diff --git a/src/node/SetupServerApi.ts b/src/node/SetupServerApi.ts
index 557ce47b5..291c66feb 100644
--- a/src/node/SetupServerApi.ts
+++ b/src/node/SetupServerApi.ts
@@ -62,10 +62,23 @@ export class SetupServerApi
         // new "abort" event listener to the parent request's
         // "AbortController" so if the parent aborts, all the
         // clones are automatically aborted.
-        setMaxListeners(
-          Math.max(defaultMaxListeners, this.currentHandlers.length),
-          request.signal,
-        )
+        try {
+          setMaxListeners(
+            Math.max(defaultMaxListeners, this.currentHandlers.length),
+            request.signal,
+          )
+        } catch (e: unknown) {
+          /**
+           * @note Mock environments (JSDOM, ...) are not able to implement an internal
+           * "kIsNodeEventTarget" Symbol that Node.js uses to identify Node.js `EventTarget`s.
+           * `setMaxListeners` throws an error for non-Node.js `EventTarget`s.
+           * At the same time, mock environments are also not able to implement the
+           * internal "events.maxEventTargetListenersWarned" Symbol, which results in
+           * "MaxListenersExceededWarning" not being printed by Node.js for those anyway.
+           * The main reason for using `setMaxListeners` is to suppress these warnings in Node.js,
+           * which won't be printed anyway if `setMaxListeners` fails.
+           */
+        }
       }
 
       const response = await handleRequest(
diff --git a/test/node/msw-api/many-request-handlers-jsdom.test.ts b/test/node/msw-api/many-request-handlers-jsdom.test.ts
new file mode 100644
index 000000000..0a1755cdd
--- /dev/null
+++ b/test/node/msw-api/many-request-handlers-jsdom.test.ts
@@ -0,0 +1,58 @@
+/**
+ * @jest-environment jsdom
+ */
+import { graphql, http, HttpResponse } from 'msw'
+import { setupServer } from 'msw/node'
+
+// Create a large number of request handlers.
+const restHandlers = new Array(100).fill(null).map((_, index) => {
+  return http.post(
+    `https://example.com/resource/${index}`,
+    async ({ request }) => {
+      const text = await request.text()
+      return HttpResponse.text(text + index.toString())
+    },
+  )
+})
+
+const graphqlHanlers = new Array(100).fill(null).map((_, index) => {
+  return graphql.query(`Get${index}`, () => {
+    return HttpResponse.json({ data: { index } })
+  })
+})
+
+const server = setupServer(...restHandlers, ...graphqlHanlers)
+
+beforeAll(() => {
+  server.listen()
+  jest.spyOn(process.stderr, 'write')
+})
+
+afterAll(() => {
+  server.close()
+  jest.restoreAllMocks()
+})
+
+it('does not print a memory leak warning when having many request handlers', async () => {
+  const httpResponse = await fetch('https://example.com/resource/42', {
+    method: 'POST',
+    body: 'request-body-',
+  }).then((response) => response.text())
+
+  const graphqlResponse = await fetch('https://example.com', {
+    method: 'POST',
+    headers: {
+      'Content-Type': 'application/json',
+    },
+    body: JSON.stringify({
+      query: `query Get42 { index }`,
+    }),
+  }).then((response) => response.json())
+
+  // Must not print any memory leak warnings.
+  expect(process.stderr.write).not.toHaveBeenCalled()
+
+  // Must return the mocked response.
+  expect(httpResponse).toBe('request-body-42')
+  expect(graphqlResponse).toEqual({ data: { index: 42 } })
+})