forked from 0x2447196/raypeatarchive
-
Notifications
You must be signed in to change notification settings - Fork 0
/
Copy pathkmud-150619-continuing-research-on-urea.vtt
1496 lines (997 loc) · 55.1 KB
/
kmud-150619-continuing-research-on-urea.vtt
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
555
556
557
558
559
560
561
562
563
564
565
566
567
568
569
570
571
572
573
574
575
576
577
578
579
580
581
582
583
584
585
586
587
588
589
590
591
592
593
594
595
596
597
598
599
600
601
602
603
604
605
606
607
608
609
610
611
612
613
614
615
616
617
618
619
620
621
622
623
624
625
626
627
628
629
630
631
632
633
634
635
636
637
638
639
640
641
642
643
644
645
646
647
648
649
650
651
652
653
654
655
656
657
658
659
660
661
662
663
664
665
666
667
668
669
670
671
672
673
674
675
676
677
678
679
680
681
682
683
684
685
686
687
688
689
690
691
692
693
694
695
696
697
698
699
700
701
702
703
704
705
706
707
708
709
710
711
712
713
714
715
716
717
718
719
720
721
722
723
724
725
726
727
728
729
730
731
732
733
734
735
736
737
738
739
740
741
742
743
744
745
746
747
748
749
750
751
752
753
754
755
756
757
758
759
760
761
762
763
764
765
766
767
768
769
770
771
772
773
774
775
776
777
778
779
780
781
782
783
784
785
786
787
788
789
790
791
792
793
794
795
796
797
798
799
800
801
802
803
804
805
806
807
808
809
810
811
812
813
814
815
816
817
818
819
820
821
822
823
824
825
826
827
828
829
830
831
832
833
834
835
836
837
838
839
840
841
842
843
844
845
846
847
848
849
850
851
852
853
854
855
856
857
858
859
860
861
862
863
864
865
866
867
868
869
870
871
872
873
874
875
876
877
878
879
880
881
882
883
884
885
886
887
888
889
890
891
892
893
894
895
896
897
898
899
900
901
902
903
904
905
906
907
908
909
910
911
912
913
914
915
916
917
918
919
920
921
922
923
924
925
926
927
928
929
930
931
932
933
934
935
936
937
938
939
940
941
942
943
944
945
946
947
948
949
950
951
952
953
954
955
956
957
958
959
960
961
962
963
964
965
966
967
968
969
970
971
972
973
974
975
976
977
978
979
980
981
982
983
984
985
986
987
988
989
990
991
992
993
994
995
996
997
998
999
1000
WEBVTT
00:00:00.000 --> 00:00:06.280
and organic produce, natural groceries, nutritional supplements and body care products.
00:00:06.280 --> 00:00:12.480
Chautauqua Natural Foods is open Monday through Saturday 9 to 7, Sunday 10 to 5, just off the town square in Garberville.
00:00:12.480 --> 00:00:17.620
More information online, facebook.com/chautauquanaturals.
00:00:17.620 --> 00:00:20.560
Alright, Ask Your Herb Doctor coming up, stay tuned.
00:00:20.560 --> 00:00:21.360
My name's Andrew Murray.
00:00:21.360 --> 00:00:22.960
My name's Sarah Johannison Murray.
00:00:22.960 --> 00:00:28.460
Now for those of you who perhaps have never listened to the shows which run every third Friday of the month from 7 to 8 p.m.,
00:00:28.460 --> 00:00:33.200
we're both licensed medical herbalists who trained in England and graduated there with a degree in herbal medicine.
00:00:33.200 --> 00:00:39.640
We run a clinic in Garberville where we consult with clients about a wide range of conditions and recommend herbal medicine and dietary advice.
00:00:39.640 --> 00:00:43.480
So you're listening to Ask Your Herb Doctor on KMED Garberville 91.1 FM.
00:00:43.480 --> 00:00:52.920
And from 7.30 until the end of the show at 8 o'clock, you're invited to call in with any questions related or unrelated to this month's subject of the continuing research on urea.
00:00:52.920 --> 00:01:04.260
The number if you live in the area is 923 3911, or if you live outside the area, there's a toll-free number which is 1-800-KMUD-RAD, which is 1-800-568-3723.
00:01:04.260 --> 00:01:11.200
And we can also be reached toll-free on 1-888-WBM-HERB for consultations or further information Monday through Friday.
00:01:11.200 --> 00:01:17.340
Okay, so once again, we're very pleased to have Dr. Raymond Peat joining us on the show to share in his latest research.
00:01:17.340 --> 00:01:18.480
Dr. Peat, are you there?
00:01:18.480 --> 00:01:18.980
Yes.
00:01:18.980 --> 00:01:20.780
Okay, thanks so much for joining us again.
00:01:20.780 --> 00:01:30.320
As always, just like to start the show by giving you the opportunity here to let people know your academic and scientific background, what you do and who you are.
00:01:30.320 --> 00:01:42.200
I got my PhD in biology, specializing in physiology and biochemistry, especially reproductive physiology at University of Oregon 1972.
00:01:42.200 --> 00:01:56.820
And before that, I had been interested in language, philosophy, and psychology and planned to study brain biology, but I found that the reproductive physiology seemed more scientific and more interesting.
00:01:56.820 --> 00:02:02.060
So I specialized in that but continued to be interested in the rest of the organism.
