diff --git a/src/node_contextify.cc b/src/node_contextify.cc
index ec0f68671301d0..85cdd4b3e74163 100644
--- a/src/node_contextify.cc
+++ b/src/node_contextify.cc
@@ -1468,6 +1468,7 @@ void ContextifyContext::ContainsModuleSyntax(
       String::NewFromUtf8(isolate, "__dirname").ToLocalChecked()};
 
   TryCatchScope try_catch(env);
+  ShouldNotAbortOnUncaughtScope no_abort_scope(env);
 
   ContextifyContext::CompileFunctionAndCacheResult(env,
                                                    context,
diff --git a/test/es-module/test-esm-detect-ambiguous.mjs b/test/es-module/test-esm-detect-ambiguous.mjs
index 34c5f17f007c8f..43537f26f5304a 100644
--- a/test/es-module/test-esm-detect-ambiguous.mjs
+++ b/test/es-module/test-esm-detect-ambiguous.mjs
@@ -235,3 +235,23 @@ describe('--experimental-detect-module', { concurrency: true }, () => {
     }
   });
 });
+
+// Validate temporarily disabling `--abort-on-uncaught-exception`
+// while running `containsModuleSyntax`.
+// Ref: https://github.com/nodejs/node/issues/50878
+describe('Wrapping a `require` of an ES module while using `--abort-on-uncaught-exception`', () => {
+  it('should work', async () => {
+    const { code, signal, stdout, stderr } = await spawnPromisified(process.execPath, [
+      '--abort-on-uncaught-exception',
+      '--eval',
+      'assert.throws(() => require("./package-type-module/esm.js"), { code: "ERR_REQUIRE_ESM" })',
+    ], {
+      cwd: fixtures.path('es-modules'),
+    });
+
+    strictEqual(stderr, '');
+    strictEqual(stdout, '');
+    strictEqual(code, 0);
+    strictEqual(signal, null);
+  });
+});