diff --git a/src/env.cc b/src/env.cc
index 7d76ee8186ad28..eeab8711e3a512 100644
--- a/src/env.cc
+++ b/src/env.cc
@@ -42,11 +42,13 @@ using v8::NewStringType;
 using v8::Number;
 using v8::Object;
 using v8::Private;
+using v8::Script;
 using v8::SnapshotCreator;
 using v8::StackTrace;
 using v8::String;
 using v8::Symbol;
 using v8::TracingController;
+using v8::TryCatch;
 using v8::Undefined;
 using v8::Value;
 using worker::Worker;
@@ -394,7 +396,30 @@ Environment::Environment(IsolateData* isolate_data,
 }
 
 Environment::~Environment() {
-  if (interrupt_data_ != nullptr) *interrupt_data_ = nullptr;
+  if (Environment** interrupt_data = interrupt_data_.load()) {
+    // There are pending RequestInterrupt() callbacks. Tell them not to run,
+    // then force V8 to run interrupts by compiling and running an empty script
+    // so as not to leak memory.
+    *interrupt_data = nullptr;
+
+    Isolate::AllowJavascriptExecutionScope allow_js_here(isolate());
+    HandleScope handle_scope(isolate());
+    TryCatch try_catch(isolate());
+    Context::Scope context_scope(context());
+
+#ifdef DEBUG
+    bool consistency_check = false;
+    isolate()->RequestInterrupt([](Isolate*, void* data) {
+      *static_cast<bool*>(data) = true;
+    }, &consistency_check);
+#endif
+
+    Local<Script> script;
+    if (Script::Compile(context(), String::Empty(isolate())).ToLocal(&script))
+      USE(script->Run(context()));
+
+    DCHECK(consistency_check);
+  }
 
   // FreeEnvironment() should have set this.
   CHECK(is_stopping());
@@ -735,12 +760,23 @@ void Environment::RunAndClearNativeImmediates(bool only_refed) {
 }
 
 void Environment::RequestInterruptFromV8() {
-  if (interrupt_data_ != nullptr) return;  // Already scheduled.
-
   // The Isolate may outlive the Environment, so some logic to handle the
   // situation in which the Environment is destroyed before the handler runs
   // is required.
-  interrupt_data_ = new Environment*(this);
+
+  // We allocate a new pointer to a pointer to this Environment instance, and
+  // try to set it as interrupt_data_. If interrupt_data_ was already set, then
+  // callbacks are already scheduled to run and we can delete our own pointer
+  // and just return. If it was nullptr previously, the Environment** is stored;
+  // ~Environment sets the Environment* contained in it to nullptr, so that
+  // the callback can check whether ~Environment has already run and it is thus
+  // not safe to access the Environment instance itself.
+  Environment** interrupt_data = new Environment*(this);
+  Environment** dummy = nullptr;
+  if (!interrupt_data_.compare_exchange_strong(dummy, interrupt_data)) {
+    delete interrupt_data;
+    return;  // Already scheduled.
+  }
 
   isolate()->RequestInterrupt([](Isolate* isolate, void* data) {
     std::unique_ptr<Environment*> env_ptr { static_cast<Environment**>(data) };
@@ -751,9 +787,9 @@ void Environment::RequestInterruptFromV8() {
       // handled during cleanup.
       return;
     }
-    env->interrupt_data_ = nullptr;
+    env->interrupt_data_.store(nullptr);
     env->RunAndClearInterrupts();
-  }, interrupt_data_);
+  }, interrupt_data);
 }
 
 void Environment::ScheduleTimer(int64_t duration_ms) {
diff --git a/src/env.h b/src/env.h
index 719aca19a13803..a3df37250d4674 100644
--- a/src/env.h
+++ b/src/env.h
@@ -1256,6 +1256,9 @@ class Environment : public MemoryRetainer {
 
   inline void set_main_utf16(std::unique_ptr<v8::String::Value>);
 
+  void RunAndClearNativeImmediates(bool only_refed = false);
+  void RunAndClearInterrupts();
+
  private:
   template <typename Fn>
   inline void CreateImmediate(Fn&& cb, bool ref);
@@ -1440,9 +1443,7 @@ class Environment : public MemoryRetainer {
   // yet or already have been destroyed.
   bool task_queues_async_initialized_ = false;
 