00:02:02.060 --> 00:02:13.400
So the first thing I did after graduating was to write a book on the brain, reviewing Russian science, 19th century through the 20th century on brain biology.
00:02:13.400 --> 00:02:24.880
And so I've continued interest in how the basic energy physiology relates to things such as reproduction, aging, and brain functions.
00:02:24.880 --> 00:02:47.380
All right, well, I know that your most recent newsletter, you were continuing your discourse and your thoughts on urea and its use in pathology and how you see the function of urea as benefiting people in light of perhaps it being dismissed, if you like, by mainstream medical science.
00:02:47.380 --> 00:02:59.180
I know that you mentioned Danopoulos, the Greek physician who's been successfully using urea as a therapy, injecting it into tumors and its use in cancer.
00:02:59.180 --> 00:03:13.500
But this newsletter that you've most recently written more explores some other physiological effects of urea that perhaps people might not have been aware of, or if in fact the research has been done some time ago, it may now be buried and forgotten.
00:03:13.500 --> 00:03:18.460
So just wanted to pick up on quite a few of the things that you mentioned in your newsletter.
00:03:18.460 --> 00:03:18.820
Go ahead.
00:03:18.820 --> 00:03:21.660
So, Daphne, can you tell us what urea is?
00:03:21.660 --> 00:03:25.300
Its name chemically is carbamide.
00:03:25.300 --> 00:03:29.660
It's just a combination of ammonia with carbon dioxide.
00:03:29.660 --> 00:03:33.740
And so it's the body's way of detoxifying ammonia.
00:03:33.740 --> 00:03:40.180
And it requires oxidative production of carbon dioxide to combine with the ammonia to get rid of it.
00:03:40.180 --> 00:03:47.300
And so it regulates cell pH, which regulates water metabolism and everything else in cell function.
00:03:47.300 --> 00:03:49.340
So it's something that our bodies produce.
00:03:49.340 --> 00:03:49.660
Yeah.
00:03:49.660 --> 00:03:49.940
All right.
00:03:49.940 --> 00:04:00.260
So given that we now understand that excess water in the cell is a central feature of the major degenerative diseases that you outline, things like heart failure, dementia and cancer.
00:04:00.260 --> 00:04:12.220
How do you explain how this happens and what is the best strategy to prevent this if water accumulation in the cell is implied in such an inflammatory situation as these things that we've mentioned?
00:04:12.220 --> 00:04:23.100
One of the dimensions of thinking about water in cells is that it comes up against some of the basic dogmas of what life is and how cells work and so on.
00:04:23.100 --> 00:04:32.180
And I think the reason that adenopolis amazing results in curing cancer with simply injecting or giving intravenous urea,
00:04:32.180 --> 00:04:43.420
I think the reason it's been ignored and dismissed is that it involves some ideas that don't fit with these mechanical dogmas of 20th century biology,
00:04:43.420 --> 00:04:58.900
such as the membrane theory, the idea that there are pumps in the cell surface membranes that regulate the amount of water and minerals in cells by somehow grabbing the molecules and pushing them in or out of the cell.
00:04:58.900 --> 00:05:05.700
It's really a silly, impossible concept, but it's what everything officially is based on.
00:05:05.700 --> 00:05:18.620
So when you actually look at the facts of what's happening with water, if you think in terms of things such as what happens when gelatin gets wet and swells up,
00:05:18.620 --> 00:05:27.460
and if you put acid or alkali on what happens to its relation to water and so on, acid makes it shrink, alkali makes it swell up.
00:05:27.460 --> 00:05:35.420
And simple physical ideas like that are very useful for thinking about what happens in all of the diseases.
00:05:35.420 --> 00:05:39.340
Okay, so acid makes it shrink and alkaline situations make it swell.
00:05:39.340 --> 00:05:56.020
Yeah, and swelling has an anabolic effect and turns on cell division and uncontrollable cell division and produce everything from cancer to various skin diseases of dandruff, for example,
00:05:56.020 --> 00:06:16.020
psoriasis, overgrowth of fibrous tissue, the control of cell growth is very deeply controlled by water and pH and the membrane pump people blame everything in life on this magical pump that regulates the water and the pH.
00:06:16.020 --> 00:06:34.020
If you just think about the basic metabolic processes in which you turn sugar or fat or protein into energy and carbon dioxide, this constant streaming of substance, carbon dioxide is an acid and you're making it inside cells.
00:06:34.020 --> 00:06:47.020
And so when you're alive, you're making cells acidic and as it leaves, it takes minerals out of the cell with it in the form of carbonic acid and the alkaline minerals associated with it.
00:06:47.020 --> 00:06:50.020
This is the better state than the alkaline state, though, right?
00:06:50.020 --> 00:07:12.020
Yeah, the alkaline acidic state produced by carbon dioxide causes a shift in the whole balance electrons in the protein, fat, nucleic acid system and that shift of electrons accounts for the preference of the cell for potassium normally over sodium.
00:07:12.020 --> 00:07:20.020
If the cell is disturbed, then it shifts and loses potassium and takes up calcium and sodium.
00:07:20.020 --> 00:07:25.020
This is what Gilbert Ling has devoted his life to for the last 60 some years.
