diff --git a/.chloggen/mx-psi_host.mac.yaml b/.chloggen/mx-psi_host.mac.yaml
new file mode 100755
index 000000000000..23b74d8d396c
--- /dev/null
+++ b/.chloggen/mx-psi_host.mac.yaml
@@ -0,0 +1,27 @@
+# Use this changelog template to create an entry for release notes.
+
+# One of 'breaking', 'deprecation', 'new_component', 'enhancement', 'bug_fix'
+change_type: enhancement
+
+# The name of the component, or a single word describing the area of concern, (e.g. filelogreceiver)
+component: resourcedetectionprocessor
+
+# A brief description of the change.  Surround your text with quotes ("") if it needs to start with a backtick (`).
+note: Add detection of host.mac to system detector.
+
+# Mandatory: One or more tracking issues related to the change. You can use the PR number here if no issue exists.
+issues: [29587]
+
+# (Optional) One or more lines of additional information to render under the primary note.
+# These lines will be padded with 2 spaces and then inserted directly into the document.
+# Use pipe (|) for multiline entries.
+subtext:
+
+# If your change doesn't affect end users or the exported elements of any package,
+# you should instead start your pull request title with [chore] or use the "Skip Changelog" label.
+# Optional: The change log or logs in which this entry should be included.
+# e.g. '[user]' or '[user, api]'
+# Include 'user' if the change is relevant to end users.
+# Include 'api' if there is a change to a library API.
+# Default: '[user]'
+change_logs: []
diff --git a/internal/metadataproviders/system/metadata.go b/internal/metadataproviders/system/metadata.go
index e97b79b2092a..116ba76d9bf6 100644
--- a/internal/metadataproviders/system/metadata.go
+++ b/internal/metadataproviders/system/metadata.go
@@ -66,6 +66,9 @@ type Provider interface {
 
 	// HostIPs returns the host's IP interfaces
 	HostIPs() ([]net.IP, error)
+
+	// HostMACs returns the host's MAC addresses
+	HostMACs() ([]net.HardwareAddr, error)
 }
 
