diff --git a/lib/_http_outgoing.js b/lib/_http_outgoing.js
index 5350c08d4ce75d..b512c7f60f9dee 100644
--- a/lib/_http_outgoing.js
+++ b/lib/_http_outgoing.js
@@ -728,8 +728,27 @@ OutgoingMessage.prototype.setHeaders = function setHeaders(headers) {
     throw new ERR_INVALID_ARG_TYPE('headers', ['Headers', 'Map'], headers);
   }
 
-  for (const key of headers.keys()) {
-    this.setHeader(key, headers.get(key));
+  // Headers object joins multiple cookies with a comma when using
+  // the getter to retrieve the value,
+  // unless iterating over the headers directly.
+  // We also cannot safely split by comma.
+  // To avoid setHeader owerwriting the previous value we push
+  // set-cookie values in array and set them all at once.
+  const cookies = [];
+
+  for (const { 0: key, 1: value } of headers) {
+    if (key === 'set-cookie') {
+      if (ArrayIsArray(value)) {
+        cookies.push(...value);
+      } else {
+        cookies.push(value);
+      }
+      continue;
+    }
+    this.setHeader(key, value);
+  }
+  if (cookies.length) {
+    this.setHeader('set-cookie', cookies);
   }
 
   return this;
diff --git a/test/parallel/test-http-response-setheaders.js b/test/parallel/test-http-response-setheaders.js
index c1f697fa5d6cfe..2f52c54a49760f 100644
--- a/test/parallel/test-http-response-setheaders.js
+++ b/test/parallel/test-http-response-setheaders.js
@@ -129,3 +129,46 @@ const assert = require('assert');
     });
   }));
 }
+
+{
+  const server = http.createServer({ requireHostHeader: false }, common.mustCall((req, res) => {
+    const headers = new Headers();
+    headers.append('Set-Cookie', 'a=b');
+    headers.append('Set-Cookie', 'c=d');
+    res.setHeaders(headers);
+    res.end();
+  }));
+
+  server.listen(0, common.mustCall(() => {
+    http.get({ port: server.address().port }, (res) => {
+      assert(Array.isArray(res.headers['set-cookie']));
+      assert.strictEqual(res.headers['set-cookie'].length, 2);
+      assert.strictEqual(res.headers['set-cookie'][0], 'a=b');
+      assert.strictEqual(res.headers['set-cookie'][1], 'c=d');
+      res.resume().on('end', common.mustCall(() => {
+        server.close();
+      }));
+    });
+  }));
+}
+
+{
+  const server = http.createServer({ requireHostHeader: false }, common.mustCall((req, res) => {
+    const headers = new Map();
+    headers.set('Set-Cookie', ['a=b', 'c=d']);
+    res.setHeaders(headers);
+    res.end();
+  }));
+
+  server.listen(0, common.mustCall(() => {
+    http.get({ port: server.address().port }, (res) => {
+      assert(Array.isArray(res.headers['set-cookie']));
+      assert.strictEqual(res.headers['set-cookie'].length, 2);
+      assert.strictEqual(res.headers['set-cookie'][0], 'a=b');
+      assert.strictEqual(res.headers['set-cookie'][1], 'c=d');
+      res.resume().on('end', common.mustCall(() => {
+        server.close();
+      }));
+    });
+  }));
+}