diff --git a/src/compiler/checker.ts b/src/compiler/checker.ts
index 025eeecc30624..b3b48e0211ae1 100644
--- a/src/compiler/checker.ts
+++ b/src/compiler/checker.ts
@@ -26517,7 +26517,7 @@ namespace ts {
                 if (result) {
                     return result;
                 }
-                if (!(contextFlags! & ContextFlags.SkipBindingPatterns) && isBindingPattern(declaration.name)) { // This is less a contextual type and more an implied shape - in some cases, this may be undesirable
+                if (!(contextFlags! & ContextFlags.SkipBindingPatterns) && isBindingPattern(declaration.name) && declaration.name.elements.length > 0) {
                     return getTypeFromBindingPattern(declaration.name, /*includePatternInType*/ true, /*reportErrors*/ false);
                 }
             }
@@ -27051,22 +27051,20 @@ namespace ts {
                 const inferenceContext = getInferenceContext(node);
                 // If no inferences have been made, nothing is gained from instantiating as type parameters
                 // would just be replaced with their defaults similar to the apparent type.
-                if (inferenceContext && some(inferenceContext.inferences, hasInferenceCandidates)) {
+                if (inferenceContext && contextFlags! & ContextFlags.Signature && some(inferenceContext.inferences, hasInferenceCandidates)) {
                     // For contextual signatures we incorporate all inferences made so far, e.g. from return
                     // types as well as arguments to the left in a function call.
-                    if (contextFlags && contextFlags & ContextFlags.Signature) {
-                        return instantiateInstantiableTypes(contextualType, inferenceContext.nonFixingMapper);
-                    }
+                    return instantiateInstantiableTypes(contextualType, inferenceContext.nonFixingMapper);
+                }
+                if (inferenceContext?.returnMapper) {
                     // For other purposes (e.g. determining whether to produce literal types) we only
                     // incorporate inferences made from the return type in a function call. We remove
                     // the 'boolean' type from the contextual type such that contextually typed boolean
                     // literals actually end up widening to 'boolean' (see #48363).
-                    if (inferenceContext.returnMapper) {
-                        const type = instantiateInstantiableTypes(contextualType, inferenceContext.returnMapper);
-                        return type.flags & TypeFlags.Union && containsType((type as UnionType).types, regularFalseType) && containsType((type as UnionType).types, regularTrueType) ?
-                            filterType(type, t => t !== regularFalseType && t !== regularTrueType) :
-                            type;
-                    }
+                    const type = instantiateInstantiableTypes(contextualType, inferenceContext.returnMapper);
+                    return type.flags & TypeFlags.Union && containsType((type as UnionType).types, regularFalseType) && containsType((type as UnionType).types, regularTrueType) ?
+                        filterType(type, t => t !== regularFalseType && t !== regularTrueType) :
+                        type;
                 }
             }
             return contextualType;
@@ -29902,29 +29900,43 @@ namespace ts {
             // 'let f: (x: string) => number = wrap(s => s.length)', we infer from the declared type of 'f' to the
             // return type of 'wrap'.
             if (node.kind !== SyntaxKind.Decorator) {
-                const contextualType = getContextualType(node, every(signature.typeParameters, p => !!getDefaultFromTypeParameter(p)) ? ContextFlags.SkipBindingPatterns : ContextFlags.None);
+                const skipBindingPatterns = every(signature.typeParameters, p => !!getDefaultFromTypeParameter(p));
+                const contextualType = getContextualType(node, skipBindingPatterns ? ContextFlags.SkipBindingPatterns : ContextFlags.None);
                 if (contextualType) {
                     const inferenceTargetType = getReturnTypeOfSignature(signature);
                     if (couldContainTypeVariables(inferenceTargetType)) {
-                        // We clone the inference context to avoid disturbing a resolution in progress for an
-                        // outer call expression. Effectively we just want a snapshot of whatever has been
-                        // inferred for any outer call expression so far.
                         const outerContext = getInferenceContext(node);
-                        const outerMapper = getMapperFromContext(cloneInferenceContext(outerContext, InferenceFlags.NoDefault));
-                        const instantiatedType = instantiateType(contextualType, outerMapper);
-                        // If the contextual type is a generic function type with a single call signature, we
-                        // instantiate the type with its own type parameters and type arguments. This ensures that
-                        // the type parameters are not erased to type any during type inference such that they can
-                        // be inferred as actual types from the contextual type. For example:
-                        //   declare function arrayMap<T, U>(f: (x: T) => U): (a: T[]) => U[];
-                        //   const boxElements: <A>(a: A[]) => { value: A }[] = arrayMap(value => ({ value }));
-                        // Above, the type of the 'value' parameter is inferred to be 'A'.
-                        const contextualSignature = getSingleCallSignature(instantiatedType);
-                        const inferenceSourceType = contextualSignature && contextualSignature.typeParameters ?
-                            getOrCreateTypeFromSignature(getSignatureInstantiationWithoutFillingInTypeArguments(contextualSignature, contextualSignature.typeParameters)) :
-                            instantiatedType;
-                        // Inferences made from return types have lower priority than all other inferences.
-                        inferTypes(context.inferences, inferenceSourceType, inferenceTargetType, InferencePriority.ReturnType);
+                        const isFromBindingPattern = !skipBindingPatterns && getContextualType(node, ContextFlags.SkipBindingPatterns) !== contextualType;
+                        // A return type inference from a binding pattern can be used in instantiating the contextual
+                        // type of an argument later in inference, but cannot stand on its own as the final return type.
+                        // It is incorporated into `context.returnMapper` which is used in `instantiateContextualType`,
+                        // but doesn't need to go into `context.inferences`. This allows a an array binding pattern to
+                        // produce a tuple for `T` in
+                        //   declare function f<T>(cb: () => T): T;
+                        //   const [e1, e2, e3] = f(() => [1, "hi", true]);
+                        // but does not produce any inference for `T` in
+                        //   declare function f<T>(): T;
+                        //   const [e1, e2, e3] = f();
+                        if (!isFromBindingPattern) {
+                            // We clone the inference context to avoid disturbing a resolution in progress for an
+                            // outer call expression. Effectively we just want a snapshot of whatever has been
+                            // inferred for any outer call expression so far.
+                            const outerMapper = getMapperFromContext(cloneInferenceContext(outerContext, InferenceFlags.NoDefault));
+                            const instantiatedType = instantiateType(contextualType, outerMapper);
+                            // If the contextual type is a generic function type with a single call signature, we
+                            // instantiate the type with its own type parameters and type arguments. This ensures that
+                            // the type parameters are not erased to type any during type inference such that they can
+                            // be inferred as actual types from the contextual type. For example:
+                            //   declare function arrayMap<T, U>(f: (x: T) => U): (a: T[]) => U[];
+                            //   const boxElements: <A>(a: A[]) => { value: A }[] = arrayMap(value => ({ value }));
+                            // Above, the type of the 'value' parameter is inferred to be 'A'.
+                            const contextualSignature = getSingleCallSignature(instantiatedType);
+                            const inferenceSourceType = contextualSignature && contextualSignature.typeParameters ?
+                                getOrCreateTypeFromSignature(getSignatureInstantiationWithoutFillingInTypeArguments(contextualSignature, contextualSignature.typeParameters)) :
+                                instantiatedType;
+                            // Inferences made from return types have lower priority than all other inferences.
