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Episode One Supplemental: Dr. Ray Peat [H0oWFJFO1gU].vtt
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WEBVTT
00:00:00.000 --> 00:00:04.000
On the Back of a Tiger, Episode 1, Deep Dive.
00:00:04.000 --> 00:00:08.000
[Music]
00:00:08.000 --> 00:00:10.000
Hello.
00:00:10.000 --> 00:00:13.000
Hi Ray, it's Brad and Jeremy.
00:00:13.000 --> 00:00:15.000
Hi.
00:00:15.000 --> 00:00:16.000
How are you?
00:00:16.000 --> 00:00:18.000
Very good.
00:00:18.000 --> 00:00:25.000
Yeah, so we were just wondering if you could generally describe the association induction hypothesis
00:00:25.000 --> 00:00:32.000
in the most basic way and why it's so important.
00:00:32.000 --> 00:00:42.000
Association refers to the relation between two charged particles,
00:00:42.000 --> 00:00:49.000
two electric negative and positive particles,
00:00:49.000 --> 00:01:00.000
when you dissolve sodium chloride in water, they dissociate more completely the more highly diluted they are.
00:01:00.000 --> 00:01:06.000
So when they're concentrated, they tend to get pushed into association more often.
00:01:06.000 --> 00:01:16.000
And the idea of the association in the cell is that you have proteins very close to each other
00:01:16.000 --> 00:01:23.000
with lots of charges, predominantly negative charges.
00:01:23.000 --> 00:01:36.000
And so they're held in a relatively stable relationship to each other, although everything is liquid.
00:01:36.000 --> 00:01:46.000
And being concentrated negative charges, it's the opposite of a diluted solution,
00:01:46.000 --> 00:01:55.000
and so you automatically have a high degree of association between charged particles, oppositely charged.
00:01:55.000 --> 00:02:03.000
So just the fact that you have a substance with an intrinsically high negative charge
00:02:03.000 --> 00:02:12.000
means that you're going to pull positively charged particles out of the surrounding environment.
00:02:12.000 --> 00:02:23.000
And it works just as well for clay or water softening gel or hair.
00:02:23.000 --> 00:02:36.000
Lots of conventional biologists have simply preferred to be ignorant about the physics of solid substances
00:02:36.000 --> 00:02:41.000
such as clay, water softeners, and hair.
00:02:41.000 --> 00:03:01.000
But if you thoroughly wash a substance such as hair and then dip it into serum or a solution containing both sodium and potassium ions, for example,
00:03:01.000 --> 00:03:13.000
the hair will selectively take up potassium ions out of the solution, relatively excluding sodium ions.
00:03:13.000 --> 00:03:25.000
And that's something that the mainstream biologists for several decades have simply not wanted to look at.
00:03:25.000 --> 00:03:35.000
They say that there's a semi-permeable barrier doing that, letting in one kind of ion,
00:03:35.000 --> 00:03:49.000
preferably the potassium which has a lower surface of water, attached to water molecules.
00:03:49.000 --> 00:04:04.000
And that whole idea of a semi-permeable barrier membrane has been discredited for now about 80 years,
00:04:04.000 --> 00:04:09.000
thoroughly and repeatedly, but they just won't give it up.
00:04:09.000 --> 00:04:22.000
They insist that there are little motors at the surface accounting for the unequal distribution.
00:04:22.000 --> 00:04:32.000
Long ago, Gilbert Lane showed that if you block the energy systems of a cell,
00:04:32.000 --> 00:04:42.000
it's still just like hair being completely dead will selectively associate potassium.
00:04:42.000 --> 00:04:55.000
Lane demonstrated that in the state where the cell is predominantly associated with potassium,
00:04:55.000 --> 00:05:07.000
using isotopes, he showed that sodium is constantly entering the cell but being excluded.
00:05:07.000 --> 00:05:12.000
It goes in, but it goes out even faster.
00:05:12.000 --> 00:05:19.000
So it's analogous to the solubility of something.
00:05:19.000 --> 00:05:31.000
A.S. Troshin, about the time Lane was working on history, was working on the idea of different solubilities
00:05:31.000 --> 00:05:35.000
governing the properties of cells.