00:07:25.020 --> 00:07:45.020
Sorry, I just wanted to say that this, I guess, for people that are listening, I think a lot of people in the lay people associate this kind of, what we're talking about acid versus alkali, they're always thinking about an acid situation is more cancer promoting and to be alkaline is a better situation in terms of health benefits.
00:07:45.020 --> 00:07:51.020
And that's true when you apply it to the blood and the fluid outside of cell.
00:07:51.020 --> 00:08:08.020
Right. But the reason the fluid outside of cells is alkaline is that the protons, the electrons are being retracted into an acidic state inside the cell and that shift of the balance and makes it alkaline outside.
00:08:08.020 --> 00:08:20.020
So what you're saying is when the cell inside and then when the inside of the cell becomes alkaline, that's when it becomes swollen and boggy and that's what can contribute to heart disease, cancer, psoriasis, all these degenerative diseases we've mentioned.
00:08:20.020 --> 00:08:26.020
And that goes with a shift towards acidity in the blood and the outside fluid.
00:08:26.020 --> 00:08:29.020
So that's where people are thinking about.
00:08:29.020 --> 00:08:32.020
You don't want to be acidic metabolically.
00:08:32.020 --> 00:08:48.020
That refers to the fluids outside of cells and it's only since the nuclear magnetic resonance apparatuses have been used the last 40 years, mostly, that people have started to recognize that inside cells should be slightly acidic.
00:08:48.020 --> 00:08:55.020
So how do we make the inside of ourselves more acidic and keep the outside of ourselves extra cellular and the blood alkaline?
00:08:55.020 --> 00:09:02.020
Keeping the energy flowing, producing carbon dioxide constantly by consuming oxygen.
00:09:02.020 --> 00:09:05.020
So we need our cells to be consuming oxygen properly.
00:09:05.020 --> 00:09:12.020
Yeah. And just suffocating, just turning off the oxygen supply so you stop making any supply of carbon dioxide.
00:09:12.020 --> 00:09:26.020
The metabolism shifts over to making lactic acid and the lactic acid takes acid out of the cell as it's leaving and acidifies the environment but leaves the cell more alkaline.
00:09:26.020 --> 00:09:34.020
Right. And that's a negative acidic situation that most people commonly refer to when they talk about acid versus alkaline blood.
00:09:34.020 --> 00:09:38.020
Yeah. It's a local inflammatory situation.
00:09:38.020 --> 00:09:44.020
Anytime a tissue is injured, it tends to produce excess lactic acid and become inflamed and inefficient.
00:09:44.020 --> 00:09:48.020
So how does urea help our cells use oxygen better?
00:09:48.020 --> 00:09:49.020
The...
00:09:49.020 --> 00:09:51.020
Or to keep the cell more acidic?
00:09:51.020 --> 00:10:05.020
The cell holds its structure by the way proteins are folded, which requires an interaction with the... everything in the cell has to participate in that slightly acidic state.
00:10:05.020 --> 00:10:20.020
Making carbon dioxide, keeping the ATP level at a high energy state, keeping the water participating in the way proteins are folded so that there's a lot of internal surface area exposed in the cell.
00:10:20.020 --> 00:10:30.020
Now the surface of a glass of water has a sort of rubbery film on the top that you can float a piece of steel or touch on the surface tension.
00:10:30.020 --> 00:10:43.020
Inside the cell when the proteins are energized, the ATP is holding them in this state exposing their surface, keeping the cell's water in that energized tough state that helps to hold the cell together.
00:10:43.020 --> 00:11:02.020
When de-energized, the structure collapses in various ways. For example, spherical proteins that were exposing all of their surface polymerize into dock-like proteins that have less surface exposure and the water becomes more like plain bulk water under the tough surface.
00:11:02.020 --> 00:11:12.020
This water then behaves very differently and that's the kind of water that is involved in cell swelling, growth, uncontrolled cell division and so on.
00:11:12.020 --> 00:11:24.020
It's also the pH inside the cell also regulates the protein's folding ability to a large degree that proteins don't conformationally fold properly in the wrong pH.
00:11:24.020 --> 00:11:38.020
Yeah, and it's in the case of any protein jelly, even some synthetic plastics, the alkalinity has the same effect making the jelly swell up and watery and soft.
00:11:38.020 --> 00:11:44.020
So again, another reason why the alkaline internal environment would not be helpful.
00:11:44.020 --> 00:11:46.020
Inside the cell.
00:11:46.020 --> 00:11:47.020
Inside the cell, yeah, yeah.
00:11:47.020 --> 00:12:01.020
Urea happens to be a strange kind of solvent that is pretty much equally at home inside and outside the cell, but it's slightly more at home in a healthy stable cell.
00:12:01.020 --> 00:12:12.020
So that just by solubility, if you immerse cells in a solution with a certain amount of urea, the urea is going to come to rest at a higher concentration in cells.
00:12:12.020 --> 00:12:19.020
No pumping is involved, it's simply that it's soluble in the cell at a slightly higher degree than in plain water.
00:12:19.020 --> 00:12:27.020
And inside the cell participates with the relaxed or energized state of the cell in which surfaces is exposed.
00:12:27.020 --> 00:12:35.020
So the urea helps proteins to expose the energized surface that keeps cells in the functioning high energy state.
00:12:35.020 --> 00:12:43.020
And that's how Denopolis helped with cancer was by injecting the urea into the cells and that helped them maintain their shape and function to a better degree?