+                            inferTypes(context.inferences, inferenceSourceType, inferenceTargetType, InferencePriority.ReturnType);
+                        }
                         // Create a type mapper for instantiating generic contextual types using the inferences made
                         // from the return type. We need a separate inference pass here because (a) instantiation of
                         // the source type uses the outer context's return mapper (which excludes inferences made from
diff --git a/src/compiler/types.ts b/src/compiler/types.ts
index 717f802917822..f72207f24dce9 100644
--- a/src/compiler/types.ts
+++ b/src/compiler/types.ts
@@ -5867,7 +5867,7 @@ namespace ts {
         ReturnType                   = 1 << 7,  // Inference made from return type of generic function
         LiteralKeyof                 = 1 << 8,  // Inference made from a string literal to a keyof T
         NoConstraints                = 1 << 9,  // Don't infer from constraints of instantiable types
-        AlwaysStrict                 = 1 << 10,  // Always use strict rules for contravariant inferences
+        AlwaysStrict                 = 1 << 10, // Always use strict rules for contravariant inferences
         MaxValue                     = 1 << 11, // Seed for inference priority tracking
 
         PriorityImpliesCombination = ReturnType | MappedTypeConstraint | LiteralKeyof,  // These priorities imply that the resulting type should be a combination of all candidates
diff --git a/tests/baselines/reference/bindingPatternCannotBeOnlyInferenceSource.errors.txt b/tests/baselines/reference/bindingPatternCannotBeOnlyInferenceSource.errors.txt
new file mode 100644
index 0000000000000..200c56f7689a1
--- /dev/null
+++ b/tests/baselines/reference/bindingPatternCannotBeOnlyInferenceSource.errors.txt
@@ -0,0 +1,44 @@
+tests/cases/compiler/bindingPatternCannotBeOnlyInferenceSource.ts(2,7): error TS2571: Object is of type 'unknown'.
+tests/cases/compiler/bindingPatternCannotBeOnlyInferenceSource.ts(3,9): error TS2339: Property 'p1' does not exist on type 'unknown'.
+tests/cases/compiler/bindingPatternCannotBeOnlyInferenceSource.ts(4,7): error TS2461: Type 'unknown' is not an array type.
+tests/cases/compiler/bindingPatternCannotBeOnlyInferenceSource.ts(4,7): error TS2571: Object is of type 'unknown'.
+tests/cases/compiler/bindingPatternCannotBeOnlyInferenceSource.ts(5,7): error TS2461: Type 'unknown' is not an array type.
+
+
+==== tests/cases/compiler/bindingPatternCannotBeOnlyInferenceSource.ts (5 errors) ====
+    declare function f<T>(): T;
+    const {} = f();       // error (only in strictNullChecks)
+          ~~
+!!! error TS2571: Object is of type 'unknown'.
+    const { p1 } = f();   // error
+            ~~
+!!! error TS2339: Property 'p1' does not exist on type 'unknown'.
+    const [] = f();       // error
+          ~~
+!!! error TS2461: Type 'unknown' is not an array type.
+          ~~
+!!! error TS2571: Object is of type 'unknown'.
+    const [e1, e2] = f(); // error
+          ~~~~~~~~
+!!! error TS2461: Type 'unknown' is not an array type.
+    
+    // Repro from #43605
+    type Dispatch<A = { type: any; [extraProps: string]: any }> = { <T extends A>(action: T): T };
+    type IFuncs = { readonly [key: string]: (...p: any) => void };
+    type IDestructuring<T extends IFuncs> = { readonly [key in keyof T]?: (...p: Parameters<T[key]>) => void };
+    type Destructuring<T extends IFuncs, U extends IDestructuring<T>> = (dispatch: Dispatch<any>, funcs: T) => U;
+    const funcs1 = {
+        funcA: (a: boolean): void => {},
+        funcB: (b: string, bb: string): void => {},
+        funcC: (c: number, cc: number, ccc: boolean): void => {},
+    };
+    type TFuncs1 = typeof funcs1;
+    declare function useReduxDispatch1<T extends IDestructuring<TFuncs1>>(destructuring: Destructuring<TFuncs1, T>): T;
+    const {} = useReduxDispatch1(
+        (d, f) => ({
+            funcA: (...p) => d(f.funcA(...p)), // p should be inferrable
+            funcB: (...p) => d(f.funcB(...p)),
+            funcC: (...p) => d(f.funcC(...p)),
+        })
+    );
+    
\ No newline at end of file
diff --git a/tests/baselines/reference/bindingPatternCannotBeOnlyInferenceSource.js b/tests/baselines/reference/bindingPatternCannotBeOnlyInferenceSource.js
new file mode 100644
index 0000000000000..4f8e285db06f8
--- /dev/null
+++ b/tests/baselines/reference/bindingPatternCannotBeOnlyInferenceSource.js
@@ -0,0 +1,61 @@
+//// [bindingPatternCannotBeOnlyInferenceSource.ts]
+declare function f<T>(): T;
+const {} = f();       // error (only in strictNullChecks)
+const { p1 } = f();   // error
+const [] = f();       // error
+const [e1, e2] = f(); // error
+
+// Repro from #43605
+type Dispatch<A = { type: any; [extraProps: string]: any }> = { <T extends A>(action: T): T };
+type IFuncs = { readonly [key: string]: (...p: any) => void };
+type IDestructuring<T extends IFuncs> = { readonly [key in keyof T]?: (...p: Parameters<T[key]>) => void };
+type Destructuring<T extends IFuncs, U extends IDestructuring<T>> = (dispatch: Dispatch<any>, funcs: T) => U;
+const funcs1 = {
+    funcA: (a: boolean): void => {},
+    funcB: (b: string, bb: string): void => {},
+    funcC: (c: number, cc: number, ccc: boolean): void => {},
+};
+type TFuncs1 = typeof funcs1;
+declare function useReduxDispatch1<T extends IDestructuring<TFuncs1>>(destructuring: Destructuring<TFuncs1, T>): T;
+const {} = useReduxDispatch1(
+    (d, f) => ({
+        funcA: (...p) => d(f.funcA(...p)), // p should be inferrable
+        funcB: (...p) => d(f.funcB(...p)),
+        funcC: (...p) => d(f.funcC(...p)),
+    })
+);
+
+
+//// [bindingPatternCannotBeOnlyInferenceSource.js]
+var _a = f(); // error (only in strictNullChecks)
+var p1 = f().p1; // error
+var _b = f(); // error
+var _c = f(), e1 = _c[0], e2 = _c[1]; // error
+var funcs1 = {
+    funcA: function (a) { },
+    funcB: function (b, bb) { },
+    funcC: function (c, cc, ccc) { }
+};
+var _d = useReduxDispatch1(function (d, f) { return ({
+    funcA: function () {
+        var p = [];
+        for (var _i = 0; _i < arguments.length; _i++) {
+            p[_i] = arguments[_i];
+        }
+        return d(f.funcA.apply(f, p));
+    },
+    funcB: function () {
+        var p = [];
+        for (var _i = 0; _i < arguments.length; _i++) {
+            p[_i] = arguments[_i];
+        }
+        return d(f.funcB.apply(f, p));
+    },
+    funcC: function () {
+        var p = [];
+        for (var _i = 0; _i < arguments.length; _i++) {
+            p[_i] = arguments[_i];
+        }
+        return d(f.funcC.apply(f, p));
+    }
+}); });
diff --git a/tests/baselines/reference/bindingPatternCannotBeOnlyInferenceSource.symbols b/tests/baselines/reference/bindingPatternCannotBeOnlyInferenceSource.symbols
new file mode 100644
index 0000000000000..031d39e3abd8b
--- /dev/null
+++ b/tests/baselines/reference/bindingPatternCannotBeOnlyInferenceSource.symbols
@@ -0,0 +1,133 @@
+=== tests/cases/compiler/bindingPatternCannotBeOnlyInferenceSource.ts ===
+declare function f<T>(): T;
+>f : Symbol(f, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 0, 0))
+>T : Symbol(T, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 0, 19))
+>T : Symbol(T, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 0, 19))
+
+const {} = f();       // error (only in strictNullChecks)
+>f : Symbol(f, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 0, 0))
+
+const { p1 } = f();   // error
+>p1 : Symbol(p1, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 2, 7))
+>f : Symbol(f, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 0, 0))
