diff --git a/news/3 Code Health/8485.md b/news/3 Code Health/8485.md
new file mode 100644
index 00000000000..b7e871e935f
--- /dev/null
+++ b/news/3 Code Health/8485.md	
@@ -0,0 +1 @@
+Remove `jupyter.runMagicCommands` (which has been deprecared for over a year) in favor of `runStartupCommands`.
diff --git a/src/client/common/configSettings.ts b/src/client/common/configSettings.ts
index b0c75f532df..4b89348d226 100644
--- a/src/client/common/configSettings.ts
+++ b/src/client/common/configSettings.ts
@@ -79,7 +79,6 @@ export class JupyterSettings implements IWatchableJupyterSettings {
     public remoteDebuggerPort: number = 0;
     public colorizeInputBox: boolean = false;
     public addGotoCodeLenses: boolean = false;
-    public runMagicCommands: string = '';
     public runStartupCommands: string | string[] = [];
     public debugJustMyCode: boolean = false;
     public defaultCellMarker: string = '';
diff --git a/src/client/common/types.ts b/src/client/common/types.ts
index d9527e40167..f81d6d6c81e 100644
--- a/src/client/common/types.ts
+++ b/src/client/common/types.ts
@@ -162,7 +162,6 @@ export interface IJupyterSettings {
     readonly remoteDebuggerPort: number;
     readonly colorizeInputBox: boolean;
     readonly addGotoCodeLenses: boolean;
-    readonly runMagicCommands: string;
     readonly runStartupCommands: string | string[];
     readonly debugJustMyCode: boolean;
     readonly defaultCellMarker: string;
diff --git a/src/client/datascience/jupyter/kernels/kernel.ts b/src/client/datascience/jupyter/kernels/kernel.ts
index 71b9d5f630a..18a1bf27b2b 100644
--- a/src/client/datascience/jupyter/kernels/kernel.ts
+++ b/src/client/datascience/jupyter/kernels/kernel.ts
@@ -771,7 +771,7 @@ export class Kernel implements IKernel {
     private async runStartupCommands() {
         const settings = this.configService.getSettings(this.resourceUri);
         // Run any startup commands that we specified. Support the old form too
-        let setting = settings.runStartupCommands || settings.runMagicCommands;
+        let setting = settings.runStartupCommands;
 
         // Convert to string in case we get an array of startup commands.
         if (Array.isArray(setting)) {
diff --git a/src/client/datascience/notebook/intellisense/intellisenseProvider.ts b/src/client/datascience/notebook/intellisense/intellisenseProvider.ts
index c73cf62f790..add9476f7e1 100644
--- a/src/client/datascience/notebook/intellisense/intellisenseProvider.ts
+++ b/src/client/datascience/notebook/intellisense/intellisenseProvider.ts
@@ -176,7 +176,7 @@ export class IntellisenseProvider implements INotebookLanguageClientProvider, IE
     private getNotebookHeader(uri: Uri) {
         const settings = this.configService.getSettings(uri);
         // Run any startup commands that we specified. Support the old form too
-        let setting = settings.runStartupCommands || settings.runMagicCommands;
+        let setting = settings.runStartupCommands;
 
         // Convert to string in case we get an array of startup commands.
         if (Array.isArray(setting)) {
diff --git a/src/test/activation/migrateDataScienceSettingsService.unit.test.ts b/src/test/activation/migrateDataScienceSettingsService.unit.test.ts
index f915e94eaf2..56f94e060a4 100644
--- a/src/test/activation/migrateDataScienceSettingsService.unit.test.ts
+++ b/src/test/activation/migrateDataScienceSettingsService.unit.test.ts
@@ -61,7 +61,6 @@ suite('Migrate data science settings', () => {
     "python.dataScience.remoteDebuggerPort": 0,
     "python.dataScience.colorizeInputBox": true,
     "python.dataScience.addGotoCodeLenses": true,
-    "python.dataScience.runMagicCommands": "foo",
     "python.dataScience.runStartupCommands": ["foo", "bar"],
     "python.dataScience.debugJustMyCode": true,
     "python.dataScience.defaultCellMarker": "foo",
@@ -125,7 +124,6 @@ suite('Migrate data science settings', () => {
     "jupyter.remoteDebuggerPort": 0,
     "jupyter.colorizeInputBox": true,
     "jupyter.addGotoCodeLenses": true,
-    "jupyter.runMagicCommands": "foo",
     "jupyter.runStartupCommands": [
         "foo",
         "bar"
diff --git a/src/test/datascience/interactiveWindow.vscode.test.ts b/src/test/datascience/interactiveWindow.vscode.test.ts
index bb74c8e266b..d7e0b489ae6 100644
--- a/src/test/datascience/interactiveWindow.vscode.test.ts
+++ b/src/test/datascience/interactiveWindow.vscode.test.ts
@@ -22,7 +22,6 @@ import {
     waitForLastCellToComplete
 } from './helpers';
 import {
-    assertNotHasTextOutputInVSCode,
     clickOKForRestartPrompt,
     closeNotebooksAndCleanUpAfterTests,
     defaultNotebookTestTimeout,
@@ -369,32 +368,6 @@ ${actualCode}
         assert.equal(actualCellText, actualCode);
     });
 
-    async function runMagicCommandsTest(settingValue: boolean) {
-        const settings = vscode.workspace.getConfiguration('jupyter', null);
-        await settings.update('magicCommandsAsComments', settingValue);
-        const code = `# %%
-#!%%time
-print('hi')`;
-        const { activeInteractiveWindow } = await submitFromPythonFile(interactiveWindowProvider, code, disposables);
-        const lastCell = await waitForLastCellToComplete(activeInteractiveWindow);
-        await waitForTextOutput(lastCell, 'hi', undefined, false);
-        return lastCell;
-    }
-
-    test('jupyter.magicCommandsAsComments: `true`', async () => {
-        const lastCell = await runMagicCommandsTest(true);
-        await waitForTextOutput(lastCell, 'Wall time:', undefined, false);
-    });
-
-    test('jupyter.magicCommandsAsComments: `false`', async () => {
-        const lastCell = await runMagicCommandsTest(false);
-
-        // Magic should have remained commented
-        for (let outputIndex = 0; outputIndex < lastCell.outputs.length; outputIndex++) {
-            assertNotHasTextOutputInVSCode(lastCell, 'Wall time:', outputIndex, false);
-        }
-    });
-
     // todo@joyceerhl
     // test('Verify CWD', () => { });
     // test('Multiple executes go to last active window', async () => { });