00:05:35.000 --> 00:05:44.000
And he showed that, for example, he could demonstrate that cells are not osmometers,
00:05:44.000 --> 00:05:56.000
which if there's a semi-permeable membrane, they have to behave as an osmometer, like an egg membrane.
00:05:56.000 --> 00:06:04.000
It's a very thick substance compared to the idea of a cell membrane,
00:06:04.000 --> 00:06:11.000
but you do a dialysis membrane, for example, made from an intestine.
00:06:11.000 --> 00:06:18.000
It's not at all analogous to the hypothetical cell membrane.
00:06:18.000 --> 00:06:28.000
And Troshin demonstrated that urea, for example, will change the water content of a cell,
00:06:28.000 --> 00:06:31.000
but it is free to enter the cell.
00:06:31.000 --> 00:06:41.000
So it isn't pulling water out as an osmotic effect, but it enters the cell freely
00:06:41.000 --> 00:06:53.000
and simply changes the properties of the protein system so that less water is bound by the cell proteins.
00:06:53.000 --> 00:07:00.000
So for the follow-up, or one follow-up, is why does any of this matter?
00:07:00.000 --> 00:07:07.000
Why does it matter that the membrane pumps and channels theory may be incorrect
00:07:07.000 --> 00:07:11.000
and that Gilbert's theory or something like it may be more correct?
00:07:11.000 --> 00:07:13.000
How does that sort of impact?
00:07:13.000 --> 00:07:23.000
Well, the induction part of the hypothesis is that everything that sticks to the protein
00:07:23.000 --> 00:07:32.000
affects the electrical properties of the protein, and that applies literally to everything,
00:07:32.000 --> 00:07:36.000
other ions, hormones, metabolites, and so on.
00:07:36.000 --> 00:07:44.000
Carbon dioxide is an acid which affects the acidity of the protein,
00:07:44.000 --> 00:07:51.000
and so affects its potassium/sodium affinity.
00:07:51.000 --> 00:08:06.000
Once you see that the system as a cooperative organized system is acting as a different phase,
00:08:06.000 --> 00:08:15.000
the whole substance of a cell is a coordinated cooperative phase system,
00:08:15.000 --> 00:08:21.000
and everything you do to that phase is going to change its properties.
00:08:21.000 --> 00:08:34.000
The basic assumption of the foolish membrane hypothesis is that cells are controlled
00:08:34.000 --> 00:08:42.000
by that semi-permeable or pumping property of the surface membrane
00:08:42.000 --> 00:08:52.000
because the ions are equally randomly distributed on either side of the membrane,
00:08:52.000 --> 00:08:58.000
so you need something to account for why they are non-randomly distributed.
00:08:58.000 --> 00:09:05.000
Atrocin saw it as a simple matter of solubility,
00:09:05.000 --> 00:09:17.000
but the association induction shows that specifically the ions are governed by the electrical properties
00:09:17.000 --> 00:09:22.000
of the proteins which are influenced by everything.
00:09:22.000 --> 00:09:35.000
Basically, all of the mistaken medical treatments are the result of bad reasoning
00:09:35.000 --> 00:09:42.000
from the doctrine of a random solution on the inside of the cell.
00:09:42.000 --> 00:09:56.000
Randomness is essential to the working of the equations that are used to explain cell potential and ionic distribution.
00:09:56.000 --> 00:10:03.000
One of my professors, for example, Sidney Bernhardt,
00:10:03.000 --> 00:10:11.000
spent his whole career and a few years after I left graduate school,
00:10:11.000 --> 00:10:16.000
he pretty much finished what he had been working on,
00:10:16.000 --> 00:10:28.000
showing that even the glycolytic mechanism of converting glucose to pyruvic acid or lactic acid,
00:10:28.000 --> 00:10:35.000
he showed that just by careful measurement of the substrate and the proteins,
00:10:35.000 --> 00:10:41.000
he showed that the assumption of randomness,
00:10:41.000 --> 00:10:49.000
which is the basis for all of the standard enzyme substrate interactions,
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they are all based on statistical randomness.
