSP90AA1  0.4982469  0.2320232  \n",
       "ALK       0.3213085  0.1733817  \n",
       "JAK2      0.4734331  0.1865555  \n",
       "PIK3CD    0.4777847  0.2076366  \n",
       "CHEK1     0.3307647  0.3036142  \n",
       "CHUK      0.3894156   0.218467  \n",
       "PTK2      0.4924589  0.2142522  \n",
       "PDGFRA    0.4165389  0.1748388  \n",
       "HDAC3     0.3182574  0.2150069  \n",
       "WEE1      0.3323318  0.2796147  \n",
       "KIF11     0.2326825  0.2759221  \n",
       "AKT1      0.4512352  0.2282171  \n",
       "ESR1      0.4977489  0.2171086  \n",
       "PIK3CA    0.4954955  0.2139711  \n",
       "EGFR          0.994  0.1882915  \n",
       "IGF2R     0.2944031  0.1789849  \n",
       "IGF1R     0.4678892  0.2252028  \n",
       "IKBKB      0.397264  0.1875325  \n",
       "RAF1      0.4241984  0.1882915  \n",
       "PRKDC     0.4901571  0.2326296  \n",
       "SYK       0.3309904   0.177711  \n",
       "FGFR1     0.3203142  0.1730918  \n",
       "MET       0.4914385  0.1784041  \n",
       "...             ...        ...  \n",
       "TUBB      0.2764952    0.17294  \n",
       "SGK1      0.3308805  0.1870493  \n",
       "XIAP      0.4105431  0.2144304  \n",
       "FGFR2     0.3203142  0.1730918  \n",
       "CD19      0.3220468  0.1830929  \n",
       "FLT4      0.4034196  0.2160655  \n",
       "MAPT      0.3160776  0.1854285  \n",
       "HDAC1     0.3322208  0.2773934  \n",
       "MAP2K2    0.3265814  0.1773144  \n",
       "FLT1      0.4057229  0.2737328  \n",
       "WNT1      0.3100963  0.1776617  \n",
       "CSNK2A1   0.3321097  0.2229381  \n",
       "AKT3      0.3299964   0.211121  \n",
       "MAP4      0.2342953  0.1454758  \n",
       "TOP2A     0.3136096  0.2093223  \n",
       "TEK       0.3229004  0.1746627  \n",
       "PIP5K1A   0.3227789   0.173809  \n",
       "RET       0.3283577  0.1769493  \n",
       "PARP1     0.3272904  0.2299051  \n",
       "TOP1      0.4573156  0.2223693  \n",
       "FGFR4     0.2975386  0.1707877  \n",
       "BRAF        0.32083  0.1845089  \n",
       "PAWR      0.2952379  0.1800908  \n",
       "PIM1      0.3158773  0.1828601  \n",
       "FNTA              0          0  \n",
       "FNTB              0          0  \n",
       "TYMS      0.2234298  0.1648989  \n",
       "MAP2      0.3278914  0.1768138  \n",
       "ADAM17            1  0.1696119  \n",
       "CMPK1     0.1696119          1  \n",
       "\n",
       "[76 rows x 76 columns]"
      ]
     },
     "execution_count": 12,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "ppi_mat"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "ppi_mat.to_csv('Drug_expanded/ppi_net2.csv')"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Adding to feature matrix"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "metadata": {
    "collapsed": false,
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>CELL_LINE</th>\n",
       "      <th>COMPOUND_A</th>\n",
       "      <th>COMPOUND_B</th>\n",
       "      <th>MAX_CONC_A</th>\n",
       "      <th>MAX_CONC_B</th>\n",
       "      <th>IC50_A</th>\n",
       "      <th>H_A</th>\n",
       "      <th>Einf_A</th>\n",
       "      <th>IC50_B</th>\n",
       "      <th>H_B</th>\n",
       "      <th>...</th>\n",
       "      <th>B_ALogP/XLogP</th>\n",
       "      <th>B_PSA</th>\n",
       "      <th>B_#RotBonds</th>\n",
       "      <th>B_Arom Rings</th>\n",
       "      <th>B_Heavy atoms</th>\n",
       "      <th>B_QED</th>\n",
       "      <th>GEX_CLUSTER</th>\n",
       "      <th>ORIGIN_CLUSTER</th>\n",
       "      <th>THERAPY_CLUSTER</th>\n",
       "      <th>Target_share</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>1945</th>\n",
       "      <td>CAL-148</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.314329</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>43.699456</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>2.15000</td>\n",
       "      <td>144.17000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>35.000</td>\n",
       "      <td>0.43000</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1461</th>\n",
       "      <td>T47D</td>\n",
       "      <td>ESR1_1</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>3.000</td>\n",
       "      <td>0.102131</td>\n",
       "      <td>1.095705</td>\n",
       "      <td>20.057830</td>\n",
       "      <td>0.000300</td>\n",
       "      <td>0.100000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.10000</td>\n",
       "      <td>92.71000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>32.000</td>\n",
       "      <td>0.63000</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1920</th>\n",
       "      <td>HCC1143</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>SLC16A4</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>0.084926</td>\n",
       "      <td>0.712687</td>\n",
       "      <td>...</td>\n",
       "      <td>0.64891</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>326</th>\n",
       "      <td>CAMA-1</td>\n",
       "      <td>AKT</td>\n",
       "      <td>TNKS_PARP6</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.023921</td>\n",
       "      <td>1.621019</td>\n",
       "      <td>23.083495</td>\n",
       "      <td>0.145754</td>\n",
       "      <td>1.400578</td>\n",
       "      <td>...</td>\n",
       "      <td>0.64891</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1611</th>\n",
       "      <td>MCF7</td>\n",
       "      <td>HDAC_4</td>\n",
       "      <td>PARP1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.301324</td>\n",
       "      <td>1.778939</td>\n",
       "      <td>80.708031</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>1.393510</td>\n",
       "      <td>...</td>\n",
       "      <td>2.13000</td>\n",
       "      <td>82.08000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>32.000</td>\n",
       "      <td>0.80000</td>\n",
       "      <td>7</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>295</th>\n",
       "      <td>CAMA-1</td>\n",
       "      <td>AKT</td>\n",
       "      <td>PIK3CA_4</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.295413</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>94.799955</td>\n",
       "      <td>0.142178</td>\n",
       "      <td>1.297171</td>\n",
       "      <td>...</td>\n",
       "      <td>2.83000</td>\n",
       "      <td>129.45000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>30.000</td>\n",
       "      <td>0.74000</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>548</th>\n",
       "      <td>NCI-H1975</td>\n",
       "      <td>ALK</td>\n",
       "      <td>EGFR_2</td>\n",
       "      <td>1.00</td>\n",
       "      <td>3.000</td>\n",
       "      <td>0.323377</td>\n",
       "      <td>3.779439</td>\n",
       "      <td>87.426309</td>\n",
       "      <td>0.547975</td>\n",
       "      <td>1.274686</td>\n",
       "      <td>...</td>\n",
       "      <td>4.30000</td>\n",
       "      <td>68.74000</td>\n",
       "      <td>8.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>31.000</td>\n",
       "      <td>0.52000</td>\n",
       "      <td>3</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1796</th>\n",
       "      <td>NCI-H3122</td>\n",
       "      <td>IAP</td>\n",
       "      <td>Vinorelbine</td>\n",
       "      <td>0.10</td>\n",
       "      <td>0.300</td>\n",
       "      <td>0.025216</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>7.693668</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>5.40000</td>\n",
       "      <td>133.87000</td>\n",
       "      <td>10.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>57.000</td>\n",
       "      <td>0.20000</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1376</th>\n",
       "      <td>CAL-51</td>\n",
       "      <td>ERBB</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.192463</td>\n",
       "      <td>1.382213</td>\n",
       "      <td>18.976524</td>\n",
       "      <td>0.447905</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.10000</td>\n",
       "      <td>92.71000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>32.000</td>\n",
       "      <td>0.63000</td>\n",
       "      <td>3</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>270</th>\n",
       "      <td>HCC1500</td>\n",
       "      <td>AKT</td>\n",
       "      <td>HDAC_4</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.428483</td>\n",
       "      <td>1.788120</td>\n",
       "      <td>16.778327</td>\n",
       "      <td>0.325242</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>1.90000</td>\n",
       "      <td>78.40000</td>\n",
       "      <td>8.000</td>\n",
       "      <td>2.247</td>\n",
       "      <td>19.000</td>\n",
       "      <td>0.64012</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>65</th>\n",
       "      <td>MDA-MB-453</td>\n",
       "      <td>ADAM17</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>75.000</td>\n",
       "      <td>0.274518</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>14.599022</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.10000</td>\n",
       "      <td>92.71000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>32.000</td>\n",
       "      <td>0.63000</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1324</th>\n",
       "      <td>HCC1395</td>\n",
       "      <td>ERBB</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.009375</td>\n",
       "      <td>1.413786</td>\n",
       "      <td>47.213513</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.321879</td>\n",
       "      <td>...</td>\n",
       "      <td>4.20000</td>\n",
       "      <td>91.51000</td>\n",
       "      <td>8.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>34.000</td>\n",
       "      <td>0.46000</td>\n",
       "      <td>3</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>711</th>\n",
       "      <td>NCI-H522</td>\n",
       "      <td>ATR_4</td>\n",
       "      <td>IAP</td>\n",
       "      <td>0.30</td>\n",
       "      <td>3.000</td>\n",
       "      <td>0.006932</td>\n",
       "      <td>0.293182</td>\n",
       "      <td>2.478698</td>\n",
       "      <td>0.979009</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>0.64891</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>5</td>\n",
       "      <td>2</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1641</th>\n",
       "      <td>T-24</td>\n",
       "      <td>HSP90</td>\n",
       "      <td>PARP1</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.300</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>21.800190</td>\n",
       "      <td>0.098012</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>2.13000</td>\n",
       "      <td>82.08000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>32.000</td>\n",
       "      <td>0.80000</td>\n",
       "      <td>3</td>\n",
       "      <td>3</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1099</th>\n",
       "      <td>DMS-114</td>\n",
       "      <td>Carboplatin</td>\n",
       "      <td>CSNK2A1_2</td>\n",
       "      <td>0.03</td>\n",
       "      <td>3.000</td>\n",
       "      <td>0.009092</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>17.399286</td>\n",
       "      <td>1.202134</td>\n",
       "      <td>1.809929</td>\n",
       "      <td>...</td>\n",
       "      <td>1.36000</td>\n",
       "      <td>136.39000</td>\n",
       "      <td>8.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>31.000</td>\n",
       "      <td>0.43000</td>\n",
       "      <td>5</td>\n",
       "      <td>2</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>591</th>\n",
       "      <td>Calu-3</td>\n",
       "      <td>ALK_2</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.000</td>\n",
       "      <td>0.025933</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>94.575001</td>\n",
       "      <td>2.639002</td>\n",
       "      <td>2.754952</td>\n",
       "      <td>...</td>\n",
       "      <td>0.64891</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>552</th>\n",
       "      <td>NCI-H838</td>\n",
       "      <td>ALK</td>\n",
       "      <td>EGFR_2</td>\n",
       "      <td>1.00</td>\n",
       "      <td>3.000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>0.949170</td>\n",
       "      <td>1.859119</td>\n",
       "      <td>...</td>\n",
       "      <td>4.30000</td>\n",
       "      <td>68.74000</td>\n",
       "      <td>8.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>31.000</td>\n",
       "      <td>0.52000</td>\n",
       "      <td>3</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>454</th>\n",
       "      <td>CAL-148</td>\n",
       "      <td>AKT_1</td>\n",
       "      <td>PIK3C_2</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.875558</td>\n",
       "      <td>45.571761</td>\n",
       "      <td>0.261342</td>\n",
       "      <td>1.071766</td>\n",
       "      <td>...</td>\n",
       "      <td>2.34000</td>\n",
       "      <td>89.63000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>29.000</td>\n",
       "      <td>0.82000</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>351</th>\n",
       "      <td>EVSA-T</td>\n",
       "      <td>AKT_1</td>\n",
       "      <td>BCL2_2</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.000</td>\n",
       "      <td>1.557766</td>\n",
       "      <td>7.169113</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>0.498925</td>\n",
       "      <td>2.480305</td>\n",
       "      <td>...</td>\n",
       "      <td>0.64891</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1301</th>\n",
       "      <td>MDA-MB-157</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.100</td>\n",
       "      <td>0.030291</td>\n",
       "      <td>1.704302</td>\n",
       "      <td>36.604729</td>\n",
       "      <td>0.100000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>4.20000</td>\n",
       "      <td>91.51000</td>\n",
       "      <td>8.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>34.000</td>\n",
       "      <td>0.46000</td>\n",
       "      <td>4</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>101</th>\n",
       "      <td>MDA-MB-468</td>\n",
       "      <td>ADAM17</td>\n",
       "      <td>PIK3CB_PIK3CD</td>\n",
       "      <td>1.00</td>\n",
       "      <td>75.000</td>\n",
       "      <td>0.000100</td>\n",
       "      <td>0.100000</td>\n",
       "      <td>94.074502</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>1.43671</td>\n",
       "      <td>99.50709</td>\n",
       "      <td>4.289</td>\n",
       "      <td>2.737</td>\n",
       "      <td>30.490</td>\n",
       "      <td>0.62948</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1356</th>\n",
       "      <td>DU-4475</td>\n",
       "      <td>ERBB</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.029558</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>0.566343</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.23000</td>\n",
       "      <td>88.41000</td>\n",
       "      <td>6.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>27.000</td>\n",
       "      <td>0.39000</td>\n",
       "      <td>6</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>338</th>\n",
       "      <td>CAL-120</td>\n",
       "      <td>AKT_1</td>\n",
       "      <td>ALK_IGFR</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.363098</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>60.498424</td>\n",
       "      <td>0.014077</td>\n",
       "      <td>2.166135</td>\n",
       "      <td>...</td>\n",
       "      <td>2.75692</td>\n",
       "      <td>97.43558</td>\n",
       "      <td>4.903</td>\n",
       "      <td>2.427</td>\n",
       "      <td>30.291</td>\n",
       "      <td>0.61224</td>\n",
       "      <td>3</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>266</th>\n",
       "      <td>UM-UC-3</td>\n",
       "      <td>AKT</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>1.108598</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>4.20000</td>\n",
       "      <td>91.51000</td>\n",
       "      <td>8.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>34.000</td>\n",
       "      <td>0.46000</td>\n",
       "      <td>3</td>\n",
       "      <td>3</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>320</th>\n",
       "      <td>J82</td>\n",
       "      <td>AKT</td>\n",
       "      <td>TNF</td>\n",
       "      <td>0.10</td>\n",
       "      <td>3.000</td>\n",
       "      <td>0.100000</td>\n",
       "      <td>0.389236</td>\n",
       "      <td>46.631120</td>\n",
       "      <td>0.635866</td>\n",
       "      <td>0.779150</td>\n",
       "      <td>...</td>\n",
       "      <td>0.50000</td>\n",
       "      <td>102.00000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>2.804</td>\n",
       "      <td>31.000</td>\n",
       "      <td>0.65147</td>\n",
       "      <td>3</td>\n",
       "      <td>3</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1560</th>\n",
       "      <td>KMS-11</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>Proteasome_2</td>\n",
       "      <td>0.03</td>\n",
       "      <td>0.030</td>\n",
       "      <td>0.001258</td>\n",
       "      <td>4.161496</td>\n",
       "      <td>0.408675</td>\n",
       "      <td>0.028551</td>\n",
       "      <td>1.739839</td>\n",
       "      <td>...</td>\n",
       "      <td>4.70000</td>\n",
       "      <td>159.00000</td>\n",
       "      <td>20.000</td>\n",
       "      <td>3.429</td>\n",
       "      <td>52.000</td>\n",
       "      <td>0.27258</td>\n",
       "      <td>7</td>\n",
       "      <td>0</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1127</th>\n",
       "      <td>Calu-3</td>\n",
       "      <td>CHEK1</td>\n",
       "      <td>IAP</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>0.349881</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>0.64891</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2061</th>\n",
       "      <td>HCC1187</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>PIP5K1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>0.185232</td>\n",
       "      <td>2.393786</td>\n",
       "      <td>...</td>\n",
       "      <td>0.64891</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>7</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>427</th>\n",
       "      <td>MFM-223</td>\n",
       "      <td>AKT_1</td>\n",
       "      <td>ESR1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.112109</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>90.899772</td>\n",
       "      <td>0.229423</td>\n",
       "      <td>0.862415</td>\n",
       "      <td>...</td>\n",
       "      <td>0.64891</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1173</th>\n",
       "      <td>BFTC-905</td>\n",
       "      <td>Cisplatin</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.000</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>0.364798</td>\n",
       "      <td>19.465682</td>\n",
       "      <td>0.659357</td>\n",
       "      <td>2.290887</td>\n",
       "      <td>...</td>\n",
       "      <td>4.20000</td>\n",
       "      <td>91.51000</td>\n",
       "      <td>8.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>34.000</td>\n",
       "      <td>0.46000</td>\n",
       "      <td>1</td>\n",
       "      <td>3</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1808</th>\n",
       "      <td>RKO</td>\n",
       "      <td>IGFR_3</td>\n",
       "      <td>TKI</td>\n",
       "      <td>3.00</td>\n",
       "      <td>10.000</td>\n",
       "      <td>0.000300</td>\n",
       "      <td>0.100000</td>\n",
       "      <td>94.341311</td>\n",
       "      <td>3.302122</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>5.09000</td>\n",
       "      <td>59.51000</td>\n",
       "      <td>6.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>30.000</td>\n",
       "      <td>0.54000</td>\n",
       "      <td>6</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>312</th>\n",
       "      <td>HCC1428</td>\n",
       "      <td>AKT</td>\n",
       "      <td>PIP5K1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>0.64891</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1650</th>\n",
       "      <td>COLO-205</td>\n",
       "      <td>IAP</td>\n",
       "      <td>IGFR_3</td>\n",
       "      <td>10.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.572456</td>\n",
       "      <td>1.742764</td>\n",
       "      <td>27.317222</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>2.77730</td>\n",
       "      <td>91.72071</td>\n",
       "      <td>3.953</td>\n",
       "      <td>2.456</td>\n",
       "      <td>29.916</td>\n",
       "      <td>0.67374</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>926</th>\n",
       "      <td>HCC38</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>PIM1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>0.199227</td>\n",
       "      <td>2.564842</td>\n",
       "      <td>...</td>\n",
       "      <td>3.28000</td>\n",
       "      <td>100.72000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>27.000</td>\n",
       "      <td>0.80000</td>\n",
       "      <td>3</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1754</th>\n",
       "      <td>KU-19-19</td>\n",
       "      <td>IAP</td>\n",
       "      <td>TNF</td>\n",
       "      <td>0.10</td>\n",
       "      <td>3.000</td>\n",
       "      <td>0.002845</td>\n",