00:12:43.020 --> 00:12:52.020
And to keep it towards the slightly acidic metabolizing state in which it doesn't tend to proliferate.
00:12:52.020 --> 00:12:55.020
A relatively slightly dehydrated effect.
00:12:55.020 --> 00:13:06.020
So it's like you have now a new solvent solute substance when it has the right amount of urea mixed in with the proteins and fat and water.
00:13:06.020 --> 00:13:18.020
It creates a new state of matter that has its own solubility properties for other things, including the preference for potassium over sodium and for magnesium over calcium and so on.
00:13:18.020 --> 00:13:22.020
Right. So it's helping the mineral balance of the cell be more balanced.
00:13:22.020 --> 00:13:28.020
Now, I think you also stated that urea itself is not an osmolite and it does not affect pH. Is that right?
00:13:28.020 --> 00:13:32.020
Yeah, that's been known for over 100 years.
00:13:32.020 --> 00:13:49.020
People simply use the semi-permeable membrane setup found that doesn't behave like sodium or potassium or other things that are known to be osmolites and to pull water across a semi-permeable membrane and so on.
00:13:49.020 --> 00:14:03.020
In 1914, I think it was the first one, but around the First World War, someone was demonstrating that you could make it five or six times more concentrated than it should be osmotically.
00:14:03.020 --> 00:14:07.020
And it would be in balance and not cause cells to lose water.
00:14:07.020 --> 00:14:16.020
Hold the cell in the proper state where if you add five or six times the concentration of sugar or salt, you would dry up.
00:14:16.020 --> 00:14:17.020
You'd be in trouble.
00:14:17.020 --> 00:14:20.020
When you put salt on the slug, it drinks it.
00:14:20.020 --> 00:14:21.020
Takes all the water out of it.
00:14:21.020 --> 00:14:25.020
Presumably, a slug wouldn't find concentrated urea.
00:14:25.020 --> 00:14:36.020
Interesting. And I think you've also mentioned that that concentration, five to six times, is nothing as much as, say, a hundred times, which is still compatible with life.
00:14:36.020 --> 00:14:40.020
It has a very, very low toxicity. It's not at all toxic, is it?
00:14:40.020 --> 00:14:47.020
No. And sea organisms, sharks, for example, have a very, very high level of urea imbalance.
00:14:47.020 --> 00:14:56.020
And experiments have shown that even more than a hundred times what we normally have doesn't cause any damage that can be seen in cells.
00:14:56.020 --> 00:15:11.020
And therapeutically, Danopoulos and others have found that maybe a hundred times our normal urea level in the serum is actually therapeutic for certain things, cancer and brain function, for example.
00:15:11.020 --> 00:15:23.020
Because I think there's quite a lot of references to urea from a "scientific community" that are not really interested in it or just trying to play it down as being irrelevant.
00:15:23.020 --> 00:15:31.020
And they have urea analogs, I think, which are far more problematic that they would want to suggest or not even mention urea.
00:15:31.020 --> 00:15:37.020
Sickle cell anemia, for example, was being treated successfully with urea.
00:15:37.020 --> 00:15:45.020
And normal cells under stress tend to be hardened the way sickle cells become stiff and won't go through capillaries.
00:15:45.020 --> 00:15:55.020
Just during heart surgery, the stress causes ordinary round blood cells to become stiffened and malfunction, tending to kill the patient.
00:15:55.020 --> 00:16:00.020
And with a supplement of urea, that hardening of the red cells by stress is prevented.
00:16:00.020 --> 00:16:05.020
And it was therapeutic for the sickle cell patients.
00:16:05.020 --> 00:16:22.020
But because of the myth of urea being an osmolite, someone used plain urea at a certain concentration without the normal sodium and other minerals in the solution and found that it broke, immediately caused red blood cells to break down.
00:16:22.020 --> 00:16:24.020
So they said that can't be good.
00:16:24.020 --> 00:16:31.020
They stopped using it and shifted over to very toxic carcinogenic hydroxyurea, which is still in use.
00:16:31.020 --> 00:16:35.020
But you do know doctors that use this current day, right?
00:16:35.020 --> 00:16:39.020
There are publications currently recommending us to use hydroxyurea.
00:16:39.020 --> 00:16:41.020
Did you mean using real urea?
00:16:41.020 --> 00:16:44.020
Yeah, I was meaning the real urea.
00:16:44.020 --> 00:16:50.020
A few people are using it, for example, to prevent killing patients in heart surgery.
00:16:50.020 --> 00:16:53.020
But it definitely isn't a well-recognized treatment.
00:16:53.020 --> 00:17:02.020
Did you say, did I understand you correctly when you said that urea in the absence of the other electrolytes would have a negative effect?
00:17:02.020 --> 00:17:07.020
Yeah, it acts like distilled water as far as the osmotic property goes.
00:17:07.020 --> 00:17:13.020
So it has to be osmotically balanced with the regular concentration of solutes that you'd normally find in blood.
00:17:13.020 --> 00:17:19.020
It would take about six times as much urea as normal to not break down the red cells.
00:17:19.020 --> 00:17:28.020
Interesting. So if you, whatever they, I'm not too sure what it is, but for example, just for people that are listening to understand the concept that I'm trying to describe to you and that you're describing to me,
00:17:28.020 --> 00:17:34.020
is that if you have, for example, a one millimolar concentration of urea in your blood normally,
00:17:34.020 --> 00:17:43.020
then if you were to inject a five or six millimolar concentration of urea into the capillary or into the artery or whatever, it wouldn't have a negative effect.