00:10:53.000 --> 00:11:00.000
He showed that there is no possible room for application of those equations
00:11:00.000 --> 00:11:09.000
because the substrate is about at the same concentration as the enzyme,
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basically one substrate molecule per one enzyme.
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So the substrate has to be essentially handled directly from one protein to another
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rather than randomly diffusing.
00:11:24.000 --> 00:11:31.000
So all of the equations, assuming random diffusion, are irrelevant to biochemistry.
00:11:31.000 --> 00:11:36.000
That part seems really important, sort of culturally.
00:11:36.000 --> 00:11:40.000
Could you talk to us a little bit more about what it means, basically,
00:11:40.000 --> 00:11:44.000
to build everything on top of the wrong assumptions?
00:11:44.000 --> 00:11:55.000
Yeah, everything. When I talk to cardiologists or pulmonologists or any of the specialties,
00:11:55.000 --> 00:12:07.000
they build important therapeutic approaches on that assumption of standard explanation of how enzymes work,
00:12:07.000 --> 00:12:11.000
how hormones act on cells and so on.
00:12:11.000 --> 00:12:21.000
If you follow their reasoning, you can connect the membrane theory
00:12:21.000 --> 00:12:28.000
and the randomness theory to specific mistakes they make in their treatment.
00:12:28.000 --> 00:12:43.000
For example, most thyroid doctors think of thyroid hormone as increasing excitability
00:12:43.000 --> 00:12:46.000
rather than decreasing excitability of cells.
00:12:46.000 --> 00:12:58.000
And carbon dioxide metabolism in cells is usually 180 degrees misinterpreted
00:12:58.000 --> 00:13:09.000
because they think of the equations of bicarbonate rather than the intrinsically acidic
00:13:09.000 --> 00:13:16.000
modifying effects of the carbon dioxide itself acting on the cell structure.
00:13:16.000 --> 00:13:23.000
Could we do a thought experiment as if, let's say, we're now living in a world
00:13:23.000 --> 00:13:32.000
where doctors and scientists, biochemists, have decided to accept the AIH,
00:13:32.000 --> 00:13:34.000
or at least that as a starting point?
00:13:34.000 --> 00:13:38.000
How would you see that changing how medicine or research is done?
00:13:38.000 --> 00:13:48.000
They would start realizing that right at the center of cell structure and function,
00:13:48.000 --> 00:14:00.000
the energy process consisting of the production of carbon dioxide from fuel and oxygen,
00:14:00.000 --> 00:14:09.000
that is the essential acidifying process that governs the structure of the cell,
00:14:09.000 --> 00:14:14.000
the potassium favoring properties of the cytoplasm,
00:14:14.000 --> 00:14:24.000
and therefore the structure of the cytoplasm and the readiness to work and be stimulated.
00:14:24.000 --> 00:14:36.000
So it leads to, for example, seeing interpreting mania as a deficiency of cellular energy.
00:14:36.000 --> 00:14:41.000
Epilepsy is a deficiency of cellular energy.
00:14:41.000 --> 00:14:51.000
When things are overactive, it's because they don't have the energizing structural effects
00:14:51.000 --> 00:14:56.000
of oxidative metabolism all the way to carbon dioxide.
00:14:56.000 --> 00:15:07.000
So muscle cramps, hardening of the heart muscle, losing contractive force,
00:15:07.000 --> 00:15:18.000
nerve symptoms, a great variety of nerve symptoms, kidney malfunction,
00:15:18.000 --> 00:15:30.000
every system you look at, the approach to treating it comes down to optimizing the energy
00:15:30.000 --> 00:15:37.000
which regulates the pH ion selectivity and fuel selectivity.
00:15:37.000 --> 00:15:42.000
Do you think that it would also, continuing this thought experiment,
00:15:42.000 --> 00:15:50.000
how would it trickle down scientists sort of using or considering the AIH as the hypothesis
00:15:50.000 --> 00:15:55.000
to pharmaceuticals and pharmaceutical industry drugs?
00:15:55.000 --> 00:16:01.000
Would those be different and how research is done on them be different in treating some chronic diseases?