 type systemMetadataProvider struct {
@@ -196,3 +199,20 @@ func (p systemMetadataProvider) HostIPs() (ips []net.IP, err error) {
 	}
 	return ips, err
 }
+
+func (p systemMetadataProvider) HostMACs() (macs []net.HardwareAddr, err error) {
+	ifaces, err := net.Interfaces()
+	if err != nil {
+		return nil, err
+	}
+
+	for _, iface := range ifaces {
+		// skip if the interface is down or is a loopback interface
+		if iface.Flags&net.FlagUp == 0 || iface.Flags&net.FlagLoopback != 0 {
+			continue
+		}
+
+		macs = append(macs, iface.HardwareAddr)
+	}
+	return macs, err
+}
diff --git a/processor/resourcedetectionprocessor/README.md b/processor/resourcedetectionprocessor/README.md
index 1e2deb0057ad..8937c1c7a740 100644
--- a/processor/resourcedetectionprocessor/README.md
+++ b/processor/resourcedetectionprocessor/README.md
@@ -49,6 +49,7 @@ Queries the host machine to retrieve the following resource attributes:
     * host.name
     * host.id
     * host.ip
+    * host.mac
     * host.cpu.vendor.id
     * host.cpu.family
     * host.cpu.model.id
diff --git a/processor/resourcedetectionprocessor/internal/system/internal/metadata/generated_config.go b/processor/resourcedetectionprocessor/internal/system/internal/metadata/generated_config.go
index 121383329fc0..e21708c5c6e3 100644
--- a/processor/resourcedetectionprocessor/internal/system/internal/metadata/generated_config.go
+++ b/processor/resourcedetectionprocessor/internal/system/internal/metadata/generated_config.go
@@ -34,6 +34,7 @@ type ResourceAttributesConfig struct {
 	HostCPUVendorID    ResourceAttributeConfig `mapstructure:"host.cpu.vendor.id"`
 	HostID             ResourceAttributeConfig `mapstructure:"host.id"`
 	HostIP             ResourceAttributeConfig `mapstructure:"host.ip"`
+	HostMac            ResourceAttributeConfig `mapstructure:"host.mac"`
 	HostName           ResourceAttributeConfig `mapstructure:"host.name"`
 	OsDescription      ResourceAttributeConfig `mapstructure:"os.description"`
 	OsType             ResourceAttributeConfig `mapstructure:"os.type"`
@@ -68,6 +69,9 @@ func DefaultResourceAttributesConfig() ResourceAttributesConfig {
 		HostIP: ResourceAttributeConfig{
 			Enabled: false,
 		},
+		HostMac: ResourceAttributeConfig{
+			Enabled: false,
+		},
 		HostName: ResourceAttributeConfig{
 			Enabled: true,
 		},
diff --git a/processor/resourcedetectionprocessor/internal/system/internal/metadata/generated_config_test.go b/processor/resourcedetectionprocessor/internal/system/internal/metadata/generated_config_test.go
index 22c74d9ed2f0..b3892d04ee88 100644
--- a/processor/resourcedetectionprocessor/internal/system/internal/metadata/generated_config_test.go
+++ b/processor/resourcedetectionprocessor/internal/system/internal/metadata/generated_config_test.go
@@ -34,6 +34,7 @@ func TestResourceAttributesConfig(t *testing.T) {
 				HostCPUVendorID:    ResourceAttributeConfig{Enabled: true},
 				HostID:             ResourceAttributeConfig{Enabled: true},
 				HostIP:             ResourceAttributeConfig{Enabled: true},
+				HostMac:            ResourceAttributeConfig{Enabled: true},
 				HostName:           ResourceAttributeConfig{Enabled: true},
 				OsDescription:      ResourceAttributeConfig{Enabled: true},
 				OsType:             ResourceAttributeConfig{Enabled: true},
@@ -51,6 +52,7 @@ func TestResourceAttributesConfig(t *testing.T) {
 				HostCPUVendorID:    ResourceAttributeConfig{Enabled: false},
 				HostID:             ResourceAttributeConfig{Enabled: false},
 				HostIP:             ResourceAttributeConfig{Enabled: false},
+				HostMac:            ResourceAttributeConfig{Enabled: false},
 				HostName:           ResourceAttributeConfig{Enabled: false},
 				OsDescription:      ResourceAttributeConfig{Enabled: false},
 				OsType:             ResourceAttributeConfig{Enabled: false},
diff --git a/processor/resourcedetectionprocessor/internal/system/internal/metadata/generated_resource.go b/processor/resourcedetectionprocessor/internal/system/internal/metadata/generated_resource.go
index 0391f5824501..b4470e936493 100644
--- a/processor/resourcedetectionprocessor/internal/system/internal/metadata/generated_resource.go
+++ b/processor/resourcedetectionprocessor/internal/system/internal/metadata/generated_resource.go
@@ -84,6 +84,13 @@ func (rb *ResourceBuilder) SetHostIP(val []any) {
 	}
 }
 