+
+const [] = f();       // error
+>f : Symbol(f, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 0, 0))
+
+const [e1, e2] = f(); // error
+>e1 : Symbol(e1, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 4, 7))
+>e2 : Symbol(e2, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 4, 10))
+>f : Symbol(f, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 0, 0))
+
+// Repro from #43605
+type Dispatch<A = { type: any; [extraProps: string]: any }> = { <T extends A>(action: T): T };
+>Dispatch : Symbol(Dispatch, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 4, 21))
+>A : Symbol(A, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 7, 14))
+>type : Symbol(type, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 7, 19))
+>extraProps : Symbol(extraProps, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 7, 32))
+>T : Symbol(T, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 7, 65))
+>A : Symbol(A, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 7, 14))
+>action : Symbol(action, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 7, 78))
+>T : Symbol(T, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 7, 65))
+>T : Symbol(T, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 7, 65))
+
+type IFuncs = { readonly [key: string]: (...p: any) => void };
+>IFuncs : Symbol(IFuncs, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 7, 94))
+>key : Symbol(key, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 8, 26))
+>p : Symbol(p, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 8, 41))
+
+type IDestructuring<T extends IFuncs> = { readonly [key in keyof T]?: (...p: Parameters<T[key]>) => void };
+>IDestructuring : Symbol(IDestructuring, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 8, 62))
+>T : Symbol(T, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 9, 20))
+>IFuncs : Symbol(IFuncs, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 7, 94))
+>key : Symbol(key, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 9, 52))
+>T : Symbol(T, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 9, 20))
+>p : Symbol(p, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 9, 71))
+>Parameters : Symbol(Parameters, Decl(lib.es5.d.ts, --, --))
+>T : Symbol(T, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 9, 20))
+>key : Symbol(key, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 9, 52))
+
+type Destructuring<T extends IFuncs, U extends IDestructuring<T>> = (dispatch: Dispatch<any>, funcs: T) => U;
+>Destructuring : Symbol(Destructuring, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 9, 107))
+>T : Symbol(T, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 10, 19))
+>IFuncs : Symbol(IFuncs, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 7, 94))
+>U : Symbol(U, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 10, 36))
+>IDestructuring : Symbol(IDestructuring, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 8, 62))
+>T : Symbol(T, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 10, 19))
+>dispatch : Symbol(dispatch, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 10, 69))
+>Dispatch : Symbol(Dispatch, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 4, 21))
+>funcs : Symbol(funcs, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 10, 93))
+>T : Symbol(T, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 10, 19))
+>U : Symbol(U, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 10, 36))
+
+const funcs1 = {
+>funcs1 : Symbol(funcs1, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 11, 5))
+
+    funcA: (a: boolean): void => {},
+>funcA : Symbol(funcA, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 11, 16))
+>a : Symbol(a, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 12, 12))
+
+    funcB: (b: string, bb: string): void => {},
+>funcB : Symbol(funcB, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 12, 36))
+>b : Symbol(b, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 13, 12))
+>bb : Symbol(bb, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 13, 22))
+
+    funcC: (c: number, cc: number, ccc: boolean): void => {},
+>funcC : Symbol(funcC, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 13, 47))
+>c : Symbol(c, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 14, 12))
+>cc : Symbol(cc, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 14, 22))
+>ccc : Symbol(ccc, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 14, 34))
+
+};
+type TFuncs1 = typeof funcs1;
+>TFuncs1 : Symbol(TFuncs1, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 15, 2))
+>funcs1 : Symbol(funcs1, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 11, 5))
+
+declare function useReduxDispatch1<T extends IDestructuring<TFuncs1>>(destructuring: Destructuring<TFuncs1, T>): T;
+>useReduxDispatch1 : Symbol(useReduxDispatch1, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 16, 29))
+>T : Symbol(T, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 17, 35))
+>IDestructuring : Symbol(IDestructuring, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 8, 62))
+>TFuncs1 : Symbol(TFuncs1, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 15, 2))
+>destructuring : Symbol(destructuring, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 17, 70))
+>Destructuring : Symbol(Destructuring, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 9, 107))
+>TFuncs1 : Symbol(TFuncs1, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 15, 2))
+>T : Symbol(T, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 17, 35))
+>T : Symbol(T, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 17, 35))
+
+const {} = useReduxDispatch1(
+>useReduxDispatch1 : Symbol(useReduxDispatch1, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 16, 29))
+
+    (d, f) => ({
+>d : Symbol(d, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 19, 5))
+>f : Symbol(f, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 19, 7))
+
+        funcA: (...p) => d(f.funcA(...p)), // p should be inferrable
+>funcA : Symbol(funcA, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 19, 16))
+>p : Symbol(p, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 20, 16))
+>d : Symbol(d, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 19, 5))
+>f.funcA : Symbol(funcA, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 11, 16))
+>f : Symbol(f, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 19, 7))
+>funcA : Symbol(funcA, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 11, 16))
+>p : Symbol(p, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 20, 16))
+
+        funcB: (...p) => d(f.funcB(...p)),
+>funcB : Symbol(funcB, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 20, 42))
+>p : Symbol(p, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 21, 16))
+>d : Symbol(d, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 19, 5))
+>f.funcB : Symbol(funcB, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 12, 36))
+>f : Symbol(f, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 19, 7))
+>funcB : Symbol(funcB, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 12, 36))
+>p : Symbol(p, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 21, 16))
+
+        funcC: (...p) => d(f.funcC(...p)),
+>funcC : Symbol(funcC, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 21, 42))
+>p : Symbol(p, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 22, 16))
+>d : Symbol(d, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 19, 5))
+>f.funcC : Symbol(funcC, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 13, 47))
+>f : Symbol(f, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 19, 7))