00:16:01.000 --> 00:16:08.000
The drug research industry is so far unrelated to reality
00:16:08.000 --> 00:16:15.000
that many other things could abolish essentially our whole drug industry
00:16:15.000 --> 00:16:23.000
because it's corrupt and based on nothing but selling substitute products
00:16:23.000 --> 00:16:33.000
for basically old herbal and biological drugs that were available 100 years ago
00:16:33.000 --> 00:16:40.000
could substitute for our multi-billion or trillion dollar drug industry.
00:16:40.000 --> 00:16:47.000
Do you think considering the AIH or taking it seriously could affect some chronic diseases,
00:16:47.000 --> 00:16:52.000
people suffering with them like Alzheimer's or cancer or heart disease?
00:16:52.000 --> 00:17:01.000
Yeah, exactly the same as epilepsy, heart disease, kidney disease, lung disease and so on.
00:17:01.000 --> 00:17:07.000
Gilbert Ling, one of his articles or books several years ago was
00:17:07.000 --> 00:17:13.000
"Cancer won't be solved along the present line of thinking."
00:17:13.000 --> 00:17:19.000
If you don't know Gilbert Ling's work thoroughly,
00:17:19.000 --> 00:17:26.000
it's hard to understand the idiocy behind contemporary
00:17:26.000 --> 00:17:32.000
last 80 years of biological and medical thinking.
00:17:32.000 --> 00:17:39.000
It's a type of insanity that is reinforced by the culture,
00:17:39.000 --> 00:17:42.000
the fact that it can make vast profits.
00:17:42.000 --> 00:17:47.000
And then another smaller important piece to me seems that
00:17:47.000 --> 00:17:54.000
you get a different understanding of how life works that at the smallest level
00:17:54.000 --> 00:18:00.000
all you really need is the association of water and proteins?
00:18:00.000 --> 00:18:10.000
And fuel, oxygen and sugar are the equivalent.
00:18:10.000 --> 00:18:20.000
And Sidney Fox's demonstration that hot amino acids put on a hot rock
00:18:20.000 --> 00:18:25.000
will spontaneously polymerize into protein-like molecules.
00:18:25.000 --> 00:18:32.000
Randomness doesn't occur anywhere in the origin of life.
00:18:32.000 --> 00:18:41.000
The whole assumption of randomness associated with the Darwinian approach.
00:18:41.000 --> 00:18:49.000
Sidney Fox showed that a random mixture of amino acids polymerizes spontaneously
00:18:49.000 --> 00:18:52.000
into protein-like elongated molecules.
00:18:52.000 --> 00:18:58.000
But if you put water on that hot protoprotein substance,
00:18:58.000 --> 00:19:08.000
it produces very symmetrical cell-like particles about the size of a big bacterium
00:19:08.000 --> 00:19:15.000
spontaneously forming these spheres, microspheres.
00:19:15.000 --> 00:19:23.000
And these spontaneously formed proteins have enzyme-like functions.
00:19:23.000 --> 00:19:29.000
And he showed that precursors of the nucleic acids could be polymerized
00:19:29.000 --> 00:19:33.000
by these spontaneously formed amino acids.
00:19:33.000 --> 00:19:41.000
It's just a chemical, physical way of showing that the assumption of randomness
00:19:41.000 --> 00:19:48.000
is basically a crazy religious doctrine that was built in 200 years ago
00:19:48.000 --> 00:19:56.000
in the conventional science thinking for religious reasons such as the Big Bang.
00:19:56.000 --> 00:20:01.000
They had a creation theory and so they fitted their physics to it.
00:20:01.000 --> 00:20:10.000
Thermodynamic thinking likewise was fitted to associate the idea
00:20:10.000 --> 00:20:17.000
that God created a universe and that it has been running down ever since,
00:20:17.000 --> 00:20:26.000
tending toward entropy with no basis other than religious assumptions.
00:20:26.000 --> 00:20:33.000
The alternative, it isn't necessarily an anti-Christian idea,
00:20:33.000 --> 00:20:36.000
but it's associated with Hinduism,
00:20:36.000 --> 00:20:41.000
is that the universe is alive and maybe growing
00:20:41.000 --> 00:20:50.000
and that randomness in the universe tends to be decreasing rather than increasing, if anything.
