diff --git a/libs/langgraph/langgraph/pregel/retry.py b/libs/langgraph/langgraph/pregel/retry.py
index cdf7b33d3..553b25468 100644
--- a/libs/langgraph/langgraph/pregel/retry.py
+++ b/libs/langgraph/langgraph/pregel/retry.py
@@ -2,7 +2,7 @@
 import logging
 import random
 import time
-from typing import Optional
+from typing import Optional, Sequence
 
 from langgraph.constants import CONFIG_KEY_RESUMING
 from langgraph.errors import GraphInterrupt
@@ -38,11 +38,21 @@ def run_with_retry(
             # increment attempts
             attempts += 1
             # check if we should retry
-            if callable(retry_policy.retry_on):
+            if isinstance(retry_policy.retry_on, Sequence):
+                if not isinstance(exc, tuple(retry_policy.retry_on)):
+                    raise
+            elif isinstance(retry_policy.retry_on, type) and issubclass(
+                retry_policy.retry_on, Exception
+            ):
+                if not isinstance(exc, retry_policy.retry_on):
+                    raise
+            elif callable(retry_policy.retry_on):
                 if not retry_policy.retry_on(exc):
                     raise
-            elif not isinstance(exc, retry_policy.retry_on):
-                raise
+            else:
+                raise TypeError(
+                    "retry_on must be an Exception class, a list or tuple of Exception classes, or a callable"
+                )
             # check if we should give up
             if attempts >= retry_policy.max_attempts:
                 raise
@@ -94,11 +104,21 @@ async def arun_with_retry(
             # increment attempts
             attempts += 1
             # check if we should retry
-            if callable(retry_policy.retry_on):
+            if isinstance(retry_policy.retry_on, Sequence):
+                if not isinstance(exc, tuple(retry_policy.retry_on)):
+                    raise
+            elif isinstance(retry_policy.retry_on, type) and issubclass(
+                retry_policy.retry_on, Exception
+            ):
+                if not isinstance(exc, retry_policy.retry_on):
+                    raise
+            elif callable(retry_policy.retry_on):
                 if not retry_policy.retry_on(exc):
                     raise
-            elif not isinstance(exc, retry_policy.retry_on):
-                raise
+            else:
+                raise TypeError(
+                    "retry_on must be an Exception class, a list or tuple of Exception classes, or a callable"
+                )
             # check if we should give up
             if attempts >= retry_policy.max_attempts:
                 raise
diff --git a/libs/langgraph/langgraph/pregel/types.py b/libs/langgraph/langgraph/pregel/types.py
index 589ed43ab..f8682d50b 100644
--- a/libs/langgraph/langgraph/pregel/types.py
+++ b/libs/langgraph/langgraph/pregel/types.py
@@ -1,5 +1,5 @@
 from collections import deque
-from typing import Any, Callable, Literal, NamedTuple, Optional, Type, Union
+from typing import Any, Callable, Literal, NamedTuple, Optional, Sequence, Type, Union
 
 from langchain_core.runnables import Runnable, RunnableConfig
 
@@ -52,7 +52,7 @@ class RetryPolicy(NamedTuple):
     jitter: bool = True
     """Whether to add random jitter to the interval between retries."""
     retry_on: Union[
-        Type[Exception], tuple[Type[Exception], ...], Callable[[Exception], bool]
+        Type[Exception], Sequence[Type[Exception]], Callable[[Exception], bool]
     ] = default_retry_on
     """List of exception classes that should trigger a retry, or a callable that returns True for exceptions that should trigger a retry."""