+>funcC : Symbol(funcC, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 13, 47))
+>p : Symbol(p, Decl(bindingPatternCannotBeOnlyInferenceSource.ts, 22, 16))
+
+    })
+);
+
diff --git a/tests/baselines/reference/bindingPatternCannotBeOnlyInferenceSource.types b/tests/baselines/reference/bindingPatternCannotBeOnlyInferenceSource.types
new file mode 100644
index 0000000000000..1c81cf4f8db5b
--- /dev/null
+++ b/tests/baselines/reference/bindingPatternCannotBeOnlyInferenceSource.types
@@ -0,0 +1,128 @@
+=== tests/cases/compiler/bindingPatternCannotBeOnlyInferenceSource.ts ===
+declare function f<T>(): T;
+>f : <T>() => T
+
+const {} = f();       // error (only in strictNullChecks)
+>f() : unknown
+>f : <T>() => T
+
+const { p1 } = f();   // error
+>p1 : any
+>f() : unknown
+>f : <T>() => T
+
+const [] = f();       // error
+>f() : unknown
+>f : <T>() => T
+
+const [e1, e2] = f(); // error
+>e1 : any
+>e2 : any
+>f() : unknown
+>f : <T>() => T
+
+// Repro from #43605
+type Dispatch<A = { type: any; [extraProps: string]: any }> = { <T extends A>(action: T): T };
+>Dispatch : Dispatch<A>
+>type : any
+>extraProps : string
+>action : T
+
+type IFuncs = { readonly [key: string]: (...p: any) => void };
+>IFuncs : { readonly [key: string]: (...p: any) => void; }
+>key : string
+>p : any
+
+type IDestructuring<T extends IFuncs> = { readonly [key in keyof T]?: (...p: Parameters<T[key]>) => void };
+>IDestructuring : IDestructuring<T>
+>p : Parameters<T[key]>
+
+type Destructuring<T extends IFuncs, U extends IDestructuring<T>> = (dispatch: Dispatch<any>, funcs: T) => U;
+>Destructuring : Destructuring<T, U>
+>dispatch : Dispatch<any>
+>funcs : T
+
+const funcs1 = {
+>funcs1 : { funcA: (a: boolean) => void; funcB: (b: string, bb: string) => void; funcC: (c: number, cc: number, ccc: boolean) => void; }
+>{    funcA: (a: boolean): void => {},    funcB: (b: string, bb: string): void => {},    funcC: (c: number, cc: number, ccc: boolean): void => {},} : { funcA: (a: boolean) => void; funcB: (b: string, bb: string) => void; funcC: (c: number, cc: number, ccc: boolean) => void; }
+
+    funcA: (a: boolean): void => {},
+>funcA : (a: boolean) => void
+>(a: boolean): void => {} : (a: boolean) => void
+>a : boolean
+
+    funcB: (b: string, bb: string): void => {},
+>funcB : (b: string, bb: string) => void
+>(b: string, bb: string): void => {} : (b: string, bb: string) => void
+>b : string
+>bb : string
+
+    funcC: (c: number, cc: number, ccc: boolean): void => {},
+>funcC : (c: number, cc: number, ccc: boolean) => void
+>(c: number, cc: number, ccc: boolean): void => {} : (c: number, cc: number, ccc: boolean) => void
+>c : number
+>cc : number
+>ccc : boolean
+
+};
+type TFuncs1 = typeof funcs1;
+>TFuncs1 : { funcA: (a: boolean) => void; funcB: (b: string, bb: string) => void; funcC: (c: number, cc: number, ccc: boolean) => void; }
+>funcs1 : { funcA: (a: boolean) => void; funcB: (b: string, bb: string) => void; funcC: (c: number, cc: number, ccc: boolean) => void; }
+
+declare function useReduxDispatch1<T extends IDestructuring<TFuncs1>>(destructuring: Destructuring<TFuncs1, T>): T;
+>useReduxDispatch1 : <T extends IDestructuring<{ funcA: (a: boolean) => void; funcB: (b: string, bb: string) => void; funcC: (c: number, cc: number, ccc: boolean) => void; }>>(destructuring: Destructuring<TFuncs1, T>) => T
+>destructuring : Destructuring<{ funcA: (a: boolean) => void; funcB: (b: string, bb: string) => void; funcC: (c: number, cc: number, ccc: boolean) => void; }, T>
+
+const {} = useReduxDispatch1(
+>useReduxDispatch1(    (d, f) => ({        funcA: (...p) => d(f.funcA(...p)), // p should be inferrable        funcB: (...p) => d(f.funcB(...p)),        funcC: (...p) => d(f.funcC(...p)),    })) : { funcA: (a: boolean) => void; funcB: (b: string, bb: string) => void; funcC: (c: number, cc: number, ccc: boolean) => void; }
+>useReduxDispatch1 : <T extends IDestructuring<{ funcA: (a: boolean) => void; funcB: (b: string, bb: string) => void; funcC: (c: number, cc: number, ccc: boolean) => void; }>>(destructuring: Destructuring<{ funcA: (a: boolean) => void; funcB: (b: string, bb: string) => void; funcC: (c: number, cc: number, ccc: boolean) => void; }, T>) => T
+
+    (d, f) => ({
+>(d, f) => ({        funcA: (...p) => d(f.funcA(...p)), // p should be inferrable        funcB: (...p) => d(f.funcB(...p)),        funcC: (...p) => d(f.funcC(...p)),    }) : (d: Dispatch<any>, f: { funcA: (a: boolean) => void; funcB: (b: string, bb: string) => void; funcC: (c: number, cc: number, ccc: boolean) => void; }) => { funcA: (a: boolean) => void; funcB: (b: string, bb: string) => void; funcC: (c: number, cc: number, ccc: boolean) => void; }
+>d : Dispatch<any>
+>f : { funcA: (a: boolean) => void; funcB: (b: string, bb: string) => void; funcC: (c: number, cc: number, ccc: boolean) => void; }
+>({        funcA: (...p) => d(f.funcA(...p)), // p should be inferrable        funcB: (...p) => d(f.funcB(...p)),        funcC: (...p) => d(f.funcC(...p)),    }) : { funcA: (a: boolean) => void; funcB: (b: string, bb: string) => void; funcC: (c: number, cc: number, ccc: boolean) => void; }
+>{        funcA: (...p) => d(f.funcA(...p)), // p should be inferrable        funcB: (...p) => d(f.funcB(...p)),        funcC: (...p) => d(f.funcC(...p)),    } : { funcA: (a: boolean) => void; funcB: (b: string, bb: string) => void; funcC: (c: number, cc: number, ccc: boolean) => void; }
+
+        funcA: (...p) => d(f.funcA(...p)), // p should be inferrable
+>funcA : (a: boolean) => void
+>(...p) => d(f.funcA(...p)) : (a: boolean) => void
+>p : [a: boolean]
+>d(f.funcA(...p)) : void
+>d : Dispatch<any>
+>f.funcA(...p) : void
+>f.funcA : (a: boolean) => void
+>f : { funcA: (a: boolean) => void; funcB: (b: string, bb: string) => void; funcC: (c: number, cc: number, ccc: boolean) => void; }
+>funcA : (a: boolean) => void
+>...p : boolean
+>p : [a: boolean]
+
+        funcB: (...p) => d(f.funcB(...p)),
+>funcB : (b: string, bb: string) => void
+>(...p) => d(f.funcB(...p)) : (b: string, bb: string) => void
+>p : [b: string, bb: string]
+>d(f.funcB(...p)) : void
+>d : Dispatch<any>
+>f.funcB(...p) : void
+>f.funcB : (b: string, bb: string) => void
+>f : { funcA: (a: boolean) => void; funcB: (b: string, bb: string) => void; funcC: (c: number, cc: number, ccc: boolean) => void; }
+>funcB : (b: string, bb: string) => void
+>...p : string
+>p : [b: string, bb: string]
+
+        funcC: (...p) => d(f.funcC(...p)),
+>funcC : (c: number, cc: number, ccc: boolean) => void
+>(...p) => d(f.funcC(...p)) : (c: number, cc: number, ccc: boolean) => void
+>p : [c: number, cc: number, ccc: boolean]
+>d(f.funcC(...p)) : void
+>d : Dispatch<any>
+>f.funcC(...p) : void
+>f.funcC : (c: number, cc: number, ccc: boolean) => void
+>f : { funcA: (a: boolean) => void; funcB: (b: string, bb: string) => void; funcC: (c: number, cc: number, ccc: boolean) => void; }
+>funcC : (c: number, cc: number, ccc: boolean) => void
+>...p : number | boolean
+>p : [c: number, cc: number, ccc: boolean]
+
+    })
+);
+
diff --git a/tests/baselines/reference/bindingPatternContextualTypeDoesNotCauseWidening.js b/tests/baselines/reference/bindingPatternContextualTypeDoesNotCauseWidening.js
new file mode 100644
index 0000000000000..fa74aadf41e43
--- /dev/null
+++ b/tests/baselines/reference/bindingPatternContextualTypeDoesNotCauseWidening.js
@@ -0,0 +1,9 @@
+//// [bindingPatternContextualTypeDoesNotCauseWidening.ts]
+declare function pick<O, T extends keyof O>(keys: T[], obj?: O): Pick<O, T>;
+const _    = pick(['b'], { a: 'a', b: 'b' }); // T: "b"