       "      <td>9.003956</td>\n",
       "      <td>94.166817</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>0.50000</td>\n",
       "      <td>102.00000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>2.804</td>\n",
       "      <td>31.000</td>\n",
       "      <td>0.65147</td>\n",
       "      <td>3</td>\n",
       "      <td>3</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1673</th>\n",
       "      <td>BFTC-905</td>\n",
       "      <td>IAP</td>\n",
       "      <td>PARP1</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.000</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>1.425394</td>\n",
       "      <td>46.178018</td>\n",
       "      <td>0.000300</td>\n",
       "      <td>0.267009</td>\n",
       "      <td>...</td>\n",
       "      <td>2.13000</td>\n",
       "      <td>82.08000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>32.000</td>\n",
       "      <td>0.80000</td>\n",
       "      <td>1</td>\n",
       "      <td>3</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1792</th>\n",
       "      <td>NCI-H2228</td>\n",
       "      <td>IAP</td>\n",
       "      <td>Vinorelbine</td>\n",
       "      <td>0.10</td>\n",
       "      <td>0.300</td>\n",
       "      <td>0.035879</td>\n",
       "      <td>2.667383</td>\n",
       "      <td>31.957828</td>\n",
       "      <td>0.014444</td>\n",
       "      <td>0.844313</td>\n",
       "      <td>...</td>\n",
       "      <td>5.40000</td>\n",
       "      <td>133.87000</td>\n",
       "      <td>10.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>57.000</td>\n",
       "      <td>0.20000</td>\n",
       "      <td>3</td>\n",
       "      <td>2</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>455</th>\n",
       "      <td>CAL-51</td>\n",
       "      <td>AKT_1</td>\n",
       "      <td>PIK3C_2</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.756050</td>\n",
       "      <td>1.912547</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>0.339476</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>2.34000</td>\n",
       "      <td>89.63000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>29.000</td>\n",
       "      <td>0.82000</td>\n",
       "      <td>3</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>41</th>\n",
       "      <td>CAL-148</td>\n",
       "      <td>ADAM17</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>75.000</td>\n",
       "      <td>0.011726</td>\n",
       "      <td>2.129381</td>\n",
       "      <td>92.371276</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.23000</td>\n",
       "      <td>88.41000</td>\n",
       "      <td>6.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>27.000</td>\n",
       "      <td>0.39000</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1416</th>\n",
       "      <td>HCC1187</td>\n",
       "      <td>ESR1</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>91.800024</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>4.20000</td>\n",
       "      <td>91.51000</td>\n",
       "      <td>8.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>34.000</td>\n",
       "      <td>0.46000</td>\n",
       "      <td>7</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1263</th>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>Doxorubicin</td>\n",
       "      <td>TOP2</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.300</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>0.471923</td>\n",
       "      <td>32.846372</td>\n",
       "      <td>0.003126</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>5.40000</td>\n",
       "      <td>67.00000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>30.000</td>\n",
       "      <td>0.44000</td>\n",
       "      <td>5</td>\n",
       "      <td>2</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1582</th>\n",
       "      <td>BT-20</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>TNKS_PARP6</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.033756</td>\n",
       "      <td>2.368814</td>\n",
       "      <td>2.172432</td>\n",
       "      <td>0.094899</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>0.64891</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1115</th>\n",
       "      <td>NCI-H1563</td>\n",
       "      <td>CarboTaxol</td>\n",
       "      <td>CSNK2A1_2</td>\n",
       "      <td>0.03</td>\n",
       "      <td>0.003</td>\n",
       "      <td>0.010190</td>\n",
       "      <td>1.110350</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>0.001023</td>\n",
       "      <td>1.388495</td>\n",
       "      <td>...</td>\n",
       "      <td>1.36000</td>\n",
       "      <td>136.39000</td>\n",
       "      <td>8.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>31.000</td>\n",
       "      <td>0.43000</td>\n",
       "      <td>3</td>\n",
       "      <td>2</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1536</th>\n",
       "      <td>MCF7</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>MTOR_3</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.000100</td>\n",
       "      <td>0.128020</td>\n",
       "      <td>3.291008</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.866167</td>\n",
       "      <td>...</td>\n",
       "      <td>5.90000</td>\n",
       "      <td>205.00000</td>\n",
       "      <td>9.000</td>\n",
       "      <td>3.190</td>\n",
       "      <td>68.000</td>\n",
       "      <td>0.23458</td>\n",
       "      <td>7</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>707</th>\n",
       "      <td>NCI-H226</td>\n",
       "      <td>ATR_4</td>\n",
       "      <td>IAP</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.000</td>\n",
       "      <td>0.000300</td>\n",
       "      <td>0.112910</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>0.999839</td>\n",
       "      <td>1.431927</td>\n",
       "      <td>...</td>\n",
       "      <td>0.64891</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>3</td>\n",
       "      <td>2</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>331</th>\n",
       "      <td>HCC38</td>\n",
       "      <td>AKT</td>\n",
       "      <td>TNKS_PARP6</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.033507</td>\n",
       "      <td>1.827697</td>\n",
       "      <td>11.321559</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>0.64891</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>3</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1345</th>\n",
       "      <td>T-24</td>\n",
       "      <td>ERBB</td>\n",
       "      <td>Gemcitabine</td>\n",
       "      <td>0.10</td>\n",
       "      <td>3.000</td>\n",
       "      <td>0.002177</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>50.848329</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>0.748298</td>\n",
       "      <td>...</td>\n",
       "      <td>-0.90000</td>\n",
       "      <td>121.00000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>1.728</td>\n",
       "      <td>18.000</td>\n",
       "      <td>0.62381</td>\n",
       "      <td>3</td>\n",
       "      <td>3</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1126</th>\n",
       "      <td>C32</td>\n",
       "      <td>CHEK1</td>\n",
       "      <td>IAP</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.001645</td>\n",
       "      <td>2.137302</td>\n",
       "      <td>11.374636</td>\n",
       "      <td>0.600844</td>\n",
       "      <td>2.912589</td>\n",
       "      <td>...</td>\n",
       "      <td>0.64891</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>4</td>\n",
       "      <td>0</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1687</th>\n",
       "      <td>COLO-205</td>\n",
       "      <td>IAP</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>10.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.936699</td>\n",
       "      <td>1.337730</td>\n",
       "      <td>8.667356</td>\n",
       "      <td>0.031023</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>2.15000</td>\n",
       "      <td>144.17000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>35.000</td>\n",
       "      <td>0.43000</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1843</th>\n",
       "      <td>MFM-223</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.137875</td>\n",
       "      <td>1.513378</td>\n",
       "      <td>19.571895</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.10000</td>\n",
       "      <td>92.71000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>32.000</td>\n",
       "      <td>0.63000</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1566</th>\n",
       "      <td>NCI-SNU-16</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>Proteasome_2</td>\n",
       "      <td>0.10</td>\n",
       "      <td>0.010</td>\n",
       "      <td>0.002246</td>\n",
       "      <td>5.098623</td>\n",
       "      <td>0.390186</td>\n",
       "      <td>0.007885</td>\n",
       "      <td>3.244023</td>\n",
       "      <td>...</td>\n",
       "      <td>4.70000</td>\n",
       "      <td>159.00000</td>\n",
       "      <td>20.000</td>\n",
       "      <td>3.429</td>\n",
       "      <td>52.000</td>\n",
       "      <td>0.27258</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>367</th>\n",
       "      <td>HCC70</td>\n",
       "      <td>AKT_1</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>0.496070</td>\n",
       "      <td>0.862244</td>\n",
       "      <td>...</td>\n",
       "      <td>5.36446</td>\n",
       "      <td>158.48754</td>\n",
       "      <td>11.564</td>\n",
       "      <td>2.847</td>\n",
       "      <td>60.555</td>\n",
       "      <td>0.19713</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1407</th>\n",
       "      <td>Hs-578-T</td>\n",
       "      <td>ERBB</td>\n",
       "      <td>PIK3CA_4</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.304208</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>81.299849</td>\n",
       "      <td>0.173764</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>2.83000</td>\n",
       "      <td>129.45000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>30.000</td>\n",
       "      <td>0.74000</td>\n",
       "      <td>3</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>546</th>\n",
       "      <td>NCI-H1437</td>\n",
       "      <td>ALK</td>\n",
       "      <td>EGFR_2</td>\n",
       "      <td>1.00</td>\n",
       "      <td>3.000</td>\n",
       "      <td>0.037287</td>\n",
       "      <td>0.296344</td>\n",
       "      <td>72.290890</td>\n",
       "      <td>0.704059</td>\n",
       "      <td>0.807068</td>\n",
       "      <td>...</td>\n",
       "      <td>4.30000</td>\n",
       "      <td>68.74000</td>\n",
       "      <td>8.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>31.000</td>\n",
       "      <td>0.52000</td>\n",
       "      <td>3</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>173</th>\n",
       "      <td>MDA-MB-453</td>\n",
       "      <td>AKT</td>\n",
       "      <td>Chloroquine</td>\n",
       "      <td>10.00</td>\n",
       "      <td>3.000</td>\n",
       "      <td>0.265877</td>\n",
       "      <td>1.221960</td>\n",
       "      <td>88.641016</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>0.359418</td>\n",
       "      <td>...</td>\n",
       "      <td>4.60000</td>\n",
       "      <td>28.20000</td>\n",
       "      <td>8.000</td>\n",
       "      <td>3.461</td>\n",
       "      <td>22.000</td>\n",
       "      <td>0.57535</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>335</th>\n",
       "      <td>MDA-MB-468</td>\n",
       "      <td>AKT</td>\n",
       "      <td>TNKS_PARP6</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.030741</td>\n",
       "      <td>1.805914</td>\n",
       "      <td>1.546169</td>\n",
       "      <td>0.561024</td>\n",
       "      <td>1.059781</td>\n",
       "      <td>...</td>\n",
       "      <td>0.64891</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2093</th>\n",
       "      <td>NCI-H2228</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>Topotecan</td>\n",
       "      <td>0.10</td>\n",
       "      <td>3.000</td>\n",
       "      <td>0.039712</td>\n",
       "      <td>0.471266</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>0.230177</td>\n",
       "      <td>...</td>\n",
       "      <td>1.58000</td>\n",
       "      <td>103.20000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>31.000</td>\n",
       "      <td>0.73000</td>\n",
       "      <td>3</td>\n",
       "      <td>2</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>920</th>\n",
       "      <td>BFTC-905</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>PIM1</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>1.489457</td>\n",
       "      <td>1.554690</td>\n",
       "      <td>...</td>\n",
       "      <td>3.28000</td>\n",
       "      <td>100.72000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>27.000</td>\n",
       "      <td>0.80000</td>\n",
       "      <td>1</td>\n",
       "      <td>3</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2081</th>\n",
       "      <td>HCC1937</td>\n",
       "      <td>PIK3C_2</td>\n",
       "      <td>PIK3CA_4</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.965270</td>\n",
       "      <td>79.337934</td>\n",
       "      <td>0.367983</td>\n",
       "      <td>3.271301</td>\n",
       "      <td>...</td>\n",
       "      <td>2.83000</td>\n",
       "      <td>129.45000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>30.000</td>\n",
       "      <td>0.74000</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>252</th>\n",
       "      <td>HCC1395</td>\n",
       "      <td>AKT</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000</td>\n",
       "      <td>0.009466</td>\n",
       "      <td>1.435014</td>\n",
       "      <td>48.154951</td>\n",
       "      <td>0.374680</td>\n",
       "      <td>0.920986</td>\n",
       "      <td>...</td>\n",
       "      <td>4.20000</td>\n",
       "      <td>91.51000</td>\n",
       "      <td>8.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>34.000</td>\n",
       "      <td>0.46000</td>\n",
       "      <td>3</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>2154 rows × 38 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "       CELL_LINE   COMPOUND_A     COMPOUND_B  MAX_CONC_A  MAX_CONC_B  \\\n",
       "1945     CAL-148       MTOR_1          PIK3C        1.00       1.000   \n",
       "1461        T47D       ESR1_1         MTOR_1        1.00       3.000   \n",
       "1920     HCC1143      MAP2K_1        SLC16A4        1.00       1.000   \n",
       "326       CAMA-1          AKT     TNKS_PARP6        1.00       1.000   \n",
       "1611        MCF7       HDAC_4          PARP1        1.00       1.000   \n",
       "295       CAMA-1          AKT       PIK3CA_4        1.00       1.000   \n",
       "548    NCI-H1975          ALK         EGFR_2        1.00       3.000   \n",
       "1796   NCI-H3122          IAP    Vinorelbine        0.10       0.300   \n",
       "1376      CAL-51         ERBB         MTOR_1        1.00       1.000   \n",
       "270      HCC1500          AKT         HDAC_4        1.00       1.000   \n",
       "65    MDA-MB-453       ADAM17         MTOR_1        1.00      75.000   \n",
       "1324     HCC1395         ERBB           FGFR        1.00       1.000   \n",
       "711     NCI-H522        ATR_4            IAP        0.30       3.000   \n",
       "1641        T-24        HSP90          PARP1        3.00       0.300   \n",
       "1099     DMS-114  Carboplatin      CSNK2A1_2        0.03       3.000   \n",
       "591       Calu-3        ALK_2         PIK3CB        3.00       3.000   \n",
       "552     NCI-H838          ALK         EGFR_2        1.00       3.000   \n",
       "454      CAL-148        AKT_1        PIK3C_2        1.00       1.000   \n",
       "351       EVSA-T        AKT_1         BCL2_2        3.00       3.000   \n",
       "1301  MDA-MB-157         EGFR           FGFR        1.00       0.100   \n",
       "101   MDA-MB-468       ADAM17  PIK3CB_PIK3CD        1.00      75.000   \n",
       "1356     DU-4475         ERBB        MAP2K_1        1.00       1.000   \n",
       "338      CAL-120        AKT_1       ALK_IGFR        1.00       1.000   \n",
       "266      UM-UC-3          AKT           FGFR        3.00       3.000   \n",
       "320          J82          AKT            TNF        0.10       3.000   \n",
       "1560      KMS-11         FGFR   Proteasome_2        0.03       0.030   \n",
       "1127      Calu-3        CHEK1            IAP        1.00       1.000   \n",
       "2061     HCC1187        PIK3C         PIP5K1        1.00       1.000   \n",
       "427      MFM-223        AKT_1           ESR1        1.00       1.000   \n",
       "1173    BFTC-905    Cisplatin           FGFR        3.00       3.000   \n",
       "...          ...          ...            ...         ...         ...   \n",
       "1808         RKO       IGFR_3            TKI        3.00      10.000   \n",
       "312      HCC1428          AKT         PIP5K1        1.00       1.000   \n",
       "1650    COLO-205          IAP         IGFR_3       10.00       1.000   \n",
       "926        HCC38  BCL2_BCL2L1           PIM1        1.00       1.000   \n",
       "1754    KU-19-19          IAP            TNF        0.10       3.000   \n",
       "1673    BFTC-905          IAP          PARP1        3.00       3.000   \n",
       "1792   NCI-H2228          IAP    Vinorelbine        0.10       0.300   \n",
       "455       CAL-51        AKT_1        PIK3C_2        1.00       1.000   \n",
       "41       CAL-148       ADAM17        MAP2K_1        1.00      75.000   \n",
       "1416     HCC1187         ESR1           FGFR        1.00       1.000   \n",
       "1263   NCI-H1299  Doxorubicin           TOP2        3.00       0.300   \n",
       "1582       BT-20         FGFR     TNKS_PARP6        1.00       1.000   \n",
       "1115   NCI-H1563   CarboTaxol      CSNK2A1_2        0.03       0.003   \n",
       "1536        MCF7         FGFR         MTOR_3        1.00       1.000   \n",
       "707     NCI-H226        ATR_4            IAP        3.00       3.000   \n",
       "331        HCC38          AKT     TNKS_PARP6        1.00       1.000   \n",
       "1345        T-24         ERBB    Gemcitabine        0.10       3.000   \n",
       "1126         C32        CHEK1            IAP        1.00       1.000   \n",
       "1687    COLO-205          IAP          PIK3C       10.00       1.000   \n",
       "1843     MFM-223      MAP2K_1         MTOR_1        1.00       1.000   \n",
       "1566  NCI-SNU-16         FGFR   Proteasome_2        0.10       0.010   \n",
       "367        HCC70        AKT_1    BCL2_BCL2L1        1.00       1.000   \n",
       "1407    Hs-578-T         ERBB       PIK3CA_4        1.00       1.000   \n",
       "546    NCI-H1437          ALK         EGFR_2        1.00       3.000   \n",
       "173   MDA-MB-453          AKT    Chloroquine       10.00       3.000   \n",
       "335   MDA-MB-468          AKT     TNKS_PARP6        1.00       1.000   \n",
       "2093   NCI-H2228       PIK3CB      Topotecan        0.10       3.000   \n",
       "920     BFTC-905  BCL2_BCL2L1           PIM1        3.00       3.000   \n",
       "2081     HCC1937      PIK3C_2       PIK3CA_4        1.00       1.000   \n",
       "252      HCC1395          AKT           FGFR        1.00       1.000   \n",
       "\n",
       "        IC50_A        H_A      Einf_A    IC50_B        H_B      ...       \\\n",
       "1945  0.314329  10.000000   43.699456  1.000000  10.000000      ...        \n",
       "1461  0.102131   1.095705   20.057830  0.000300   0.100000      ...        \n",
       "1920  1.000000   0.000000  100.000000  0.084926   0.712687      ...        \n",
       "326   0.023921   1.621019   23.083495  0.145754   1.400578      ...        \n",
       "1611  0.301324   1.778939   80.708031  1.000000   1.393510      ...        \n",
       "295   0.295413  10.000000   94.799955  0.142178   1.297171      ...        \n",
       "548   0.323377   3.779439   87.426309  0.547975   1.274686      ...        \n",
       "1796  0.025216  10.000000    7.693668  1.000000   0.000000      ...        \n",
       "1376  0.192463   1.382213   18.976524  0.447905  10.000000      ...        \n",
       "270   0.428483   1.788120   16.778327  0.325242  10.000000      ...        \n",
       "65    0.274518  10.000000   14.599022  1.000000   0.000000      ...        \n",
       "1324  0.009375   1.413786   47.213513  1.000000   0.321879      ...        \n",
       "711   0.006932   0.293182    2.478698  0.979009  10.000000      ...        \n",
       "1641  3.000000  10.000000   21.800190  0.098012  10.000000      ...        \n",
       "1099  0.009092  10.000000   17.399286  1.202134   1.809929      ...        \n",
       "591   0.025933  10.000000   94.575001  2.639002   2.754952      ...        \n",
       "552   1.000000   0.000000  100.000000  0.949170   1.859119      ...        \n",
       "454   1.000000   0.875558   45.571761  0.261342   1.071766      ...        \n",
       "351   1.557766   7.169113    0.000000  0.498925   2.480305      ...        \n",
       "1301  0.030291   1.704302   36.604729  0.100000  10.000000      ...        \n",
       "101   0.000100   0.100000   94.074502  1.000000   0.000000      ...        \n",