00:20:50.000 --> 00:20:53.000
Let's talk in terms of metaphors or analogy.
00:20:53.000 --> 00:21:01.000
I liked how you said the pumps and channels is like there being motors or engines
00:21:01.000 --> 00:21:06.000
on the surface of the cell or another something that Pollock had said,
00:21:06.000 --> 00:21:12.000
pumps and channels, it's sort of like doggy doors that only let in certain size dogs.
00:21:12.000 --> 00:21:14.000
What would be an analogy?
00:21:14.000 --> 00:21:19.000
And they have to have an attendant to push the wrong dogs out.
00:21:19.000 --> 00:21:26.000
Right. What would be an analogy for the AIH in that sense then?
00:21:26.000 --> 00:21:37.000
Say you have a thermostat and food growing inside the house.
00:21:37.000 --> 00:21:46.000
If you have the right kind of temperature and food, the right dog will come in,
00:21:46.000 --> 00:21:54.000
a dog that can't digest beans, for example, might be excluded
00:21:54.000 --> 00:21:58.000
if you're only growing beans in the house.
00:21:58.000 --> 00:22:06.000
It's a matter of affinity, not selectivity in the sense of a doggy door.
00:22:06.000 --> 00:22:11.000
Yeah, I like that. And then sort of going from there, and this might be a hard task,
00:22:11.000 --> 00:22:14.000
but in just like a couple sentences,
00:22:14.000 --> 00:22:22.000
could you say how the AIH differs from the pumps and channels theory?
00:22:22.000 --> 00:22:39.000
If you look at nature, hair, clay, anything that is a selective iron preferring substance,
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you simply see that that's a natural property of nature.
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For example, soil prefers to associate with potassium,
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and the sodium washes out and gets into the ocean.
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So if you wonder why soil contains potassium and the ocean is full of sodium,
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you have to start thinking why is a cell full of potassium and the serum full of sodium?
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It's simply a physical preference, the structure and electrical properties of the solid matter.
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The solidity being anchored in space governs the tendency to associate more fully.
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Dilution changes the tendency to associate and dissociate things.
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Given a solid matrix of potassium throughout the world,
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soil tends to prefer to associate with potassium.
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How did you first hear of the AIH?
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What were you doing research-wise or scientifically?
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I had just enrolled in graduate school,
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and I was taking my first course in nerve biology.
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As the lectures went on, by about the fourth week,
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I decided that the professor giving the standard line was a crackpot.
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He would refer us to papers in the 50s, 40s, and 30s.
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Each time he referred us to a paper that he said was the origin of the thinking that he was expounding on,
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I would look through the journal and see what people were saying at the same time.
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I realized that most of the other articles sounded better than the ones he was referring to us.
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As weeks went by, I read more and more about the history.
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Looking at the articles he would refer to, I would read the whole rest of the journal.
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I started seeing Gilbert Lange's work around 1950 and on.
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I realized that he was solving all of the problems that were evident in what was being taught in 1968.
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So I wrote to him and outlined the problems that he had obviously solved.
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I said, "How is this? These people are going on about this membrane regulation."
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His answer was, "You just don't understand science. Science is about money and prestige and power.
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It has nothing to do with understanding reality accurately."
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Would you say that without adjusting our understanding of the basic model that we'll kind of be at a standstill?
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Yes. They'll never get any further. Just more and more drugs and techniques.
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But never any progress against preventing and curing heart disease, kidney disease, lung disease, brain disease, and so on.
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Why does it seem like Gilbert has been the only one who has offered this complete alternate model of the cell?
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It seems like he's just this lone voice in the wilderness.
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And now that he's passed on, will this all be forgotten?
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Oh, no. All along there have been people who were just less diligent and energetic in doing the work.
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Trotian, his basic book on sorption, is something everyone should read.
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It will revolutionize your thinking as much as Gilbert Ling's.
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It just happens that Ling covered all of the essential arguments that the membrane people have offered their bad solutions to
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and does it in a very elegant way.
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Besides that one letter that you wrote to him and that you got a reply from, did you two ever chat or exchange more letters or chat on the phone?