+// SetHostMac sets provided value as "host.mac" attribute.
+func (rb *ResourceBuilder) SetHostMac(val []any) {
+	if rb.config.HostMac.Enabled {
+		rb.res.Attributes().PutEmptySlice("host.mac").FromRaw(val)
+	}
+}
+
 // SetHostName sets provided value as "host.name" attribute.
 func (rb *ResourceBuilder) SetHostName(val string) {
 	if rb.config.HostName.Enabled {
diff --git a/processor/resourcedetectionprocessor/internal/system/internal/metadata/generated_resource_test.go b/processor/resourcedetectionprocessor/internal/system/internal/metadata/generated_resource_test.go
index 38e5c08065bb..2d9e2811c358 100644
--- a/processor/resourcedetectionprocessor/internal/system/internal/metadata/generated_resource_test.go
+++ b/processor/resourcedetectionprocessor/internal/system/internal/metadata/generated_resource_test.go
@@ -22,6 +22,7 @@ func TestResourceBuilder(t *testing.T) {
 			rb.SetHostCPUVendorID("host.cpu.vendor.id-val")
 			rb.SetHostID("host.id-val")
 			rb.SetHostIP([]any{"host.ip-item1", "host.ip-item2"})
+			rb.SetHostMac([]any{"host.mac-item1", "host.mac-item2"})
 			rb.SetHostName("host.name-val")
 			rb.SetOsDescription("os.description-val")
 			rb.SetOsType("os.type-val")
@@ -33,7 +34,7 @@ func TestResourceBuilder(t *testing.T) {
 			case "default":
 				assert.Equal(t, 2, res.Attributes().Len())
 			case "all_set":
-				assert.Equal(t, 12, res.Attributes().Len())
+				assert.Equal(t, 13, res.Attributes().Len())
 			case "none_set":
 				assert.Equal(t, 0, res.Attributes().Len())
 				return
@@ -86,6 +87,11 @@ func TestResourceBuilder(t *testing.T) {
 			if ok {
 				assert.EqualValues(t, []any{"host.ip-item1", "host.ip-item2"}, val.Slice().AsRaw())
 			}
+			val, ok = res.Attributes().Get("host.mac")
+			assert.Equal(t, test == "all_set", ok)
+			if ok {
+				assert.EqualValues(t, []any{"host.mac-item1", "host.mac-item2"}, val.Slice().AsRaw())
+			}
 			val, ok = res.Attributes().Get("host.name")
 			assert.True(t, ok)
 			if ok {
diff --git a/processor/resourcedetectionprocessor/internal/system/internal/metadata/testdata/config.yaml b/processor/resourcedetectionprocessor/internal/system/internal/metadata/testdata/config.yaml
index d258480c7b00..8bd597a02e25 100644
--- a/processor/resourcedetectionprocessor/internal/system/internal/metadata/testdata/config.yaml
+++ b/processor/resourcedetectionprocessor/internal/system/internal/metadata/testdata/config.yaml
@@ -19,6 +19,8 @@ all_set:
       enabled: true
     host.ip:
       enabled: true
+    host.mac:
+      enabled: true
     host.name:
       enabled: true
     os.description:
@@ -45,6 +47,8 @@ none_set:
       enabled: false
     host.ip:
       enabled: false
+    host.mac:
+      enabled: false
     host.name:
       enabled: false
     os.description:
diff --git a/processor/resourcedetectionprocessor/internal/system/metadata.yaml b/processor/resourcedetectionprocessor/internal/system/metadata.yaml
index 3b5acbcbef55..93de1f2f9d3c 100644
--- a/processor/resourcedetectionprocessor/internal/system/metadata.yaml
+++ b/processor/resourcedetectionprocessor/internal/system/metadata.yaml
@@ -27,6 +27,10 @@ resource_attributes:
     description: IP addresses for the host
     type: slice
     enabled: false
+  host.mac:
+    description: MAC addresses for the host
+    type: slice
+    enabled: false
   host.cpu.vendor.id:
     description: The host.cpu.vendor.id
     type: string
diff --git a/processor/resourcedetectionprocessor/internal/system/system.go b/processor/resourcedetectionprocessor/internal/system/system.go
index a62eab4287e7..7d46a902fdd3 100644
--- a/processor/resourcedetectionprocessor/internal/system/system.go
+++ b/processor/resourcedetectionprocessor/internal/system/system.go
@@ -7,7 +7,9 @@ import (
 	"context"
 	"errors"
 	"fmt"
+	"net"
 	"strconv"
+	"strings"
 
 	"github.com/shirou/gopsutil/v3/cpu"
 	"go.opentelemetry.io/collector/featuregate"
@@ -69,6 +71,17 @@ func NewDetector(p processor.CreateSettings, dcfg internal.DetectorConfig) (inte
 	}, nil
 }
 
+// toIEEERA converts a MAC address to IEEE RA format.
+// Per the spec: "MAC Addresses MUST be represented in IEEE RA hexadecimal form: as hyphen-separated
+// octets in uppercase hexadecimal form from most to least significant."
+// Golang returns MAC addresses as colon-separated octets in lowercase hexadecimal form from most
+// to least significant, so we need to:
+// - Replace colons with hyphens
+// - Convert to uppercase
+func toIEEERA(mac net.HardwareAddr) string {
+	return strings.ToUpper(strings.ReplaceAll(mac.String(), ":", "-"))
+}
+
 // Detect detects system metadata and returns a resource with the available ones
 func (d *Detector) Detect(ctx context.Context) (resource pcommon.Resource, schemaURL string, err error) {
 	var hostname string
@@ -94,6 +107,17 @@ func (d *Detector) Detect(ctx context.Context) (resource pcommon.Resource, schem
 		}
 	}
 