00:17:43.020 --> 00:17:44.020
It would be acceptable.
00:17:44.020 --> 00:17:49.020
But if it was injected as a one millimolar solution, which you'd find naturally in the blood, it would have a problem.
00:17:49.020 --> 00:17:57.020
You'd have a problem with that. Yeah. Assuming the other things like sodium and calcium and potassium aren't compensating for the difference in urea.
00:17:57.020 --> 00:17:59.020
So what about taking it orally?
00:17:59.020 --> 00:18:04.020
That's been done also for over 100 years of treating heart failure.
00:18:04.020 --> 00:18:13.020
And one person reported on, I think he said he had had heart failure patients doing well on oral urea for as long as nine years.
00:18:13.020 --> 00:18:16.020
And this is because it's a diuretic and it's.
00:18:16.020 --> 00:18:26.020
Yeah, that was the argument that they were using it because it did relieve the swollen legs and such that occur in heart failure.
00:18:26.020 --> 00:18:34.020
But I think since you also see it bringing people back from brain damage and traumatic head injury and strokes and such,
00:18:34.020 --> 00:18:42.020
I think has much deeper therapeutic effects, stabilizing cells in many ways, reducing the swelling by causing diuresis.
00:18:42.020 --> 00:18:47.020
OK, well, you're listening to AskUrEUp, Dr. KMED 91.1 FM Garbovill.
00:18:47.020 --> 00:18:54.020
This month, Dr. Peat is being questioned about his latest newsletter on urea.
00:18:54.020 --> 00:19:01.020
I know we've mentioned urea and Greek physician Dr. Danopoulos several months back in his treatment of cancer.
00:19:01.020 --> 00:19:10.020
But this month, we're going to be talking more about the other beneficial aspects of urea and certain other inflammatory conditions,
00:19:10.020 --> 00:19:12.020
dementia, cancer, etc.
00:19:12.020 --> 00:19:16.020
We'll be bringing out some of the reasons how urea could actually be very helpful for this.
00:19:16.020 --> 00:19:20.020
The number, if you live in the area, is 923-2513.
00:19:20.020 --> 00:19:23.020
923, sorry, beg your pardon, 923-3911.
00:19:23.020 --> 00:19:26.020
Or there is a toll free number, which is 1-800-KMED-RAD.
00:19:26.020 --> 00:19:30.020
So from 730 till the end of the show, people are invited to call in with any questions.
00:19:30.020 --> 00:19:34.020
It would be good if people could keep to the subject matter.
00:19:34.020 --> 00:19:39.020
OK, so anyway, the other question I wanted to ask you about the diuretic activity of urea,
00:19:39.020 --> 00:19:46.020
and you've mentioned it being useful in congestive heart failure and other edema type water swelling situations
00:19:46.020 --> 00:19:48.020
because of its ability to mobilize water.
00:19:48.020 --> 00:19:55.020
Do you have any comparisons, if you like, for traditional diuretics?
00:19:55.020 --> 00:19:58.020
I know that there used to be non-potassium sparing,
00:19:58.020 --> 00:20:02.020
and then they brought out these kind of loop diuretics that were potassium sparing.
00:20:02.020 --> 00:20:06.020
Well, I mean, the common furosemide that's still used is not potassium sparing.
00:20:06.020 --> 00:20:08.020
You have to take a potassium supplement with that.
00:20:08.020 --> 00:20:18.020
How do you--are you able to answer that, whether you have any opinion about diuretics and use versus something like urea?
00:20:18.020 --> 00:20:22.020
Yeah, I have opinions, but I finished thinking about the subject.
00:20:22.020 --> 00:20:25.020
You remember, mercury was a traditional diuretic,
00:20:25.020 --> 00:20:31.020
and it apparently worked just by sort of killing the tubes of the kidney
00:20:31.020 --> 00:20:33.020
and letting the water kind of fall out of the body.
00:20:33.020 --> 00:20:35.020
Not to be recommended.
00:20:35.020 --> 00:20:39.020
So unlike, you know, radiation was useful for treating psoriasis,
00:20:39.020 --> 00:20:43.020
x-rays were useful for treating psoriasis and arthritis, right?
00:20:43.020 --> 00:20:51.020
Yeah, and I think some of the chemical diuretics are about as well-founded as mercury diuretics.
00:20:51.020 --> 00:20:58.020
The chemicals that made the kidneys give up more water don't necessarily really improve the person's health.
00:20:58.020 --> 00:21:00.020
The cells could be still holding onto the water and not--
00:21:00.020 --> 00:21:08.020
Yeah, and besides stress, for example, in heart surgery, it involves water retention,
00:21:08.020 --> 00:21:14.020
failure of the kidney function leading to things like hardening of the red blood cells
00:21:14.020 --> 00:21:16.020
and stiffening of the capillaries and so on.
00:21:16.020 --> 00:21:23.020
Any stress involves a series of reactions, all of which relate to the way cells handle water.
00:21:23.020 --> 00:21:28.020
Nitric oxide is a universally produced thing by injury and stress,
00:21:28.020 --> 00:21:32.020
and it causes de-energizing and swelling of cells.
