diff --git a/__tests__/application/respond.js b/__tests__/application/respond.js
index ccc57e269..db1af4543 100644
--- a/__tests__/application/respond.js
+++ b/__tests__/application/respond.js
@@ -570,6 +570,93 @@ describe('app.respond', () => {
     })
   })
 
+  describe('when .body is a Blob', () => {
+    it('should respond', async () => {
+      const app = new Koa()
+
+      app.use(ctx => {
+        ctx.body = new Blob(['Hello'])
+      })
+
+      const expectedBlob = new Blob(['Hello'])
+
+      const server = app.listen()
+
+      const res = await request(server)
+        .get('/')
+        .expect(200)
+
+      assert.deepStrictEqual(res.body, Buffer.from(await expectedBlob.arrayBuffer()))
+    })
+
+    it('should keep Blob headers', async () => {
+      const app = new Koa()
+
+      app.use(ctx => {
+        ctx.body = new Blob(['hello world'])
+      })
+
+      const server = app.listen()
+
+      return request(server)
+        .head('/')
+        .expect(200)
+        .expect('content-type', 'application/octet-stream')
+        .expect('content-length', '11')
+    })
+  })
+
+  describe('when .body is a ReadableStream', () => {
+    it('should respond', async () => {
+      const app = new Koa()
+
+      app.use(async ctx => {
+        ctx.body = new ReadableStream()
+      })
+
+      const server = app.listen()
+
+      return request(server)
+        .head('/')
+        .expect(200)
+        .expect('content-type', 'application/octet-stream')
+    })
+  })
+
+  describe('when .body is a Response', () => {
+    it('should keep Response headers', () => {
+      const app = new Koa()
+
+      app.use(ctx => {
+        ctx.body = new Response(null, { status: 201, statusText: 'OK', headers: { 'Content-Type': 'text/plain' } })
+      })
+
+      const server = app.listen()
+
+      return request(server)
+        .head('/')
+        .expect(201)
+        .expect('content-type', 'text/plain')
+        .expect('content-length', '2')
+    })
+
+    it('should default to octet-stream', () => {
+      const app = new Koa()
+
+      app.use(ctx => {
+        ctx.body = new Response(null, { status: 200, statusText: 'OK' })
+      })
+
+      const server = app.listen()
+
+      return request(server)
+        .head('/')
+        .expect(200)
+        .expect('content-type', 'application/octet-stream')
+        .expect('content-length', '2')
+    })
+  })
+
   describe('when .body is a Stream', () => {
     it('should respond', async () => {
       const app = new Koa()
diff --git a/__tests__/response/body.js b/__tests__/response/body.js
index 5af050786..41c97a6db 100644
--- a/__tests__/response/body.js
+++ b/__tests__/response/body.js
@@ -141,4 +141,48 @@ describe('res.body=', () => {
       assert.strictEqual('application/json; charset=utf-8', res.header['content-type'])
     })
   })
+
+  describe('when a ReadableStream is given', () => {
+    it('should default to an octet stream', () => {
+      const res = response()
+      res.body = new ReadableStream()
+      assert.strictEqual('application/octet-stream', res.header['content-type'])
+    })
+  })
+
+  describe('when a Blob is given', () => {
+    it('should default to an octet stream', () => {
+      const res = response()
+      res.body = new Blob([new Uint8Array([1, 2, 3])], { type: 'application/octet-stream' })
+      assert.strictEqual('application/octet-stream', res.header['content-type'])
+    })
+
+    it('should set length', () => {
+      const res = response()
+      res.body = new Blob([new Uint8Array([1, 2, 3])], { type: 'application/octet-stream' })
+      assert.strictEqual('3', res.header['content-length'])
+    })
+  })
+
+  describe('when a response is given', () => {
+    it('should set the status', () => {
+      const res = response()
+      res.body = new Response(null, { status: 201 })
+      assert.strictEqual(201, res.status)
+    })
+
+    it('should set headers', () => {
+      const res = response()
+      res.body = new Response(null, { status: 200, headers: { 'x-fizz': 'buzz', 'x-foo': 'bar' } })
+      assert.strictEqual('buzz', res.header['x-fizz'])
+      assert.strictEqual('bar', res.header['x-foo'])
+    })
+
+    it('should redirect', () => {
+      const res = response()
+      res.body = Response.redirect('https://www.example.com/', 301)
+      assert.strictEqual(301, res.status)
+      assert.strictEqual('https://www.example.com/', res.header.location)
+    })
+  })
 })
diff --git a/docs/api/response.md b/docs/api/response.md
index e75b30152..1ac65cc8e 100644
--- a/docs/api/response.md
+++ b/docs/api/response.md
@@ -351,3 +351,7 @@ ctx.response.etag = crypto.createHash('md5').update(ctx.body).digest('hex');
 ### response.flushHeaders()
 