-  void RunAndClearNativeImmediates(bool only_refed = false);
-  void RunAndClearInterrupts();
-  Environment** interrupt_data_ = nullptr;
+  std::atomic<Environment**> interrupt_data_ {nullptr};
   void RequestInterruptFromV8();
   static void CheckImmediate(uv_check_t* handle);
 
diff --git a/src/inspector/main_thread_interface.cc b/src/inspector/main_thread_interface.cc
index 48a964d564fec2..a15cd52d239e40 100644
--- a/src/inspector/main_thread_interface.cc
+++ b/src/inspector/main_thread_interface.cc
@@ -1,5 +1,6 @@
 #include "main_thread_interface.h"
 
+#include "env-inl.h"
 #include "node_mutex.h"
 #include "v8-inspector.h"
 #include "util-inl.h"
@@ -85,19 +86,6 @@ class CallRequest : public Request {
   Fn fn_;
 };
 
-class DispatchMessagesTask : public v8::Task {
- public:
-  explicit DispatchMessagesTask(std::weak_ptr<MainThreadInterface> thread)
-                                : thread_(thread) {}
-
-  void Run() override {
-    if (auto thread = thread_.lock()) thread->DispatchMessages();
-  }
-
- private:
-  std::weak_ptr<MainThreadInterface> thread_;
-};
-
 template <typename T>
 class AnotherThreadObjectReference {
  public:
@@ -212,12 +200,7 @@ class ThreadSafeDelegate : public InspectorSessionDelegate {
 }  // namespace
 
 
-MainThreadInterface::MainThreadInterface(Agent* agent, uv_loop_t* loop,
-                                         v8::Isolate* isolate,
-                                         v8::Platform* platform)
-                                         : agent_(agent), isolate_(isolate),
-                                           platform_(platform) {
-}
+MainThreadInterface::MainThreadInterface(Agent* agent) : agent_(agent) {}
 
 MainThreadInterface::~MainThreadInterface() {
   if (handle_)
@@ -225,23 +208,15 @@ MainThreadInterface::~MainThreadInterface() {
 }
 
 void MainThreadInterface::Post(std::unique_ptr<Request> request) {
+  CHECK_NOT_NULL(agent_);
   Mutex::ScopedLock scoped_lock(requests_lock_);
   bool needs_notify = requests_.empty();
   requests_.push_back(std::move(request));
   if (needs_notify) {
-    if (isolate_ != nullptr && platform_ != nullptr) {
-      std::shared_ptr<v8::TaskRunner> taskrunner =
-          platform_->GetForegroundTaskRunner(isolate_);
-      std::weak_ptr<MainThreadInterface>* interface_ptr =
-          new std::weak_ptr<MainThreadInterface>(shared_from_this());
-      taskrunner->PostTask(
-          std::make_unique<DispatchMessagesTask>(*interface_ptr));
-      isolate_->RequestInterrupt([](v8::Isolate* isolate, void* opaque) {
-        std::unique_ptr<std::weak_ptr<MainThreadInterface>> interface_ptr {
-          static_cast<std::weak_ptr<MainThreadInterface>*>(opaque) };
-        if (auto iface = interface_ptr->lock()) iface->DispatchMessages();
-      }, static_cast<void*>(interface_ptr));
-    }
+    std::weak_ptr<MainThreadInterface> weak_self {shared_from_this()};
+    agent_->env()->RequestInterrupt([weak_self](Environment*) {
+      if (auto iface = weak_self.lock()) iface->DispatchMessages();
+    });
   }
   incoming_message_cond_.Broadcast(scoped_lock);
 }
@@ -274,7 +249,7 @@ void MainThreadInterface::DispatchMessages() {
       std::swap(dispatching_message_queue_.front(), task);
       dispatching_message_queue_.pop_front();
 
-      v8::SealHandleScope seal_handle_scope(isolate_);
+      v8::SealHandleScope seal_handle_scope(agent_->env()->isolate());
       task->Call(this);
     }
   } while (had_messages);
diff --git a/src/inspector/main_thread_interface.h b/src/inspector/main_thread_interface.h
index 78337a25e43808..3ec5b3db3e1600 100644
--- a/src/inspector/main_thread_interface.h
+++ b/src/inspector/main_thread_interface.h
@@ -72,8 +72,7 @@ class MainThreadHandle : public std::enable_shared_from_this<MainThreadHandle> {
 class MainThreadInterface :
     public std::enable_shared_from_this<MainThreadInterface> {
  public:
-  MainThreadInterface(Agent* agent, uv_loop_t*, v8::Isolate* isolate,
-                      v8::Platform* platform);
+  explicit MainThreadInterface(Agent* agent);
   ~MainThreadInterface();
 