+	var hostMACAttribute []any
+	if d.cfg.ResourceAttributes.HostMac.Enabled {
+		hostMACs, errMACs := d.provider.HostMACs()
+		if errMACs != nil {
+			return pcommon.NewResource(), "", fmt.Errorf("failed to get host MAC addresses: %w", errMACs)
+		}
+		for _, mac := range hostMACs {
+			hostMACAttribute = append(hostMACAttribute, toIEEERA(mac))
+		}
+	}
+
 	osDescription, err := d.provider.OSDescription(ctx)
 	if err != nil {
 		return pcommon.NewResource(), "", fmt.Errorf("failed getting OS description: %w", err)
@@ -119,6 +143,7 @@ func (d *Detector) Detect(ctx context.Context) (resource pcommon.Resource, schem
 			}
 			d.rb.SetHostArch(hostArch)
 			d.rb.SetHostIP(hostIPAttribute)
+			d.rb.SetHostMac(hostMACAttribute)
 			d.rb.SetOsDescription(osDescription)
 			if len(cpuInfo) > 0 {
 				err = setHostCPUInfo(d, cpuInfo[0])
diff --git a/processor/resourcedetectionprocessor/internal/system/system_test.go b/processor/resourcedetectionprocessor/internal/system/system_test.go
index 497f134ddf8f..13c53071dde1 100644
--- a/processor/resourcedetectionprocessor/internal/system/system_test.go
+++ b/processor/resourcedetectionprocessor/internal/system/system_test.go
@@ -72,9 +72,17 @@ func (m *mockMetadata) HostIPs() ([]net.IP, error) {
 	return args.Get(0).([]net.IP), args.Error(1)
 }
 
+func (m *mockMetadata) HostMACs() ([]net.HardwareAddr, error) {
+	args := m.MethodCalled("HostMACs")
+	return args.Get(0).([]net.HardwareAddr), args.Error(1)
+}
+
 var (
 	testIPsAttribute = []any{"192.168.1.140", "fe80::abc2:4a28:737a:609e"}
 	testIPsAddresses = []net.IP{net.ParseIP(testIPsAttribute[0].(string)), net.ParseIP(testIPsAttribute[1].(string))}
+
+	testMACsAttribute = []any{"00-00-00-00-00-01", "DE-AD-BE-EF-00-00"}
+	testMACsAddresses = []net.HardwareAddr{{0x00, 0x00, 0x00, 0x00, 0x00, 0x01}, {0xDE, 0xAD, 0xBE, 0xEF, 0x00, 0x00}}
 )
 
 func TestNewDetector(t *testing.T) {
@@ -104,11 +112,34 @@ func TestNewDetector(t *testing.T) {
 	}
 }
 
+func TestToIEEERA(t *testing.T) {
+	tests := []struct {
+		addr     net.HardwareAddr
+		expected string
+	}{
+		{
+			addr:     testMACsAddresses[0],
+			expected: testMACsAttribute[0].(string),
+		},
+		{
+			addr:     testMACsAddresses[1],
+			expected: testMACsAttribute[1].(string),
+		},
+	}
+
+	for _, tt := range tests {
+		t.Run(tt.expected, func(t *testing.T) {
+			assert.Equal(t, tt.expected, toIEEERA(tt.addr))
+		})
+	}
+}
+
 func allEnabledConfig() metadata.ResourceAttributesConfig {
 	cfg := metadata.DefaultResourceAttributesConfig()
 	cfg.HostArch.Enabled = true
 	cfg.HostID.Enabled = true
 	cfg.HostIP.Enabled = true
+	cfg.HostMac.Enabled = true
 	cfg.OsDescription.Enabled = true
 	return cfg
 }
@@ -121,6 +152,7 @@ func TestDetectFQDNAvailable(t *testing.T) {
 	md.On("HostID").Return("2", nil)
 	md.On("HostArch").Return("amd64", nil)
 	md.On("HostIPs").Return(testIPsAddresses, nil)
+	md.On("HostMACs").Return(testMACsAddresses, nil)
 
