diff --git a/packages/material-ui/src/Tooltip/Tooltip.js b/packages/material-ui/src/Tooltip/Tooltip.js
index 92ca464604d828..e461a6a68a083f 100644
--- a/packages/material-ui/src/Tooltip/Tooltip.js
+++ b/packages/material-ui/src/Tooltip/Tooltip.js
@@ -78,13 +78,14 @@ export const styles = (theme) => ({
     padding: '4px 8px',
     fontSize: theme.typography.pxToRem(11),
     maxWidth: 300,
+    margin: 2,
     wordWrap: 'break-word',
     fontWeight: theme.typography.fontWeightMedium,
   },
   /* Styles applied to the tooltip (label wrapper) element if `arrow={true}`. */
   tooltipArrow: {
     position: 'relative',
-    margin: '0',
+    margin: 0,
   },
   /* Styles applied to the arrow element. */
   arrow: {
@@ -240,14 +241,23 @@ const Tooltip = React.forwardRef(function Tooltip(props, ref) {
 
   const id = useId(idProp);
 
+  const prevUserSelect = React.useRef();
+  const stopTouchInteraction = React.useCallback(() => {
+    if (prevUserSelect.current !== undefined) {
+      document.body.style.WebkitUserSelect = prevUserSelect.current;
+      prevUserSelect.current = undefined;
+    }
+    clearTimeout(touchTimer.current);
+  }, []);
+
   React.useEffect(() => {
     return () => {
       clearTimeout(closeTimer.current);
       clearTimeout(enterTimer.current);
       clearTimeout(leaveTimer.current);
-      clearTimeout(touchTimer.current);
+      stopTouchInteraction();
     };
-  }, []);
+  }, [stopTouchInteraction]);
 
   const handleOpen = (event) => {
     clearTimeout(hystersisTimer);
@@ -369,9 +379,15 @@ const Tooltip = React.forwardRef(function Tooltip(props, ref) {
     detectTouchStart(event);
     clearTimeout(leaveTimer.current);
     clearTimeout(closeTimer.current);
-    clearTimeout(touchTimer.current);
+    stopTouchInteraction();
     event.persist();
+
+    prevUserSelect.current = document.body.style.WebkitUserSelect;
+    // Prevent iOS text selection on long-tap.
+    document.body.style.WebkitUserSelect = 'none';
+
     touchTimer.current = setTimeout(() => {
+      document.body.style.WebkitUserSelect = prevUserSelect.current;
       handleEnter(event);
     }, enterTouchDelay);
   };
diff --git a/packages/material-ui/src/Tooltip/Tooltip.test.js b/packages/material-ui/src/Tooltip/Tooltip.test.js
index b757cefab1d17b..83a6c9431c89cd 100644
--- a/packages/material-ui/src/Tooltip/Tooltip.test.js
+++ b/packages/material-ui/src/Tooltip/Tooltip.test.js
@@ -410,9 +410,7 @@ describe('<Tooltip />', () => {
           title="Hello World"
           TransitionProps={{ timeout: transitionTimeout }}
         >
-          <button id="testChild" type="submit">
-            Hello World
-          </button>
+          <button type="submit">Hello World</button>
         </Tooltip>,
       );
       act(() => {
@@ -1083,4 +1081,70 @@ describe('<Tooltip />', () => {
       }
     });
   });
+
+  describe('user-select state', () => {
+    let prevWebkitUserSelect;
+    beforeEach(() => {
+      prevWebkitUserSelect = document.body.style.WebkitUserSelect;
+    });
+
+    afterEach(() => {
+      document.body.style.WebkitUserSelect = prevWebkitUserSelect;
+    });
+
+    it('prevents text-selection during touch-longpress', () => {
+      const enterTouchDelay = 700;
+      const enterDelay = 100;
+      const leaveTouchDelay = 1500;
+      const transitionTimeout = 10;
+      const { getByRole } = render(
+        <Tooltip
+          enterTouchDelay={enterTouchDelay}
+          enterDelay={enterDelay}
+          leaveTouchDelay={leaveTouchDelay}
+          title="Hello World"
+          TransitionProps={{ timeout: transitionTimeout }}
+        >
+          <button type="submit">Hello World</button>
+        </Tooltip>,
+      );
+      document.body.style.WebkitUserSelect = 'revert';
+
+      fireEvent.touchStart(getByRole('button'));
+
+      expect(document.body.style.WebkitUserSelect).to.equal('none');
+
+      act(() => {
+        clock.tick(enterTouchDelay + enterDelay);
+      });
+      expect(document.body.style.WebkitUserSelect.toLowerCase()).to.equal('revert');
+    });
+
+    it('restores user-select when unmounted during longpress', () => {
+      const enterTouchDelay = 700;
+      const enterDelay = 100;
+      const leaveTouchDelay = 1500;
+      const transitionTimeout = 10;
+      const { unmount, getByRole } = render(
+        <Tooltip
+          enterTouchDelay={enterTouchDelay}
+          enterDelay={enterDelay}
+          leaveTouchDelay={leaveTouchDelay}
+          title="Hello World"
+          TransitionProps={{ timeout: transitionTimeout }}
+        >
+          <button type="submit">Hello World</button>
+        </Tooltip>,
+      );
+
+      document.body.style.WebkitUserSelect = 'revert';
+      // Let updates flush before unmounting
+      act(() => {
+        fireEvent.touchStart(getByRole('button'));
+      });
+      unmount();
+
+      expect(document.body.style.WebkitUserSelect.toLowerCase()).to.equal('revert');
+    });
+  });
 });