diff --git a/llvm/lib/Target/AArch64/AArch64TargetTransformInfo.cpp b/llvm/lib/Target/AArch64/AArch64TargetTransformInfo.cpp
index 79c0e45e3aa5b..c27c56d4557b1 100644
--- a/llvm/lib/Target/AArch64/AArch64TargetTransformInfo.cpp
+++ b/llvm/lib/Target/AArch64/AArch64TargetTransformInfo.cpp
@@ -1174,7 +1174,8 @@ static std::optional<Instruction *> instCombineSVECmpNE(InstCombiner &IC,
     return std::nullopt;
 
   // Where the dupq is a lane 0 replicate of a vector insert
-  if (!cast<ConstantInt>(DupQLane->getArgOperand(1))->isZero())
+  auto *DupQLaneOp1 = dyn_cast<ConstantInt>(DupQLane->getArgOperand(1));
+  if (!DupQLaneOp1 || !DupQLaneOp1->isZero())
     return std::nullopt;
 
   auto *VecIns = dyn_cast<IntrinsicInst>(DupQLane->getArgOperand(0));
diff --git a/llvm/test/Transforms/InstCombine/AArch64/sve-inst-combine-cmpne.ll b/llvm/test/Transforms/InstCombine/AArch64/sve-inst-combine-cmpne.ll
new file mode 100644
index 0000000000000..b21f2f538d3ca
--- /dev/null
+++ b/llvm/test/Transforms/InstCombine/AArch64/sve-inst-combine-cmpne.ll
@@ -0,0 +1,58 @@
+; RUN: opt -S -mtriple=aarch64-unknown-linux-gnu -O2 < %s | FileCheck %s
+ 
+; Function Attrs: nofree nosync nounwind readnone uwtable vscale_range(1,16)
+define dso_local i32 @testInstCombineSVECmpNE() local_unnamed_addr #0 {
+entry:
+  %0 = tail call <vscale x 16 x i8> @llvm.aarch64.sve.index.nxv16i8(i8 42, i8 1)
+  %1 = tail call <vscale x 16 x i1> @llvm.aarch64.sve.ptrue.nxv16i1(i32 31)
+  br label %for.body
+ 
+for.cond.cleanup:                                 ; preds = %for.inc
+  %2 = tail call i1 @llvm.aarch64.sve.ptest.any.nxv16i1(<vscale x 16 x i1> %1, <vscale x 16 x i1> %cmp_rslt.1)
+  %not. = xor i1 %2, true
+  %. = zext i1 %not. to i32
+  ret i32 %.
+ 
+for.body:                                         ; preds = %entry, %for.inc
+  %i.010 = phi i64 [ 0, %entry ], [ %inc, %for.inc ]
+  %cmp1 = icmp ugt i64 %i.010, 32
+  %3 = tail call <vscale x 16 x i8> @llvm.aarch64.sve.dupq.lane.nxv16i8(<vscale x 16 x i8> %0, i64 %i.010)
+  br i1 %cmp1, label %if.then, label %if.else
+ 
+if.then:                                          ; preds = %for.body
+  %4 = tail call <vscale x 16 x i1> @llvm.aarch64.sve.cmpne.nxv16i8(<vscale x 16 x i1> %1, <vscale x 16 x i8> %3, <vscale x 16 x i8> zeroinitializer)
+  br label %for.inc
+  ; CHECK: %4 = tail call <vscale x 16 x i1> @llvm.aarch64.sve.cmpne.nxv16i8(<vscale x 16 x i1> %1, <vscale x 16 x i8> %3, <vscale x 16 x i8> zeroinitializer)
+  ; CHECK-NEXT: br label %for.inc
+ 
+if.else:                                          ; preds = %for.body
+  %5 = tail call <vscale x 16 x i1> @llvm.aarch64.sve.cmpne.nxv16i8(<vscale x 16 x i1> %1, <vscale x 16 x i8> %3, <vscale x 16 x i8> shufflevector (<vscale x 16 x i8> insertelement (<vscale x 16 x i8> poison, i8 1, i32 0), <vscale x 16 x i8> poison, <vscale x 16 x i32> zeroinitializer))
+  br label %for.inc
+ 
+for.inc:                                          ; preds = %if.then, %if.else
+  %cmp_rslt.1 = phi <vscale x 16 x i1> [ %4, %if.then ], [ %5, %if.else ]
+  %inc = add nuw nsw i64 %i.010, 1
+  %exitcond.not = icmp eq i64 %inc, 63
+  br i1 %exitcond.not, label %for.cond.cleanup, label %for.body, !llvm.loop !6
+}
+ 
+; Function Attrs: mustprogress nocallback nofree nosync nounwind readnone willreturn
+declare <vscale x 16 x i8> @llvm.aarch64.sve.index.nxv16i8(i8, i8) #1
+ 
+; Function Attrs: mustprogress nocallback nofree nosync nounwind readnone willreturn
+declare <vscale x 16 x i1> @llvm.aarch64.sve.ptrue.nxv16i1(i32 immarg) #1
+ 
+; Function Attrs: mustprogress nocallback nofree nosync nounwind readnone willreturn
+declare <vscale x 16 x i8> @llvm.aarch64.sve.dupq.lane.nxv16i8(<vscale x 16 x i8>, i64) #1
+ 
+; Function Attrs: mustprogress nocallback nofree nosync nounwind readnone willreturn
+declare <vscale x 16 x i1> @llvm.aarch64.sve.cmpne.nxv16i8(<vscale x 16 x i1>, <vscale x 16 x i8>, <vscale x 16 x i8>) #1
+ 
+; Function Attrs: mustprogress nocallback nofree nosync nounwind readnone willreturn
+declare i1 @llvm.aarch64.sve.ptest.any.nxv16i1(<vscale x 16 x i1>, <vscale x 16 x i1>) #1
+ 
+attributes #0 = { nofree nosync nounwind readnone uwtable vscale_range(1,16) "frame-pointer"="non-leaf" "min-legal-vector-width"="0" "no-trapping-math"="true" "stack-protector-buffer-size"="8" "target-cpu"="generic" "target-features"="+neon,+sve,+v8.2a" }
+attributes #1 = { mustprogress nocallback nofree nosync nounwind readnone willreturn }
+ 
+!6 = distinct !{!6, !7}
+!7 = !{!"llvm.loop.mustprogress"}