diff --git a/packages/react-native/ReactCommon/jsc/JSCRuntime.cpp b/packages/react-native/ReactCommon/jsc/JSCRuntime.cpp
index 7958519e683f6d..523b1be36937ee 100644
--- a/packages/react-native/ReactCommon/jsc/JSCRuntime.cpp
+++ b/packages/react-native/ReactCommon/jsc/JSCRuntime.cpp
@@ -302,6 +302,9 @@ class JSCRuntime : public jsi::Runtime {
 #if __IPHONE_OS_VERSION_MIN_REQUIRED < __IPHONE_10_0
 #define _JSC_NO_ARRAY_BUFFERS
 #endif
+#if __IPHONE_OS_VERSION_MAX_ALLOWED >= 160400
+#define _JSC_HAS_INSPECTABLE
+#endif
 #endif
 #if defined(__MAC_OS_X_VERSION_MIN_REQUIRED)
 #if __MAC_OS_X_VERSION_MIN_REQUIRED >= __MAC_10_11
@@ -398,6 +401,13 @@ JSCRuntime::JSCRuntime(JSGlobalContextRef ctx)
       stringCounter_(0)
 #endif
 {
+#ifndef NDEBUG
+#ifdef _JSC_HAS_INSPECTABLE
+  if (__builtin_available(macOS 13.3, iOS 16.4, tvOS 16.4, *)) {
+    JSGlobalContextSetInspectable(ctx_, true);
+  }
+#endif
+#endif
 }
 
 JSCRuntime::~JSCRuntime() {