diff --git a/src/fromOpenApi/fromOpenApi.ts b/src/fromOpenApi/fromOpenApi.ts
index f9ef0bf..10a7e9a 100644
--- a/src/fromOpenApi/fromOpenApi.ts
+++ b/src/fromOpenApi/fromOpenApi.ts
@@ -1,5 +1,6 @@
 import { invariant } from 'outvariant'
 import { datatype, internet, random } from 'faker'
+import { headersToObject } from 'headers-utils'
 import { randexp } from 'randexp'
 import {
   RestContext,
@@ -147,10 +148,23 @@ function createResponseResolver(
     if ('content' in response && response.content != null) {
       let body: unknown
 
-      const explicitContentType = req.url.searchParams.get('type')
-      const contentType = explicitContentType
-        ? explicitContentType
-        : Object.keys(response.content)[0]
+      const requestHeaders = headersToObject(req.headers)
+      const acceptedMimeTypes = ([] as string[]).concat(requestHeaders.accept)
+      const explicitContentType = acceptedMimeTypes[0]
+      const explicitContentTypeRegexp = new RegExp(
+        explicitContentType.replace(/\/+/g, '\\/').replace(/\*/g, '.+?'),
+      )
+
+      const allContentTypes = Object.keys(response.content)
+
+      const contentType =
+        allContentTypes.find((contentType) => {
+          // Find the first declared response content type
+          // that matches the "Accept" request header.
+          // Keep in mind that values like "*/*" and "application/*"
+          // are completely valid.
+          return explicitContentTypeRegexp.test(contentType)
+        }) || allContentTypes[0]
 
       transformers.push(ctx.set('Content-Type', contentType))
 
@@ -167,7 +181,7 @@ function createResponseResolver(
           mediaTypeObject.examples,
         )[0] as OpenAPIV3.ExampleObject
 
-        // Response body must always be string.
+        // Response body must always be a string.
         body = value
       }
       // JSON Schema is populated with random values.
diff --git a/test/oas/oas-json-schema.test.ts b/test/oas/oas-json-schema.test.ts
index 419dd31..c539fb3 100644
--- a/test/oas/oas-json-schema.test.ts
+++ b/test/oas/oas-json-schema.test.ts
@@ -173,3 +173,53 @@ it('responds with 501 to a request for explicit non-existing response status', a
     expect(await res.text()).toEqual('')
   })
 })
+
+it('respects the "Accept" request header', async () => {
+  const handlers = await fromOpenApi(
+    createOpenApiSpec({
+      paths: {
+        '/user': {
+          get: {
+            responses: {
+              200: {
+                content: {
+                  'application/json': {
+                    example: { id: 'user-1' },
+                  },
+                  'application/xml': {
+                    example: `<id>xml-1</id>`,
+                  },
+                },
+              },
+            },
+          },
+        },
+      },
+    }),
+  )
+
+  // The "Accept" request header with a single value.
+  await withHandlers(handlers, () => {
+    return fetch('http://localhost/user', {
+      headers: {
+        Accept: 'application/xml',
+      },
+    })
+  }).then(async (res) => {
+    expect(res.status).toEqual(200)
+    expect(await res.text()).toEqual(`<id>xml-1</id>`)
+  })
+
+  // The "Accept" request header with multiple values.
+  await withHandlers(handlers, () => {
+    return fetch('http://localhost/user', {
+      headers: {
+        Accept: 'application/json, application/xml',
+      },
+    })
+  }).then(async (res) => {
+    expect(res.status).toEqual(200)
+    // The first MimeType is used for the mocked data.
+    expect(await res.text()).toEqual(`{"id":"user-1"}`)
+  })
+})