   Flush any set headers, and begin the body.
+
+### response.writable
+
+  A boolean that indicates whether the response is still writable
diff --git a/lib/application.js b/lib/application.js
index bbee69067..0ba1c8907 100644
--- a/lib/application.js
+++ b/lib/application.js
@@ -16,7 +16,7 @@ const Emitter = require('events')
 const util = require('util')
 const Stream = require('stream')
 const http = require('http')
-const only = require('only')
+const only = require('./only.js')
 const { HttpError } = require('http-errors')
 
 /** @typedef {typeof import ('./context') & {
@@ -300,9 +300,13 @@ function respond (ctx) {
   }
 
   // responses
+
   if (Buffer.isBuffer(body)) return res.end(body)
   if (typeof body === 'string') return res.end(body)
   if (body instanceof Stream) return body.pipe(res)
+  if (body instanceof Blob) return Stream.Readable.from(body.stream()).pipe(res)
+  if (body instanceof ReadableStream) return Stream.Readable.from(body).pipe(res)
+  if (body instanceof Response) return Stream.Readable.from(body?.body).pipe(res)
 
   // body: json
   body = JSON.stringify(body)
diff --git a/lib/only.js b/lib/only.js
new file mode 100644
index 000000000..0551a3354
--- /dev/null
+++ b/lib/only.js
@@ -0,0 +1,11 @@
+module.exports = (obj, keys) => {
+  obj = obj || {}
+  if (typeof keys === 'string') keys = keys.split(/ +/)
+  const ret = {}
+  for (let i = 0; i < keys.length; i++) {
+    const key = keys[i]
+    if (obj[key] == null) continue
+    ret[key] = obj[key]
+  }
+  return ret
+}
diff --git a/lib/request.js b/lib/request.js
index 7a1a07c12..b756a7a06 100644
--- a/lib/request.js
+++ b/lib/request.js
@@ -13,7 +13,7 @@ const parse = require('parseurl')
 const qs = require('querystring')
 const typeis = require('type-is')
 const fresh = require('fresh')
-const only = require('only')
+const only = require('./only.js')
 const util = require('util')
 
 const IP = Symbol('context#ip')
diff --git a/lib/response.js b/lib/response.js
index cbe587142..3dcd6e65e 100644
--- a/lib/response.js
+++ b/lib/response.js
@@ -14,7 +14,7 @@ const destroy = require('destroy')
 const assert = require('assert')
 const extname = require('path').extname
 const vary = require('vary')
-const only = require('only')
+const only = require('./only.js')
 const util = require('util')
 const encodeUrl = require('encodeurl')
 const Stream = require('stream')
@@ -126,15 +126,15 @@ module.exports = {
   /**
    * Set response body.
    *
-   * @param {String|Buffer|Object|Stream} val
+   * @param {String|Buffer|Object|Stream|ReadableStream|Blob|Response} val
    * @api public
    */
 
   set body (val) {
     const original = this._body
     this._body = val
-
     // no content
+
     if (val == null) {
       if (!statuses.empty[this.status]) {
         if (this.type === 'application/json') {
@@ -183,6 +183,34 @@ module.exports = {
       return
     }
 
+    // ReadableStream
+    if (val instanceof ReadableStream) {
+      if (setType) this.type = 'bin'
+      return
+    }
+
+    // blob
+    if (val instanceof Blob) {
+      if (setType) this.type = 'bin'
+      this.length = val.size
+      return
+    }
+
+    // Response
+    if (val instanceof Response) {
+      this.status = val.status
+      if (setType) this.type = 'bin'
+      const headers = val.headers
+      for (const key of headers.keys()) {
+        this.set(key, headers.get(key))
+      }
+
+      if (val.redirected) {
+        this.redirect(val.url)
+      }
+      return
+    }
+
     // json
     this.remove('Content-Length')
     this.type = 'json'
diff --git a/package-lock.json b/package-lock.json
index e9a7c684e..676339fa7 100644
--- a/package-lock.json
+++ b/package-lock.json
@@ -24,7 +24,6 @@
         "http-errors": "^1.6.3",
         "koa-compose": "^4.1.0",
         "on-finished": "^2.3.0",
-        "only": "~0.0.2",
         "parseurl": "^1.3.2",
         "statuses": "^1.5.0",
         "type-is": "^1.6.16",
@@ -5380,11 +5379,6 @@
         "url": "https://github.com/sponsors/sindresorhus"
       }
     },
-    "node_modules/only": {
-      "version": "0.0.2",
-      "resolved": "https://registry.npmjs.org/only/-/only-0.0.2.tgz",
-      "integrity": "sha1-Kv3oTQPlC5qO3EROMGEKcCle37Q="
-    },
     "node_modules/optionator": {
       "version": "0.9.3",
       "resolved": "https://registry.npmjs.org/optionator/-/optionator-0.9.3.tgz",
diff --git a/package.json b/package.json
index a8e3378e4..820ca40cc 100644
--- a/package.json
+++ b/package.json
@@ -51,7 +51,6 @@
     "http-errors": "^1.6.3",
     "koa-compose": "^4.1.0",
     "on-finished": "^2.3.0",
-    "only": "~0.0.2",
     "parseurl": "^1.3.2",
     "statuses": "^1.5.0",
     "type-is": "^1.6.16",