00:21:32.020 --> 00:21:38.020
And estrogen is a physiological producer of swelling, imitating a stress reaction
00:21:38.020 --> 00:21:40.020
and being produced by stress.
00:21:40.020 --> 00:21:45.020
And one of the brain or pituitary hormones, antidiuretic hormone,
00:21:45.020 --> 00:21:50.020
is another stress-induced producer of water retention and edema.
00:21:50.020 --> 00:21:55.020
And old people as well as traumatized people who are hospitalized
00:21:55.020 --> 00:22:00.020
fairly often develop a state of water retention with sodium loss.
00:22:00.020 --> 00:22:06.020
They call it hyponatremia or the syndrome of inappropriate antidiuretic hormone.
00:22:06.020 --> 00:22:10.020
Estrogen happens to produce the same effect,
00:22:10.020 --> 00:22:16.020
and so they say estrogen activates receptors of the antidiuretic hormone.
00:22:16.020 --> 00:22:20.020
When you can't find the actual hormone at the same conditions,
00:22:20.020 --> 00:22:23.020
they say it's because the receptors are acting independent.
00:22:23.020 --> 00:22:30.020
Nitric oxide, estrogen, and antidiuretic hormone produce the state of getting waterlogged
00:22:30.020 --> 00:22:35.020
while losing sodium into the urine and producing fairly concentrated urine
00:22:35.020 --> 00:22:40.020
but keeping overhydrated cells and blood supply.
00:22:40.020 --> 00:22:46.020
And the normal basic thing that regulates the ability to release water through the kidneys
00:22:46.020 --> 00:22:52.020
while retaining sodium is the particular energized electronic state of the cells
00:22:52.020 --> 00:22:58.020
governing the way the tube of the kidney electrically relates to its surroundings.
00:22:58.020 --> 00:23:05.020
The production of carbon dioxide and carbonic acid, the carbonic anhydrase enzyme,
00:23:05.020 --> 00:23:09.020
is one of the targets of some of the diuretics such as acetazolamide
00:23:09.020 --> 00:23:14.020
so that the body retains more carbon dioxide and thus doesn't lose so much sodium.
00:23:14.020 --> 00:23:21.020
And the normal regulator of carbon dioxide and so of sodium water balance
00:23:21.020 --> 00:23:27.020
is the thyroid hormone, and hypothyroid people always tend towards this syndrome
00:23:27.020 --> 00:23:32.020
of inappropriate antidiuretic hormone secretion or the appearance,
00:23:32.020 --> 00:23:37.020
simply hyponatremia, of being waterlogged, having enough water, enough sodium.
00:23:37.020 --> 00:23:42.020
So the sodium itself, sodium chloride or sodium bicarbonate,
00:23:42.020 --> 00:23:45.020
can cure a lot of these stress conditions.
00:23:45.020 --> 00:23:51.020
And the same waterlogging could be borne out in things like a boggy intestine or a swollen intestine
00:23:51.020 --> 00:23:57.020
that fails to move food along properly and contributes to endotoxin reabsorption
00:23:57.020 --> 00:23:59.020
because of the inefficient movement?
00:23:59.020 --> 00:24:04.020
Yeah, the intestine is especially exposed to things such as endotoxin,
00:24:04.020 --> 00:24:11.020
which release nitric oxide, which has this de-energizing cell swelling effect, waterlogging effect.
00:24:11.020 --> 00:24:14.020
And the bicarbonate of soda you mentioned just before I interrupted there
00:24:14.020 --> 00:24:18.020
would be another good way of liberating CO2,
00:24:18.020 --> 00:24:22.020
and taken internally would have a local topical activity too?
00:24:22.020 --> 00:24:28.020
Yeah, and surprisingly, even sodium chloride has a diuretic effect, most people.
00:24:28.020 --> 00:24:35.020
When you use the baking soda, the kidneys are able to retain as much sodium as they want,
00:24:35.020 --> 00:24:39.020
but the bicarbonate can be changed back into carbon dioxide
00:24:39.020 --> 00:24:46.020
and it can actually help to acidify cells on the inside while maintaining the sodium on the outside.
00:24:46.020 --> 00:24:51.020
So that's something people can just swallow by a quarter teaspoon or half teaspoon mixed with water?
00:24:51.020 --> 00:24:57.020
Yeah, I know people who have taken a teaspoon two or three times a day with water many years.
00:24:57.020 --> 00:25:02.020
Athletes sometimes take a tablespoon with water before an endurance race.
00:25:02.020 --> 00:25:09.020
I think part of the effect on endurance is more basic than just preventing getting waterlogged.
00:25:09.020 --> 00:25:14.020
I think it's actually helping to prevent excess nitric oxide production.
00:25:14.020 --> 00:25:18.020
Am I not right in thinking that the endurance runners, marathon runners,
00:25:18.020 --> 00:25:27.020
some of these people collapsing from cardiac arrest are hyponatremic, so they suddenly get low sodium?
00:25:27.020 --> 00:25:33.020
Yeah, I think that's probably the most common reason for endurance runners collapsing and dying.
00:25:33.020 --> 00:25:39.020
Okay, well you're listening to Ask Your Ob-Doctor, KMED Galvapour 91.1 FM, and from now until 8 o'clock.
