mgpo-base.obo

format-version: 1.2
data-version: mgpo/releases/2024-04-18/mgpo-base.owl
remark: Testing approach where occupancy and composition and levels phenotypes are all grouped as siblings under a abnormal glycosylation parent.  This approach should simplify integration with HPO.\n\nThe challenge remains w.r.t. confusion around when to annotate to a level vs a composition phenotype (e.g. abnormal fucosylated glycan levels vs abnormal glycan fucose content), but we can try to clarify the rules here, and see what feedback we get when  we test.  Also, it may be fine just to say annotate to both if both would apply, and this doesn't really hurt anything.
ontology: mgpo/mgpo-base
property_value: http://purl.org/dc/elements/1.1/type IAO:8000001
property_value: owl:versionInfo "2024-04-18" xsd:string

[Term]
id: MGPO:0001001
name: Phenotype

[Term]
id: MGPO:0002001
name: abnormal glycan metabolism
def: "An abnormality in the process of glycan catabolism or biosynthesis." []
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002002
name: abnormal glycan level
name: abnormal glycan levels
def: "An abnormal level of glycan." []
def: "An increase or decrease in the amount of a type or specific species of glycan present in the body, cell, or specific compartment  therein." []
is_a: MGPO:0001001 ! Phenotype
property_value: MGPO:0002032 "Here we make distinction between free and conjugated only deeper in the hierarchy - since often we don’t know origin. Often MS-based phenotypes simply refer to altered levels of a class of glycans - and these clearly go here. Other cases are trickier - e.g. elevated levels of mannose rich cores species. Here, if an MS-based phenotype cannot be best characterized with a residue-specific composition class, they should be documented here as a levels phenotype. Challenge is that the curator has to understand the expert interpretation of thee data to make selection here, and these interpretations can be quite nuanced/subjective." xsd:string

[Term]
id: MGPO:0002003
name: abnormal glycan occupancy
def: "An increase or decrease in the number of glycan chains conjugated to an aglycone target." []
comment: "Occupancy" is used here to describe the extent of conjugation of a glycan chain to glycosylation sites on an aglycone target. Abnormal occupancy does not speak to the structure or composition of the glycan chain, just the relative abundance of glycan chains on some protein or lipid target.
is_a: MGPO:0002009 ! abnormal glycosylation
property_value: MGPO:0002032 "Relevant Classification Axes (in order shown for exemplar classes below):\n1  glycosylation/target type (N-linked vs O-linked vs proteoglycan)\n1.1  glycosylated residue (e.g. Asn, Ser, Thr)\n1.2  specific aglycone target (e.g. transferrin)\n1.2.1  anatomical/cellular location (e.g. serum, golgi)\n" xsd:string

[Term]
id: MGPO:0002004
name: abnormal glycan structure
comment: A change in the molecular structure of a glycan, including altered sugar composition, chain length, linkage or branching patterns, or modifications on a sugar residues
comment: Former logical definition:\n\n'has part' some \n    (structure\n     and ('has modifier' some abnormal)\n     and ('inheres in' some glycan))
comment: The distinction between abnormal glycan levels and abnormal glycan structure/composition is confounded by the fact that specific phenotypes in both categories are typically reported in the literature by describing  the amount of a particular type of glycan. For example, "increased sialylated oligosaccharides in the lysosome" is verbatim text reporting a ‘compositional’ defect, and "increased levels of complex N-Glycans in the serum"  is verbatim text reporting a ‘level’ defect. The key difference is that the former defect indicates that glycans contain abnormalities in their sialyl content that make them compositionally different that glycan end products normally found in the lysosome. And biologically, this defect likely results from defects in glycosylation, deglycosylation, or isomerase enzymes.  By contrast, the latter defect does not reflect a structural/compositional abnormality in the specified glycan, but rather that the level of a certain normal type of glycan end-product is elevated. Compared to a compositional phenotype, this defect likely has a very different biological cause related to abnormal glycan degradation or trafficking.
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002005
name: abnormal glycan-related process
def: "Abnormality in a biological process that has a glycan or glycan-containing entity as a product or active  participant." []
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002006
name: abnormal glycan binding
def: "An abnormality in the process of a glycan binding to its target." []
is_a: MGPO:0002005 ! abnormal glycan-related process