       "1356  0.029558  10.000000    0.566343  1.000000   0.000000      ...        \n",
       "338   0.363098  10.000000   60.498424  0.014077   2.166135      ...        \n",
       "266   1.000000   0.000000  100.000000  1.108598  10.000000      ...        \n",
       "320   0.100000   0.389236   46.631120  0.635866   0.779150      ...        \n",
       "1560  0.001258   4.161496    0.408675  0.028551   1.739839      ...        \n",
       "1127  1.000000   0.000000  100.000000  0.349881  10.000000      ...        \n",
       "2061  1.000000   0.000000  100.000000  0.185232   2.393786      ...        \n",
       "427   0.112109  10.000000   90.899772  0.229423   0.862415      ...        \n",
       "1173  3.000000   0.364798   19.465682  0.659357   2.290887      ...        \n",
       "...        ...        ...         ...       ...        ...      ...        \n",
       "1808  0.000300   0.100000   94.341311  3.302122  10.000000      ...        \n",
       "312   1.000000   0.000000  100.000000  1.000000   0.000000      ...        \n",
       "1650  0.572456   1.742764   27.317222  1.000000  10.000000      ...        \n",
       "926   1.000000   0.000000  100.000000  0.199227   2.564842      ...        \n",
       "1754  0.002845   9.003956   94.166817  1.000000   0.000000      ...        \n",
       "1673  3.000000   1.425394   46.178018  0.000300   0.267009      ...        \n",
       "1792  0.035879   2.667383   31.957828  0.014444   0.844313      ...        \n",
       "455   0.756050   1.912547    0.000000  0.339476  10.000000      ...        \n",
       "41    0.011726   2.129381   92.371276  1.000000   0.000000      ...        \n",
       "1416  1.000000  10.000000   91.800024  1.000000   0.000000      ...        \n",
       "1263  3.000000   0.471923   32.846372  0.003126  10.000000      ...        \n",
       "1582  0.033756   2.368814    2.172432  0.094899  10.000000      ...        \n",
       "1115  0.010190   1.110350    0.000000  0.001023   1.388495      ...        \n",
       "1536  0.000100   0.128020    3.291008  1.000000   0.866167      ...        \n",
       "707   0.000300   0.112910    0.000000  0.999839   1.431927      ...        \n",
       "331   0.033507   1.827697   11.321559  1.000000  10.000000      ...        \n",
       "1345  0.002177  10.000000   50.848329  3.000000   0.748298      ...        \n",
       "1126  0.001645   2.137302   11.374636  0.600844   2.912589      ...        \n",
       "1687  0.936699   1.337730    8.667356  0.031023  10.000000      ...        \n",
       "1843  0.137875   1.513378   19.571895  1.000000   0.000000      ...        \n",
       "1566  0.002246   5.098623    0.390186  0.007885   3.244023      ...        \n",
       "367   1.000000   0.000000  100.000000  0.496070   0.862244      ...        \n",
       "1407  0.304208  10.000000   81.299849  0.173764  10.000000      ...        \n",
       "546   0.037287   0.296344   72.290890  0.704059   0.807068      ...        \n",
       "173   0.265877   1.221960   88.641016  3.000000   0.359418      ...        \n",
       "335   0.030741   1.805914    1.546169  0.561024   1.059781      ...        \n",
       "2093  0.039712   0.471266    0.000000  3.000000   0.230177      ...        \n",
       "920   1.000000   0.000000  100.000000  1.489457   1.554690      ...        \n",
       "2081  1.000000   0.965270   79.337934  0.367983   3.271301      ...        \n",
       "252   0.009466   1.435014   48.154951  0.374680   0.920986      ...        \n",
       "\n",
       "      B_ALogP/XLogP      B_PSA  B_#RotBonds  B_Arom Rings  B_Heavy atoms  \\\n",
       "1945        2.15000  144.17000        5.000         4.000         35.000   \n",
       "1461        3.10000   92.71000        4.000         3.000         32.000   \n",
       "1920        0.64891   92.76332        3.068         2.597         23.849   \n",
       "326         0.64891   92.76332        3.068         2.597         23.849   \n",
       "1611        2.13000   82.08000        4.000         2.000         32.000   \n",
       "295         2.83000  129.45000        5.000         2.000         30.000   \n",
       "548         4.30000   68.74000        8.000         3.000         31.000   \n",
       "1796        5.40000  133.87000       10.000         3.000         57.000   \n",
       "1376        3.10000   92.71000        4.000         3.000         32.000   \n",
       "270         1.90000   78.40000        8.000         2.247         19.000   \n",
       "65          3.10000   92.71000        4.000         3.000         32.000   \n",
       "1324        4.20000   91.51000        8.000         4.000         34.000   \n",
       "711         0.64891   92.76332        3.068         2.597         23.849   \n",
       "1641        2.13000   82.08000        4.000         2.000         32.000   \n",
       "1099        1.36000  136.39000        8.000         3.000         31.000   \n",
       "591         0.64891   92.76332        3.068         2.597         23.849   \n",
       "552         4.30000   68.74000        8.000         3.000         31.000   \n",
       "454         2.34000   89.63000        4.000         2.000         29.000   \n",
       "351         0.64891   92.76332        3.068         2.597         23.849   \n",
       "1301        4.20000   91.51000        8.000         4.000         34.000   \n",
       "101         1.43671   99.50709        4.289         2.737         30.490   \n",
       "1356        3.23000   88.41000        6.000         3.000         27.000   \n",
       "338         2.75692   97.43558        4.903         2.427         30.291   \n",
       "266         4.20000   91.51000        8.000         4.000         34.000   \n",
       "320         0.50000  102.00000        3.000         2.804         31.000   \n",
       "1560        4.70000  159.00000       20.000         3.429         52.000   \n",
       "1127        0.64891   92.76332        3.068         2.597         23.849   \n",
       "2061        0.64891   92.76332        3.068         2.597         23.849   \n",
       "427         0.64891   92.76332        3.068         2.597         23.849   \n",
       "1173        4.20000   91.51000        8.000         4.000         34.000   \n",
       "...             ...        ...          ...           ...            ...   \n",
       "1808        5.09000   59.51000        6.000         3.000         30.000   \n",
       "312         0.64891   92.76332        3.068         2.597         23.849   \n",
       "1650        2.77730   91.72071        3.953         2.456         29.916   \n",
       "926         3.28000  100.72000        3.000         2.000         27.000   \n",
       "1754        0.50000  102.00000        3.000         2.804         31.000   \n",
       "1673        2.13000   82.08000        4.000         2.000         32.000   \n",
       "1792        5.40000  133.87000       10.000         3.000         57.000   \n",
       "455         2.34000   89.63000        4.000         2.000         29.000   \n",
       "41          3.23000   88.41000        6.000         3.000         27.000   \n",
       "1416        4.20000   91.51000        8.000         4.000         34.000   \n",
       "1263        5.40000   67.00000        2.000         4.000         30.000   \n",
       "1582        0.64891   92.76332        3.068         2.597         23.849   \n",
       "1115        1.36000  136.39000        8.000         3.000         31.000   \n",
       "1536        5.90000  205.00000        9.000         3.190         68.000   \n",
       "707         0.64891   92.76332        3.068         2.597         23.849   \n",
       "331         0.64891   92.76332        3.068         2.597         23.849   \n",
       "1345       -0.90000  121.00000        2.000         1.728         18.000   \n",
       "1126        0.64891   92.76332        3.068         2.597         23.849   \n",
       "1687        2.15000  144.17000        5.000         4.000         35.000   \n",
       "1843        3.10000   92.71000        4.000         3.000         32.000   \n",
       "1566        4.70000  159.00000       20.000         3.429         52.000   \n",
       "367         5.36446  158.48754       11.564         2.847         60.555   \n",
       "1407        2.83000  129.45000        5.000         2.000         30.000   \n",
       "546         4.30000   68.74000        8.000         3.000         31.000   \n",
       "173         4.60000   28.20000        8.000         3.461         22.000   \n",
       "335         0.64891   92.76332        3.068         2.597         23.849   \n",
       "2093        1.58000  103.20000        3.000         2.000         31.000   \n",
       "920         3.28000  100.72000        3.000         2.000         27.000   \n",
       "2081        2.83000  129.45000        5.000         2.000         30.000   \n",
       "252         4.20000   91.51000        8.000         4.000         34.000   \n",
       "\n",
       "        B_QED  GEX_CLUSTER  ORIGIN_CLUSTER  THERAPY_CLUSTER  Target_share  \n",
       "1945  0.43000            2               1                3             0  \n",
       "1461  0.63000            2               1                3             0  \n",
       "1920  0.63639            1               1                0             0  \n",
       "326   0.63639            2               1                3             0  \n",
       "1611  0.80000            7               1                0             0  \n",
       "295   0.74000            2               1                0             0  \n",
       "548   0.52000            3               2                0             0  \n",
       "1796  0.20000            1               2                2             0  \n",
       "1376  0.63000            3               1                2             0  \n",
       "270   0.64012            2               1                2             0  \n",
       "65    0.63000            2               1                2             0  \n",
       "1324  0.46000            3               1                2             0  \n",
       "711   0.63639            5               2                2             0  \n",
       "1641  0.80000            3               3                3             0  \n",
       "1099  0.43000            5               2                3             0  \n",
       "591   0.63639            1               2                0             0  \n",
       "552   0.52000            3               2                0             0  \n",
       "454   0.82000            2               1                3             0  \n",
       "351   0.63639            2               1                3             0  \n",
       "1301  0.46000            4               1                2             0  \n",
       "101   0.62948            1               1                1             0  \n",
       "1356  0.39000            6               1                2             0  \n",
       "338   0.61224            3               1                1             0  \n",
       "266   0.46000            3               3                1             0  \n",
       "320   0.65147            3               3                3             0  \n",
       "1560  0.27258            7               0                3             0  \n",
       "1127  0.63639            1               2                0             0  \n",
       "2061  0.63639            7               1                0             0  \n",
       "427   0.63639            2               1                0             0  \n",
       "1173  0.46000            1               3                3             0  \n",
       "...       ...          ...             ...              ...           ...  \n",
       "1808  0.54000            6               0                1             0  \n",
       "312   0.63639            2               1                1             0  \n",
       "1650  0.67374            0               0                2             0  \n",
       "926   0.80000            3               1                0             0  \n",
       "1754  0.65147            3               3                1             0  \n",
       "1673  0.80000            1               3                3             0  \n",
       "1792  0.20000            3               2                3             0  \n",
       "455   0.82000            3               1                2             0  \n",
       "41    0.39000            2               1                1             0  \n",
       "1416  0.46000            7               1                1             0  \n",
       "1263  0.44000            5               2                2             1  \n",
       "1582  0.63639            1               1                2             0  \n",
       "1115  0.43000            3               2                3             0  \n",
       "1536  0.23458            7               1                2             0  \n",
       "707   0.63639            3               2                3             0  \n",
       "331   0.63639            3               1                2             0  \n",
       "1345  0.62381            3               3                2             0  \n",
       "1126  0.63639            4               0                3             0  \n",
       "1687  0.43000            0               0                2             0  \n",
       "1843  0.63000            2               1                2             0  \n",
       "1566  0.27258            0               0                3             0  \n",
       "367   0.19713            1               1                0             0  \n",
       "1407  0.74000            3               1                1             0  \n",
       "546   0.52000            3               2                0             0  \n",
       "173   0.57535            2               1                0             0  \n",
       "335   0.63639            1               1                3             0  \n",
       "2093  0.73000            3               2                3             0  \n",
       "920   0.80000            1               3                1             0  \n",
       "2081  0.74000            1               1                1             1  \n",
       "252   0.46000            3               1                0             0  \n",
       "\n",
       "[2154 rows x 38 columns]"
      ]
     },
     "execution_count": 13,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "df = pd.DataFrame.from_csv('Train_data/with_targets2.csv')\n",
    "df"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "metadata": {
    "collapsed": false,
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>Target</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>ADAM17</th>\n",
       "      <td>ADAM17</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>AKT</th>\n",
       "      <td>AKT1,AKT2,AKT3</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>AKT_1</th>\n",
       "      <td>AKT1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>AKT_PIK3C</th>\n",
       "      <td>AKT1,PIK3CA</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>AKT_SGK</th>\n",
       "      <td>AKT1,SGK1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ALK</th>\n",
       "      <td>ALK</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ALK_2</th>\n",
       "      <td>ALK</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ALK_IGFR</th>\n",
       "      <td>ALK,IGF1R,IGF2R</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>AR</th>\n",
       "      <td>AR</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>AR_1</th>\n",
       "      <td>AR</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ATM</th>\n",
       "      <td>ATM</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ATR_1</th>\n",
       "      <td>ATR</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ATR_2</th>\n",
       "      <td>ATR</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ATR_3</th>\n",
       "      <td>ATR</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ATR_4</th>\n",
       "      <td>ATR</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>Azacytidine</th>\n",
       "      <td>Methylation</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BCL2</th>\n",
       "      <td>BCL2</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BCL2_2</th>\n",
       "      <td>BCL2</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BCL2_3</th>\n",
       "      <td>BCL2</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BCL2_BCL2L1</th>\n",
       "      <td>BCL2,BCL2L1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BCL2_BCL2L1_BCL2L2</th>\n",
       "      <td>BCL2,BCL2L1,BCL2L2</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BCL2L1</th>\n",
       "      <td>BCL2L1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BIRC5</th>\n",
       "      <td>BIRC5</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BRAF_2</th>\n",
       "      <td>BRAF</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BRAF_M</th>\n",
       "      <td>BRAF_mut</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BRAF_M2</th>\n",
       "      <td>BRAF_V600E</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BRAF_VEGFC</th>\n",
       "      <td>BRAF,VEGFC,KDR</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>Carboplatin</th>\n",
       "      <td>DNA</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>CarboTaxol</th>\n",
       "      <td>DNA</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>CD19</th>\n",
       "      <td>CD19antibody</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PIK3CA_3</th>\n",
       "      <td>PIK3CA</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PIK3CA_4</th>\n",
       "      <td>PIK3CA</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PIK3CB</th>\n",
       "      <td>PIK3CB</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PIK3CB_PIK3CD</th>\n",
       "      <td>PIK3CB,PIK3CD</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PIM1</th>\n",
       "      <td>PIM1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PIP5K1</th>\n",
       "      <td>PIP5K1A</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PRKC</th>\n",
       "      <td>PAWR</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PRKDC_2</th>\n",
       "      <td>PRKDC</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>Proteasome</th>\n",
       "      <td>Proteasome</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>Proteasome_2</th>\n",
       "      <td>Proteasome</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PTK2</th>\n",
       "      <td>PTK2</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PTK2_2</th>\n",
       "      <td>PTK2</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SLC16A4</th>\n",
       "      <td>SLC16A3,SLC16A4</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SN38</th>\n",
       "      <td>TOP1,TOP2A</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SRC</th>\n",
       "      <td>SRC</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SYK</th>\n",
       "      <td>SYK</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TKI</th>\n",
       "      <td>KDR,EGFR,RET</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TKI_2</th>\n",
       "      <td>VEGFC,KDR,TEK</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TNF</th>\n",
       "      <td>TNF</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TNFSF10</th>\n",
       "      <td>TNFSF10</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TNKS_PARP6</th>\n",
       "      <td>TNKS,PARP6</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TOP2</th>\n",
       "      <td>TOP2A,PRKDC</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TOP2_2</th>\n",
       "      <td>TOP2A</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>Topotecan</th>\n",
       "      <td>TOP1,TOP1MT,DNA</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TTK</th>\n",
       "      <td>TTK</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TYMS</th>\n",
       "      <td>TYMS</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>VEGF</th>\n",
       "      <td>KDR,FLT1,FLT4</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>Vinorelbine</th>\n",
       "      <td>microtubule,TUBB</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>WEE1</th>\n",
       "      <td>WEE1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>WNT</th>\n",
       "      <td>WNT1,TNKS</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>119 rows × 1 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                                Target\n",
       "ADAM17                          ADAM17\n",
       "AKT                     AKT1,AKT2,AKT3\n",
       "AKT_1                             AKT1\n",
       "AKT_PIK3C                  AKT1,PIK3CA\n",
       "AKT_SGK                      AKT1,SGK1\n",
       "ALK                                ALK\n",
       "ALK_2                              ALK\n",
       "ALK_IGFR               ALK,IGF1R,IGF2R\n",
       "AR                                  AR\n",
       "AR_1                                AR\n",
       "ATM                                ATM\n",
       "ATR_1                              ATR\n",
       "ATR_2                              ATR\n",
       "ATR_3                              ATR\n",
       "ATR_4                              ATR\n",
       "Azacytidine                Methylation\n",
       "BCL2                              BCL2\n",
