diff --git a/src/OpenTelemetry.Instrumentation.Http/CHANGELOG.md b/src/OpenTelemetry.Instrumentation.Http/CHANGELOG.md
index 2c22ca8c063..1a5041471bc 100644
--- a/src/OpenTelemetry.Instrumentation.Http/CHANGELOG.md
+++ b/src/OpenTelemetry.Instrumentation.Http/CHANGELOG.md
@@ -2,6 +2,9 @@
 
 ## Unreleased
 
+* Added `http.scheme` tag to tracing instrumentation.
+  ([#3464](https://github.com/open-telemetry/opentelemetry-dotnet/pull/3464))
+
 * [Breaking] Removes `SetHttpFlavor` option. "http.flavor" is
   now always automatically populated.
   To remove this tag, set "http.flavor" to null using `ActivityProcessor`.
diff --git a/src/OpenTelemetry.Instrumentation.Http/Implementation/HttpHandlerDiagnosticListener.cs b/src/OpenTelemetry.Instrumentation.Http/Implementation/HttpHandlerDiagnosticListener.cs
index 428cce5701f..549537080f9 100644
--- a/src/OpenTelemetry.Instrumentation.Http/Implementation/HttpHandlerDiagnosticListener.cs
+++ b/src/OpenTelemetry.Instrumentation.Http/Implementation/HttpHandlerDiagnosticListener.cs
@@ -111,6 +111,7 @@ public override void OnStartActivity(Activity activity, object payload)
                 ActivityInstrumentationHelper.SetActivitySourceProperty(activity, ActivitySource);
                 ActivityInstrumentationHelper.SetKindProperty(activity, ActivityKind.Client);
 