[Term]
id: MGPO:0002007
name: abnormal deglycosylation
def: "An abnormality in the process of glycan deglycosylation." []
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002008
name: abnormal glycan catabolism
is_a: MGPO:0002001 ! abnormal glycan metabolism

[Term]
id: MGPO:0002009
name: abnormal glycosylation
def: "An abnormality in the structure or composition of glycans, or their attachment to aglycone conjugation targets." []
comment: Abnormal glycosylation phenotypes cover altered glycan composition, including altered sugar residue content, chain length, linkage, or branching patterns, as well as altered occupancy, characterized by abnormal degree or pattens or conjugation of glycan chains to aglycone targets.\n\nAbnormal glycosylation phenotypes typically result from defects in the machinery that directly (glycosyltransferase, glycosidase, oligosaccharyltransferase enzymes) or indierctly (isomerasaes, transport proteins, chaperones, glycan residue synthesis/activation pathways, etc.) contribute to the building/remodeling of glycan chains, or their attachement to aglycone targets.
is_a: MGPO:0001001 ! Phenotype
property_value: MGPO:0002032 "Can we logically define this . . . a ssome abnormal structure that inheres in some molecular entity that has part some gycan? This wont work if we have the abnormal glycosylation activity phenotypes in this hierarchy." xsd:string
property_value: MGPO:0002037 "abnormal glycan structure" xsd:string
property_value: MGPO:0002037 "abnormal glycosylation structure" xsd:string

[Term]
id: MGPO:0002010
name: abnormal glycan branching
def: "A change in the structure of a glycan chain due to altered branching patterns. " []
is_a: MGPO:0002009 ! abnormal glycosylation
property_value: MGPO:0002032 "Relevant Classification Axes (in order shown for exemplar classes above):\n1  attachment (conjugated vs free glycans)\n1.1  aglycone class (e.g. glycoprotein-linked vs glycopeptide-linked)\n1.1.1  more specific aglycone class (e.g. N-glycan  vs O-glycan for proteins)\n" xsd:string

[Term]
id: MGPO:0002011
name: abnormal glycan composition
def: "A change in the strucutre of a glycan chain due to variations in number and/or type of sugar residue constituents - typically an increased or decreased abundance of a given type of residue, or the substitution of on residue type for another." []
comment: abnormal glycosylation of glycans
is_a: MGPO:0002009 ! abnormal glycosylation
property_value: MGPO:0002037 "abnormal glycan chain composition" xsd:string

[Term]
id: MGPO:0002012
name: abnormal N-linked glycoprotein occupancy
def: "An increase or decrease in the number of N-glycan chains conjugated to aglycone targets." []
is_a: MGPO:0002003 ! abnormal glycan occupancy
is_a: MGPO:0002201 ! abnormal protein N-linked glycosylation

[Term]
id: MGPO:0002013
name: abnormal O-linked glycoprotein occupancy
def: "An increase or decrease in the number of O-glycan chains conjugated to aglycone targets." []
is_a: MGPO:0002003 ! abnormal glycan occupancy
is_a: MGPO:0002202 ! abnormal protein O-linked glycosylation

[Term]
id: MGPO:0002017
name: abnormal IDUA activity
def: "Altered IDUA enzymatic activity in an organism, cell, or part thereof." []
is_a: MGPO:0002036 ! abnormal glycosidase activity

[Term]
id: MGPO:0002018
name: abnormal heparan sulfate degradation
is_a: MGPO:0002008 ! abnormal glycan catabolism

[Term]
id: MGPO:0002019
name: abnormal R-type lectin binding
is_a: MGPO:0002006 ! abnormal glycan binding

[Term]
id: MGPO:0002023
name: abnormal transferrin N-glycan occupancy
def: "An increase or decrease in the number of N-glycan chains conjugated to transferrin protein." []
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002024
name: abnormal serum transferrin N-glycan occupancy
def: "An increase or decrease in the number of N-glycan chains conjugated to transferrin protein in blood serum." []
is_a: MGPO:0002023 ! abnormal transferrin N-glycan occupancy

