diff --git a/packages/editor-ui/src/plugins/i18n/locales/en.json b/packages/editor-ui/src/plugins/i18n/locales/en.json
index ce0d01074685b..a42987864c391 100644
--- a/packages/editor-ui/src/plugins/i18n/locales/en.json
+++ b/packages/editor-ui/src/plugins/i18n/locales/en.json
@@ -1951,6 +1951,7 @@
 	"workflowPreview.showError.previewError.title": "Preview error",
 	"workflowRun.noActiveConnectionToTheServer": "Lost connection to the server",
 	"workflowRun.showError.title": "Problem running workflow",
+	"workflowRun.showError.payloadTooLarge": "Please execute the whole workflow, rather than just the node. (Existing execution data is too large.)",
 	"workflowRun.showMessage.message": "Please fix them before executing",
 	"workflowRun.showMessage.title": "Workflow has issues",
 	"workflowSettings.callerIds": "IDs of workflows that can call this one",
diff --git a/packages/editor-ui/src/stores/workflows.store.ts b/packages/editor-ui/src/stores/workflows.store.ts
index 074c14916bf1a..a61e311516193 100644
--- a/packages/editor-ui/src/stores/workflows.store.ts
+++ b/packages/editor-ui/src/stores/workflows.store.ts
@@ -82,6 +82,8 @@ import { useNodeTypesStore } from '@/stores/nodeTypes.store';
 import { useUsersStore } from '@/stores/users.store';
 import { useSettingsStore } from '@/stores/settings.store';
 import { getCredentialOnlyNodeTypeName } from '@/utils/credentialOnlyNodes';
+import { ResponseError } from '@/utils/apiUtils';
+import { i18n } from '@/plugins/i18n';
 
 const defaults: Omit<IWorkflowDb, 'id'> & { settings: NonNullable<IWorkflowDb['settings']> } = {
 	name: '',
@@ -1338,12 +1340,22 @@ export const useWorkflowsStore = defineStore(STORES.WORKFLOWS, {
 
 		async runWorkflow(startRunData: IStartRunData): Promise<IExecutionPushResponse> {
 			const rootStore = useRootStore();
-			return await makeRestApiRequest(
-				rootStore.getRestApiContext,
-				'POST',
-				'/workflows/run',
-				startRunData as unknown as IDataObject,
-			);
+			try {
+				return await makeRestApiRequest(
+					rootStore.getRestApiContext,
+					'POST',
+					'/workflows/run',
+					startRunData as unknown as IDataObject,
+				);
+			} catch (error) {
+				if (error.response?.status === 413) {
+					throw new ResponseError(i18n.baseText('workflowRun.showError.payloadTooLarge'), {
+						errorCode: 413,
+						httpStatusCode: 413,
+					});
+				}
+				throw error;
+			}
 		},
 
 		async removeTestWebhook(workflowId: string): Promise<boolean> {
diff --git a/packages/editor-ui/src/utils/apiUtils.ts b/packages/editor-ui/src/utils/apiUtils.ts
index 4c935a63f1612..cc6b73c2b948f 100644
--- a/packages/editor-ui/src/utils/apiUtils.ts
+++ b/packages/editor-ui/src/utils/apiUtils.ts
@@ -6,7 +6,7 @@ import { parse } from 'flatted';
 
 export const NO_NETWORK_ERROR_CODE = 999;
 
-class ResponseError extends Error {
+export class ResponseError extends Error {
 	// The HTTP status code of response
 	httpStatusCode?: number;