00:25:39.020 --> 00:25:44.020
You're invited to call in with any questions surrounding this month's continuing topic of urea
00:25:44.020 --> 00:25:49.020
and its treatment in such things as cardiac illnesses, dementia, cancer,
00:25:49.020 --> 00:25:52.020
and we'll get into a few others here later on.
00:25:52.020 --> 00:26:00.020
The number is, like I said, 93391 or 3911, or if you live outside the area, there's a 1800 number, which is 1800 KMED Rad.
00:26:00.020 --> 00:26:05.020
So going on to aging seems a little bit indistinct perhaps from this month's subject,
00:26:05.020 --> 00:26:13.020
but in terms of the concept of hydration and skin and the appearance of skin and the water content of cells,
00:26:13.020 --> 00:26:19.020
not necessarily being helpful but being more detrimental and in a lower energy state,
00:26:19.020 --> 00:26:28.020
I wanted you to just discuss the idea of young babies and newborns and young teenagers and young adults
00:26:28.020 --> 00:26:32.020
having a kind of a fairly plump, healthy skin that's fairly thick.
00:26:32.020 --> 00:26:39.020
I don't want to confuse that with the skin being boggy because that would seem to imply that there's too much water in the cells,
00:26:39.020 --> 00:26:44.020
but in terms of the aging and youth and the skin's appearance and the production of keratin,
00:26:44.020 --> 00:26:48.020
which is that kind of flaky layer, maybe more associated with older people,
00:26:48.020 --> 00:26:56.020
is there anything perhaps that can be done to improve the quality of the skin that would be related to water?
00:26:56.020 --> 00:27:00.020
The plumpness is largely the water content.
00:27:00.020 --> 00:27:06.020
Any cell, all the way from fertilized ovum all the way to a 100-year-old person,
00:27:06.020 --> 00:27:15.020
the cell water content decreases pretty steadily with aging until an old cell, which is still very functional.
00:27:15.020 --> 00:27:22.020
There's no disease evident. It's pretty dried up relative to the 92% water of fertilized ovum.
00:27:22.020 --> 00:27:31.020
It gets down to something like 65% water in old cells as a steady progression without any particular disease happening.
00:27:31.020 --> 00:27:40.020
As that happens, cell division is slowed so that in your skin, over time, you see fewer cells in the skin,
00:27:40.020 --> 00:27:46.020
meaning that it's thinner. There just isn't as much living skin there in old people.
00:27:46.020 --> 00:27:54.020
The column of growing cells in the surface layer, the squamous epithelium of skin and the mucous membranes,
00:27:54.020 --> 00:27:58.020
there's a column of eight or 10 growing cells in the young skin,
00:27:58.020 --> 00:28:04.020
and only maybe two or three cells that are still actively growing in old skin.
00:28:04.020 --> 00:28:10.020
That's partly just because they're slowing down, but they're also the piling up,
00:28:10.020 --> 00:28:16.020
collapsed, cornified or keratinized cells accumulate in the old skin.
00:28:16.020 --> 00:28:24.020
The maturing process comes on prematurely with aging or with some type of stress.
00:28:24.020 --> 00:28:32.020
For example, a vitamin A deficiency will cause premature keratinizing or hardening of the skin
00:28:32.020 --> 00:28:37.020
and will become thinner and tougher, lower water content.
00:28:37.020 --> 00:28:44.020
Estrogen does this normally cyclically in the mucous membranes, causing at first a faster growth
00:28:44.020 --> 00:28:51.020
because there's a greater water uptake under the influence of estrogen, rapid thickening and growing,
00:28:51.020 --> 00:28:56.020
but then an increased formation of keratin fibers and hardening surface.
00:28:56.020 --> 00:29:01.020
So some of the effects of estrogen are just like vitamin A deficiency,
00:29:01.020 --> 00:29:05.020
and you can offset some of the effects both of aging and estrogen
00:29:05.020 --> 00:29:10.020
by simply supplementing some vitamin A and vitamin E directly into the skin.
00:29:10.020 --> 00:29:15.020
And urea, old skin has much less urea in it than young skin,
00:29:15.020 --> 00:29:21.020
and that's probably both the cause and effect of the lower water content with aging.
00:29:21.020 --> 00:29:24.020
We do have another call, not another, we have the first call on the line,
00:29:24.020 --> 00:29:28.020
so let me hold you there Dr. Peat if you don't mind, and let's take this next call and see where we're going.
00:29:28.020 --> 00:29:30.020
Hi, caller, you're on there, and where are you from?
00:29:30.020 --> 00:29:31.020
I'm from White Thorn.
00:29:31.020 --> 00:29:32.020
Okay, hi.
00:29:32.020 --> 00:29:37.020
Hi, my dad is in the hospital right now with CHF and dementia,
00:29:37.020 --> 00:29:45.020
and also interactions between his medicine for the most of my for the diuretic and gabapentin
00:29:45.020 --> 00:29:49.020
and one for his heart too, but his lactic acid was normal,
00:29:49.020 --> 00:29:52.020
but the creatinine was not normal,
00:29:52.020 --> 00:30:00.020
and I'm wondering if the oral urea would be better for him to take and not take the fluorosamide.
00:30:00.020 --> 00:30:07.020
Dr. Peat, you can find articles about the use of urea in heart failure,
00:30:07.020 --> 00:30:10.020
comparing it to other diuretics on PubMed, for example.