[Term]
id: MGPO:0002027
name: abnormal golgi biantennary N-glycan levels
def: "An increase or decrease in the amount or concentration of normal biantennary N-gycan structures present in the golgi complex." []
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002028
name: DeprecatedClass

[Term]
id: MGPO:0002029
name: abnormal glycan-related activity
def: "An alteration in the activity of a molecular entity such as an enzyme or transporter protein that acts on glycans or glycan-containing entities." []
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002030
name: abnormal glycan biosynthesis
is_a: MGPO:0002001 ! abnormal glycan metabolism

[Term]
id: MGPO:0002031
name: abnormal glycosaminoglycan degradation
is_a: MGPO:0002008 ! abnormal glycan catabolism

[Term]
id: MGPO:0002033
name: abnormal glycan phenotype
def: "A phenotype characterized by abnormality in the levels or structural composition of a glycan." []
comment: previous logical def: '\n\nhas part' some \n    (quality\n     and ('has modifier' some abnormal)\n     and ('inheres in' some glycan))
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002035
name: abnormal glycosyltransferase activity
def: "Altered glycosyltransferase activity in an organism, cell, or part thereof." []
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002036
name: abnormal glycosidase activity
def: "Altered glycosidase enzymatic activity in an organism, cell, or part thereof." []
is_a: MGPO:0002028 ! DeprecatedClass
property_value: MGPO:0002037 "abnormal glycosyl-hydrolase activity" xsd:string

[Term]
id: MGPO:0002038
name: abnormal proteoglycan occupancy
def: "An increase or decrease in the extent of number of glycan chains conjugated to proteoglycans." []
comment: Former logical def:\n\n'has part' some \n    ('altered number of'\n     and ('has modifier' some abnormal)\n     and ('inheres in' some proteoglycan)\n     and (towards some 'conjugated glycan chain'))
is_a: MGPO:0002209 ! Triaged Candidates

[Term]
id: MGPO:0002039
name: abnormal N-linked glycoprotein asparagine occupancy
def: "An increase or decrease in the number of N-glycan chains conjugated to asparagine residues on aglycone targets." []
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002041
name: abnormal glycan length
def: "A change in the strucutre of a glycan chain due to variations in the number of sugar residue constituents." []
is_a: MGPO:0002009 ! abnormal glycosylation
property_value: MGPO:0002032 "Relevant Classification Axes (in order shown for exemplar classes above):\n1  attachment (conjugated vs free glycans)\n1.1  aglycone class (e.g. glycoprotein-linked vs glycolipid-linked)\n1.1.1  more specific aglycone class (e.g. N-glycan  vs O-glycan for proteins)" xsd:string
property_value: MGPO:0002037 "abnormal length of glycan species" xsd:string

[Term]
id: MGPO:0002042
name: abnormal glycan linkage
def: "A change in the strucutre of a glycan chain due to altered types of linkages between sugar residues. " []
is_a: MGPO:0002028 ! DeprecatedClass
property_value: MGPO:0002032 "Relevant Classification Axes (in order shown for exemplar classes above):\n1  attachment (conjugated vs free glycans)\n1.1  aglycone class (e.g. glycoprotein-linked vs glycopeptide-linked)\n1.1.1  more specific aglycone class (e.g. N-glycan  vs O-glycan for proteins)" xsd:string

[Term]
id: MGPO:0002048
name: abnormal sialyl content in serum N-glycans
def: "A change in the strucutre of a serum-localized N-glycan chain due to variations in number and/or location of sialyl residues - typically an increased or decreased abundance of sialyl residues, or the substitution of sialyl residues for another residue type." []
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002050
name: abnormal glycolipid glycan composition
def: "A change in the strucutre of a glycolipid glycan chain due to variations in number and/or type of sugar residue constituents - typically an increased or decreased abundance of a given type of residue, or the substitution of on residue type for another." []
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002051
name: abnormal glycosphingolipid glycan composition
is_a: MGPO:0002050 ! abnormal glycolipid glycan composition

[Term]
id: MGPO:0002052
name: abnormal glycoglycerolipid glycan composition
is_a: MGPO:0002050 ! abnormal glycolipid glycan composition