+                activity.SetTag(SemanticConventions.AttributeHttpScheme, request.RequestUri.Scheme);
                 activity.SetTag(SemanticConventions.AttributeHttpMethod, HttpTagHelper.GetNameForHttpMethod(request.Method));
                 activity.SetTag(SemanticConventions.AttributeHttpHost, HttpTagHelper.GetHostTagValueFromRequestUri(request.RequestUri));
                 activity.SetTag(SemanticConventions.AttributeHttpUrl, HttpTagHelper.GetUriTagValueFromRequestUri(request.RequestUri));
diff --git a/test/OpenTelemetry.Instrumentation.Http.Tests/HttpClientTests.netcore31.cs b/test/OpenTelemetry.Instrumentation.Http.Tests/HttpClientTests.netcore31.cs
index 43072c3c5f6..27db9e89fba 100644
--- a/test/OpenTelemetry.Instrumentation.Http.Tests/HttpClientTests.netcore31.cs
+++ b/test/OpenTelemetry.Instrumentation.Http.Tests/HttpClientTests.netcore31.cs
@@ -198,6 +198,7 @@ public async Task DebugIndividualTestAsync()
     ""spanStatus"": ""UNSET"",
     ""spanKind"": ""Client"",
     ""spanAttributes"": {
+      ""http.scheme"": ""http"",
       ""http.method"": ""GET"",
       ""http.host"": ""{host}:{port}"",
       ""http.status_code"": ""399"",
diff --git a/test/OpenTelemetry.Instrumentation.Http.Tests/http-out-test-cases.json b/test/OpenTelemetry.Instrumentation.Http.Tests/http-out-test-cases.json
index b938d83305d..aeae7bf8ade 100644
--- a/test/OpenTelemetry.Instrumentation.Http.Tests/http-out-test-cases.json
+++ b/test/OpenTelemetry.Instrumentation.Http.Tests/http-out-test-cases.json
@@ -7,6 +7,7 @@
     "spanStatus": "UNSET",
     "responseExpected": true,
     "spanAttributes": {
+      "http.scheme": "http",
       "http.method": "GET",
       "http.host": "{host}:{port}",
       "http.flavor": "2.0",
@@ -22,6 +23,7 @@
     "spanStatus": "UNSET",
     "responseExpected": true,
     "spanAttributes": {
+      "http.scheme": "http",
       "http.method": "POST",
       "http.host": "{host}:{port}",
       "http.flavor": "2.0",
@@ -38,6 +40,7 @@
     "spanStatus": "UNSET",
     "responseExpected": true,
     "spanAttributes": {
+      "http.scheme": "http",
       "http.method": "GET",
       "http.host": "{host}:{port}",
       "http.flavor": "2.0",
@@ -54,6 +57,7 @@
     "spanStatus": "UNSET",
     "responseExpected": true,
     "spanAttributes": {
+      "http.scheme": "http",
       "http.method": "GET",
       "http.host": "{host}:{port}",
       "http.flavor": "2.0",
@@ -70,6 +74,7 @@
     "spanStatus": "UNSET",
     "responseExpected": true,
     "spanAttributes": {
+      "http.scheme": "http",
       "http.method": "GET",
       "http.host": "{host}:{port}",
       "http.flavor": "2.0",
@@ -87,6 +92,7 @@
     "responseExpected": false,
     "recordException": false,
     "spanAttributes": {
+      "http.scheme": "https",
       "http.method": "GET",
       "http.host": "sdlfaldfjalkdfjlkajdflkajlsdjf.sdlkjafsdjfalfadslkf.com",
       "http.flavor": "2.0",
@@ -103,6 +109,7 @@
     "responseExpected": false,
     "recordException": true,
     "spanAttributes": {
+      "http.scheme": "https",
       "http.method": "GET",
       "http.host": "sdlfaldfjalkdfjlkajdflkajlsdjf.sdlkjafsdjfalfadslkf.com",
       "http.flavor": "2.0",
@@ -118,6 +125,7 @@
     "spanStatus": "UNSET",
     "responseExpected": true,
     "spanAttributes": {
+      "http.scheme": "http",
       "http.method": "GET",
       "http.host": "{host}:{port}",
       "http.flavor": "2.0",
@@ -134,6 +142,7 @@
     "spanStatus": "UNSET",
     "responseExpected": true,
     "spanAttributes": {
+      "http.scheme": "http",
       "http.method": "GET",
       "http.host": "{host}:{port}",
       "http.flavor": "2.0",
@@ -150,6 +159,7 @@
     "spanStatus": "UNSET",
     "responseExpected": true,
     "spanAttributes": {
+      "http.scheme": "http",
       "http.method": "GET",
       "http.host": "{host}:{port}",
       "http.flavor": "2.0",
@@ -166,6 +176,7 @@
     "spanStatus": "ERROR",
     "responseExpected": true,
     "spanAttributes": {
+      "http.scheme": "http",
       "http.method": "GET",
       "http.host": "{host}:{port}",
       "http.flavor": "2.0",
@@ -182,6 +193,7 @@
     "spanStatus": "ERROR",
     "responseExpected": true,
     "spanAttributes": {
+      "http.scheme": "http",
       "http.method": "GET",
       "http.host": "{host}:{port}",
       "http.flavor": "2.0",
@@ -198,6 +210,7 @@
     "spanStatus": "ERROR",
     "responseExpected": true,
     "spanAttributes": {
+      "http.scheme": "http",
       "http.method": "GET",
       "http.host": "{host}:{port}",
       "http.flavor": "2.0",
@@ -214,6 +227,7 @@
     "spanStatus": "ERROR",
     "responseExpected": true,
     "spanAttributes": {
+      "http.scheme": "http",
       "http.method": "GET",
       "http.host": "{host}:{port}",
       "http.flavor": "2.0",
@@ -230,6 +244,7 @@
     "spanStatus": "ERROR",
     "responseExpected": true,
     "spanAttributes": {
+      "http.scheme": "http",
       "http.method": "GET",
       "http.host": "{host}:{port}",
       "http.flavor": "2.0",
@@ -246,6 +261,7 @@
     "spanStatus": "ERROR",
     "responseExpected": true,
     "spanAttributes": {
+      "http.scheme": "http",
       "http.method": "GET",
       "http.host": "{host}:{port}",
       "http.flavor": "2.0",
@@ -262,6 +278,7 @@
     "spanStatus": "ERROR",
     "responseExpected": true,
     "spanAttributes": {
+      "http.scheme": "http",
       "http.method": "GET",
       "http.host": "{host}:{port}",
       "http.flavor": "2.0",
@@ -278,6 +295,7 @@
     "spanStatus": "ERROR",
     "responseExpected": true,
     "spanAttributes": {
+      "http.scheme": "http",
       "http.method": "GET",
       "http.host": "{host}:{port}",
       "http.flavor": "2.0",
@@ -294,6 +312,7 @@
     "spanStatus": "ERROR",
     "responseExpected": true,
     "spanAttributes": {
+      "http.scheme": "http",
       "http.method": "GET",
       "http.host": "{host}:{port}",
       "http.flavor": "2.0",
@@ -310,6 +329,7 @@
     "spanStatus": "UNSET",
     "responseExpected": true,
     "spanAttributes": {
+      "http.scheme": "http",
       "http.method": "GET",
       "http.host": "{host}:{port}",
       "http.flavor": "2.0",