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Using Alt+Ref instead of true depth #50

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arichards2564 opened this issue Jun 6, 2022 · 0 comments
Open

Using Alt+Ref instead of true depth #50

arichards2564 opened this issue Jun 6, 2022 · 0 comments

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@arichards2564
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arichards2564 commented Jun 6, 2022

maf[, t_depth := t_alt_count + t_ref_count]

Here, we overwrite the true read depth with alt+ref. Normally, this doesn't change much but I've seen positions where there are 3 alleles present at a given position and the mutation being called is not the major allele and neither is the reference allele. This changes the calculation quite a bit.

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