       "BCL2_2                            BCL2\n",
       "BCL2_3                            BCL2\n",
       "BCL2_BCL2L1                BCL2,BCL2L1\n",
       "BCL2_BCL2L1_BCL2L2  BCL2,BCL2L1,BCL2L2\n",
       "BCL2L1                          BCL2L1\n",
       "BIRC5                            BIRC5\n",
       "BRAF_2                            BRAF\n",
       "BRAF_M                        BRAF_mut\n",
       "BRAF_M2                     BRAF_V600E\n",
       "BRAF_VEGFC              BRAF,VEGFC,KDR\n",
       "Carboplatin                        DNA\n",
       "CarboTaxol                         DNA\n",
       "CD19                      CD19antibody\n",
       "...                                ...\n",
       "PIK3CA_3                        PIK3CA\n",
       "PIK3CA_4                        PIK3CA\n",
       "PIK3CB                          PIK3CB\n",
       "PIK3CB_PIK3CD            PIK3CB,PIK3CD\n",
       "PIM1                              PIM1\n",
       "PIP5K1                         PIP5K1A\n",
       "PRKC                              PAWR\n",
       "PRKDC_2                          PRKDC\n",
       "Proteasome                  Proteasome\n",
       "Proteasome_2                Proteasome\n",
       "PTK2                              PTK2\n",
       "PTK2_2                            PTK2\n",
       "SLC16A4                SLC16A3,SLC16A4\n",
       "SN38                        TOP1,TOP2A\n",
       "SRC                                SRC\n",
       "SYK                                SYK\n",
       "TKI                       KDR,EGFR,RET\n",
       "TKI_2                    VEGFC,KDR,TEK\n",
       "TNF                                TNF\n",
       "TNFSF10                        TNFSF10\n",
       "TNKS_PARP6                  TNKS,PARP6\n",
       "TOP2                       TOP2A,PRKDC\n",
       "TOP2_2                           TOP2A\n",
       "Topotecan              TOP1,TOP1MT,DNA\n",
       "TTK                                TTK\n",
       "TYMS                              TYMS\n",
       "VEGF                     KDR,FLT1,FLT4\n",
       "Vinorelbine           microtubule,TUBB\n",
       "WEE1                              WEE1\n",
       "WNT                          WNT1,TNKS\n",
       "\n",
       "[119 rows x 1 columns]"
      ]
     },
     "execution_count": 14,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "d2t = pd.DataFrame.from_csv('Drug_expanded/targets.csv')\n",
    "d2t"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 15,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "2154"
      ]
     },
     "execution_count": 15,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "len(df)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 16,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "df['Target_interaction'] = ''\n",
    "for i in range(len(df)):\n",
    "    dA, dB = df.ix[i, 'COMPOUND_A'], df.ix[i, 'COMPOUND_B']           # get the two compounds\n",
    "    Atargs, Btargs = d2t.ix[dA, 'Target'], d2t.ix[dB, 'Target']       # get target string\n",
    "    Atargs, Btargs = Atargs.split(','), Btargs.split(',')             # get target array\n",
    "    \n",
    "    intScore = 0.0\n",
    "    for atarg in Atargs:\n",
    "        for btarg in Btargs:\n",
    "            if atarg in ppi_mat.columns and btarg in ppi_mat.columns:\n",
    "                interaction = ppi_mat.ix[atarg, btarg]\n",
    "                if interaction > intScore:\n",
    "                    intScore = interaction                  # set score to HIGHEST interaction among targets\n",
    "    df.set_value(i, 'Target_interaction', intScore)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 59,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "df.to_csv('Train_data/with_interaction.csv')"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Model training"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 109,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "from sklearn.ensemble import GradientBoostingRegressor, GradientBoostingClassifier\n",
    "from sklearn.svm import SVR, SVC\n",
    "from sklearn import cross_validation, metrics\n",
    "from scipy.stats import stats\n",
    "import scoring"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 293,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "def print_scores(model, X_test=X_test, y_test=y_test):\n",
    "    print(\"R^2: \" + str(model.score(X_test, y_test)))\n",
    "    print(\"RMSE: \" + str(scoring.rmse(y_test, model.predict(X_test))) ) # root mean squared error\n",
    "    print(\"MAE: \" + str(metrics.mean_absolute_error(y_test, model.predict(X_test)))) # mean absolute error\n",
    "    print(\"MAPE: \" + str(scoring.mape(y_test, model.predict(X_test)))) # mean absolute percent error\n",
    "    print(\"Error within 20: \" + str(scoring.error_within(0.2, y_test, model.predict(X_test)))) # error within\n",
    "    print(\"Pearson: \" + str(stats.pearsonr(y_test, model.predict(X_test)))) # pearson correlation"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 19,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "df = df.iloc[np.random.permutation(len(df))]\n",
    "Ypd = df['SYNERGY_SCORE']\n",
    "# Xpd = pd.get_dummies(df.drop(['SYNERGY_SCORE', 'A_HBA', 'A_cLogP', 'A_HBD', 'A_Lipinski', 'A_MW', 'A_ALogP/XLogP', 'A_PSA',\n",
    "#                              'A_#RotBonds','A_Arom Rings','A_Heavy atoms','A_QED','B_HBA','B_cLogP','B_HBD','B_Lipinski','B_MW',\n",
    "#                              'B_ALogP/XLogP','B_PSA','B_#RotBonds','B_Arom Rings','B_Heavy atoms','B_QED'], axis=1), columns=['CELL_LINE', 'COMPOUND_A', 'COMPOUND_B'])\n",
    "Xpd = pd.get_dummies(df.drop('SYNERGY_SCORE', axis=1), columns=['CELL_LINE', 'COMPOUND_A', 'COMPOUND_B'])\n",
    "\n",
    "# df = df.drop('SYNERGY_SCORE', axis=1)\n",
    "# orig_data = pd.DataFrame.from_csv('Clean_data/train2.csv', header=0, index_col=None)\n",
    "# df = df.iloc[np.random.permutation(len(orig_data))]\n",
    "# Xpd = pd.get_dummies(df, columns=['CELL_LINE', 'COMPOUND_A', 'COMPOUND_B'])\n",
    "# Ypd = orig_data['SYNERGY_SCORE'].reindex(Xpd.index)\n",
    "\n",
    "Xvals = Xpd.values\n",
    "yvals = Ypd.values"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 23,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "X_train, X_test, y_train, y_test = cross_validation.train_test_split(Xvals, yvals)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 24,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "GradientBoostingRegressor(alpha=0.9, init=None, learning_rate=0.03, loss='ls',\n",
       "             max_depth=7, max_features='log2', max_leaf_nodes=None,\n",
       "             min_samples_leaf=1, min_samples_split=2,\n",
       "             min_weight_fraction_leaf=0.0, n_estimators=1000,\n",
       "             random_state=None, subsample=1.0, verbose=0, warm_start=False)"
      ]
     },
     "execution_count": 24,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "gbr = GradientBoostingRegressor(n_estimators=1000, max_depth=7,\n",
    "                                max_features='log2', learning_rate=0.03)\n",
    "gbr.fit(X_train, y_train)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 25,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "R^2: 0.391561192447\n",
      "RMSE: 30.35882130634745\n",
      "MAE: 21.1869610395\n",
      "MAPE: 7.01738392496\n",
      "Error within 20: 0.499072356215\n",
      "Pearson: (0.62664053545381482, 3.8586087453479626e-60)\n"
     ]
    }
   ],
   "source": [
    "print_scores(gbr)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 328,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "0.105525881632, 0.504370339507\n",
      "0.131650621028, 0.474224622387\n",
      "0.368667328517, 0.608097129511\n",
      "0.207095912395, 0.539101288223\n",
      "0.330915679094, 0.576262343638\n",
      "0.395046273607, 0.640899959192\n",
      "0.343429856126, 0.592197716798\n",
      "0.349264586973, 0.598951181056\n",
      "0.39574412195, 0.629960487285\n",
      "0.0644152072839, 0.470691999593\n",
      "0.407617610354, 0.650993877221\n",
      "0.296069202291, 0.58698954614\n",
      "0.298807477369, 0.576871642577\n",
      "0.396156224032, 0.634230255649\n",
      "0.359678316325, 0.604435974294\n",
      " \n",
      "Average: 0.296672286598, 0.579218557538\n"
     ]
    }
   ],
   "source": [
    "r2s = []\n",
    "pearsons = []\n",
    "for i in range(15):\n",
    "    X_train, X_test, y_train, y_test = cross_validation.train_test_split(Xvals, yvals)\n",
    "    gbr = GradientBoostingRegressor(n_estimators=1000, max_depth=5,\n",
    "                                max_features='log2', learning_rate=0.03)\n",
    "    gbr.fit(X_train, y_train)\n",
    "    r2 = gbr.score(X_test, y_test)\n",
    "    r2s.append(r2)\n",
    "    p = stats.pearsonr(y_test, gbr.predict(X_test))[0]\n",
    "    pearsons.append(p)\n",
    "    \n",
    "    print(str(r2) + \", \" + str(p))\n",
    "print(\" \")\n",
    "print(\"Average: \" + str(np.mean(r2s)) + \", \" + str(np.mean(pearsons)))"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {
    "collapsed": true
   },
   "source": [
    "# Biogrid data"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 57,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "targets = (\"ADAM17 AKT1 AKT2 AKT3 PIK3CA PIK3CB PIK3CD SGK1 ALK IGF1R IGF2R AR ATM ATR BCL2 \"\n",
    "           \"BIRC5 BIRC2 BIRC3 BRAF VEGFC KDR CD19 CHEK1 CSNK2A1 TUBB MAP2 MAP4 MAPT TOP1 TOP2 \"\n",
    "           \"DNMT1 KIF11 EGFR ESR1 FASN FGFR1 FGFR2 FGFR3 FGFR4 FNTA FNTB RRM1 TYMS CMPK1 HDAC1 \"\n",
    "           \"HDAC3 HSP90AA1 XIAP CHUK IKBKB JAK1 JAK2 MAP2K1 MAP2K2 RAF1 MET MTOR NAE1 UBA3 PARP1 \"\n",
    "           \"PDGFRA PIM1 PIP5K1A PAWR PRKDC PTK2 SLC16A3 SLC16A4 SRC SYK RET TEK TNF TNFSF10 TNKS \"\n",
    "           \"PARP6 TTK FLT1 FLT4 WEE1 WNT1\")\n",
    "targets = targets.split()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 58,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "bnodes = []\n",
    "bn1 = []\n",
    "bn2 = []\n",
    "with open('Biogrid/mod4_single_connection.csv','r') as f:\n",
    "    reader = csv.DictReader(f, delimiter=',')\n",
    "    for row in reader:\n",
    "        t1 = row['Official Symbol Interactor A']\n",
    "        t2 = row['Official Symbol Interactor B']\n",
    "        bn1.append(t1)\n",
    "        bn2.append(t2)\n",
    "        \n",
    "        if t1 not in bnodes:\n",
    "            bnodes.append(t1)\n",
    "        if t2 not in bnodes:\n",
    "            bnodes.append(t2)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 59,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "bnet = defaultdict(list)\n",
    "for i in range(len(bn1)):\n",
    "    # add corresponding edge for both nodes, DEFAULT WEIGHT 1\n",
    "    e1 = Edge(bn2[i], 1)\n",
    "    bnet[bn1[i]].append(e1)\n",
    "        \n",
    "    e2 = Edge(bn1[i], 1)\n",
    "    bnet[bn2[i]].append(e2)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 60,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "{'ATM': 2, 'IGF1R': 2, 'AR': 1, 'MAP2': 3, 'CSNK2A1': 1, 'SGK1': 2, 'CHEK1': 1, 'BIRC5': 2, 'CHUK': 1, 'TUBB': 1, 'EGFR': 1, 'MTOR': 1, 'XIAP': 1, 'PDGFRA': 2, 'CD19': 3, 'BRAF': 1, 'AKT1': 0, 'FLT4': 2, 'SRC': 2, 'PIM1': 2, 'PTK2': 2, 'MAP2K1': 2, 'HDAC3': 1, 'MET': 2, 'ESR1': 1, 'RET': 2, 'PIK3CD': 3, 'DNMT1': 1, 'MAPT': 1, 'UBA3': inf, 'TNF': 2, 'BIRC2': 2, 'JAK2': 2, 'HDAC1': 2, 'RAF1': 1, 'BCL2': 2, 'KDR': 3, 'PIK3CB': 1, 'WEE1': 2, 'FGFR3': 2, 'FNTA': inf, 'SYK': 2, 'JAK1': 2, 'PARP1': 2, 'PRKDC': 1, 'FNTB': inf, 'VEGFC': 3, 'FGFR1': 2, 'FASN': 2, 'IKBKB': 1, 'HSP90AA1': 1, 'IGF2R': 2, 'FLT1': 4, 'BIRC3': 2, 'ALK': 2, 'PIK3CA': 1, 'ATR': 2, 'AKT2': 2, 'MAP2K2': 2, 'TOP1': 2, 'NAE1': inf}\n"
     ]
    }
   ],
   "source": [
    "print(dijkstra(bnet, 'AKT1'))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 61,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "ppi_bgrid = pd.DataFrame(columns=bnodes, index=bnodes)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 62,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "for node in bnodes:\n",
    "    dist = dijkstra(bnet, node)\n",
    "    for prot, score in dist.items():\n",
    "        if score == 0:\n",
    "            score = 0.5                            # same protein/target: score of 2 (see below)\n",
    "        ppi_bgrid.set_value(prot, node, 1/score)     # scale to range 0-1 (0 is no interaction, 1 is direct path)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 63,
   "metadata": {
    "collapsed": false,
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>AKT1</th>\n",
       "      <th>AR</th>\n",
       "      <th>CHEK1</th>\n",
       "      <th>CSNK2A1</th>\n",
       "      <th>HSP90AA1</th>\n",
       "      <th>PRKDC</th>\n",
       "      <th>SRC</th>\n",
       "      <th>ESR1</th>\n",
       "      <th>XIAP</th>\n",
       "      <th>ATR</th>\n",
       "      <th>...</th>\n",
       "      <th>MAP2K2</th>\n",
       "      <th>IGF2R</th>\n",
       "      <th>WEE1</th>\n",
       "      <th>TUBB</th>\n",
       "      <th>MAPT</th>\n",
       "      <th>FASN</th>\n",
       "      <th>PDGFRA</th>\n",
       "      <th>FNTB</th>\n",
       "      <th>FNTA</th>\n",
       "      <th>PIK3CD</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>AKT1</th>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>AR</th>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>CHEK1</th>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>CSNK2A1</th>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>HSP90AA1</th>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PRKDC</th>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SRC</th>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ESR1</th>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>XIAP</th>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>2</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ATR</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>2</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ATM</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PIK3CA</th>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>EGFR</th>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>...</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>HDAC3</th>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FLT1</th>\n",
       "      <td>0.25</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.25</td>\n",
       "      <td>...</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.2</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>KDR</th>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.25</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PTK2</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>HDAC1</th>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>1</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>DNMT1</th>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TOP1</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BRAF</th>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>1</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>RAF1</th>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>1</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FLT4</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>VEGFC</th>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.25</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>JAK2</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MAP2</th>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.25</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BCL2</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MAP2K1</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>...</td>\n",
       "      <td>1</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.25</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>JAK1</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>IGF1R</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PIM1</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>IKBKB</th>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>CHUK</th>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>AKT2</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SYK</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MTOR</th>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MET</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>CD19</th>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.25</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PARP1</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>1</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>NAE1</th>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>UBA3</th>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SGK1</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BIRC2</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BIRC3</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BIRC5</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ALK</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PIK3CB</th>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FGFR1</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TNF</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>...</td>\n",
       "      <td>1</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FGFR3</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MAP2K2</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>2</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>IGF2R</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>2</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.25</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>WEE1</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>2</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.25</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TUBB</th>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>2</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MAPT</th>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>2</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FASN</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>1</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>2</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PDGFRA</th>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>...</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FNTB</th>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FNTA</th>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>...</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PIK3CD</th>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.5</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>...</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.25</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>2</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>61 rows × 61 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "               AKT1         AR      CHEK1    CSNK2A1   HSP90AA1      PRKDC  \\\n",
       "AKT1              2          1          1          1          1          1   \n",
       "AR                1          2        0.5        0.5          1          1   \n",
       "CHEK1             1        0.5          2          1          1          1   \n",
       "CSNK2A1           1        0.5          1          2          1          1   \n",
       "HSP90AA1          1          1          1          1          2          1   \n",
       "PRKDC             1          1          1          1          1          2   \n",
       "SRC             0.5          1        0.5          1          1        0.5   \n",
       "ESR1              1        0.5        0.5        0.5          1          1   \n",
       "XIAP              1        0.5          1        0.5        0.5        0.5   \n",
       "ATR             0.5        0.5          1        0.5          1        0.5   \n",
       "ATM             0.5        0.5          1        0.5        0.5          1   \n",
       "PIK3CA            1        0.5        0.5        0.5        0.5        0.5   \n",
       "EGFR              1          1        0.5          1          1          1   \n",
       "HDAC3             1          1        0.5          1        0.5          1   \n",
       "FLT1           0.25  0.3333333       0.25  0.3333333  0.3333333       0.25   \n",
       "KDR       0.3333333        0.5  0.3333333        0.5        0.5  0.3333333   \n",
       "PTK2            0.5        0.5        0.5        0.5          1        0.5   \n",
       "HDAC1           0.5          1        0.5          1        0.5        0.5   \n",
       "DNMT1             1        0.5          1        0.5        0.5        0.5   \n",
       "TOP1            0.5  0.3333333        0.5          1        0.5        0.5   \n",
       "BRAF              1        0.5        0.5        0.5          1        0.5   \n",
       "RAF1              1          1        0.5        0.5          1        0.5   \n",
       "FLT4            0.5        0.5        0.5        0.5          1        0.5   \n",
       "VEGFC     0.3333333  0.3333333  0.3333333  0.3333333        0.5  0.3333333   \n",
       "JAK2            0.5        0.5        0.5        0.5          1        0.5   \n",
       "MAP2      0.3333333        0.5  0.3333333        0.5        0.5  0.3333333   \n",
       "BCL2            0.5        0.5        0.5        0.5          1        0.5   \n",
       "MAP2K1          0.5        0.5  0.3333333  0.3333333        0.5  0.3333333   \n",
