diff --git a/packages/mui-material/src/Autocomplete/Autocomplete.js b/packages/mui-material/src/Autocomplete/Autocomplete.js
index a2e39002f3302b..c946c2579c9d27 100644
--- a/packages/mui-material/src/Autocomplete/Autocomplete.js
+++ b/packages/mui-material/src/Autocomplete/Autocomplete.js
@@ -552,7 +552,14 @@ const Autocomplete = React.forwardRef(function Autocomplete(inProps, ref) {
   );
 
   const renderGroup = renderGroupProp || defaultRenderGroup;
-  const defaultRenderOption = (props2, option) => <li {...props2}>{getOptionLabel(option)}</li>;
+  const defaultRenderOption = (props2, option) => {
+    const { key, ...otherProps } = props2;
+    return (
+      <li key={key} {...otherProps}>
+        {getOptionLabel(option)}
+      </li>
+    );
+  };
   const renderOption = renderOptionProp || defaultRenderOption;
 
   const renderListOption = (option, index) => {