   void DispatchMessages();
@@ -98,8 +97,6 @@ class MainThreadInterface :
   ConditionVariable incoming_message_cond_;
   // Used from any thread
   Agent* const agent_;
-  v8::Isolate* const isolate_;
-  v8::Platform* const platform_;
   std::shared_ptr<MainThreadHandle> handle_;
   std::unordered_map<int, std::unique_ptr<Deletable>> managed_objects_;
 };
diff --git a/src/inspector_agent.cc b/src/inspector_agent.cc
index b7ccf641c299f5..74b7fc13cde4c0 100644
--- a/src/inspector_agent.cc
+++ b/src/inspector_agent.cc
@@ -47,7 +47,6 @@ using v8::Message;
 using v8::Object;
 using v8::String;
 using v8::Task;
-using v8::TaskRunner;
 using v8::Value;
 
 using v8_inspector::StringBuffer;
@@ -63,18 +62,6 @@ static std::atomic_bool start_io_thread_async_initialized { false };
 // Protects the Agent* stored in start_io_thread_async.data.
 static Mutex start_io_thread_async_mutex;
 
-class StartIoTask : public Task {
- public:
-  explicit StartIoTask(Agent* agent) : agent(agent) {}
-
-  void Run() override {
-    agent->StartIoThread();
-  }
-
- private:
-  Agent* agent;
-};
-
 std::unique_ptr<StringBuffer> ToProtocolString(Isolate* isolate,
                                                Local<Value> value) {
   TwoByteValue buffer(isolate, value);
@@ -86,10 +73,6 @@ void StartIoThreadAsyncCallback(uv_async_t* handle) {
   static_cast<Agent*>(handle->data)->StartIoThread();
 }
 
-void StartIoInterrupt(Isolate* isolate, void* agent) {
-  static_cast<Agent*>(agent)->StartIoThread();
-}
-
 
 #ifdef __POSIX__
 static void StartIoThreadWakeup(int signo, siginfo_t* info, void* ucontext) {
@@ -357,32 +340,26 @@ class InspectorTimer {
     int64_t interval_ms = 1000 * interval_s;
     uv_timer_start(&timer_, OnTimer, interval_ms, interval_ms);
     timer_.data = this;
-
-    env->AddCleanupHook(CleanupHook, this);
   }
 
   InspectorTimer(const InspectorTimer&) = delete;
 
   void Stop() {
-    env_->RemoveCleanupHook(CleanupHook, this);
+    if (timer_.data == nullptr) return;
 
-    if (timer_.data == this) {
-      timer_.data = nullptr;
-      uv_timer_stop(&timer_);
-      env_->CloseHandle(reinterpret_cast<uv_handle_t*>(&timer_), TimerClosedCb);
-    }
+    timer_.data = nullptr;
+    uv_timer_stop(&timer_);
+    env_->CloseHandle(reinterpret_cast<uv_handle_t*>(&timer_), TimerClosedCb);
   }
 
+  inline Environment* env() const { return env_; }
+
  private:
   static void OnTimer(uv_timer_t* uvtimer) {
     InspectorTimer* timer = node::ContainerOf(&InspectorTimer::timer_, uvtimer);
     timer->callback_(timer->data_);
   }
 
-  static void CleanupHook(void* data) {
-    static_cast<InspectorTimer*>(data)->Stop();
-  }
-
   static void TimerClosedCb(uv_handle_t* uvtimer) {
     std::unique_ptr<InspectorTimer> timer(
         node::ContainerOf(&InspectorTimer::timer_,
@@ -405,16 +382,29 @@ class InspectorTimerHandle {
   InspectorTimerHandle(Environment* env, double interval_s,
                        V8InspectorClient::TimerCallback callback, void* data) {
     timer_ = new InspectorTimer(env, interval_s, callback, data);
+
+    env->AddCleanupHook(CleanupHook, this);
   }
 
   InspectorTimerHandle(const InspectorTimerHandle&) = delete;
 
   ~InspectorTimerHandle() {
-    CHECK_NOT_NULL(timer_);
-    timer_->Stop();
-    timer_ = nullptr;
+    Stop();
   }
+
  private:
+  void Stop() {
+    if (timer_ != nullptr) {
+      timer_->env()->RemoveCleanupHook(CleanupHook, this);
+      timer_->Stop();
+    }
+    timer_ = nullptr;
+  }
+
+  static void CleanupHook(void* data) {
+    static_cast<InspectorTimerHandle*>(data)->Stop();
+  }
+
   InspectorTimer* timer_;
 };
 