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Yeah, I wrote to him a couple of times and talked to him once at a meeting in New York.
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I noticed he, I think it was in the 90s, I asked him a question about carbon dioxide.
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And he said, "I have untraded your letters," as if it had been a regular thing, but he kept a good file of who had written to him, obviously.
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Is there a chance that Gilbert's wrong and the AIH is wrong or some parts of it?
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Well, in the 1970s I wrote him and asked him if he didn't think that Michael Polanyi's adsorption isotherm would be more appropriate for explaining cells
00:28:43.000 --> 00:28:53.000
than the sort of elaborate London Langmuir theory I think he was using.
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And he said, "No, this one works all right."
00:28:57.000 --> 00:29:17.000
But if I was starting out where he started, I would have used Polanyi's isotherm because it gives an image of a long-range potential
00:29:17.000 --> 00:29:32.000
that he takes a lot of math to arrive at where Polanyi's isotherm would give you a sketchy approach to it right from the start.
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Yeah, one thing that we have noticed in this journey is that, I don't know if it's the way that Gilbert breaks things down or if it's just that the hypothesis is so complicated,
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but it seems like he hasn't done a great job of communicating it to people, especially lay people.
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The membrane theory is so easy for lay people to understand.
00:29:59.000 --> 00:30:04.000
I don't think it is easy for anyone to understand.
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There are only a few membranes that will make it work that resemble in any way the hypothetical membrane.
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The phospholipid bilayer membrane, all kinds of facts contradict it so intuitively it's impossible to have any substance to it and conceive it.
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The way it stains indicates that it can't possibly be what the hypothesis says it is.
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Nothing supports it except their assertion that it's there doing something.
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Do you feel though that, was it a sort of failure on Gilbert's part of communicating or writing about his theory that, you know, so many people just sort of couldn't get through it or understand it?
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No, I didn't think it was at all hard to see what he was doing.
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I didn't have any background in school biology at all when I started, but since I didn't have that background, it was immediately obvious that the whole membrane pump thing was phony and impossible to believe.
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It's only this sort of religious background of assumptions, it's all built on assumptions that are dogmatically proclaimed.
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The random selection of genes, for example, in Darwinism, totally counter-empirical. It's all a religious set of assumptions.
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One thing I wanted to ask was, because I know that you keep up with a lot of different spheres of research that are going on and new studies that are coming out, have you noticed that any AIH-like theories or experiments have been going on that are getting some more mainstream traction or anything you've seen that you're sort of hopeful about?
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A guy in Germany at Ulm University, Andre Sommer, S-O-M-M-E-R, is doing the organized water in cells approach.
00:32:57.000 --> 00:33:14.000
At MIT in physics, Jeremy England is taking the approach that order builds itself spontaneously given the flow of energy.
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That approach is basically denying this 200 year long assumption that matter is an inert, randomly moving something.
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The idea that order is intrinsic to matter is a big assumption that has to be changed.
00:33:49.000 --> 00:34:08.000
The idea that an atom is identical at all points of time and everywhere in every context is a purely platonic, idealist doctrine with no evidence whatsoever.
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It is saying that the elements of matter are nothing but a mathematical, changeless thing until they change.
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This change is only described by a randomness describing statistical approach. Even Leibniz would have a better grasp of reality in seeing that everything depends on its relationship to other things.
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Every atom is slightly different depending on where and when it is. The inductive effect says that every atom is sensitive to its surroundings.
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Once you have the membrane assumption that things move randomly inside of cells, even Leibniz's recognition would tear down the whole approach.
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Do you have any hope whatsoever that something like the AIH or the AIH will eventually one day be taken seriously?
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Yes, if the next election for example could theoretically overthrow the whole drug medical establishment and establish by legislation the insistence on being empirical and rational in everything done in research.
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Who do you think would do that?
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Theoretically, Bernie Sanders could look at all of this criminal waste of resources on phony medical approaches, phony military approaches. There would be roughly $20 trillion a year left to do something intelligent.
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Right, that would be amazing.
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Well thank you so much Ray.
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Yeah, we really appreciate your time.