+const {  } = pick(['b'], { a: 'a', b: 'b' }); // T: "b" | "a" ??? (before fix)
+
+
+//// [bindingPatternContextualTypeDoesNotCauseWidening.js]
+var _ = pick(['b'], { a: 'a', b: 'b' }); // T: "b"
+var _a = pick(['b'], { a: 'a', b: 'b' }); // T: "b" | "a" ??? (before fix)
diff --git a/tests/baselines/reference/bindingPatternContextualTypeDoesNotCauseWidening.symbols b/tests/baselines/reference/bindingPatternContextualTypeDoesNotCauseWidening.symbols
new file mode 100644
index 0000000000000..bce99caf157b4
--- /dev/null
+++ b/tests/baselines/reference/bindingPatternContextualTypeDoesNotCauseWidening.symbols
@@ -0,0 +1,25 @@
+=== tests/cases/compiler/bindingPatternContextualTypeDoesNotCauseWidening.ts ===
+declare function pick<O, T extends keyof O>(keys: T[], obj?: O): Pick<O, T>;
+>pick : Symbol(pick, Decl(bindingPatternContextualTypeDoesNotCauseWidening.ts, 0, 0))
+>O : Symbol(O, Decl(bindingPatternContextualTypeDoesNotCauseWidening.ts, 0, 22))
+>T : Symbol(T, Decl(bindingPatternContextualTypeDoesNotCauseWidening.ts, 0, 24))
+>O : Symbol(O, Decl(bindingPatternContextualTypeDoesNotCauseWidening.ts, 0, 22))
+>keys : Symbol(keys, Decl(bindingPatternContextualTypeDoesNotCauseWidening.ts, 0, 44))
+>T : Symbol(T, Decl(bindingPatternContextualTypeDoesNotCauseWidening.ts, 0, 24))
+>obj : Symbol(obj, Decl(bindingPatternContextualTypeDoesNotCauseWidening.ts, 0, 54))
+>O : Symbol(O, Decl(bindingPatternContextualTypeDoesNotCauseWidening.ts, 0, 22))
+>Pick : Symbol(Pick, Decl(lib.es5.d.ts, --, --))
+>O : Symbol(O, Decl(bindingPatternContextualTypeDoesNotCauseWidening.ts, 0, 22))
+>T : Symbol(T, Decl(bindingPatternContextualTypeDoesNotCauseWidening.ts, 0, 24))
+
+const _    = pick(['b'], { a: 'a', b: 'b' }); // T: "b"
+>_ : Symbol(_, Decl(bindingPatternContextualTypeDoesNotCauseWidening.ts, 1, 5))
+>pick : Symbol(pick, Decl(bindingPatternContextualTypeDoesNotCauseWidening.ts, 0, 0))
+>a : Symbol(a, Decl(bindingPatternContextualTypeDoesNotCauseWidening.ts, 1, 26))
+>b : Symbol(b, Decl(bindingPatternContextualTypeDoesNotCauseWidening.ts, 1, 34))
+
+const {  } = pick(['b'], { a: 'a', b: 'b' }); // T: "b" | "a" ??? (before fix)
+>pick : Symbol(pick, Decl(bindingPatternContextualTypeDoesNotCauseWidening.ts, 0, 0))
+>a : Symbol(a, Decl(bindingPatternContextualTypeDoesNotCauseWidening.ts, 2, 26))
+>b : Symbol(b, Decl(bindingPatternContextualTypeDoesNotCauseWidening.ts, 2, 34))
+
diff --git a/tests/baselines/reference/bindingPatternContextualTypeDoesNotCauseWidening.types b/tests/baselines/reference/bindingPatternContextualTypeDoesNotCauseWidening.types
new file mode 100644
index 0000000000000..2aa44d96f6a97
--- /dev/null
+++ b/tests/baselines/reference/bindingPatternContextualTypeDoesNotCauseWidening.types
@@ -0,0 +1,29 @@
+=== tests/cases/compiler/bindingPatternContextualTypeDoesNotCauseWidening.ts ===
+declare function pick<O, T extends keyof O>(keys: T[], obj?: O): Pick<O, T>;
+>pick : <O, T extends keyof O>(keys: T[], obj?: O) => Pick<O, T>
+>keys : T[]
+>obj : O
+
+const _    = pick(['b'], { a: 'a', b: 'b' }); // T: "b"
+>_ : Pick<{ a: string; b: string; }, "b">
+>pick(['b'], { a: 'a', b: 'b' }) : Pick<{ a: string; b: string; }, "b">
+>pick : <O, T extends keyof O>(keys: T[], obj?: O) => Pick<O, T>
+>['b'] : "b"[]
+>'b' : "b"
+>{ a: 'a', b: 'b' } : { a: string; b: string; }
+>a : string
+>'a' : "a"
+>b : string
+>'b' : "b"
+
+const {  } = pick(['b'], { a: 'a', b: 'b' }); // T: "b" | "a" ??? (before fix)
+>pick(['b'], { a: 'a', b: 'b' }) : Pick<{ a: string; b: string; }, "b">
+>pick : <O, T extends keyof O>(keys: T[], obj?: O) => Pick<O, T>
+>['b'] : "b"[]
+>'b' : "b"
+>{ a: 'a', b: 'b' } : { a: string; b: string; }
+>a : string
+>'a' : "a"
+>b : string
+>'b' : "b"
+
diff --git a/tests/baselines/reference/declarationEmitDestructuring4.errors.txt b/tests/baselines/reference/declarationEmitDestructuring4.errors.txt
deleted file mode 100644
index 2787d5e66749f..0000000000000
--- a/tests/baselines/reference/declarationEmitDestructuring4.errors.txt
+++ /dev/null
@@ -1,17 +0,0 @@
-tests/cases/compiler/declarationEmitDestructuring4.ts(9,22): error TS2353: Object literal may only specify known properties, and 'x' does not exist in type '{}'.
-
-
-==== tests/cases/compiler/declarationEmitDestructuring4.ts (1 errors) ====
-    // For an array binding pattern with empty elements,
-    // we will not make any modification and will emit
-    // the similar binding pattern users' have written
-    function baz([]) { }
-    function baz1([] = [1,2,3]) { }
-    function baz2([[]] = [[1,2,3]]) { }
-    
-    function baz3({}) { }
-    function baz4({} = { x: 10 }) { }
-                         ~
-!!! error TS2353: Object literal may only specify known properties, and 'x' does not exist in type '{}'.
-    
-    
\ No newline at end of file
diff --git a/tests/baselines/reference/declarationEmitDestructuringObjectLiteralPattern.errors.txt b/tests/baselines/reference/declarationEmitDestructuringObjectLiteralPattern.errors.txt
index 63b68a6fc6b7f..9d89a96cf3c2c 100644
--- a/tests/baselines/reference/declarationEmitDestructuringObjectLiteralPattern.errors.txt
+++ b/tests/baselines/reference/declarationEmitDestructuringObjectLiteralPattern.errors.txt
@@ -1,17 +1,11 @@
-tests/cases/compiler/declarationEmitDestructuringObjectLiteralPattern.ts(1,13): error TS2353: Object literal may only specify known properties, and 'x' does not exist in type '{}'.
-tests/cases/compiler/declarationEmitDestructuringObjectLiteralPattern.ts(1,19): error TS2353: Object literal may only specify known properties, and 'y' does not exist in type '{}'.
 tests/cases/compiler/declarationEmitDestructuringObjectLiteralPattern.ts(2,23): error TS2353: Object literal may only specify known properties, and 'y4' does not exist in type '{ x4: any; }'.
 tests/cases/compiler/declarationEmitDestructuringObjectLiteralPattern.ts(3,16): error TS2353: Object literal may only specify known properties, and 'x5' does not exist in type '{ y5: any; }'.
 tests/cases/compiler/declarationEmitDestructuringObjectLiteralPattern.ts(5,27): error TS2353: Object literal may only specify known properties, and 'y7' does not exist in type '{ x7: any; }'.
 tests/cases/compiler/declarationEmitDestructuringObjectLiteralPattern.ts(6,20): error TS2353: Object literal may only specify known properties, and 'x8' does not exist in type '{ y8: any; }'.
 
 
-==== tests/cases/compiler/declarationEmitDestructuringObjectLiteralPattern.ts (6 errors) ====
+==== tests/cases/compiler/declarationEmitDestructuringObjectLiteralPattern.ts (4 errors) ====
     var { } = { x: 5, y: "hello" };
-                ~
-!!! error TS2353: Object literal may only specify known properties, and 'x' does not exist in type '{}'.
-                      ~
-!!! error TS2353: Object literal may only specify known properties, and 'y' does not exist in type '{}'.
     var { x4 } = { x4: 5, y4: "hello" };
                           ~~
 !!! error TS2353: Object literal may only specify known properties, and 'y4' does not exist in type '{ x4: any; }'.
diff --git a/tests/baselines/reference/declarationEmitDestructuringObjectLiteralPattern1.errors.txt b/tests/baselines/reference/declarationEmitDestructuringObjectLiteralPattern1.errors.txt
index bb8ec829b35f2..1bee984285cd1 100644
--- a/tests/baselines/reference/declarationEmitDestructuringObjectLiteralPattern1.errors.txt
+++ b/tests/baselines/reference/declarationEmitDestructuringObjectLiteralPattern1.errors.txt
@@ -1,17 +1,11 @@
-tests/cases/compiler/declarationEmitDestructuringObjectLiteralPattern1.ts(1,13): error TS2353: Object literal may only specify known properties, and 'x' does not exist in type '{}'.