00:30:10.020 --> 00:30:15.020
If you put in urea heart failure, you can find the articles on PubMed.
00:30:15.020 --> 00:30:16.020
Okay, thank you.
00:30:16.020 --> 00:30:19.020
Would that be something he could use orally?
00:30:19.020 --> 00:30:24.020
It's very tasteless, a little maybe on the salty side,
00:30:24.020 --> 00:30:30.020
so it's usually taken with orange juice or grapefruit juice just so you don't taste it,
00:30:30.020 --> 00:30:35.020
a small amount, anywhere from a fourth of a teaspoon to a glass, up to maybe a teaspoon per glass.
00:30:35.020 --> 00:30:36.020
Okay, good.
00:30:36.020 --> 00:30:41.020
Would it be okay to take that with his diuretic he has already prescribed?
00:30:41.020 --> 00:30:46.020
I don't think it interferes with diuretics, but it just makes them unnecessary.
00:30:46.020 --> 00:30:48.020
Okay, well, that's good to hear.
00:30:48.020 --> 00:30:50.020
I thank you for helping me.
00:30:50.020 --> 00:30:51.020
All right, thanks for your call.
00:30:51.020 --> 00:30:54.020
We've got two more callers on the air, so let's take the next caller.
00:30:54.020 --> 00:30:56.020
Caller, you're on the air, and where are you from?
00:30:56.020 --> 00:30:57.020
Yes, hello, Philipsville.
00:30:57.020 --> 00:30:58.020
Oh, hi.
00:30:58.020 --> 00:31:07.020
Yes, I would like to know what one should ingest to make the cells more acidic on the inside
00:31:07.020 --> 00:31:12.020
and the blood better, you know, more alkaline on the outside, like you're saying is good for you.
00:31:12.020 --> 00:31:13.020
Protein.
00:31:13.020 --> 00:31:16.020
You say that ingesting this urea is good.
00:31:16.020 --> 00:31:23.020
Getting adequate protein in your diet is probably the thing that most people could make the biggest difference with.
00:31:23.020 --> 00:31:25.020
Oh, that increases urea, you're saying, Dr. Peat?
00:31:25.020 --> 00:31:34.020
Yes, you can measure the increased output of urea in the urine in proportion to the amount of protein you're eating
00:31:34.020 --> 00:31:38.020
if your digestion is good and if your thyroid function is good.
00:31:38.020 --> 00:31:40.020
So eating red meat is good for that?
00:31:40.020 --> 00:31:43.020
It shouldn't be too high in phosphate.
00:31:43.020 --> 00:31:48.020
Meat is very high in phosphate, and so gelatin is good as a supplement.
00:31:48.020 --> 00:31:55.020
If you make soup with the collagenous joint tissue, for example.
00:31:55.020 --> 00:31:57.020
Like oxtail or shank.
00:31:57.020 --> 00:31:58.020
Oxtail, yes.
00:31:58.020 --> 00:32:02.020
Do you recommend then just eating a little bit of meat and not too much?
00:32:02.020 --> 00:32:09.020
Yeah, I think it's better to get a big part of your protein from other foods such as eggs, milk, and cheese.
00:32:09.020 --> 00:32:10.020
Eggs?
00:32:10.020 --> 00:32:14.020
And some high-quality vegetables like potatoes and mushrooms.
00:32:14.020 --> 00:32:17.020
Eggs, milk, and cheese, potatoes, mushrooms, those are some high-protein.
00:32:17.020 --> 00:32:18.020
Are eggs good?
00:32:18.020 --> 00:32:19.020
Yes.
00:32:19.020 --> 00:32:20.020
Eggs are very good.
00:32:20.020 --> 00:32:22.020
Okay, and you mentioned sodium chloride.
00:32:22.020 --> 00:32:23.020
That's salt.
00:32:23.020 --> 00:32:28.020
Is salt good for your heart or for your blood?
00:32:28.020 --> 00:32:32.020
I'm sorry, what were you talking about?
00:32:32.020 --> 00:32:33.020
Is putting salt in your food good?
00:32:33.020 --> 00:32:36.020
There are some articles on my website about salt.
00:32:36.020 --> 00:32:39.020
You can use the little search device on the website to find--
00:32:39.020 --> 00:32:42.020
I don't have a computer.
00:32:42.020 --> 00:32:45.020
Yeah, salting your food to taste is the best way to tell.
00:32:45.020 --> 00:32:48.020
And that will keep your kidneys functioning better?
00:32:48.020 --> 00:32:51.020
Yeah, in people who are under stress.
00:32:51.020 --> 00:32:54.020
For example, women with toxemia of pregnancy.
00:32:54.020 --> 00:33:02.020
Well, what about just in general, just normal, you know, aging and wanting to keep as healthy as you can when you're getting older?
00:33:02.020 --> 00:33:12.020
Yeah, I've known many young women and a few old people who have been put on a low-sodium diet because of various problems.
00:33:12.020 --> 00:33:19.020
And using the studies on pregnant toxemia people, I suggested that they try the same thing.
00:33:19.020 --> 00:33:20.020
Now, what about potassium?
00:33:20.020 --> 00:33:22.020
What does that do for you?
00:33:22.020 --> 00:33:24.020
I know low potassium isn't good.
00:33:24.020 --> 00:33:32.020
Too much potassium can slow your heart rate, but the right amount, such as having lots of fruit and vegetables,