[Term]
id: MGPO:0002053
name: abnormal lipopolysaccharide glycan composition
def: "A change in the strucutre of a lipopolysaccharide glycan chain due to variations in number and/or type of sugar residue constituents - typically an increased or decreased abundance of a given type of residue, or the substitution of on residue type for another." []
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002054
name: abnormal conjugated glycan length
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002055
name: abnormal free glycan length
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002056
name: abnormal glycoprotein glycan length
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002057
name: abnormal glycolipid glycan length
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002058
name: abnormal lipopolysaccharide glycan length
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002059
name: abnormal N-glycan length
is_a: MGPO:0002056 ! abnormal glycoprotein glycan length

[Term]
id: MGPO:0002060
name: abnormal O-glycan length
is_a: MGPO:0002056 ! abnormal glycoprotein glycan length

[Term]
id: MGPO:0002062
name: abnormal glycopeptide glycan length
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002068
name: abnormal free glycan linkage
def: "A change in the strucutre of a free glycan chain due to altered types of linkages between sugar residues. " []
is_a: MGPO:0002042 ! abnormal glycan linkage

[Term]
id: MGPO:0002069
name: abnormal conjugated glycan linkage
def: "A change in the strucutre of a conjugated glycan chain due to altered types of linkages between sugar residues. " []
is_a: MGPO:0002042 ! abnormal glycan linkage

[Term]
id: MGPO:0002070
name: abnormal glycoprotein glycan linkage
def: "A change in the strucutre of a glycoprotein glycan chain due to altered types of linkages between sugar residues. " []
is_a: MGPO:0002069 ! abnormal conjugated glycan linkage

[Term]
id: MGPO:0002071
name: abnormal glycopeptide glycan linkage
def: "A change in the strucutre of a glycopeptide glycan chain due to altered types of linkages between sugar residues. " []
is_a: MGPO:0002069 ! abnormal conjugated glycan linkage

[Term]
id: MGPO:0002073
name: abnormal O-glycan linkage
def: "A change in the strucutre of an O-glycan chain due to altered types of linkages between sugar residues. " []
is_a: MGPO:0002070 ! abnormal glycoprotein glycan linkage

[Term]
id: MGPO:0002074
name: abnormal N-glycan linkage
def: "A change in the strucutre of n N-glycan chain due to altered types of linkages between sugar residues. " []
is_a: MGPO:0002070 ! abnormal glycoprotein glycan linkage

[Term]
id: MGPO:0002078
name: abnormal glycopeptide glycan levels
def: "An increase or decrease in the amount or concentration of normal glycopeptide gycan structures present in the body, cell, or specific location therein." []
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002081
name: abnormal glycosaminoglycan length
is_a: MGPO:0002056 ! abnormal glycoprotein glycan length

[Term]
id: MGPO:0002085
name: abnormal glycan levels in the serum
def: "An increase or decrease in the amount or concentration of glycan structures present in the blood serum.." []
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002086
name: abnormal glycan levels in the CSF
def: "An increase or decrease in the amount or concentration of glycan structures present in the CSF fluid." []
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002092
name: abnormal Man9GlcNAc2 glycan levels
def: "An increase or decrease in the amount or concentration of Man9GlcNAc2 gycan structures present in the body, cell, or specific location therein." []
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002093
name: abnormal oligomannose N-glycan levels in golgi
def: "An increase or decrease in the amount or concentration of normal oligomannose N-gycan structures present in the golgi complex." []
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002094
name: abnormal transferrin-linked oligomannose N-glycan levels
def: "An increase or decrease in the amount or concentration of transferring-linked oligomannose N-gycan structures present in the body, cell, or specific location therein." []
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002096
name: abnormal Tn core O-glycan levels in blood cell plasma membrane
def: "An increase or decrease in the amount or concentration of Tn core O-gycan structures present in the plasma membrane of blood cells." []
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002097
name: abnormal GlcNAcT-II activity
is_a: MGPO:0002035 ! abnormal glycosyltransferase activity
property_value: MGPO:0002098 "see PMID:11805078" xsd:string

[Term]
id: MGPO:0002099
name: decreased complex N-glycan levels
is_a: MGPO:0002028 ! DeprecatedClass
property_value: MGPO:0002098 "see PMID:11805078" xsd:string