       "JAK1            0.5        0.5        0.5        0.5          1        0.5   \n",
       "IGF1R           0.5        0.5        0.5        0.5          1        0.5   \n",
       "...             ...        ...        ...        ...        ...        ...   \n",
       "PIM1            0.5        0.5        0.5        0.5          1        0.5   \n",
       "IKBKB             1        0.5        0.5        0.5          1          1   \n",
       "CHUK              1        0.5          1          1          1          1   \n",
       "AKT2            0.5        0.5          1        0.5          1          1   \n",
       "SYK             0.5        0.5  0.3333333        0.5        0.5        0.5   \n",
       "MTOR              1        0.5        0.5        0.5        0.5        0.5   \n",
       "MET             0.5        0.5        0.5        0.5          1        0.5   \n",
       "CD19      0.3333333  0.3333333       0.25  0.3333333  0.3333333  0.3333333   \n",
       "PARP1           0.5        0.5        0.5        0.5        0.5          1   \n",
       "NAE1              0          0          0          0          0          0   \n",
       "UBA3              0          0          0          0          0          0   \n",
       "SGK1            0.5        0.5        0.5        0.5          1        0.5   \n",
       "BIRC2           0.5        0.5        0.5        0.5        0.5        0.5   \n",
       "BIRC3           0.5        0.5        0.5        0.5        0.5        0.5   \n",
       "BIRC5           0.5        0.5        0.5        0.5          1          1   \n",
       "ALK             0.5        0.5        0.5        0.5          1        0.5   \n",
       "PIK3CB            1        0.5        0.5        0.5        0.5        0.5   \n",
       "FGFR1           0.5        0.5        0.5        0.5          1        0.5   \n",
       "TNF             0.5  0.3333333        0.5        0.5        0.5        0.5   \n",
       "FGFR3           0.5        0.5        0.5        0.5          1        0.5   \n",
       "MAP2K2          0.5        0.5  0.3333333        0.5        0.5        0.5   \n",
       "IGF2R           0.5  0.3333333        0.5          1        0.5        0.5   \n",
       "WEE1            0.5  0.3333333        0.5          1        0.5        0.5   \n",
       "TUBB              1        0.5        0.5        0.5          1        0.5   \n",
       "MAPT              1        0.5        0.5          1        0.5        0.5   \n",
       "FASN            0.5        0.5        0.5        0.5          1        0.5   \n",
       "PDGFRA          0.5        0.5  0.3333333        0.5        0.5        0.5   \n",
       "FNTB              0          0          0          0          0          0   \n",
       "FNTA              0          0          0          0          0          0   \n",
       "PIK3CD    0.3333333  0.3333333        0.5  0.3333333        0.5        0.5   \n",
       "\n",
       "                SRC       ESR1       XIAP        ATR    ...         MAP2K2  \\\n",
       "AKT1            0.5          1          1        0.5    ...            0.5   \n",
       "AR                1        0.5        0.5        0.5    ...            0.5   \n",
       "CHEK1           0.5        0.5          1          1    ...      0.3333333   \n",
       "CSNK2A1           1        0.5        0.5        0.5    ...            0.5   \n",
       "HSP90AA1          1          1        0.5          1    ...            0.5   \n",
       "PRKDC           0.5          1        0.5        0.5    ...            0.5   \n",
       "SRC               2          1        0.5        0.5    ...            0.5   \n",
       "ESR1              1          2        0.5        0.5    ...            0.5   \n",
       "XIAP            0.5        0.5          2        0.5    ...            0.5   \n",
       "ATR             0.5        0.5        0.5          2    ...            0.5   \n",
       "ATM       0.3333333        0.5        0.5          1    ...      0.3333333   \n",
       "PIK3CA          0.5          1        0.5          1    ...      0.3333333   \n",
       "EGFR              1          1        0.5          1    ...              1   \n",
       "HDAC3             1          1        0.5  0.3333333    ...      0.3333333   \n",
       "FLT1            0.5  0.3333333       0.25       0.25    ...           0.25   \n",
       "KDR               1        0.5  0.3333333  0.3333333    ...      0.3333333   \n",
       "PTK2              1        0.5  0.3333333        0.5    ...            0.5   \n",
       "HDAC1           0.5          1  0.3333333          1    ...      0.3333333   \n",
       "DNMT1           0.5        0.5        0.5        0.5    ...      0.3333333   \n",
       "TOP1            0.5          1  0.3333333        0.5    ...      0.3333333   \n",
       "BRAF            0.5        0.5        0.5        0.5    ...              1   \n",
       "RAF1              1        0.5          1        0.5    ...              1   \n",
       "FLT4            0.5        0.5  0.3333333        0.5    ...            0.5   \n",
       "VEGFC     0.3333333  0.3333333       0.25  0.3333333    ...      0.3333333   \n",
       "JAK2              1        0.5        0.5        0.5    ...            0.5   \n",
       "MAP2              1        0.5  0.3333333  0.3333333    ...      0.3333333   \n",
       "BCL2            0.5        0.5        0.5        0.5    ...            0.5   \n",
       "MAP2K1          0.5  0.3333333        0.5  0.3333333    ...              1   \n",
       "JAK1            0.5        0.5        0.5        0.5    ...            0.5   \n",
       "IGF1R           0.5          1  0.3333333        0.5    ...            0.5   \n",
       "...             ...        ...        ...        ...    ...            ...   \n",
       "PIM1            0.5        0.5  0.3333333        0.5    ...            0.5   \n",
       "IKBKB             1        0.5        0.5        0.5    ...            0.5   \n",
       "CHUK              1          1        0.5        0.5    ...            0.5   \n",
       "AKT2            0.5          1          1        0.5    ...            0.5   \n",
       "SYK               1        0.5  0.3333333        0.5    ...            0.5   \n",
       "MTOR            0.5        0.5        0.5        0.5    ...            0.5   \n",
       "MET               1        0.5  0.3333333        0.5    ...      0.3333333   \n",
       "CD19            0.5  0.3333333       0.25  0.3333333    ...      0.3333333   \n",
       "PARP1           0.5          1  0.3333333        0.5    ...      0.3333333   \n",
       "NAE1              0          0          0          0    ...              0   \n",
       "UBA3              0          0          0          0    ...              0   \n",
       "SGK1            0.5        0.5        0.5        0.5    ...            0.5   \n",
       "BIRC2           0.5        0.5          1        0.5    ...            0.5   \n",
       "BIRC3           0.5        0.5          1        0.5    ...            0.5   \n",
       "BIRC5           0.5        0.5          1        0.5    ...      0.3333333   \n",
       "ALK               1        0.5  0.3333333        0.5    ...      0.3333333   \n",
       "PIK3CB          0.5        0.5        0.5        0.5    ...            0.5   \n",
       "FGFR1             1        0.5  0.3333333        0.5    ...      0.3333333   \n",
       "TNF             0.5        0.5        0.5  0.3333333    ...              1   \n",
       "FGFR3           0.5        0.5  0.3333333        0.5    ...      0.3333333   \n",
       "MAP2K2          0.5        0.5        0.5        0.5    ...              2   \n",
       "IGF2R           0.5  0.3333333  0.3333333  0.3333333    ...      0.3333333   \n",
       "WEE1            0.5  0.3333333  0.3333333  0.3333333    ...      0.3333333   \n",
       "TUBB            0.5          1        0.5        0.5    ...            0.5   \n",
       "MAPT              1        0.5        0.5        0.5    ...            0.5   \n",
       "FASN            0.5        0.5  0.3333333        0.5    ...      0.3333333   \n",
       "PDGFRA          0.5        0.5  0.3333333        0.5    ...            0.5   \n",
       "FNTB              0          0          0          0    ...              0   \n",
       "FNTA              0          0          0          0    ...              0   \n",
       "PIK3CD    0.3333333        0.5        0.5  0.3333333    ...      0.3333333   \n",
       "\n",
       "              IGF2R       WEE1       TUBB       MAPT       FASN     PDGFRA  \\\n",
       "AKT1            0.5        0.5          1          1        0.5        0.5   \n",
       "AR        0.3333333  0.3333333        0.5        0.5        0.5        0.5   \n",
       "CHEK1           0.5        0.5        0.5        0.5        0.5  0.3333333   \n",
       "CSNK2A1           1          1        0.5          1        0.5        0.5   \n",
       "HSP90AA1        0.5        0.5          1        0.5          1        0.5   \n",
       "PRKDC           0.5        0.5        0.5        0.5        0.5        0.5   \n",
       "SRC             0.5        0.5        0.5          1        0.5        0.5   \n",
       "ESR1      0.3333333  0.3333333          1        0.5        0.5        0.5   \n",
       "XIAP      0.3333333  0.3333333        0.5        0.5  0.3333333  0.3333333   \n",
       "ATR       0.3333333  0.3333333        0.5        0.5        0.5        0.5   \n",
       "ATM       0.3333333  0.3333333        0.5  0.3333333  0.3333333  0.3333333   \n",
       "PIK3CA    0.3333333  0.3333333        0.5        0.5  0.3333333  0.3333333   \n",
       "EGFR            0.5        0.5          1          1        0.5          1   \n",
       "HDAC3           0.5        0.5        0.5        0.5  0.3333333  0.3333333   \n",
       "FLT1           0.25       0.25       0.25  0.3333333       0.25       0.25   \n",
       "KDR       0.3333333  0.3333333  0.3333333        0.5  0.3333333  0.3333333   \n",
       "PTK2      0.3333333  0.3333333        0.5        0.5        0.5        0.5   \n",
       "HDAC1           0.5        0.5        0.5        0.5  0.3333333  0.3333333   \n",
       "DNMT1     0.3333333  0.3333333        0.5        0.5  0.3333333  0.3333333   \n",
       "TOP1            0.5        0.5        0.5        0.5  0.3333333  0.3333333   \n",
       "BRAF      0.3333333  0.3333333        0.5        0.5        0.5  0.3333333   \n",
       "RAF1      0.3333333  0.3333333        0.5        0.5        0.5        0.5   \n",
       "FLT4      0.3333333  0.3333333        0.5  0.3333333        0.5  0.3333333   \n",
       "VEGFC          0.25       0.25  0.3333333       0.25  0.3333333       0.25   \n",
       "JAK2      0.3333333  0.3333333        0.5        0.5        0.5        0.5   \n",
       "MAP2      0.3333333  0.3333333  0.3333333        0.5  0.3333333  0.3333333   \n",
       "BCL2      0.3333333  0.3333333        0.5  0.3333333        0.5  0.3333333   \n",
       "MAP2K1         0.25       0.25  0.3333333  0.3333333  0.3333333  0.3333333   \n",
       "JAK1      0.3333333  0.3333333        0.5        0.5        0.5        0.5   \n",
       "IGF1R     0.3333333  0.3333333        0.5        0.5        0.5        0.5   \n",
       "...             ...        ...        ...        ...        ...        ...   \n",
       "PIM1      0.3333333  0.3333333        0.5        0.5        0.5        0.5   \n",
       "IKBKB     0.3333333  0.3333333        0.5        0.5        0.5  0.3333333   \n",
       "CHUK            0.5        0.5        0.5        0.5        0.5  0.3333333   \n",
       "AKT2      0.3333333  0.3333333        0.5        0.5        0.5        0.5   \n",
       "SYK       0.3333333  0.3333333          1          1  0.3333333        0.5   \n",
       "MTOR      0.3333333  0.3333333        0.5        0.5  0.3333333        0.5   \n",
       "MET       0.3333333  0.3333333        0.5        0.5        0.5  0.3333333   \n",
       "CD19           0.25       0.25        0.5        0.5       0.25  0.3333333   \n",
       "PARP1     0.3333333  0.3333333          1  0.3333333  0.3333333  0.3333333   \n",
       "NAE1              0          0          0          0          0          0   \n",
       "UBA3              0          0          0          0          0          0   \n",
       "SGK1      0.3333333  0.3333333        0.5          1        0.5  0.3333333   \n",
       "BIRC2     0.3333333  0.3333333        0.5        0.5  0.3333333        0.5   \n",
       "BIRC3     0.3333333  0.3333333        0.5        0.5  0.3333333        0.5   \n",
       "BIRC5     0.3333333  0.3333333        0.5  0.3333333        0.5  0.3333333   \n",
       "ALK       0.3333333  0.3333333        0.5        0.5        0.5  0.3333333   \n",
       "PIK3CB    0.3333333  0.3333333        0.5        0.5  0.3333333        0.5   \n",
       "FGFR1     0.3333333  0.3333333        0.5        0.5        0.5  0.3333333   \n",
       "TNF       0.3333333  0.3333333  0.3333333  0.3333333  0.3333333  0.3333333   \n",
       "FGFR3     0.3333333  0.3333333        0.5  0.3333333        0.5  0.3333333   \n",
       "MAP2K2    0.3333333  0.3333333        0.5        0.5  0.3333333        0.5   \n",
       "IGF2R             2        0.5  0.3333333        0.5  0.3333333  0.3333333   \n",
       "WEE1            0.5          2  0.3333333        0.5  0.3333333  0.3333333   \n",
       "TUBB      0.3333333  0.3333333          2        0.5        0.5        0.5   \n",
       "MAPT            0.5        0.5        0.5          2  0.3333333        0.5   \n",
       "FASN      0.3333333  0.3333333        0.5  0.3333333          2  0.3333333   \n",
       "PDGFRA    0.3333333  0.3333333        0.5        0.5  0.3333333          2   \n",
       "FNTB              0          0          0          0          0          0   \n",
       "FNTA              0          0          0          0          0          0   \n",
       "PIK3CD         0.25       0.25  0.3333333  0.3333333  0.3333333  0.3333333   \n",
       "\n",
       "         FNTB FNTA     PIK3CD  \n",
       "AKT1        0    0  0.3333333  \n",
       "AR          0    0  0.3333333  \n",
       "CHEK1       0    0        0.5  \n",
       "CSNK2A1     0    0  0.3333333  \n",
       "HSP90AA1    0    0        0.5  \n",
       "PRKDC       0    0        0.5  \n",
       "SRC         0    0  0.3333333  \n",
       "ESR1        0    0        0.5  \n",
       "XIAP        0    0        0.5  \n",
       "ATR         0    0  0.3333333  \n",
       "ATM         0    0  0.3333333  \n",
       "PIK3CA      0    0  0.3333333  \n",
       "EGFR        0    0        0.5  \n",
       "HDAC3       0    0  0.3333333  \n",
       "FLT1        0    0        0.2  \n",
       "KDR         0    0       0.25  \n",
       "PTK2        0    0  0.3333333  \n",
       "HDAC1       0    0  0.3333333  \n",
       "DNMT1       0    0  0.3333333  \n",
       "TOP1        0    0  0.3333333  \n",
       "BRAF        0    0  0.3333333  \n",
       "RAF1        0    0  0.3333333  \n",
       "FLT4        0    0  0.3333333  \n",
       "VEGFC       0    0       0.25  \n",
       "JAK2        0    0  0.3333333  \n",
       "MAP2        0    0       0.25  \n",
       "BCL2        0    0  0.3333333  \n",
       "MAP2K1      0    0       0.25  \n",
       "JAK1        0    0  0.3333333  \n",
       "IGF1R       0    0  0.3333333  \n",
       "...       ...  ...        ...  \n",
       "PIM1        0    0  0.3333333  \n",
       "IKBKB       0    0  0.3333333  \n",
       "CHUK        0    0        0.5  \n",
       "AKT2        0    0          1  \n",
       "SYK         0    0  0.3333333  \n",
       "MTOR        0    0  0.3333333  \n",
       "MET         0    0  0.3333333  \n",
       "CD19        0    0       0.25  \n",
       "PARP1       0    0  0.3333333  \n",
       "NAE1        0    0          0  \n",
       "UBA3        0    0          0  \n",
       "SGK1        0    0  0.3333333  \n",
       "BIRC2       0    0  0.3333333  \n",
       "BIRC3       0    0  0.3333333  \n",
       "BIRC5       0    0  0.3333333  \n",
       "ALK         0    0  0.3333333  \n",
       "PIK3CB      0    0        0.5  \n",
       "FGFR1       0    0  0.3333333  \n",
       "TNF         0    0  0.3333333  \n",
       "FGFR3       0    0  0.3333333  \n",
       "MAP2K2      0    0  0.3333333  \n",
       "IGF2R       0    0       0.25  \n",
       "WEE1        0    0       0.25  \n",
       "TUBB        0    0  0.3333333  \n",
       "MAPT        0    0  0.3333333  \n",
       "FASN        0    0  0.3333333  \n",
       "PDGFRA      0    0  0.3333333  \n",
       "FNTB        2    1          0  \n",
       "FNTA        1    2          0  \n",
       "PIK3CD      0    0          2  \n",
       "\n",
       "[61 rows x 61 columns]"
      ]
     },
     "execution_count": 63,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "ppi_bgrid"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 64,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "ppi_bgrid.to_csv('Drug_expanded/ppi_bgrid.csv')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 65,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "dfb = df.copy()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 66,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "dfb['Target_interaction'] = ''\n",
    "for i in range(len(dfb)):\n",
    "    dA, dB = dfb.ix[i, 'COMPOUND_A'], dfb.ix[i, 'COMPOUND_B']           # get the two compounds\n",
    "    Atargs, Btargs = d2t.ix[dA, 'Target'], d2t.ix[dB, 'Target']       # get target string\n",
    "    Atargs, Btargs = Atargs.split(','), Btargs.split(',')             # get target array\n",
    "    \n",
    "    intScore = 0.0\n",
    "    for atarg in Atargs:\n",
    "        for btarg in Btargs:\n",
    "            if atarg in ppi_bgrid.columns and btarg in ppi_bgrid.columns:\n",
    "                interaction = ppi_bgrid.ix[atarg, btarg]\n",
    "                if interaction > intScore:\n",
    "                    intScore = interaction                  # set score to HIGHEST interaction among targets\n",
    "    dfb.set_value(i, 'Target_interaction', intScore)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Model Training"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 211,
   "metadata": {
    "collapsed": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>CELL_LINE</th>\n",
       "      <th>COMPOUND_A</th>\n",
       "      <th>COMPOUND_B</th>\n",
       "      <th>MAX_CONC_A</th>\n",
       "      <th>MAX_CONC_B</th>\n",
       "      <th>IC50_A</th>\n",
       "      <th>H_A</th>\n",
       "      <th>Einf_A</th>\n",
       "      <th>IC50_B</th>\n",
       "      <th>H_B</th>\n",
       "      <th>...</th>\n",
       "      <th>B_PSA</th>\n",
       "      <th>B_#RotBonds</th>\n",
       "      <th>B_Arom Rings</th>\n",
       "      <th>B_Heavy atoms</th>\n",
       "      <th>B_QED</th>\n",
       "      <th>GEX_CLUSTER</th>\n",
       "      <th>THERAPY_CLUSTER</th>\n",
       "      <th>Target_share</th>\n",
       "      <th>Target_interaction</th>\n",
       "      <th>Disease_area</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>587</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>ALK_2</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.321662</td>\n",
       "      <td>0.957786</td>\n",
       "      <td>19.228871</td>\n",
       "      <td>0.227408</td>\n",
       "      <td>0.891974</td>\n",
       "      <td>...</td>\n",
       "      <td>92.71000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>32.000</td>\n",
       "      <td>0.63000</td>\n",
       "      <td>1</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>Lung</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>887</th>\n",
       "      <td>KU-19-19</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>IAP</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>1.251460</td>\n",
       "      <td>...</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Urology</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>919</th>\n",
       "      <td>647-V</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>PIM1</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>2.653789</td>\n",
       "      <td>0.682784</td>\n",
       "      <td>...</td>\n",
       "      <td>100.72000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>27.000</td>\n",
       "      <td>0.80000</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Urology</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1225</th>\n",
       "      <td>NCI-H1563</td>\n",
       "      <td>CSNK2A1_2</td>\n",
       "      <td>SYK</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.03</td>\n",
       "      <td>0.711825</td>\n",
       "      <td>0.908353</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>0.008815</td>\n",
       "      <td>1.019147</td>\n",
       "      <td>...</td>\n",
       "      <td>128.75000</td>\n",
       "      <td>7.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>34.000</td>\n",
       "      <td>0.47000</td>\n",
       "      <td>3</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Lung</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>568</th>\n",
       "      <td>DMS-114</td>\n",
       "      <td>ALK</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>1.301792</td>\n",
       "      <td>1.036814</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>0.587162</td>\n",
