diff --git a/src/node_crypto.cc b/src/node_crypto.cc
index 78acf6d3972b41..8d7603ecb28c4e 100644
--- a/src/node_crypto.cc
+++ b/src/node_crypto.cc
@@ -235,8 +235,6 @@ static X509_NAME *cnnic_ev_name =
     d2i_X509_NAME(nullptr, &cnnic_ev_p,
                   sizeof(CNNIC_EV_ROOT_CA_SUBJECT_DATA)-1);
 
-static Mutex* mutexes;
-
 static const char* const root_certs[] = {
 #include "node_root_certs.h"  // NOLINT(build/include_order)
 };
@@ -303,6 +301,9 @@ template int SSLWrap<TLSWrap>::SelectALPNCallback(
     void* arg);
 #endif  // TLSEXT_TYPE_application_layer_protocol_negotiation
 
+#if OPENSSL_VERSION_NUMBER < 0x10100000L
+static Mutex* mutexes;
+
 static void crypto_threadid_cb(CRYPTO_THREADID* tid) {
   static_assert(sizeof(uv_thread_t) <= sizeof(void*),
                 "uv_thread_t does not fit in a pointer");
@@ -325,6 +326,7 @@ static void crypto_lock_cb(int mode, int n, const char* file, int line) {
   else
     mutex->Unlock();
 }
+#endif
 
 
 static int PasswordCallback(char *buf, int size, int rwflag, void *u) {
@@ -6162,9 +6164,11 @@ void InitCryptoOnce() {
   SSL_library_init();
   OpenSSL_add_all_algorithms();
 
+#if OPENSSL_VERSION_NUMBER < 0x10100000L
   crypto_lock_init();
   CRYPTO_set_locking_callback(crypto_lock_cb);
   CRYPTO_THREADID_set_callback(crypto_threadid_cb);
+#endif
 
 #ifdef NODE_FIPS_MODE
   /* Override FIPS settings in cnf file, if needed. */