-tests/cases/compiler/declarationEmitDestructuringObjectLiteralPattern1.ts(1,19): error TS2353: Object literal may only specify known properties, and 'y' does not exist in type '{}'.
 tests/cases/compiler/declarationEmitDestructuringObjectLiteralPattern1.ts(2,23): error TS2353: Object literal may only specify known properties, and 'y4' does not exist in type '{ x4: any; }'.
 tests/cases/compiler/declarationEmitDestructuringObjectLiteralPattern1.ts(3,16): error TS2353: Object literal may only specify known properties, and 'x5' does not exist in type '{ y5: any; }'.
 tests/cases/compiler/declarationEmitDestructuringObjectLiteralPattern1.ts(5,27): error TS2353: Object literal may only specify known properties, and 'y7' does not exist in type '{ x7: any; }'.
 tests/cases/compiler/declarationEmitDestructuringObjectLiteralPattern1.ts(6,20): error TS2353: Object literal may only specify known properties, and 'x8' does not exist in type '{ y8: any; }'.
 
 
-==== tests/cases/compiler/declarationEmitDestructuringObjectLiteralPattern1.ts (6 errors) ====
+==== tests/cases/compiler/declarationEmitDestructuringObjectLiteralPattern1.ts (4 errors) ====
     var { } = { x: 5, y: "hello" };
-                ~
-!!! error TS2353: Object literal may only specify known properties, and 'x' does not exist in type '{}'.
-                      ~
-!!! error TS2353: Object literal may only specify known properties, and 'y' does not exist in type '{}'.
     var { x4 } = { x4: 5, y4: "hello" };
                           ~~
 !!! error TS2353: Object literal may only specify known properties, and 'y4' does not exist in type '{ x4: any; }'.
diff --git a/tests/baselines/reference/declarationsAndAssignments.errors.txt b/tests/baselines/reference/declarationsAndAssignments.errors.txt
index 3a0b00b570ecf..1349f109dc125 100644
--- a/tests/baselines/reference/declarationsAndAssignments.errors.txt
+++ b/tests/baselines/reference/declarationsAndAssignments.errors.txt
@@ -1,6 +1,4 @@
 tests/cases/conformance/es6/destructuring/declarationsAndAssignments.ts(5,16): error TS2493: Tuple type '[number, string]' of length '2' has no element at index '2'.
-tests/cases/conformance/es6/destructuring/declarationsAndAssignments.ts(22,17): error TS2353: Object literal may only specify known properties, and 'x' does not exist in type '{}'.
-tests/cases/conformance/es6/destructuring/declarationsAndAssignments.ts(22,23): error TS2353: Object literal may only specify known properties, and 'y' does not exist in type '{}'.
 tests/cases/conformance/es6/destructuring/declarationsAndAssignments.ts(23,25): error TS2353: Object literal may only specify known properties, and 'y' does not exist in type '{ x: any; }'.
 tests/cases/conformance/es6/destructuring/declarationsAndAssignments.ts(24,19): error TS2353: Object literal may only specify known properties, and 'x' does not exist in type '{ y: any; }'.
 tests/cases/conformance/es6/destructuring/declarationsAndAssignments.ts(28,28): error TS2353: Object literal may only specify known properties, and 'y' does not exist in type '{ x: any; }'.
@@ -22,7 +20,7 @@ tests/cases/conformance/es6/destructuring/declarationsAndAssignments.ts(138,6):
 tests/cases/conformance/es6/destructuring/declarationsAndAssignments.ts(138,9): error TS2322: Type 'number' is not assignable to type 'string'.
 
 
-==== tests/cases/conformance/es6/destructuring/declarationsAndAssignments.ts (22 errors) ====
+==== tests/cases/conformance/es6/destructuring/declarationsAndAssignments.ts (20 errors) ====
     function f0() {
         var [] = [1, "hello"];
         var [x] = [1, "hello"];
@@ -46,11 +44,7 @@ tests/cases/conformance/es6/destructuring/declarationsAndAssignments.ts(138,9):
     }
     
     function f2() {
-        var { } = { x: 5, y: "hello" };       // Error, no x and y in target
-                    ~
-!!! error TS2353: Object literal may only specify known properties, and 'x' does not exist in type '{}'.
-                          ~
-!!! error TS2353: Object literal may only specify known properties, and 'y' does not exist in type '{}'.
+        var { } = { x: 5, y: "hello" };       // Ok, empty binding pattern means nothing
         var { x } = { x: 5, y: "hello" };     // Error, no y in target
                             ~
 !!! error TS2353: Object literal may only specify known properties, and 'y' does not exist in type '{ x: any; }'.
diff --git a/tests/baselines/reference/declarationsAndAssignments.js b/tests/baselines/reference/declarationsAndAssignments.js
index f092d0c1f928f..7f803eb8021b0 100644
--- a/tests/baselines/reference/declarationsAndAssignments.js
+++ b/tests/baselines/reference/declarationsAndAssignments.js
@@ -20,7 +20,7 @@ function f1() {
 }
 
 function f2() {
-    var { } = { x: 5, y: "hello" };       // Error, no x and y in target
+    var { } = { x: 5, y: "hello" };       // Ok, empty binding pattern means nothing
     var { x } = { x: 5, y: "hello" };     // Error, no y in target
     var { y } = { x: 5, y: "hello" };     // Error, no x in target
     var { x, y } = { x: 5, y: "hello" };
@@ -206,7 +206,7 @@ function f1() {
     var z;
 }
 function f2() {
-    var _a = { x: 5, y: "hello" }; // Error, no x and y in target
+    var _a = { x: 5, y: "hello" }; // Ok, empty binding pattern means nothing
     var x = { x: 5, y: "hello" }.x; // Error, no y in target
     var y = { x: 5, y: "hello" }.y; // Error, no x in target
     var _b = { x: 5, y: "hello" }, x = _b.x, y = _b.y;
diff --git a/tests/baselines/reference/declarationsAndAssignments.symbols b/tests/baselines/reference/declarationsAndAssignments.symbols
index e5971d121f105..ce37c9e231f39 100644
--- a/tests/baselines/reference/declarationsAndAssignments.symbols
+++ b/tests/baselines/reference/declarationsAndAssignments.symbols
@@ -59,7 +59,7 @@ function f1() {
 function f2() {
 >f2 : Symbol(f2, Decl(declarationsAndAssignments.ts, 18, 1))
 
-    var { } = { x: 5, y: "hello" };       // Error, no x and y in target
+    var { } = { x: 5, y: "hello" };       // Ok, empty binding pattern means nothing
 >x : Symbol(x, Decl(declarationsAndAssignments.ts, 21, 15))
 >y : Symbol(y, Decl(declarationsAndAssignments.ts, 21, 21))
 
diff --git a/tests/baselines/reference/declarationsAndAssignments.types b/tests/baselines/reference/declarationsAndAssignments.types
index 8faf550681e2a..a7b72a6809424 100644
--- a/tests/baselines/reference/declarationsAndAssignments.types
+++ b/tests/baselines/reference/declarationsAndAssignments.types
@@ -81,7 +81,7 @@ function f1() {
 function f2() {
 >f2 : () => void
 
-    var { } = { x: 5, y: "hello" };       // Error, no x and y in target
+    var { } = { x: 5, y: "hello" };       // Ok, empty binding pattern means nothing
 >{ x: 5, y: "hello" } : { x: number; y: string; }
 >x : number
 >5 : 5
diff --git a/tests/baselines/reference/emptyObjectBindingPatternParameter04.errors.txt b/tests/baselines/reference/emptyObjectBindingPatternParameter04.errors.txt
deleted file mode 100644
index 52b69127f79c2..0000000000000
--- a/tests/baselines/reference/emptyObjectBindingPatternParameter04.errors.txt
+++ /dev/null
@@ -1,15 +0,0 @@
-tests/cases/conformance/es6/destructuring/emptyObjectBindingPatternParameter04.ts(1,18): error TS2353: Object literal may only specify known properties, and 'a' does not exist in type '{}'.