       "      <td>1.296381</td>\n",
       "      <td>...</td>\n",
       "      <td>144.17000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>35.000</td>\n",
       "      <td>0.43000</td>\n",
       "      <td>5</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>Lung</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>482</th>\n",
       "      <td>CAMA-1</td>\n",
       "      <td>AKT_SGK</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.268071</td>\n",
       "      <td>2.693095</td>\n",
       "      <td>80.550395</td>\n",
       "      <td>0.128381</td>\n",
       "      <td>1.522306</td>\n",
       "      <td>...</td>\n",
       "      <td>158.48754</td>\n",
       "      <td>11.564</td>\n",
       "      <td>2.847</td>\n",
       "      <td>60.555</td>\n",
       "      <td>0.19713</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1495</th>\n",
       "      <td>MDA-MB-436</td>\n",
       "      <td>FASN</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.368812</td>\n",
       "      <td>20.910493</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>88.41000</td>\n",
       "      <td>6.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>27.000</td>\n",
       "      <td>0.39000</td>\n",
       "      <td>3</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1736</th>\n",
       "      <td>SW620</td>\n",
       "      <td>IAP</td>\n",
       "      <td>PIK3CB</td>\n",
       "      <td>10.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.001002</td>\n",
       "      <td>0.100000</td>\n",
       "      <td>94.036477</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>6</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>GI</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>952</th>\n",
       "      <td>KMS-11</td>\n",
       "      <td>BCL2_BCL2L1_BCL2L2</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>0.03</td>\n",
       "      <td>0.30</td>\n",
       "      <td>0.030000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>13.800820</td>\n",
       "      <td>0.289039</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>91.51000</td>\n",
       "      <td>8.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>34.000</td>\n",
       "      <td>0.46000</td>\n",
       "      <td>7</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Haems</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1917</th>\n",
       "      <td>CAL-148</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>SLC16A4</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>0.037474</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1049</th>\n",
       "      <td>COLO-205</td>\n",
       "      <td>BRAF_M2</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.074560</td>\n",
       "      <td>0.997635</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>0.563370</td>\n",
       "      <td>0.871428</td>\n",
       "      <td>...</td>\n",
       "      <td>88.41000</td>\n",
       "      <td>6.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>27.000</td>\n",
       "      <td>0.39000</td>\n",
       "      <td>0</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>GI</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>930</th>\n",
       "      <td>MDA-MB-231</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>PIM1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.267757</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>92.999970</td>\n",
       "      <td>0.422353</td>\n",
       "      <td>1.948100</td>\n",
       "      <td>...</td>\n",
       "      <td>100.72000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>27.000</td>\n",
       "      <td>0.80000</td>\n",
       "      <td>3</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>343</th>\n",
       "      <td>HCC1143</td>\n",
       "      <td>AKT_1</td>\n",
       "      <td>ALK_IGFR</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>90.800078</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.732731</td>\n",
       "      <td>...</td>\n",
       "      <td>97.43558</td>\n",
       "      <td>4.903</td>\n",
       "      <td>2.427</td>\n",
       "      <td>30.291</td>\n",
       "      <td>0.61224</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>847</th>\n",
       "      <td>HCC70</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>FASN</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>64.16000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>35.000</td>\n",
       "      <td>0.39000</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>722</th>\n",
       "      <td>HCC1143</td>\n",
       "      <td>ATR_4</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.048078</td>\n",
       "      <td>0.721101</td>\n",
       "      <td>44.265628</td>\n",
       "      <td>0.397592</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>88.41000</td>\n",
       "      <td>6.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>27.000</td>\n",
       "      <td>0.39000</td>\n",
       "      <td>1</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1955</th>\n",
       "      <td>HCC38</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.282912</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>76.499917</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.855220</td>\n",
       "      <td>...</td>\n",
       "      <td>144.17000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>35.000</td>\n",
       "      <td>0.43000</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>627</th>\n",
       "      <td>MDA-MB-468</td>\n",
       "      <td>ALK_IGFR</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>1.658284</td>\n",
       "      <td>41.719062</td>\n",
       "      <td>0.000317</td>\n",
       "      <td>0.100000</td>\n",
       "      <td>...</td>\n",
       "      <td>92.71000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>32.000</td>\n",
       "      <td>0.63000</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1683</th>\n",
       "      <td>TCCSUP</td>\n",
       "      <td>IAP</td>\n",
       "      <td>PARP1</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.03</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>0.960874</td>\n",
       "      <td>37.683182</td>\n",
       "      <td>0.030000</td>\n",
       "      <td>0.173312</td>\n",
       "      <td>...</td>\n",
       "      <td>82.08000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>32.000</td>\n",
       "      <td>0.80000</td>\n",
       "      <td>3</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>Urology</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1911</th>\n",
       "      <td>HT-29</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>PTK2</td>\n",
       "      <td>10.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.666165</td>\n",
       "      <td>4.547947</td>\n",
       "      <td>7.225506</td>\n",
       "      <td>0.089859</td>\n",
       "      <td>1.209154</td>\n",
       "      <td>...</td>\n",
       "      <td>90.94507</td>\n",
       "      <td>4.059</td>\n",
       "      <td>2.497</td>\n",
       "      <td>29.963</td>\n",
       "      <td>0.68621</td>\n",
       "      <td>0</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>GI</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2036</th>\n",
       "      <td>MDA-MB-157</td>\n",
       "      <td>PARP1</td>\n",
       "      <td>PIK3CB_PIK3CD</td>\n",
       "      <td>1.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.433860</td>\n",
       "      <td>13.810602</td>\n",
       "      <td>0.980042</td>\n",
       "      <td>0.839295</td>\n",
       "      <td>...</td>\n",
       "      <td>99.50709</td>\n",
       "      <td>4.289</td>\n",
       "      <td>2.737</td>\n",
       "      <td>30.490</td>\n",
       "      <td>0.62948</td>\n",
       "      <td>4</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>819</th>\n",
       "      <td>NCI-H1975</td>\n",
       "      <td>BCL2_2</td>\n",
       "      <td>Vinorelbine</td>\n",
       "      <td>0.03</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.025385</td>\n",
       "      <td>2.348173</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>133.87000</td>\n",
       "      <td>10.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>57.000</td>\n",
       "      <td>0.20000</td>\n",
       "      <td>3</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Lung</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1968</th>\n",
       "      <td>CAL-120</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>PIK3CA_4</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.088010</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>77.749684</td>\n",
       "      <td>0.197582</td>\n",
       "      <td>0.803260</td>\n",
       "      <td>...</td>\n",
       "      <td>129.45000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>30.000</td>\n",
       "      <td>0.74000</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>612</th>\n",
       "      <td>NCI-H520</td>\n",
       "      <td>ALK_2</td>\n",
       "      <td>TOP2</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>2.962161</td>\n",
       "      <td>0.678884</td>\n",
       "      <td>15.203455</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>3.905525</td>\n",
       "      <td>...</td>\n",
       "      <td>67.00000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>30.000</td>\n",
       "      <td>0.44000</td>\n",
       "      <td>7</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Lung</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>99</th>\n",
       "      <td>M14</td>\n",
       "      <td>ADAM17</td>\n",
       "      <td>PIK3CB_PIK3CD</td>\n",
       "      <td>1.00</td>\n",
       "      <td>75.00</td>\n",
       "      <td>0.475350</td>\n",
       "      <td>0.675796</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>0.461424</td>\n",
       "      <td>1.472944</td>\n",
       "      <td>...</td>\n",
       "      <td>99.50709</td>\n",
       "      <td>4.289</td>\n",
       "      <td>2.737</td>\n",
       "      <td>30.490</td>\n",
       "      <td>0.62948</td>\n",
       "      <td>4</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>Niche</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1920</th>\n",
       "      <td>HCC1143</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>SLC16A4</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>0.084926</td>\n",
       "      <td>0.712687</td>\n",
       "      <td>...</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>917</th>\n",
       "      <td>MDA-MB-453</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>PIK3CA_4</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.208745</td>\n",
       "      <td>0.920606</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>0.320005</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>129.45000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>30.000</td>\n",
       "      <td>0.74000</td>\n",
       "      <td>2</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>460</th>\n",
       "      <td>HCC38</td>\n",
       "      <td>AKT_1</td>\n",
       "      <td>PIK3C_2</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.836445</td>\n",
       "      <td>2.560558</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>0.000100</td>\n",
       "      <td>4.129823</td>\n",
       "      <td>...</td>\n",
       "      <td>89.63000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>29.000</td>\n",
       "      <td>0.82000</td>\n",
       "      <td>3</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>184</th>\n",
       "      <td>Calu-3</td>\n",
       "      <td>AKT</td>\n",
       "      <td>CSNK2A1_2</td>\n",
       "      <td>0.03</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.030000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>3.000014</td>\n",
       "      <td>1.313230</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>136.39000</td>\n",
       "      <td>8.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>31.000</td>\n",
       "      <td>0.43000</td>\n",
       "      <td>1</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>Lung</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>MDA-MB-453</td>\n",
       "      <td>ADAM17</td>\n",
       "      <td>AKT</td>\n",
       "      <td>1.00</td>\n",
       "      <td>75.00</td>\n",
       "      <td>0.282664</td>\n",
       "      <td>2.263455</td>\n",
       "      <td>34.219723</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>120.16000</td>\n",
       "      <td>6.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>30.000</td>\n",
       "      <td>0.57000</td>\n",
       "      <td>2</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>219</th>\n",
       "      <td>CAL-120</td>\n",
       "      <td>AKT</td>\n",
       "      <td>ERBB</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>93.200109</td>\n",
       "      <td>0.102681</td>\n",
       "      <td>1.269677</td>\n",
       "      <td>...</td>\n",
       "      <td>88.61000</td>\n",
       "      <td>7.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>33.000</td>\n",
       "      <td>0.54000</td>\n",
       "      <td>3</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1085</th>\n",
       "      <td>MDA-MB-436</td>\n",
       "      <td>BRAF_M2</td>\n",
       "      <td>MAP2K_3</td>\n",
       "      <td>0.30</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.046794</td>\n",
       "      <td>0.952113</td>\n",
       "      <td>70.246208</td>\n",
       "      <td>0.524050</td>\n",
       "      <td>1.555066</td>\n",
       "      <td>...</td>\n",
       "      <td>102.06000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>37.000</td>\n",
       "      <td>0.50000</td>\n",
       "      <td>3</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1754</th>\n",
       "      <td>KU-19-19</td>\n",
       "      <td>IAP</td>\n",
       "      <td>TNF</td>\n",
       "      <td>0.10</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.002845</td>\n",
       "      <td>9.003956</td>\n",
       "      <td>94.166817</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>102.00000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>2.804</td>\n",
       "      <td>31.000</td>\n",
       "      <td>0.65147</td>\n",
       "      <td>3</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>Urology</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>309</th>\n",
       "      <td>CAMA-1</td>\n",
       "      <td>AKT</td>\n",
       "      <td>PIP5K1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.400556</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>90.498990</td>\n",
       "      <td>0.126079</td>\n",
       "      <td>1.342466</td>\n",
       "      <td>...</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>832</th>\n",
       "      <td>HCC1187</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>0.10</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>88.61000</td>\n",
       "      <td>8.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>34.000</td>\n",
       "      <td>0.47000</td>\n",
       "      <td>7</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>55</th>\n",
       "      <td>DU-4475</td>\n",
       "      <td>ADAM17</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>75.00</td>\n",
       "      <td>0.204544</td>\n",
       "      <td>2.534173</td>\n",
       "      <td>21.566877</td>\n",
       "      <td>39.488708</td>\n",
       "      <td>0.843183</td>\n",
       "      <td>...</td>\n",
       "      <td>92.71000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>32.000</td>\n",
       "      <td>0.63000</td>\n",
       "      <td>6</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>297</th>\n",
       "      <td>HCC1187</td>\n",
       "      <td>AKT</td>\n",
       "      <td>PIK3CA_4</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.155580</td>\n",
       "      <td>1.447416</td>\n",
       "      <td>51.593515</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.893120</td>\n",
       "      <td>...</td>\n",
       "      <td>129.45000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>30.000</td>\n",
       "      <td>0.74000</td>\n",
       "      <td>7</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>59</th>\n",
       "      <td>HCC1428</td>\n",
       "      <td>ADAM17</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>75.00</td>\n",
       "      <td>0.325342</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>50.599339</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>92.71000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>32.000</td>\n",
       "      <td>0.63000</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1939</th>\n",
       "      <td>MDA-MB-453</td>\n",
       "      <td>MAP2K_3</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.30</td>\n",
       "      <td>0.725841</td>\n",
       "      <td>0.658544</td>\n",
       "      <td>8.438496</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>144.17000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>35.000</td>\n",
       "      <td>0.43000</td>\n",
       "      <td>2</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1552</th>\n",
       "      <td>MDA-MB-175-VII</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>PIK3C_MTOR</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.269950</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>7.396944</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>124.00000</td>\n",
       "      <td>6.000</td>\n",
       "      <td>3.084</td>\n",
       "      <td>31.000</td>\n",
       "      <td>0.60263</td>\n",
       "      <td>3</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1986</th>\n",
       "      <td>M14</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>SLC16A4</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.101872</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>82.149811</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.621071</td>\n",
       "      <td>...</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>4</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>Niche</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>834</th>\n",
       "      <td>HCC1428</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>0.10</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>0.144687</td>\n",
       "      <td>0.873652</td>\n",
       "      <td>...</td>\n",
       "      <td>88.61000</td>\n",
       "      <td>8.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>34.000</td>\n",
       "      <td>0.47000</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1836</th>\n",
       "      <td>J82</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>1.080224</td>\n",
       "      <td>0.820321</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>0.294483</td>\n",
       "      <td>...</td>\n",
       "      <td>92.71000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>32.000</td>\n",
       "      <td>0.63000</td>\n",
       "      <td>3</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Urology</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2074</th>\n",
       "      <td>T-24</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>TNFSF10</td>\n",
       "      <td>0.03</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.010822</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>44.897931</td>\n",
       "      <td>1.210067</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>3</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>Urology</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>202</th>\n",
       "      <td>NCI-H520</td>\n",
       "      <td>AKT</td>\n",
       "      <td>CSNK2A1_2</td>\n",
       "      <td>0.03</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.007808</td>\n",
       "      <td>0.915461</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>0.548968</td>\n",
       "      <td>0.913053</td>\n",
       "      <td>...</td>\n",
       "      <td>136.39000</td>\n",
       "      <td>8.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>31.000</td>\n",
       "      <td>0.43000</td>\n",
       "      <td>7</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>Lung</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>77</th>\n",
       "      <td>MDA-MB-157</td>\n",
       "      <td>ADAM17</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>1.00</td>\n",
       "      <td>75.00</td>\n",
       "      <td>0.213489</td>\n",
       "      <td>0.890822</td>\n",
       "      <td>54.800152</td>\n",
       "      <td>33.769554</td>\n",
       "      <td>1.397694</td>\n",
       "      <td>...</td>\n",
       "      <td>144.17000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>35.000</td>\n",
       "      <td>0.43000</td>\n",
       "      <td>4</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1873</th>\n",
       "      <td>T47D</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.166243</td>\n",
       "      <td>0.978454</td>\n",
       "      <td>11.286392</td>\n",
       "      <td>0.014740</td>\n",
       "      <td>0.925424</td>\n",
       "      <td>...</td>\n",
       "      <td>144.17000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>35.000</td>\n",
       "      <td>0.43000</td>\n",
       "      <td>2</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1934</th>\n",
       "      <td>EVSA-T</td>\n",
