diff --git a/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp b/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
index 34b0f8b86049745..522c31f9e3e7161 100644
--- a/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
+++ b/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
@@ -3130,6 +3130,13 @@ Instruction *InstCombinerImpl::foldICmpAddConstant(ICmpInst &Cmp,
     return new ICmpInst(ICmpInst::ICMP_EQ, Builder.CreateAnd(X, -C),
                         ConstantExpr::getNeg(cast<Constant>(Y)));
 
+  // X+C2 <u C -> (X & C) == 2C
+  //   iff C == -(C2)
+  //       C2 is a power of 2
+  if (Pred == ICmpInst::ICMP_ULT && C2->isPowerOf2() && C == -*C2)
+    return new ICmpInst(ICmpInst::ICMP_NE, Builder.CreateAnd(X, C),
+                        ConstantInt::get(Ty, C * 2));
+
   // X+C >u C2 -> (X & ~C2) != C
   //   iff C & C2 == 0
   //       C2+1 is a power of 2
diff --git a/llvm/test/Transforms/InstCombine/icmp-add.ll b/llvm/test/Transforms/InstCombine/icmp-add.ll
index 6b4e5a5372c5237..baa6f3d51a40ef8 100644
--- a/llvm/test/Transforms/InstCombine/icmp-add.ll
+++ b/llvm/test/Transforms/InstCombine/icmp-add.ll
@@ -3023,4 +3023,82 @@ define i1 @icmp_addnuw_nonzero_fail_multiuse(i32 %x, i32 %y) {
   ret i1 %c
 }
 
+define i1 @ult_add_C2_pow2_C_neg(i8 %x) {
+; CHECK-LABEL: @ult_add_C2_pow2_C_neg(
+; CHECK-NEXT:    [[TMP1:%.*]] = and i8 [[X:%.*]], -32
+; CHECK-NEXT:    [[C:%.*]] = icmp ne i8 [[TMP1]], -64
+; CHECK-NEXT:    ret i1 [[C]]
+;
+  %i = add i8 %x, 32
+  %c = icmp ult i8 %i, -32
+  ret i1 %c
+}
+
+define i1 @ult_add_nsw_C2_pow2_C_neg(i8 %x) {
+; CHECK-LABEL: @ult_add_nsw_C2_pow2_C_neg(
+; CHECK-NEXT:    [[TMP1:%.*]] = and i8 [[X:%.*]], -32
+; CHECK-NEXT:    [[C:%.*]] = icmp ne i8 [[TMP1]], -64
+; CHECK-NEXT:    ret i1 [[C]]
+;
+  %i = add nsw i8 %x, 32
+  %c = icmp ult i8 %i, -32
+  ret i1 %c
+}
+
+define i1 @ult_add_nuw_nsw_C2_pow2_C_neg(i8 %x) {
+; CHECK-LABEL: @ult_add_nuw_nsw_C2_pow2_C_neg(
+; CHECK-NEXT:    [[C:%.*]] = icmp ult i8 [[X:%.*]], -64
+; CHECK-NEXT:    ret i1 [[C]]
+;
+  %i = add nuw nsw i8 %x, 32
+  %c = icmp ult i8 %i, -32
+  ret i1 %c
+}
+
+define i1 @ult_add_C2_neg_C_pow2(i8 %x) {
+; CHECK-LABEL: @ult_add_C2_neg_C_pow2(
+; CHECK-NEXT:    [[TMP1:%.*]] = and i8 [[X:%.*]], -32
+; CHECK-NEXT:    [[C:%.*]] = icmp eq i8 [[TMP1]], 32
+; CHECK-NEXT:    ret i1 [[C]]
+;
+  %i = add i8 %x, -32
+  %c = icmp ult i8 %i, 32
+  ret i1 %c
+}
+
+define <2 x i1> @ult_add_C2_pow2_C_neg_vec(<2 x i8> %x) {
+; CHECK-LABEL: @ult_add_C2_pow2_C_neg_vec(
+; CHECK-NEXT:    [[TMP1:%.*]] = and <2 x i8> [[X:%.*]], <i8 -32, i8 -32>
+; CHECK-NEXT:    [[C:%.*]] = icmp ne <2 x i8> [[TMP1]], <i8 -64, i8 -64>
+; CHECK-NEXT:    ret <2 x i1> [[C]]
+;
+  %i = add <2 x i8> %x, <i8 32, i8 32>
+  %c = icmp ult <2 x i8> %i, <i8 -32, i8 -32>
+  ret <2 x i1> %c
+}
+
+define i1 @ult_add_C2_pow2_C_neg_multiuse(i8 %x) {
+; CHECK-LABEL: @ult_add_C2_pow2_C_neg_multiuse(
+; CHECK-NEXT:    [[I:%.*]] = add i8 [[X:%.*]], 32
+; CHECK-NEXT:    [[C:%.*]] = icmp ult i8 [[I]], -32
+; CHECK-NEXT:    call void @use(i8 [[I]])
+; CHECK-NEXT:    ret i1 [[C]]
+;
+  %i = add i8 %x, 32
+  %c = icmp ult i8 %i, -32
+  call void @use(i8 %i)
+  ret i1 %c
+}
+
+define i1 @uge_add_C2_pow2_C_neg(i8 %x) {
+; CHECK-LABEL: @uge_add_C2_pow2_C_neg(
+; CHECK-NEXT:    [[TMP1:%.*]] = and i8 [[X:%.*]], -32
+; CHECK-NEXT:    [[C:%.*]] = icmp eq i8 [[TMP1]], -64
+; CHECK-NEXT:    ret i1 [[C]]
+;
+  %i = add i8 %x, 32
+  %c = icmp uge i8 %i, -32
+  ret i1 %c
+}
+
 declare void @llvm.assume(i1)