-tests/cases/conformance/es6/destructuring/emptyObjectBindingPatternParameter04.ts(1,24): error TS2353: Object literal may only specify known properties, and 'b' does not exist in type '{}'.
-tests/cases/conformance/es6/destructuring/emptyObjectBindingPatternParameter04.ts(1,32): error TS2353: Object literal may only specify known properties, and 'c' does not exist in type '{}'.
-
-
-==== tests/cases/conformance/es6/destructuring/emptyObjectBindingPatternParameter04.ts (3 errors) ====
-    function f({} = {a: 1, b: "2", c: true}) {
-                     ~
-!!! error TS2353: Object literal may only specify known properties, and 'a' does not exist in type '{}'.
-                           ~
-!!! error TS2353: Object literal may only specify known properties, and 'b' does not exist in type '{}'.
-                                   ~
-!!! error TS2353: Object literal may only specify known properties, and 'c' does not exist in type '{}'.
-        var x, y, z;
-    }
\ No newline at end of file
diff --git a/tests/baselines/reference/inferTupleFromBindingPattern.js b/tests/baselines/reference/inferTupleFromBindingPattern.js
new file mode 100644
index 0000000000000..19dce48f837f6
--- /dev/null
+++ b/tests/baselines/reference/inferTupleFromBindingPattern.js
@@ -0,0 +1,7 @@
+//// [inferTupleFromBindingPattern.ts]
+declare function f<T>(cb: () => T): T;
+const [e1, e2, e3] = f(() => [1, "hi", true]);
+
+
+//// [inferTupleFromBindingPattern.js]
+var _a = f(function () { return [1, "hi", true]; }), e1 = _a[0], e2 = _a[1], e3 = _a[2];
diff --git a/tests/baselines/reference/inferTupleFromBindingPattern.symbols b/tests/baselines/reference/inferTupleFromBindingPattern.symbols
new file mode 100644
index 0000000000000..015e3f2fe5aad
--- /dev/null
+++ b/tests/baselines/reference/inferTupleFromBindingPattern.symbols
@@ -0,0 +1,14 @@
+=== tests/cases/compiler/inferTupleFromBindingPattern.ts ===
+declare function f<T>(cb: () => T): T;
+>f : Symbol(f, Decl(inferTupleFromBindingPattern.ts, 0, 0))
+>T : Symbol(T, Decl(inferTupleFromBindingPattern.ts, 0, 19))
+>cb : Symbol(cb, Decl(inferTupleFromBindingPattern.ts, 0, 22))
+>T : Symbol(T, Decl(inferTupleFromBindingPattern.ts, 0, 19))
+>T : Symbol(T, Decl(inferTupleFromBindingPattern.ts, 0, 19))
+
+const [e1, e2, e3] = f(() => [1, "hi", true]);
+>e1 : Symbol(e1, Decl(inferTupleFromBindingPattern.ts, 1, 7))
+>e2 : Symbol(e2, Decl(inferTupleFromBindingPattern.ts, 1, 10))
+>e3 : Symbol(e3, Decl(inferTupleFromBindingPattern.ts, 1, 14))
+>f : Symbol(f, Decl(inferTupleFromBindingPattern.ts, 0, 0))
+
diff --git a/tests/baselines/reference/inferTupleFromBindingPattern.types b/tests/baselines/reference/inferTupleFromBindingPattern.types
new file mode 100644
index 0000000000000..72292a6be0427
--- /dev/null
+++ b/tests/baselines/reference/inferTupleFromBindingPattern.types
@@ -0,0 +1,17 @@
+=== tests/cases/compiler/inferTupleFromBindingPattern.ts ===
+declare function f<T>(cb: () => T): T;
+>f : <T>(cb: () => T) => T
+>cb : () => T
+
+const [e1, e2, e3] = f(() => [1, "hi", true]);
+>e1 : number
+>e2 : string
+>e3 : boolean
+>f(() => [1, "hi", true]) : [number, string, boolean]
+>f : <T>(cb: () => T) => T
+>() => [1, "hi", true] : () => [number, string, boolean]
+>[1, "hi", true] : [number, string, true]
+>1 : 1
+>"hi" : "hi"
+>true : true
+
diff --git a/tests/baselines/reference/missingAndExcessProperties.errors.txt b/tests/baselines/reference/missingAndExcessProperties.errors.txt
index 7972d770320e6..a6e949f3a8930 100644
--- a/tests/baselines/reference/missingAndExcessProperties.errors.txt
+++ b/tests/baselines/reference/missingAndExcessProperties.errors.txt
@@ -10,8 +10,6 @@ tests/cases/conformance/es6/destructuring/missingAndExcessProperties.ts(12,8): e
 tests/cases/conformance/es6/destructuring/missingAndExcessProperties.ts(12,11): error TS2525: Initializer provides no value for this binding element and the binding element has no default value.
 tests/cases/conformance/es6/destructuring/missingAndExcessProperties.ts(13,18): error TS2525: Initializer provides no value for this binding element and the binding element has no default value.
 tests/cases/conformance/es6/destructuring/missingAndExcessProperties.ts(14,8): error TS2525: Initializer provides no value for this binding element and the binding element has no default value.
-tests/cases/conformance/es6/destructuring/missingAndExcessProperties.ts(20,17): error TS2353: Object literal may only specify known properties, and 'x' does not exist in type '{}'.
-tests/cases/conformance/es6/destructuring/missingAndExcessProperties.ts(20,23): error TS2353: Object literal may only specify known properties, and 'y' does not exist in type '{}'.
 tests/cases/conformance/es6/destructuring/missingAndExcessProperties.ts(21,25): error TS2353: Object literal may only specify known properties, and 'y' does not exist in type '{ x: any; }'.
 tests/cases/conformance/es6/destructuring/missingAndExcessProperties.ts(22,19): error TS2353: Object literal may only specify known properties, and 'x' does not exist in type '{ y: any; }'.
 tests/cases/conformance/es6/destructuring/missingAndExcessProperties.ts(29,14): error TS2353: Object literal may only specify known properties, and 'x' does not exist in type '{}'.
@@ -20,7 +18,7 @@ tests/cases/conformance/es6/destructuring/missingAndExcessProperties.ts(30,22):
 tests/cases/conformance/es6/destructuring/missingAndExcessProperties.ts(31,16): error TS2353: Object literal may only specify known properties, and 'x' does not exist in type '{ y: number; }'.
 
 
-==== tests/cases/conformance/es6/destructuring/missingAndExcessProperties.ts (20 errors) ====
+==== tests/cases/conformance/es6/destructuring/missingAndExcessProperties.ts (18 errors) ====
     // Missing properties
     function f1() {
         var { x, y } = {};
@@ -69,10 +67,6 @@ tests/cases/conformance/es6/destructuring/missingAndExcessProperties.ts(31,16):
     // Excess properties
     function f3() {
         var { } = { x: 0, y: 0 };
-                    ~
-!!! error TS2353: Object literal may only specify known properties, and 'x' does not exist in type '{}'.