       "      <td>MAP2K_3</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.30</td>\n",
       "      <td>0.401860</td>\n",
       "      <td>0.886398</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>0.000030</td>\n",
       "      <td>0.100000</td>\n",
       "      <td>...</td>\n",
       "      <td>144.17000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>35.000</td>\n",
       "      <td>0.43000</td>\n",
       "      <td>2</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1212</th>\n",
       "      <td>NCI-H1437</td>\n",
       "      <td>CSNK2A1_2</td>\n",
       "      <td>PIK3CA_3</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.10</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>0.405386</td>\n",
       "      <td>35.420443</td>\n",
       "      <td>0.009025</td>\n",
       "      <td>2.953876</td>\n",
       "      <td>...</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>3</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Lung</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1288</th>\n",
       "      <td>T-24</td>\n",
       "      <td>EG5</td>\n",
       "      <td>PIM1</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.000300</td>\n",
       "      <td>0.100000</td>\n",
       "      <td>94.990170</td>\n",
       "      <td>0.000317</td>\n",
       "      <td>7.649786</td>\n",
       "      <td>...</td>\n",
       "      <td>100.72000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>27.000</td>\n",
       "      <td>0.80000</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>Urology</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>649</th>\n",
       "      <td>CAL-120</td>\n",
       "      <td>ATR_4</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.059653</td>\n",
       "      <td>3.022304</td>\n",
       "      <td>37.922530</td>\n",
       "      <td>0.289851</td>\n",
       "      <td>3.290459</td>\n",
       "      <td>...</td>\n",
       "      <td>158.48754</td>\n",
       "      <td>11.564</td>\n",
       "      <td>2.847</td>\n",
       "      <td>60.555</td>\n",
       "      <td>0.19713</td>\n",
       "      <td>3</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1817</th>\n",
       "      <td>HCT-116</td>\n",
       "      <td>JAK</td>\n",
       "      <td>MTOR</td>\n",
       "      <td>0.30</td>\n",
       "      <td>3.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>2.898833</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>93.07000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>34.000</td>\n",
       "      <td>0.61000</td>\n",
       "      <td>6</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>GI</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1753</th>\n",
       "      <td>KMS-11</td>\n",
       "      <td>IAP</td>\n",
       "      <td>TNF</td>\n",
       "      <td>0.10</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.100000</td>\n",
       "      <td>1.737578</td>\n",
       "      <td>67.917650</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>102.00000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>2.804</td>\n",
       "      <td>31.000</td>\n",
       "      <td>0.65147</td>\n",
       "      <td>7</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>Haems</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1823</th>\n",
       "      <td>647-V</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.320194</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>53.599453</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>1.016034</td>\n",
       "      <td>...</td>\n",
       "      <td>92.71000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>32.000</td>\n",
       "      <td>0.63000</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Urology</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1530</th>\n",
       "      <td>NCI-SNU-16</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.01</td>\n",
       "      <td>0.487432</td>\n",
       "      <td>2.021942</td>\n",
       "      <td>9.800686</td>\n",
       "      <td>0.007513</td>\n",
       "      <td>2.715880</td>\n",
       "      <td>...</td>\n",
       "      <td>92.71000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>32.000</td>\n",
       "      <td>0.63000</td>\n",
       "      <td>0</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>GI</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>293</th>\n",
       "      <td>BT-20</td>\n",
       "      <td>AKT</td>\n",
       "      <td>PIK3CA_4</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.208946</td>\n",
       "      <td>1.263169</td>\n",
       "      <td>58.795974</td>\n",
       "      <td>0.190101</td>\n",
       "      <td>3.241219</td>\n",
       "      <td>...</td>\n",
       "      <td>129.45000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>30.000</td>\n",
       "      <td>0.74000</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>277</th>\n",
       "      <td>TCCSUP</td>\n",
       "      <td>AKT</td>\n",
       "      <td>HDAC_4</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.601997</td>\n",
       "      <td>1.199469</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>0.082556</td>\n",
       "      <td>0.667063</td>\n",
       "      <td>...</td>\n",
       "      <td>78.40000</td>\n",
       "      <td>8.000</td>\n",
       "      <td>2.247</td>\n",
       "      <td>19.000</td>\n",
       "      <td>0.64012</td>\n",
       "      <td>3</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Urology</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>911</th>\n",
       "      <td>HCC1143</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>PIK3CA_4</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.683122</td>\n",
       "      <td>50.058333</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.958035</td>\n",
       "      <td>...</td>\n",
       "      <td>129.45000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>30.000</td>\n",
       "      <td>0.74000</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0.3333333</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>124</th>\n",
       "      <td>DU-4475</td>\n",
       "      <td>AKT</td>\n",
       "      <td>ALK_IGFR</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.007158</td>\n",
       "      <td>0.368006</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.540673</td>\n",
       "      <td>...</td>\n",
       "      <td>97.43558</td>\n",
       "      <td>4.903</td>\n",
       "      <td>2.427</td>\n",
       "      <td>30.291</td>\n",
       "      <td>0.61224</td>\n",
       "      <td>6</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>0.5</td>\n",
       "      <td>Breast</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>695</th>\n",
       "      <td>TCCSUP</td>\n",
       "      <td>ATR_4</td>\n",
       "      <td>HDAC_4</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.589470</td>\n",
       "      <td>1.403749</td>\n",
       "      <td>8.999143</td>\n",
       "      <td>0.985759</td>\n",
       "      <td>0.958230</td>\n",
       "      <td>...</td>\n",
       "      <td>78.40000</td>\n",
       "      <td>8.000</td>\n",
       "      <td>2.247</td>\n",
       "      <td>19.000</td>\n",
       "      <td>0.64012</td>\n",
       "      <td>3</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>Urology</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1241</th>\n",
       "      <td>NCI-H226</td>\n",
       "      <td>CSNK2A1_2</td>\n",
       "      <td>TNFSF10</td>\n",
       "      <td>0.03</td>\n",
       "      <td>0.10</td>\n",
       "      <td>0.011123</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>80.899062</td>\n",
       "      <td>0.005038</td>\n",
       "      <td>2.174639</td>\n",
       "      <td>...</td>\n",
       "      <td>92.76332</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>3</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>Lung</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>2154 rows × 39 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "           CELL_LINE          COMPOUND_A     COMPOUND_B  MAX_CONC_A  \\\n",
       "587         NCI-H358               ALK_2         MTOR_1        3.00   \n",
       "887         KU-19-19         BCL2_BCL2L1            IAP        3.00   \n",
       "919            647-V         BCL2_BCL2L1           PIM1        3.00   \n",
       "1225       NCI-H1563           CSNK2A1_2            SYK        3.00   \n",
       "568          DMS-114                 ALK          PIK3C        3.00   \n",
       "482           CAMA-1             AKT_SGK    BCL2_BCL2L1        1.00   \n",
       "1495      MDA-MB-436                FASN        MAP2K_1        1.00   \n",
       "1736           SW620                 IAP         PIK3CB       10.00   \n",
       "952           KMS-11  BCL2_BCL2L1_BCL2L2           FGFR        0.03   \n",
       "1917         CAL-148             MAP2K_1        SLC16A4        1.00   \n",
       "1049        COLO-205             BRAF_M2        MAP2K_1        1.00   \n",
       "930       MDA-MB-231         BCL2_BCL2L1           PIM1        1.00   \n",
       "343          HCC1143               AKT_1       ALK_IGFR        1.00   \n",
       "847            HCC70         BCL2_BCL2L1           FASN        1.00   \n",
       "722          HCC1143               ATR_4        MAP2K_1        1.00   \n",
       "1955           HCC38              MTOR_1          PIK3C        1.00   \n",
       "627       MDA-MB-468            ALK_IGFR         MTOR_1        1.00   \n",
       "1683          TCCSUP                 IAP          PARP1        3.00   \n",
       "1911           HT-29             MAP2K_1           PTK2       10.00   \n",
       "2036      MDA-MB-157               PARP1  PIK3CB_PIK3CD        1.00   \n",
       "819        NCI-H1975              BCL2_2    Vinorelbine        0.03   \n",
       "1968         CAL-120              MTOR_1       PIK3CA_4        1.00   \n",
       "612         NCI-H520               ALK_2           TOP2        3.00   \n",
       "99               M14              ADAM17  PIK3CB_PIK3CD        1.00   \n",
       "1920         HCC1143             MAP2K_1        SLC16A4        1.00   \n",
       "917       MDA-MB-453         BCL2_BCL2L1       PIK3CA_4        1.00   \n",
       "460            HCC38               AKT_1        PIK3C_2        1.00   \n",
       "184           Calu-3                 AKT      CSNK2A1_2        0.03   \n",
       "13        MDA-MB-453              ADAM17            AKT        1.00   \n",
       "219          CAL-120                 AKT           ERBB        1.00   \n",
       "...              ...                 ...            ...         ...   \n",
       "1085      MDA-MB-436             BRAF_M2        MAP2K_3        0.30   \n",
       "1754        KU-19-19                 IAP            TNF        0.10   \n",
       "309           CAMA-1                 AKT         PIP5K1        1.00   \n",
       "832          HCC1187         BCL2_BCL2L1           EGFR        0.10   \n",
       "55           DU-4475              ADAM17         MTOR_1        1.00   \n",
       "297          HCC1187                 AKT       PIK3CA_4        1.00   \n",
       "59           HCC1428              ADAM17         MTOR_1        1.00   \n",
       "1939      MDA-MB-453             MAP2K_3          PIK3C        3.00   \n",
       "1552  MDA-MB-175-VII                FGFR     PIK3C_MTOR        1.00   \n",
       "1986             M14              MTOR_1        SLC16A4        1.00   \n",
       "834          HCC1428         BCL2_BCL2L1           EGFR        0.10   \n",
       "1836             J82             MAP2K_1         MTOR_1        3.00   \n",
       "2074            T-24               PIK3C        TNFSF10        0.03   \n",
       "202         NCI-H520                 AKT      CSNK2A1_2        0.03   \n",
       "77        MDA-MB-157              ADAM17          PIK3C        1.00   \n",
       "1873            T47D             MAP2K_1          PIK3C        3.00   \n",
       "1934          EVSA-T             MAP2K_3          PIK3C        3.00   \n",
       "1212       NCI-H1437           CSNK2A1_2       PIK3CA_3        3.00   \n",
       "1288            T-24                 EG5           PIM1        3.00   \n",
       "649          CAL-120               ATR_4    BCL2_BCL2L1        1.00   \n",
       "1817         HCT-116                 JAK           MTOR        0.30   \n",
       "1753          KMS-11                 IAP            TNF        0.10   \n",
       "1823           647-V             MAP2K_1         MTOR_1        1.00   \n",
       "1530      NCI-SNU-16                FGFR         MTOR_1        1.00   \n",
       "293            BT-20                 AKT       PIK3CA_4        1.00   \n",
       "277           TCCSUP                 AKT         HDAC_4        3.00   \n",
       "911          HCC1143         BCL2_BCL2L1       PIK3CA_4        1.00   \n",
       "124          DU-4475                 AKT       ALK_IGFR        1.00   \n",
       "695           TCCSUP               ATR_4         HDAC_4        3.00   \n",
       "1241        NCI-H226           CSNK2A1_2        TNFSF10        0.03   \n",
       "\n",
       "      MAX_CONC_B    IC50_A        H_A      Einf_A     IC50_B        H_B  \\\n",
       "587         3.00  0.321662   0.957786   19.228871   0.227408   0.891974   \n",
       "887         3.00  1.000000   0.000000  100.000000   3.000000   1.251460   \n",
       "919         3.00  1.000000   0.000000  100.000000   2.653789   0.682784   \n",
       "1225        0.03  0.711825   0.908353    0.000000   0.008815   1.019147   \n",
       "568         3.00  1.301792   1.036814    0.000000   0.587162   1.296381   \n",
       "482         1.00  0.268071   2.693095   80.550395   0.128381   1.522306   \n",
       "1495        1.00  1.000000   0.368812   20.910493   1.000000   0.000000   \n",
       "1736        1.00  0.001002   0.100000   94.036477   1.000000   0.000000   \n",
       "952         0.30  0.030000  10.000000   13.800820   0.289039  10.000000   \n",
       "1917        1.00  1.000000   0.000000  100.000000   0.037474  10.000000   \n",
       "1049        3.00  0.074560   0.997635    0.000000   0.563370   0.871428   \n",
       "930         1.00  0.267757  10.000000   92.999970   0.422353   1.948100   \n",
       "343         1.00  1.000000  10.000000   90.800078   1.000000   0.732731   \n",
       "847         1.00  1.000000   0.000000  100.000000   1.000000   0.000000   \n",
       "722         1.00  0.048078   0.721101   44.265628   0.397592  10.000000   \n",
       "1955        1.00  0.282912  10.000000   76.499917   1.000000   0.855220   \n",
       "627         1.00  1.000000   1.658284   41.719062   0.000317   0.100000   \n",
       "1683        0.03  3.000000   0.960874   37.683182   0.030000   0.173312   \n",
       "1911        3.00  0.666165   4.547947    7.225506   0.089859   1.209154   \n",
       "2036        3.00  1.000000   0.433860   13.810602   0.980042   0.839295   \n",
       "819         3.00  0.025385   2.348173    0.000000   1.000000   0.000000   \n",
       "1968        1.00  0.088010  10.000000   77.749684   0.197582   0.803260   \n",
       "612         3.00  2.962161   0.678884   15.203455   3.000000   3.905525   \n",
       "99         75.00  0.475350   0.675796    0.000000   0.461424   1.472944   \n",
       "1920        1.00  1.000000   0.000000  100.000000   0.084926   0.712687   \n",
       "917         1.00  0.208745   0.920606    0.000000   0.320005  10.000000   \n",
       "460         1.00  0.836445   2.560558    0.000000   0.000100   4.129823   \n",
       "184         3.00  0.030000  10.000000    3.000014   1.313230  10.000000   \n",
       "13         75.00  0.282664   2.263455   34.219723   1.000000   0.000000   \n",
       "219         1.00  1.000000  10.000000   93.200109   0.102681   1.269677   \n",
       "...          ...       ...        ...         ...        ...        ...   \n",
       "1085        3.00  0.046794   0.952113   70.246208   0.524050   1.555066   \n",
       "1754        3.00  0.002845   9.003956   94.166817   1.000000   0.000000   \n",
       "309         1.00  0.400556  10.000000   90.498990   0.126079   1.342466   \n",
       "832         1.00  1.000000   0.000000  100.000000   1.000000   0.000000   \n",
       "55         75.00  0.204544   2.534173   21.566877  39.488708   0.843183   \n",
       "297         1.00  0.155580   1.447416   51.593515   1.000000   0.893120   \n",
       "59         75.00  0.325342  10.000000   50.599339   1.000000   0.000000   \n",
       "1939        0.30  0.725841   0.658544    8.438496   1.000000   0.000000   \n",
       "1552        1.00  0.269950  10.000000    7.396944   1.000000   0.000000   \n",
       "1986        1.00  0.101872  10.000000   82.149811   1.000000   0.621071   \n",
       "834         1.00  1.000000   0.000000  100.000000   0.144687   0.873652   \n",
       "1836        3.00  1.080224   0.820321    0.000000   3.000000   0.294483   \n",
       "2074        3.00  0.010822  10.000000   44.897931   1.210067  10.000000   \n",
       "202         3.00  0.007808   0.915461    0.000000   0.548968   0.913053   \n",
       "77         75.00  0.213489   0.890822   54.800152  33.769554   1.397694   \n",
       "1873        3.00  0.166243   0.978454   11.286392   0.014740   0.925424   \n",
       "1934        0.30  0.401860   0.886398    0.000000   0.000030   0.100000   \n",
       "1212        0.10  3.000000   0.405386   35.420443   0.009025   2.953876   \n",
       "1288        3.00  0.000300   0.100000   94.990170   0.000317   7.649786   \n",
       "649         1.00  0.059653   3.022304   37.922530   0.289851   3.290459   \n",
       "1817        3.00  1.000000   0.000000  100.000000   2.898833  10.000000   \n",
       "1753        3.00  0.100000   1.737578   67.917650   1.000000   0.000000   \n",
       "1823        1.00  0.320194  10.000000   53.599453   1.000000   1.016034   \n",
       "1530        0.01  0.487432   2.021942    9.800686   0.007513   2.715880   \n",
       "293         1.00  0.208946   1.263169   58.795974   0.190101   3.241219   \n",
       "277         3.00  0.601997   1.199469    0.000000   0.082556   0.667063   \n",
       "911         1.00  1.000000   0.683122   50.058333   1.000000   0.958035   \n",
       "124         1.00  0.007158   0.368006    0.000000   1.000000   0.540673   \n",
       "695         3.00  0.589470   1.403749    8.999143   0.985759   0.958230   \n",
       "1241        0.10  0.011123  10.000000   80.899062   0.005038   2.174639   \n",
       "\n",
       "          ...           B_PSA  B_#RotBonds  B_Arom Rings  B_Heavy atoms  \\\n",
       "587       ...        92.71000        4.000         3.000         32.000   \n",
       "887       ...        92.76332        3.068         2.597         23.849   \n",
       "919       ...       100.72000        3.000         2.000         27.000   \n",
       "1225      ...       128.75000        7.000         3.000         34.000   \n",
       "568       ...       144.17000        5.000         4.000         35.000   \n",
       "482       ...       158.48754       11.564         2.847         60.555   \n",
       "1495      ...        88.41000        6.000         3.000         27.000   \n",
       "1736      ...        92.76332        3.068         2.597         23.849   \n",
       "952       ...        91.51000        8.000         4.000         34.000   \n",
       "1917      ...        92.76332        3.068         2.597         23.849   \n",
       "1049      ...        88.41000        6.000         3.000         27.000   \n",
       "930       ...       100.72000        3.000         2.000         27.000   \n",
       "343       ...        97.43558        4.903         2.427         30.291   \n",
       "847       ...        64.16000        5.000         5.000         35.000   \n",
       "722       ...        88.41000        6.000         3.000         27.000   \n",
       "1955      ...       144.17000        5.000         4.000         35.000   \n",
       "627       ...        92.71000        4.000         3.000         32.000   \n",
       "1683      ...        82.08000        4.000         2.000         32.000   \n",
       "1911      ...        90.94507        4.059         2.497         29.963   \n",
       "2036      ...        99.50709        4.289         2.737         30.490   \n",
       "819       ...       133.87000       10.000         3.000         57.000   \n",
       "1968      ...       129.45000        5.000         2.000         30.000   \n",
       "612       ...        67.00000        2.000         4.000         30.000   \n",
       "99        ...        99.50709        4.289         2.737         30.490   \n",
       "1920      ...        92.76332        3.068         2.597         23.849   \n",
       "917       ...       129.45000        5.000         2.000         30.000   \n",
       "460       ...        89.63000        4.000         2.000         29.000   \n",
       "184       ...       136.39000        8.000         3.000         31.000   \n",
       "13        ...       120.16000        6.000         3.000         30.000   \n",
       "219       ...        88.61000        7.000         3.000         33.000   \n",
       "...       ...             ...          ...           ...            ...   \n",
       "1085      ...       102.06000        5.000         2.000         37.000   \n",
       "1754      ...       102.00000        3.000         2.804         31.000   \n",