[Term]
id: MGPO:0002101
name: abnormal glyco-conjugate phenotype
def: "A phenotype characterized by abnormality of a glyco-conjugate molecular entity." []
comment: Former logical def:\n\n'has part' some \n    (quality\n     and ('has modifier' some abnormal)\n     and ('inheres in' some glyco-conjugate))
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002102
name: abnormal glycoprotein phenotype
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002103
name: abnormal glycolipid phenotype
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002104
name: abnormal glycopeptide phenotype
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002105
name: abnormal glycoaminoacid phenotype
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002106
name: abnormal glyco-amino acid level
name: abnormal glycoaminoacid levels
def: "An abnormal level of glyco-amino acid." []
is_a: MGPO:0002189 ! abnormal glyco-conjugate level

[Term]
id: MGPO:0002114
name: increased glycan length
is_a: MGPO:0002041 ! abnormal glycan length
property_value: MGPO:0002037 "extended glycans" xsd:string

[Term]
id: MGPO:0002115
name: decreased glycan length
is_a: MGPO:0002041 ! abnormal glycan length
property_value: MGPO:0002037 "truncated glycans" xsd:string

[Term]
id: MGPO:0002117
name: increased N-glycan length
is_a: MGPO:0002059 ! abnormal N-glycan length
property_value: MGPO:0002037 "extended N-glycan" xsd:string

[Term]
id: MGPO:0002118
name: decreased N-glycan length
is_a: MGPO:0002059 ! abnormal N-glycan length
property_value: MGPO:0002037 "truncated N-glycan" xsd:string

[Term]
id: MGPO:0002120
name: abnormal fucosylated N-glycan levels
is_a: MGPO:0002210 ! abnormal N-glycan chain level

[Term]
id: MGPO:0002121
name: increased fucosylated N-glycan levels
is_a: MGPO:0002120 ! abnormal fucosylated N-glycan levels

[Term]
id: MGPO:0002122
name: decreased fucosylated N-glycan levels
is_a: MGPO:0002120 ! abnormal fucosylated N-glycan levels

[Term]
id: MGPO:0002138
name: proteoglycan glycan chain
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002140
name: lipid-linked glycan chain
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002142
name: peptide-linked glycan chain
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002165
name: abnormal N-glycan fucosylation
is_a: MGPO:0002204 ! abnormal N-glycan composition
property_value: MGPO:0002037 "abnormal fucosylation of N-glycans" xsd:string
property_value: MGPO:0002037 "abnormal N-glycan fucose content" xsd:string

[Term]
id: MGPO:0002166
name: increased N-glycan fucosylation
is_a: MGPO:0002165 ! abnormal N-glycan fucosylation
property_value: MGPO:0002037 "hyper-fucosylation of N-glycans" xsd:string
property_value: MGPO:0002037 "increased fucosylation of N-glycans" xsd:string
property_value: MGPO:0002037 "increased N-glycan fucose content" xsd:string

[Term]
id: MGPO:0002167
name: decreased N-glycan fucosylation
is_a: MGPO:0002165 ! abnormal N-glycan fucosylation
property_value: MGPO:0002037 "decreased fucosylation of N-glycans" xsd:string
property_value: MGPO:0002037 "decreased N-glycan fucose content" xsd:string
property_value: MGPO:0002037 "hypo-fucosylation of N-glycans" xsd:string

[Term]
id: MGPO:0002182
name: abnormal glycoprotein glycan occupancy
comment: Former logical def:\n\n'has part' some \n    ('altered number of'\n     and ('has modifier' some abnormal)\n     and ('inheres in' some glycoprotein)\n     and (towards some 'conjugated glycan chain'))
is_a: MGPO:0002209 ! Triaged Candidates

[Term]
id: MGPO:0002189
name: abnormal glyco-conjugate level
name: abnormal glyco-conjugate levels
def: "An abnormal level of glyco-conjugate." []
is_a: MGPO:0001001 ! Phenotype

[Term]
id: MGPO:0002190
name: abnormal fucose metabolism/homeostasis
comment: Former logical def:\n\n'has part' some \n    (quality\n     and ('has modifier' some abnormal)\n     and ('inheres in' some 'fucose metabolic process'))
is_a: MGPO:0002209 ! Triaged Candidates

