diff --git a/CHANGELOG.md b/CHANGELOG.md
index c40c613c..612e0ea1 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -28,6 +28,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 - Fix channel i/o issue in StringTie workflow and add StringTie in github CI tests [#416](https://github.com/nf-core/rnafusion/pull/416)
 - Updated COSMIC database to fix 404 error while downloading fusionreport references [#420](https://github.com/nf-core/rnafusion/pull/420)
+- Add 'when' condition to run collectinsertsize [#444](https://github.com/nf-core/rnafusion/pull/444)
 
 ### Removed
 
diff --git a/conf/modules.config b/conf/modules.config
index 39135aa3..b7b5445c 100644
--- a/conf/modules.config
+++ b/conf/modules.config
@@ -165,6 +165,7 @@ process {
     }
 
     withName: PICARD_COLLECTINSERTSIZEMETRICS {
+        ext.when         = { !params.skip_qc && !params.fusioninspector_only && (params.starfusion || params.all) }
         ext.prefix       = { "${meta.id}_collectinsertsize"}
         publishDir = [
             path: { "${params.outdir}/picard" },