@@ -672,8 +662,7 @@ class NodeInspectorClient : public V8InspectorClient {
   std::shared_ptr<MainThreadHandle> getThreadHandle() {
     if (!interface_) {
       interface_ = std::make_shared<MainThreadInterface>(
-          env_->inspector_agent(), env_->event_loop(), env_->isolate(),
-          env_->isolate_data()->platform());
+          env_->inspector_agent());
     }
     return interface_->GetHandle();
   }
@@ -709,10 +698,9 @@ class NodeInspectorClient : public V8InspectorClient {
 
     running_nested_loop_ = true;
 
-    MultiIsolatePlatform* platform = env_->isolate_data()->platform();
     while (shouldRunMessageLoop()) {
       if (interface_) interface_->WaitForFrontendEvent();
-      while (platform->FlushForegroundTasks(env_->isolate())) {}
+      env_->RunAndClearInterrupts();
     }
     running_nested_loop_ = false;
   }
@@ -737,8 +725,9 @@ class NodeInspectorClient : public V8InspectorClient {
   bool is_main_;
   bool running_nested_loop_ = false;
   std::unique_ptr<V8Inspector> client_;
-  std::unordered_map<int, std::unique_ptr<ChannelImpl>> channels_;
+  // Note: ~ChannelImpl may access timers_ so timers_ has to come first.
   std::unordered_map<void*, InspectorTimerHandle> timers_;
+  std::unordered_map<int, std::unique_ptr<ChannelImpl>> channels_;
   int next_session_id_ = 1;
   bool waiting_for_resume_ = false;
   bool waiting_for_frontend_ = false;
@@ -970,12 +959,10 @@ void Agent::RequestIoThreadStart() {
   // for IO events)
   CHECK(start_io_thread_async_initialized);
   uv_async_send(&start_io_thread_async);
-  Isolate* isolate = parent_env_->isolate();
-  v8::Platform* platform = parent_env_->isolate_data()->platform();
-  std::shared_ptr<TaskRunner> taskrunner =
-    platform->GetForegroundTaskRunner(isolate);
-  taskrunner->PostTask(std::make_unique<StartIoTask>(this));
-  isolate->RequestInterrupt(StartIoInterrupt, this);
+  parent_env_->RequestInterrupt([this](Environment*) {
+    StartIoThread();
+  });
+
   CHECK(start_io_thread_async_initialized);
   uv_async_send(&start_io_thread_async);
 }
diff --git a/src/inspector_agent.h b/src/inspector_agent.h
index 089077370db049..efd090c49b4311 100644
--- a/src/inspector_agent.h
+++ b/src/inspector_agent.h
@@ -116,6 +116,8 @@ class Agent {
   // Interface for interacting with inspectors in worker threads
   std::shared_ptr<WorkerManager> GetWorkerManager();
 
+  inline Environment* env() const { return parent_env_; }
+
  private:
   void ToggleAsyncHook(v8::Isolate* isolate,
                        const v8::Global<v8::Function>& fn);
diff --git a/src/inspector_js_api.cc b/src/inspector_js_api.cc
index ed3b36ad5ca80e..5c9ad5e946424b 100644
--- a/src/inspector_js_api.cc
+++ b/src/inspector_js_api.cc
@@ -84,7 +84,7 @@ class JSBindingsConnection : public AsyncWrap {
 
    private:
     Environment* env_;
-    JSBindingsConnection* connection_;
+    BaseObjectPtr<JSBindingsConnection> connection_;
   };
 
   JSBindingsConnection(Environment* env,
diff --git a/test/parallel/test-inspector-connect-main-thread.js b/test/parallel/test-inspector-connect-main-thread.js
index bb21a54e90f1d1..be34981cd0c5be 100644
--- a/test/parallel/test-inspector-connect-main-thread.js
+++ b/test/parallel/test-inspector-connect-main-thread.js
@@ -76,6 +76,12 @@ function doConsoleLog(arrayBuffer) {
 // and do not interrupt the main code. Interrupting the code flow
 // can lead to unexpected behaviors.
 async function ensureListenerDoesNotInterrupt(session) {
+  // Make sure that the following code is not affected by the fact that it may
+  // run inside an inspector message callback, during which other inspector
+  // message callbacks (such as the one triggered by doConsoleLog()) would
+  // not be processed.
+  await new Promise(setImmediate);
+
   const currentTime = Date.now();
   let consoleLogHappened = false;
   session.once('Runtime.consoleAPICalled',