[Term]
id: MGPO:0002192
name: abnormal glycan binding
is_a: MGPO:0001001 ! Phenotype

[Term]
id: MGPO:0002193
name: abnormality of carbohydrate metabolism/homeostasis
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002199
name: abnormal protein glycosylation
is_a: MGPO:0002009 ! abnormal glycosylation

[Term]
id: MGPO:0002200
name: abnormal lipid glycosylation
is_a: MGPO:0002009 ! abnormal glycosylation

[Term]
id: MGPO:0002201
name: abnormal protein N-linked glycosylation
is_a: MGPO:0002199 ! abnormal protein glycosylation

[Term]
id: MGPO:0002202
name: abnormal protein O-linked glycosylation
is_a: MGPO:0002199 ! abnormal protein glycosylation

[Term]
id: MGPO:0002204
name: abnormal N-glycan composition
is_a: MGPO:0002011 ! abnormal glycan composition
is_a: MGPO:0002201 ! abnormal protein N-linked glycosylation

[Term]
id: MGPO:0002205
name: abnormal O-glycan composition
is_a: MGPO:0002011 ! abnormal glycan composition
is_a: MGPO:0002202 ! abnormal protein O-linked glycosylation

[Term]
id: MGPO:0002206
name: abnormal O-glycan fucosylation
is_a: MGPO:0002205 ! abnormal O-glycan composition
property_value: MGPO:0002037 "abnormal fucosylation of O-glycans" xsd:string
property_value: MGPO:0002037 "abnormal O-glycan fucose content" xsd:string

[Term]
id: MGPO:0002207
name: decreased O-glycan fucosylation
is_a: MGPO:0002206 ! abnormal O-glycan fucosylation
property_value: MGPO:0002037 "decreased fucosylation of O-glycans" xsd:string
property_value: MGPO:0002037 "decreased O-glycan fucose content" xsd:string
property_value: MGPO:0002037 "hypo-fucosylation of O-glycans" xsd:string

[Term]
id: MGPO:0002208
name: increased O-glycan fucosylation
is_a: MGPO:0002206 ! abnormal O-glycan fucosylation
property_value: MGPO:0002037 "hyper-fucosylation of O-glycans" xsd:string
property_value: MGPO:0002037 "increased fucosylation of O-glycans" xsd:string
property_value: MGPO:0002037 "increased O-glycan fucose content" xsd:string

[Term]
id: MGPO:0002209
name: Triaged Candidates
is_a: MGPO:0002028 ! DeprecatedClass

[Term]
id: MGPO:0002210
name: abnormal N-glycan chain level
name: abnormal N-glycan levels
def: "An abnormal level of N-glycan chain." []
is_a: MGPO:0002002 ! abnormal glycan level

[Term]
id: MGPO:0002211
name: abnormal free glycan level
name: abnormal free glycan levels
def: "An abnormal level of free glycan." []
is_a: MGPO:0002002 ! abnormal glycan level

[Term]
id: MGPO:0002212
name: increased free glycan levels in the urine
name: increased level of free glycan in urine
def: "An increase in the level of free glycan in urine." []
synonym: "increased level of free glycan in urine" EXACT []
is_a: MGPO:0002213 ! increased level of free glycan
is_a: MGPO:0002218 ! abnormal urine free glycan level

[Term]
id: MGPO:0002213
name: increased free glycan levels
name: increased level of free glycan
def: "An increased amount in the level of free glycan." []
synonym: "increased free glycan level" EXACT []
is_a: MGPO:0002211 ! abnormal free glycan level

[Term]
id: MGPO:0002214
name: decreased free glycan levels
name: decreased level of free glycan
def: "A decreased amount in the level of free glycan." []
is_a: MGPO:0002211 ! abnormal free glycan level

[Term]
id: MGPO:0002215
name: decreased free glycan levels in the urine
name: decreased level of free glycan in urine
def: "A decrease in the level of free glycan in urine." []
is_a: MGPO:0002214 ! decreased free glycan levels
is_a: MGPO:0002218 ! abnormal urine free glycan level

[Term]
id: MGPO:0002216
name: increased free oligosaccharide levels in the urine
name: increased level of oligosaccharide in urine
def: "An increase in the level of oligosaccharide in urine." []
synonym: "increased level of oligosaccharide in urine" EXACT []
is_a: MGPO:0002212 ! increased level of free glycan in urine
property_value: MGPO:0002037 "oligosacchariduria" xsd:string