-                          ~
-!!! error TS2353: Object literal may only specify known properties, and 'y' does not exist in type '{}'.
         var { x } = { x: 0, y: 0 };
                             ~
 !!! error TS2353: Object literal may only specify known properties, and 'y' does not exist in type '{ x: any; }'.
diff --git a/tests/baselines/reference/objectBindingPatternContextuallyTypesArgument.js b/tests/baselines/reference/objectBindingPatternContextuallyTypesArgument.js
new file mode 100644
index 0000000000000..6be0f4361db21
--- /dev/null
+++ b/tests/baselines/reference/objectBindingPatternContextuallyTypesArgument.js
@@ -0,0 +1,7 @@
+//// [objectBindingPatternContextuallyTypesArgument.ts]
+declare function id<T>(x: T): T;
+const { f = (x: string) => x.length } = id({ f: x => x.charAt });
+
+
+//// [objectBindingPatternContextuallyTypesArgument.js]
+var _a = id({ f: function (x) { return x.charAt; } }).f, f = _a === void 0 ? function (x) { return x.length; } : _a;
diff --git a/tests/baselines/reference/objectBindingPatternContextuallyTypesArgument.symbols b/tests/baselines/reference/objectBindingPatternContextuallyTypesArgument.symbols
new file mode 100644
index 0000000000000..77e2e0ad7d4af
--- /dev/null
+++ b/tests/baselines/reference/objectBindingPatternContextuallyTypesArgument.symbols
@@ -0,0 +1,21 @@
+=== tests/cases/compiler/objectBindingPatternContextuallyTypesArgument.ts ===
+declare function id<T>(x: T): T;
+>id : Symbol(id, Decl(objectBindingPatternContextuallyTypesArgument.ts, 0, 0))
+>T : Symbol(T, Decl(objectBindingPatternContextuallyTypesArgument.ts, 0, 20))
+>x : Symbol(x, Decl(objectBindingPatternContextuallyTypesArgument.ts, 0, 23))
+>T : Symbol(T, Decl(objectBindingPatternContextuallyTypesArgument.ts, 0, 20))
+>T : Symbol(T, Decl(objectBindingPatternContextuallyTypesArgument.ts, 0, 20))
+
+const { f = (x: string) => x.length } = id({ f: x => x.charAt });
+>f : Symbol(f, Decl(objectBindingPatternContextuallyTypesArgument.ts, 1, 7))
+>x : Symbol(x, Decl(objectBindingPatternContextuallyTypesArgument.ts, 1, 13))
+>x.length : Symbol(String.length, Decl(lib.es5.d.ts, --, --))
+>x : Symbol(x, Decl(objectBindingPatternContextuallyTypesArgument.ts, 1, 13))
+>length : Symbol(String.length, Decl(lib.es5.d.ts, --, --))
+>id : Symbol(id, Decl(objectBindingPatternContextuallyTypesArgument.ts, 0, 0))
+>f : Symbol(f, Decl(objectBindingPatternContextuallyTypesArgument.ts, 1, 44))
+>x : Symbol(x, Decl(objectBindingPatternContextuallyTypesArgument.ts, 1, 47))
+>x.charAt : Symbol(String.charAt, Decl(lib.es5.d.ts, --, --))
+>x : Symbol(x, Decl(objectBindingPatternContextuallyTypesArgument.ts, 1, 47))
+>charAt : Symbol(String.charAt, Decl(lib.es5.d.ts, --, --))
+
diff --git a/tests/baselines/reference/objectBindingPatternContextuallyTypesArgument.types b/tests/baselines/reference/objectBindingPatternContextuallyTypesArgument.types
new file mode 100644
index 0000000000000..b5c4974a07989
--- /dev/null
+++ b/tests/baselines/reference/objectBindingPatternContextuallyTypesArgument.types
@@ -0,0 +1,22 @@
+=== tests/cases/compiler/objectBindingPatternContextuallyTypesArgument.ts ===
+declare function id<T>(x: T): T;
+>id : <T>(x: T) => T
+>x : T
+
+const { f = (x: string) => x.length } = id({ f: x => x.charAt });
+>f : ((x: string) => number) | ((x: string) => (pos: number) => string)
+>(x: string) => x.length : (x: string) => number
+>x : string
+>x.length : number
+>x : string
+>length : number
+>id({ f: x => x.charAt }) : { f: (x: string) => (pos: number) => string; }
+>id : <T>(x: T) => T
+>{ f: x => x.charAt } : { f: (x: string) => (pos: number) => string; }
+>f : (x: string) => (pos: number) => string
+>x => x.charAt : (x: string) => (pos: number) => string
+>x : string
+>x.charAt : (pos: number) => string
+>x : string
+>charAt : (pos: number) => string
+
diff --git a/tests/cases/compiler/bindingPatternCannotBeOnlyInferenceSource.ts b/tests/cases/compiler/bindingPatternCannotBeOnlyInferenceSource.ts
new file mode 100644
index 0000000000000..361ae8631f62d
--- /dev/null
+++ b/tests/cases/compiler/bindingPatternCannotBeOnlyInferenceSource.ts
@@ -0,0 +1,27 @@
+// @strictNullChecks: true
+
+declare function f<T>(): T;
+const {} = f();       // error (only in strictNullChecks)
+const { p1 } = f();   // error
+const [] = f();       // error
+const [e1, e2] = f(); // error
+
+// Repro from #43605
+type Dispatch<A = { type: any; [extraProps: string]: any }> = { <T extends A>(action: T): T };
+type IFuncs = { readonly [key: string]: (...p: any) => void };
+type IDestructuring<T extends IFuncs> = { readonly [key in keyof T]?: (...p: Parameters<T[key]>) => void };
+type Destructuring<T extends IFuncs, U extends IDestructuring<T>> = (dispatch: Dispatch<any>, funcs: T) => U;
+const funcs1 = {
+    funcA: (a: boolean): void => {},
+    funcB: (b: string, bb: string): void => {},
+    funcC: (c: number, cc: number, ccc: boolean): void => {},
+};
+type TFuncs1 = typeof funcs1;
+declare function useReduxDispatch1<T extends IDestructuring<TFuncs1>>(destructuring: Destructuring<TFuncs1, T>): T;
+const {} = useReduxDispatch1(
+    (d, f) => ({
+        funcA: (...p) => d(f.funcA(...p)), // p should be inferrable
+        funcB: (...p) => d(f.funcB(...p)),
+        funcC: (...p) => d(f.funcC(...p)),
+    })
+);
diff --git a/tests/cases/compiler/bindingPatternContextualTypeDoesNotCauseWidening.ts b/tests/cases/compiler/bindingPatternContextualTypeDoesNotCauseWidening.ts
new file mode 100644
index 0000000000000..a86b8918ebf54
--- /dev/null
+++ b/tests/cases/compiler/bindingPatternContextualTypeDoesNotCauseWidening.ts
@@ -0,0 +1,3 @@
+declare function pick<O, T extends keyof O>(keys: T[], obj?: O): Pick<O, T>;
+const _    = pick(['b'], { a: 'a', b: 'b' }); // T: "b"
+const {  } = pick(['b'], { a: 'a', b: 'b' }); // T: "b" | "a" ??? (before fix)
diff --git a/tests/cases/compiler/inferTupleFromBindingPattern.ts b/tests/cases/compiler/inferTupleFromBindingPattern.ts
new file mode 100644
index 0000000000000..7c0c1dea98193
--- /dev/null
+++ b/tests/cases/compiler/inferTupleFromBindingPattern.ts
@@ -0,0 +1,2 @@
+declare function f<T>(cb: () => T): T;
+const [e1, e2, e3] = f(() => [1, "hi", true]);
diff --git a/tests/cases/compiler/objectBindingPatternContextuallyTypesArgument.ts b/tests/cases/compiler/objectBindingPatternContextuallyTypesArgument.ts
new file mode 100644
index 0000000000000..dc79200ae6e8d
--- /dev/null
+++ b/tests/cases/compiler/objectBindingPatternContextuallyTypesArgument.ts
@@ -0,0 +1,2 @@
+declare function id<T>(x: T): T;
+const { f = (x: string) => x.length } = id({ f: x => x.charAt });
diff --git a/tests/cases/conformance/es6/destructuring/declarationsAndAssignments.ts b/tests/cases/conformance/es6/destructuring/declarationsAndAssignments.ts
index 7ab33f99a1e84..9167239cefdfd 100644
--- a/tests/cases/conformance/es6/destructuring/declarationsAndAssignments.ts
+++ b/tests/cases/conformance/es6/destructuring/declarationsAndAssignments.ts
@@ -19,7 +19,7 @@ function f1() {
 }
 
 function f2() {
-    var { } = { x: 5, y: "hello" };       // Error, no x and y in target
+    var { } = { x: 5, y: "hello" };       // Ok, empty binding pattern means nothing
     var { x } = { x: 5, y: "hello" };     // Error, no y in target
     var { y } = { x: 5, y: "hello" };     // Error, no x in target
     var { x, y } = { x: 5, y: "hello" };