diff --git a/CHANGELOG.md b/CHANGELOG.md
index b2ddfa6a..71393afc 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -42,6 +42,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 - Move from ensembl to gencode base [#505](https://github.com/nf-core/rnafusion/pull/505)
 - Update from ensembl 102 to gencode 46 default references [#505](https://github.com/nf-core/rnafusion/pull/505)
 - Update`FUSIONINSPECTOR` to v2.10.0. [#601](https://github.com/nf-core/rnafusion/pull/601)
+- Remove local module `STARFUSION_DOWNLOAD` [#598](https://github.com/nf-core/rnafusion/pull/598)
 
 ### Fixed
 
diff --git a/conf/modules.config b/conf/modules.config
index c747fda7..69611e8a 100644
--- a/conf/modules.config
+++ b/conf/modules.config
@@ -371,16 +371,6 @@ process {
         ext.args = "--max_readlength ${params.read_length} --human_gencode_filter"
     }
 
-    withName: 'STARFUSION_DOWNLOAD' {
-        cpus   = { 2    * task.attempt }
-        memory = { 24.GB * task.attempt }
-        time   = { 6.h  * task.attempt }
-        publishDir = [
-            path: { "${params.genomes_base}/starfusion" },
-            mode: params.publish_dir_mode,
-            saveAs: { filename -> filename.equals('versions.yml') ? null : filename },
-        ]
-    }
 
     withName: 'STRINGTIE_MERGE' {
         publishDir = [
diff --git a/modules/local/starfusion/download/environment.yml b/modules/local/starfusion/download/environment.yml
deleted file mode 100644
index ef7f9316..00000000
--- a/modules/local/starfusion/download/environment.yml
+++ /dev/null
@@ -1,8 +0,0 @@
-channels:
-  - conda-forge
-  - bioconda
-dependencies:
-  - bioconda::dfam=3.7
-  - bioconda::hmmer=3.4
-  - bioconda::minimap2=2.28
-  - bioconda::star-fusion=1.14.0
diff --git a/modules/local/starfusion/download/main.nf b/modules/local/starfusion/download/main.nf
deleted file mode 100644
index ace18a9e..00000000
--- a/modules/local/starfusion/download/main.nf
+++ /dev/null
@@ -1,34 +0,0 @@
-process STARFUSION_DOWNLOAD {
-    tag 'star-fusion'
-
-    conda "${moduleDir}/environment.yml"
-    container "${ workflow.containerEngine == 'singularity' && !task.ext.singularity_pull_docker_container ?
-        'https://community-cr-prod.seqera.io/docker/registry/v2/blobs/sha256/be/bed86145102fdf7e381e1a506a4723676f98b4bbe1db5085d02213cef18525c9/data' :
-        'community.wave.seqera.io/library/dfam_hmmer_minimap2_star-fusion:aa3a8e3951498552'}"
-
-    output:
-    path "ctat_genome_lib_build_dir/*"            , emit: reference
-
-
-    // TODO: move to S3
-    script:
-    """
-    wget https://data.broadinstitute.org/Trinity/CTAT_RESOURCE_LIB/__genome_libs_StarFv1.10/GRCh38_gencode_v37_CTAT_lib_Mar012021.plug-n-play.tar.gz --no-check-certificate
-
-    tar xvf GRCh38_gencode_v37_CTAT_lib_Mar012021.plug-n-play.tar.gz
-
-    rm GRCh38_gencode_v37_CTAT_lib_Mar012021.plug-n-play.tar.gz
-
-    mv */ctat_genome_lib_build_dir .
-    """
-
-    stub:
-    """
-    mkdir ctat_genome_lib_build_dir
-    touch ref_annot.cdna.fa
-    cat <<-END_VERSIONS > versions.yml
-    "${task.process}":
-        STAR-Fusion: \$(STAR-Fusion --version 2>&1 | grep -i 'version' | sed 's/STAR-Fusion version: //')
-    END_VERSIONS
-    """
-}
diff --git a/modules/local/starfusion/download/meta.yml b/modules/local/starfusion/download/meta.yml
deleted file mode 100644
index 24e84252..00000000
--- a/modules/local/starfusion/download/meta.yml
+++ /dev/null
@@ -1,25 +0,0 @@
-name: starfusion_downloadgenome
-description: Download STAR-fusion genome resource required to run STAR-Fusion caller
-keywords:
-  - downoad
-tools:
-  - star-fusion:
-      description: Fusion calling algorithm for RNAseq data
-      homepage: https://github.com/STAR-Fusion/
-      documentation: https://github.com/STAR-Fusion/STAR-Fusion/wiki/installing-star-fusion
-      tool_dev_url: https://github.com/STAR-Fusion/STAR-Fusion
-      doi: "10.1186/s13059-019-1842-9"
-      licence: ["GPL v3"]
-
-output:
-  - reference:
-      type: directory
-      description: Genome resource path
-      pattern: "star-fusion-genome"
-  - gtf:
-      type: file
-      description: genome gtf file
-      pattern: "*.{gtf}"
-
-authors:
-  - "@praveenraj2018,@rannick"