[Term]
id: MGPO:0002217
name: increased free monosaccharide levels in the urine
name: increased level of monosaccharide in urine
def: "An increase in the level of monosaccharide in urine." []
synonym: "increased level of monosaccharide in urine" EXACT []
is_a: MGPO:0002212 ! increased level of free glycan in urine
property_value: MGPO:0002037 "monosacchariduria" xsd:string

[Term]
id: MGPO:0002218
name: abnormal free glycan levels in the urine
name: abnormal urine free glycan level
def: "An abnormal level of free glycan in the urine." []
is_a: MGPO:0002211 ! abnormal free glycan level

[Term]
id: MGPO:0002219
name: abnormal O-glycan chain level
name: abnormal O-glycan levels
def: "An abnormal level of O-glycan chain." []
is_a: MGPO:0002002 ! abnormal glycan level

[Term]
id: MGPO:0002220
name: abnormal fucosylated O-glycan levels
is_a: MGPO:0002219 ! abnormal O-glycan chain level

[Term]
id: MGPO:0002221
name: decreased fucosylated O-glycan levels
is_a: MGPO:0002220 ! abnormal fucosylated O-glycan levels

[Term]
id: MGPO:0002222
name: increased fucosylated O-glycan levels
is_a: MGPO:0002220 ! abnormal fucosylated O-glycan levels

[Term]
id: MGPO:0002223
name: abnormal glycosyltransferase activity
def: "Abnormal glycosyltransferase activity." []
is_a: MGPO:0002226 ! abnormal glycosylation activity

[Term]
id: MGPO:0002224
name: abnormal glycosidase activity
name: abnormal hydrolase activity, acting on glycosyl bonds
def: "Abnormal hydrolase activity, acting on glycosyl bonds." []
is_a: MGPO:0002226 ! abnormal glycosylation activity

[Term]
id: MGPO:0002225
name: abnormal oligosaccharyl transferase activity
def: "Abnormal oligosaccharyl transferase activity." []
is_a: MGPO:0002223 ! abnormal glycosyltransferase activity

[Term]
id: MGPO:0002226
name: abnormal glycosylation activity
is_a: MGPO:0002009 ! abnormal glycosylation

[Term]
id: MGPO:0002227
name: increased glycan branching
is_a: MGPO:0002010 ! abnormal glycan branching

[Term]
id: MGPO:0002228
name: decreased glycan branching
is_a: MGPO:0002010 ! abnormal glycan branching

[Term]
id: MGPO:0002229
name: abnormal transferrin N-linked glycosylation
is_a: MGPO:0002201 ! abnormal protein N-linked glycosylation
property_value: MGPO:0002032 "Not made equivalent to 'Abnrmal isoelectric focusing of serum transferrin' because there are other methods that could be used to reveal this phenotype." xsd:string

[Term]
id: MGPO:0002230
name: abnormal occupancy of transferrin by N-glycans
is_a: MGPO:0002229 ! abnormal transferrin N-linked glycosylation

[Term]
id: MGPO:0002231
name: abnormal composition of transferrin-conjugated N-glycans
is_a: MGPO:0002204 ! abnormal N-glycan composition
is_a: MGPO:0002229 ! abnormal transferrin N-linked glycosylation

[Term]
id: MGPO:0002233
name: abnormal glycoprotein level
name: abnormal glycoprotein levels
def: "An abnormal level of glycoprotein." []
is_a: MGPO:0002189 ! abnormal glyco-conjugate level

[Term]
id: MGPO:0002234
name: abnormal glycopeptide level
name: abnormal glycopeptide levels
def: "An abnormal level of glycopeptide." []
is_a: MGPO:0002189 ! abnormal glyco-conjugate level

[Term]
id: MGPO:0002235
name: decreased core-fucosylated N-glycan levels
is_a: MGPO:0002122 ! decreased fucosylated N-glycan levels

[Term]
id: MGPO:0002238
name: decreased antennary-fucosylated N-glycan levels
is_a: MGPO:0002122 ! decreased fucosylated N-glycan levels