 	detector := newTestDetector(md, []string{"dns"}, allEnabledConfig())
 	res, schemaURL, err := detector.Detect(context.Background())
@@ -135,6 +167,7 @@ func TestDetectFQDNAvailable(t *testing.T) {
 		conventions.AttributeHostID:        "2",
 		conventions.AttributeHostArch:      conventions.AttributeHostArchAMD64,
 		"host.ip":                          testIPsAttribute,
+		"host.mac":                         testMACsAttribute,
 	}
 
 	assert.Equal(t, expected, res.Attributes().AsRaw())
@@ -174,6 +207,7 @@ func TestEnableHostID(t *testing.T) {
 	mdHostname.On("HostID").Return("3", nil)
 	mdHostname.On("HostArch").Return("amd64", nil)
 	mdHostname.On("HostIPs").Return(testIPsAddresses, nil)
+	mdHostname.On("HostMACs").Return(testMACsAddresses, nil)
 
 	detector := newTestDetector(mdHostname, []string{"dns", "os"}, allEnabledConfig())
 	res, schemaURL, err := detector.Detect(context.Background())
@@ -188,6 +222,7 @@ func TestEnableHostID(t *testing.T) {
 		conventions.AttributeHostID:        "3",
 		conventions.AttributeHostArch:      conventions.AttributeHostArchAMD64,
 		"host.ip":                          testIPsAttribute,
+		"host.mac":                         testMACsAttribute,
 	}
 
 	assert.Equal(t, expected, res.Attributes().AsRaw())
@@ -201,6 +236,7 @@ func TestUseHostname(t *testing.T) {
 	mdHostname.On("HostID").Return("1", nil)
 	mdHostname.On("HostArch").Return("amd64", nil)
 	mdHostname.On("HostIPs").Return(testIPsAddresses, nil)
+	mdHostname.On("HostMACs").Return(testMACsAddresses, nil)
 
 	detector := newTestDetector(mdHostname, []string{"os"}, allEnabledConfig())
 	res, schemaURL, err := detector.Detect(context.Background())
@@ -215,6 +251,7 @@ func TestUseHostname(t *testing.T) {
 		conventions.AttributeHostID:        "1",
 		conventions.AttributeHostArch:      conventions.AttributeHostArchAMD64,
 		"host.ip":                          testIPsAttribute,
+		"host.mac":                         testMACsAttribute,
 	}
 
 	assert.Equal(t, expected, res.Attributes().AsRaw())
@@ -230,6 +267,7 @@ func TestDetectError(t *testing.T) {
 	mdFQDN.On("HostID").Return("", errors.New("err"))
 	mdFQDN.On("HostArch").Return("amd64", nil)
 	mdFQDN.On("HostIPs").Return(testIPsAddresses, nil)
+	mdFQDN.On("HostMACs").Return(testMACsAddresses, nil)
 
 	detector := newTestDetector(mdFQDN, []string{"dns"}, allEnabledConfig())
 	res, schemaURL, err := detector.Detect(context.Background())
@@ -245,6 +283,7 @@ func TestDetectError(t *testing.T) {
 	mdHostname.On("HostID").Return("", errors.New("err"))
 	mdHostname.On("HostArch").Return("amd64", nil)
 	mdHostname.On("HostIPs").Return(testIPsAddresses, nil)
+	mdHostname.On("HostMACs").Return(testMACsAddresses, nil)
 
 	detector = newTestDetector(mdHostname, []string{"os"}, allEnabledConfig())
 	res, schemaURL, err = detector.Detect(context.Background())
@@ -275,6 +314,7 @@ func TestDetectError(t *testing.T) {
 	mdHostID.On("HostID").Return("", errors.New("err"))
 	mdHostID.On("HostArch").Return("arm64", nil)
 	mdHostID.On("HostIPs").Return(testIPsAddresses, nil)
+	mdHostID.On("HostMACs").Return(testMACsAddresses, nil)
 
 	detector = newTestDetector(mdHostID, []string{"os"}, allEnabledConfig())
 	res, schemaURL, err = detector.Detect(context.Background())
@@ -286,6 +326,7 @@ func TestDetectError(t *testing.T) {
 		conventions.AttributeOSType:        "linux",
 		conventions.AttributeHostArch:      conventions.AttributeHostArchARM64,
 		"host.ip":                          testIPsAttribute,
+		"host.mac":                         testMACsAttribute,
 	}, res.Attributes().AsRaw())
 }