       "309       ...        92.76332        3.068         2.597         23.849   \n",
       "832       ...        88.61000        8.000         3.000         34.000   \n",
       "55        ...        92.71000        4.000         3.000         32.000   \n",
       "297       ...       129.45000        5.000         2.000         30.000   \n",
       "59        ...        92.71000        4.000         3.000         32.000   \n",
       "1939      ...       144.17000        5.000         4.000         35.000   \n",
       "1552      ...       124.00000        6.000         3.084         31.000   \n",
       "1986      ...        92.76332        3.068         2.597         23.849   \n",
       "834       ...        88.61000        8.000         3.000         34.000   \n",
       "1836      ...        92.71000        4.000         3.000         32.000   \n",
       "2074      ...        92.76332        3.068         2.597         23.849   \n",
       "202       ...       136.39000        8.000         3.000         31.000   \n",
       "77        ...       144.17000        5.000         4.000         35.000   \n",
       "1873      ...       144.17000        5.000         4.000         35.000   \n",
       "1934      ...       144.17000        5.000         4.000         35.000   \n",
       "1212      ...        92.76332        3.068         2.597         23.849   \n",
       "1288      ...       100.72000        3.000         2.000         27.000   \n",
       "649       ...       158.48754       11.564         2.847         60.555   \n",
       "1817      ...        93.07000        5.000         3.000         34.000   \n",
       "1753      ...       102.00000        3.000         2.804         31.000   \n",
       "1823      ...        92.71000        4.000         3.000         32.000   \n",
       "1530      ...        92.71000        4.000         3.000         32.000   \n",
       "293       ...       129.45000        5.000         2.000         30.000   \n",
       "277       ...        78.40000        8.000         2.247         19.000   \n",
       "911       ...       129.45000        5.000         2.000         30.000   \n",
       "124       ...        97.43558        4.903         2.427         30.291   \n",
       "695       ...        78.40000        8.000         2.247         19.000   \n",
       "1241      ...        92.76332        3.068         2.597         23.849   \n",
       "\n",
       "        B_QED  GEX_CLUSTER  THERAPY_CLUSTER  Target_share  Target_interaction  \\\n",
       "587   0.63000            1                3             0           0.3333333   \n",
       "887   0.63639            3                0             0                 0.5   \n",
       "919   0.80000            1                0             0                 0.5   \n",
       "1225  0.47000            3                3             0                 0.5   \n",
       "568   0.43000            5                3             0           0.3333333   \n",
       "482   0.19713            2                0             0                 0.5   \n",
       "1495  0.39000            3                2             0           0.3333333   \n",
       "1736  0.63639            6                1             0                 0.5   \n",
       "952   0.46000            7                3             0                 0.5   \n",
       "1917  0.63639            2                1             0                   0   \n",
       "1049  0.39000            0                3             0                   0   \n",
       "930   0.80000            3                1             0                 0.5   \n",
       "343   0.61224            1                0             0                 0.5   \n",
       "847   0.39000            1                1             0                 0.5   \n",
       "722   0.39000            1                3             0                 0.5   \n",
       "1955  0.43000            3                0             0                 0.5   \n",
       "627   0.63000            1                2             0                 0.5   \n",
       "1683  0.80000            3                3             0           0.3333333   \n",
       "1911  0.68621            0                3             0                 0.5   \n",
       "2036  0.62948            4                3             0           0.3333333   \n",
       "819   0.20000            3                2             0                 0.5   \n",
       "1968  0.74000            3                0             0                 0.5   \n",
       "612   0.44000            7                2             0                 0.5   \n",
       "99    0.62948            4                2             0                   0   \n",
       "1920  0.63639            1                0             0                   0   \n",
       "917   0.74000            2                2             0           0.3333333   \n",
       "460   0.82000            3                2             0                   1   \n",
       "184   0.43000            1                3             0                   1   \n",
       "13    0.57000            2                2             0                   0   \n",
       "219   0.54000            3                1             0                   1   \n",
       "...       ...          ...              ...           ...                 ...   \n",
       "1085  0.50000            3                1             0                   0   \n",
       "1754  0.65147            3                1             0                   1   \n",
       "309   0.63639            2                0             0                   0   \n",
       "832   0.47000            7                1             0                 0.5   \n",
       "55    0.63000            6                3             0                   0   \n",
       "297   0.74000            7                0             0                   1   \n",
       "59    0.63000            2                1             0                   0   \n",
       "1939  0.43000            2                2             0           0.3333333   \n",
       "1552  0.60263            3                2             0           0.3333333   \n",
       "1986  0.63639            4                0             0                   0   \n",
       "834   0.47000            2                0             0                 0.5   \n",
       "1836  0.63000            3                3             0                 0.5   \n",
       "2074  0.63639            3                2             0                   0   \n",
       "202   0.43000            7                3             0                   1   \n",
       "77    0.43000            4                1             0                   0   \n",
       "1873  0.43000            2                2             0           0.3333333   \n",
       "1934  0.43000            2                2             0           0.3333333   \n",
       "1212  0.63639            3                3             0                 0.5   \n",
       "1288  0.80000            3                0             0                   0   \n",
       "649   0.19713            3                2             0                 0.5   \n",
       "1817  0.61000            6                0             0                 0.5   \n",
       "1753  0.65147            7                1             0                   1   \n",
       "1823  0.63000            1                2             0                 0.5   \n",
       "1530  0.63000            0                3             0           0.3333333   \n",
       "293   0.74000            1                1             0                   1   \n",
       "277   0.64012            3                3             0                 0.5   \n",
       "911   0.74000            1                0             0           0.3333333   \n",
       "124   0.61224            6                3             0                 0.5   \n",
       "695   0.64012            3                3             0                   1   \n",
       "1241  0.63639            3                0             0                   0   \n",
       "\n",
       "      Disease_area  \n",
       "587           Lung  \n",
       "887        Urology  \n",
       "919        Urology  \n",
       "1225          Lung  \n",
       "568           Lung  \n",
       "482         Breast  \n",
       "1495        Breast  \n",
       "1736            GI  \n",
       "952          Haems  \n",
       "1917        Breast  \n",
       "1049            GI  \n",
       "930         Breast  \n",
       "343         Breast  \n",
       "847         Breast  \n",
       "722         Breast  \n",
       "1955        Breast  \n",
       "627         Breast  \n",
       "1683       Urology  \n",
       "1911            GI  \n",
       "2036        Breast  \n",
       "819           Lung  \n",
       "1968        Breast  \n",
       "612           Lung  \n",
       "99           Niche  \n",
       "1920        Breast  \n",
       "917         Breast  \n",
       "460         Breast  \n",
       "184           Lung  \n",
       "13          Breast  \n",
       "219         Breast  \n",
       "...            ...  \n",
       "1085        Breast  \n",
       "1754       Urology  \n",
       "309         Breast  \n",
       "832         Breast  \n",
       "55          Breast  \n",
       "297         Breast  \n",
       "59          Breast  \n",
       "1939        Breast  \n",
       "1552        Breast  \n",
       "1986         Niche  \n",
       "834         Breast  \n",
       "1836       Urology  \n",
       "2074       Urology  \n",
       "202           Lung  \n",
       "77          Breast  \n",
       "1873        Breast  \n",
       "1934        Breast  \n",
       "1212          Lung  \n",
       "1288       Urology  \n",
       "649         Breast  \n",
       "1817            GI  \n",
       "1753         Haems  \n",
       "1823       Urology  \n",
       "1530            GI  \n",
       "293         Breast  \n",
       "277        Urology  \n",
       "911         Breast  \n",
       "124         Breast  \n",
       "695        Urology  \n",
       "1241          Lung  \n",
       "\n",
       "[2154 rows x 39 columns]"
      ]
     },
     "execution_count": 211,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "cell_info = pd.DataFrame.from_csv('Sanger_molecular_data/cell_info.csv', header=0)\n",
    "dfb.drop('ORIGIN_CLUSTER', axis=1, inplace=True)\n",
    "dfb['Disease_area'] = dfb['CELL_LINE'].map(cell_info['Disease.Area']) # maps to cell_info disease area based on given cell_line\n",
    "dfb"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 366,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "dfb = dfb.iloc[np.random.permutation(len(dfb))]\n",
    "bY = dfb['SYNERGY_SCORE']\n",
    "bX = pd.get_dummies(dfb.drop('SYNERGY_SCORE', axis=1), columns=['CELL_LINE', 'COMPOUND_A', 'COMPOUND_B', 'Disease_area'])\n",
    "\n",
    "### TEST!!\n",
    "bXtest = bX.drop(['A_HBD', 'B_HBD', 'A_PSA', 'B_PSA', 'A_ALogP/XLogP', 'B_ALogP/XLogP', 'A_Lipinski', 'B_Lipinski'], axis=1)\n",
    "# bXtest = bX.drop(['A_HBA', 'A_cLogP', 'A_HBD', 'A_Lipinski', 'A_MW', 'A_ALogP/XLogP', 'A_PSA', 'A_#RotBonds', \n",
    "#                   'A_Arom Rings', 'A_Heavy atoms', 'A_QED', 'B_HBA', 'B_cLogP', 'B_HBD', 'B_Lipinski', 'B_MW', \n",
    "#                   'B_ALogP/XLogP', 'B_PSA', 'B_#RotBonds', 'B_Arom Rings', 'B_Heavy atoms', 'B_QED'], axis=1)\n",
    "bXtest = bXtest.values\n",
    "\n",
    "bX = bX.values\n",
    "by = bY.values"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 353,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "def pearson(y, y_pred):\n",
    "    return stats.pearsonr(y, y_pred)[0]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 356,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "pearson_scorer = metrics.make_scorer(pearson)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 369,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "0.369023099912, 0.60388180331\n",
      "0.381942310784, 0.600924325767\n",
      "0.36948860318, 0.600185261733\n",
      "0.373289199251, 0.597925816604\n",
      "0.376238678641, 0.599356747474\n"
     ]
    }
   ],
   "source": [
    "for i in range(5):\n",
    "    gbr = GradientBoostingRegressor(n_estimators=1000, max_depth=5, loss='huber',\n",
    "                                max_features='log2', learning_rate=0.03)\n",
    "    pearsons = cross_validation.cross_val_score(gbr, Xvals, yvals, scoring=pearson_scorer, cv=5)\n",
    "    r2s = cross_validation.cross_val_score(gbr, bXtest, bY, cv=5)\n",
    "    \n",
    "    print(str(np.mean(r2s)) + ', ' + str(np.mean(pearsons)))"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Classification"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 119,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "from sklearn.grid_search import GridSearchCV"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 199,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "from sklearn.ensemble import BaggingRegressor"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 203,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "def class_grid_search():\n",
    "    bYclass = bY > 0\n",
    "    bYclass = bYclass.astype(int)\n",
    "    X_train, X_test, y_train, y_test = cross_validation.train_test_split(bX, bYclass)\n",
    "    \n",
    "    params = {\n",
    "        'loss': ['deviance', 'exponential'],\n",
    "        'max_depth': [5, 8, 12]\n",
    "    }\n",
    "    gbc = GradientBoostingClassifier()\n",
    "\n",
    "#     params = {\n",
    "#         'n_estimators': [100, 300, 1000],\n",
    "#         'max_samples': [0.1, 0.3, 1],\n",
    "#         'max_features': [0.1, 0.3, 1]\n",
    "#     }\n",
    "#     br = BaggingRegressor()\n",
    "    grid_search = GridSearchCV(gbc, params, n_jobs=2)\n",
    "    \n",
    "    for i in range(3):\n",
    "        grid_search.fit(X_train, y_train)\n",
    "        print(grid_search.best_params_)\n",
    "        print(grid_search.best_score_)\n",
    "    \n",
    "    #print(\"Classification accuracy: \" + str(gbc.score(X_test, y_test)))\n",
    "    #print(\"AUC: \" + str(metrics.roc_auc_score(y_test, pred)))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 346,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "def class_pred(graph=False):\n",
    "    bYclass = bY > 0\n",
    "    #bYclass = bY > np.mean(bY)+np.std(bY)\n",
    "    bYclass = bYclass.astype(int)\n",
    "    \n",
    "#     m = Ypd.shape[0]\n",
    "#     Yclass = np.zeros(m)\n",
    "#     for i in range(m):\n",
    "#         if Ypd[i] > 5:\n",
    "#             Yclass[i] = 1\n",
    "#         elif Ypd[i] < -5:\n",
    "#             Yclass[i] = -1\n",
    "#         else:\n",
    "#             Yclass[i] = 0\n",
    "    X_train, X_test, y_train, y_test = cross_validation.train_test_split(bX, bYclass)\n",
    "    \n",
    "    gbc = GradientBoostingClassifier(n_estimators=1000, max_depth=5, loss='exponential',\n",
    "                                max_features='log2', learning_rate=0.03)\n",
    "    gbc.fit(X_train, y_train)\n",
    "    pred = gbc.predict(X_test)\n",
    "    \n",
    "    print(\"Classification accuracy: \" + str(gbc.score(X_test, y_test)))\n",
    "    print(\"AUC: \" + str(metrics.roc_auc_score(y_test, pred)))\n",
    "    print(\"F1: \" + str(metrics.f1_score(y_test, pred)))\n",
    "    print(\"Precision: \" + str(metrics.precision_score(y_test, pred)))\n",
    "    print(\"Recall: \" + str(metrics.recall_score(y_test, pred)))\n",
    "    \n",
    "    if graph:\n",
    "        fpr, tpr, thresholds = metrics.roc_curve(y_test, pred)\n",
    "        #roc_auc = metrics.auc(fpr, tpr)\n",
    "        roc_auc = metrics.roc_auc_score(y_test, pred)\n",
    "        \n",
    "        plt.title('Receiver Operating Characteristic')\n",
    "        plt.plot(fpr, tpr, 'b', label='AUC = %0.2f'% roc_auc) # actual data\n",
    "        plt.plot([0,1],[0,1],'r--')                           # randomness\n",
    "        plt.legend(loc='lower right')\n",
    "        plt.ylabel('True Positive Rate')\n",
    "        plt.xlabel('False Positive Rate')\n",
    "        plt.show()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 345,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Classification accuracy: 0.716141001855\n",
      "AUC: 0.685390186225\n",
      "F1: 0.781115879828\n",
      "Precision: 0.760445682451\n",
      "Recall: 0.802941176471\n",
      "Classification accuracy: 0.706864564007\n",
      "AUC: 0.658239728052\n",
      "F1: 0.784153005464\n",
      "Precision: 0.732142857143\n",
      "Recall: 0.844117647059\n",
      "Classification accuracy: 0.705009276438\n",
      "AUC: 0.662323205867\n",
      "F1: 0.77947295423\n",
      "Precision: 0.72236503856\n",
      "Recall: 0.846385542169\n",
      "Classification accuracy: 0.703153988868\n",
      "AUC: 0.673075291922\n",
      "F1: 0.770773638968\n",
      "Precision: 0.698701298701\n",
      "Recall: 0.859424920128\n",
      "Classification accuracy: 0.716141001855\n",
      "AUC: 0.667205343676\n",
      "F1: 0.792401628223\n",
      "Precision: 0.768421052632\n",
      "Recall: 0.817927170868\n"
     ]
    }
   ],
   "source": [
    "for i in range(5):\n",
    "    class_pred()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 204,
   "metadata": {
    "collapsed": false,
    "scrolled": true
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "{'loss': 'exponential', 'max_depth': 5}\n",
      "0.700309597523\n",
      "{'loss': 'exponential', 'max_depth': 5}\n",
      "0.69907120743\n",
      "{'loss': 'deviance', 'max_depth': 5}\n",
      "0.705263157895\n"
     ]
    }
   ],
   "source": [
    "class_grid_search()"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Plots"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 227,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "import matplotlib.pyplot as plt\n",
    "%matplotlib inline \n",
    "plt.rcParams['figure.figsize'] = (10, 6)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 244,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Classification accuracy: 0.73840445269\n",
      "AUC: 0.693301212776\n",
      "F1: 0.807113543092\n",
      "Precision: 0.768229166667\n",
      "Recall: 0.850144092219\n"
     ]
    },
    {
     "data": {
      "image/png": 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XRdx9ToWnSlMQi0jee+op+Ne/Qvuk7bePOhrJecXF8MknUUchIjGJJGVzzOwg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\nAAAASUVORK5CYII=\n",
      "text/plain": [
       "<matplotlib.figure.Figure at 0x110af2320>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "class_pred(graph=True)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### PCA"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 282,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "from sklearn.decomposition import PCA\n",
    "from sklearn.pipeline import Pipeline"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 290,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "image/png": 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axc5YdRnGGjBlSm1pGJMkSc1mGGuApyklSa1mZ6y6DGMNmDy5tly0CNavL7YW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\nCmQYkyRJKpBhTJIkqUD/PzDwKgmlQ7b6AAAAAElFTkSuQmCC\n",
      "text/plain": [
       "<matplotlib.figure.Figure at 0x111783630>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "pca = PCA()\n",
    "gbr = GradientBoostingRegressor(n_estimators=1000, max_depth=3, loss='huber',\n",
    "                                max_features='log2', learning_rate=0.03)\n",
    "pipe = Pipeline(steps=[('pca', pca), ('gbr', gbr)])\n",
    "\n",
    "# Plot:\n",
    "pca.fit(bXtest)\n",
    "\n",
    "plt.clf()\n",
    "plt.plot(pca.explained_variance_, linewidth=2)\n",
    "plt.axis([0, 200, 0, 10])\n",
    "plt.xlabel('n_components')\n",
    "plt.ylabel('explained_variance')\n",
    "\n",
    "# Predict\n",
    "n_components = [140, 150, 160]\n",
    "\n",
    "estimator = GridSearchCV(pipe,\n",
    "                         dict(pca__n_components=n_components))\n",
    "estimator.fit(bXtest, bY)\n",
    "\n",
    "plt.axvline(estimator.best_estimator_.named_steps['pca'].n_components,\n",
    "            linestyle=':', label='n_components chosen')\n",
    "plt.legend(prop=dict(size=12))\n",
    "plt.show()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 302,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "(2154, 218)"
      ]
     },
     "execution_count": 302,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "bXtest.shape"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 316,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "R^2: 0.333976955134\n",
      "RMSE: 36.497263911744135\n",
      "MAE: 22.2778382959\n",
      "MAPE: 6.86147338277\n",
      "Error within 20: 0.454545454545\n",
      "Pearson: (0.58105463380663858, 5.4634023778709484e-50)\n"
     ]
    }
   ],
   "source": [
    "pca = PCA(n_components=160)\n",
    "pca.fit(bXtest)\n",
    "X = pca.transform(bXtest)\n",
    "\n",
    "bX_train, bX_test, by_train, by_test = cross_validation.train_test_split(X, bY)\n",
    "gbr = GradientBoostingRegressor(n_estimators=1000, max_depth=3, loss='huber',\n",
    "                            max_features='log2', learning_rate=0.03)\n",
    "gbr.fit(bX_train, by_train)\n",
    "\n",
    "print_scores(gbr, X_test=bX_test, y_test=by_test)"
   ]
  }
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