diff --git a/build/Common.prod.props b/build/Common.prod.props
index 31bd091bfde..30d9a44af98 100644
--- a/build/Common.prod.props
+++ b/build/Common.prod.props
@@ -3,7 +3,12 @@
 
   <PropertyGroup>
     <!-- OmniSharp/VS Code requires TargetFrameworks to be in descending order for IntelliSense and analysis. -->
-    <DefaultTargetFrameworks>net6.0;netstandard2.0;net462</DefaultTargetFrameworks>
+    <TargetFrameworksForLibraries>net6.0;netstandard2.0;net462</TargetFrameworksForLibraries>
+    <TargetFrameworksForLibrariesExtended>net6.0;netstandard2.1;netstandard2.0;net462</TargetFrameworksForLibrariesExtended>
+    <TargetFrameworksForAspNetCoreInstrumentation>net7.0;net6.0;netstandard2.1;netstandard2.0</TargetFrameworksForAspNetCoreInstrumentation>
+    <TargetFrameworksForGrpcNetClientInstrumentation>net6.0;netstandard2.1;netstandard2.0</TargetFrameworksForGrpcNetClientInstrumentation>
+    <TargetFrameworksForPrometheusAspNetCore>net6.0</TargetFrameworksForPrometheusAspNetCore>
+
     <CodeAnalysisRuleSet>$(MSBuildThisFileDirectory)/OpenTelemetry.prod.ruleset</CodeAnalysisRuleSet>
     <RunApiCompat>true</RunApiCompat>
     <ApiCompatExcludeAttributeList>$(RepoRoot)\build\GlobalAttrExclusions.txt</ApiCompatExcludeAttributeList>
diff --git a/src/OpenTelemetry.Api.ProviderBuilderExtensions/OpenTelemetry.Api.ProviderBuilderExtensions.csproj b/src/OpenTelemetry.Api.ProviderBuilderExtensions/OpenTelemetry.Api.ProviderBuilderExtensions.csproj
index 3e615926d3c..d057d595f43 100644
--- a/src/OpenTelemetry.Api.ProviderBuilderExtensions/OpenTelemetry.Api.ProviderBuilderExtensions.csproj
+++ b/src/OpenTelemetry.Api.ProviderBuilderExtensions/OpenTelemetry.Api.ProviderBuilderExtensions.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk">
 
   <PropertyGroup>
-    <TargetFrameworks>$(DefaultTargetFrameworks)</TargetFrameworks>
+    <TargetFrameworks>$(TargetFrameworksForLibraries)</TargetFrameworks>
     <Description>Contains extensions to register OpenTelemetry in applications using Microsoft.Extensions.DependencyInjection</Description>
     <RootNamespace>OpenTelemetry</RootNamespace>
     <MinVerTagPrefix>core-</MinVerTagPrefix>
diff --git a/src/OpenTelemetry.Api/OpenTelemetry.Api.csproj b/src/OpenTelemetry.Api/OpenTelemetry.Api.csproj
index 9e79b2e4a20..27aa7389a8d 100644
--- a/src/OpenTelemetry.Api/OpenTelemetry.Api.csproj
+++ b/src/OpenTelemetry.Api/OpenTelemetry.Api.csproj
@@ -1,6 +1,6 @@
 <Project Sdk="Microsoft.NET.Sdk">
   <PropertyGroup>
-    <TargetFrameworks>$(DefaultTargetFrameworks)</TargetFrameworks>
+    <TargetFrameworks>$(TargetFrameworksForLibraries)</TargetFrameworks>
     <Description>OpenTelemetry .NET API</Description>
     <RootNamespace>OpenTelemetry</RootNamespace>
     <MinVerTagPrefix>core-</MinVerTagPrefix>
diff --git a/src/OpenTelemetry.Exporter.Console/OpenTelemetry.Exporter.Console.csproj b/src/OpenTelemetry.Exporter.Console/OpenTelemetry.Exporter.Console.csproj
index ec320fe746a..2cea6f1094d 100644
--- a/src/OpenTelemetry.Exporter.Console/OpenTelemetry.Exporter.Console.csproj
+++ b/src/OpenTelemetry.Exporter.Console/OpenTelemetry.Exporter.Console.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk">
 
   <PropertyGroup>
-    <TargetFrameworks>$(DefaultTargetFrameworks)</TargetFrameworks>
+    <TargetFrameworks>$(TargetFrameworksForLibraries)</TargetFrameworks>
     <Description>Console exporter for OpenTelemetry .NET</Description>
     <PackageTags>$(PackageTags);Console;distributed-tracing</PackageTags>
     <MinVerTagPrefix>core-</MinVerTagPrefix>
diff --git a/src/OpenTelemetry.Exporter.InMemory/OpenTelemetry.Exporter.InMemory.csproj b/src/OpenTelemetry.Exporter.InMemory/OpenTelemetry.Exporter.InMemory.csproj
index a9d886322c5..ca347c71baf 100644
--- a/src/OpenTelemetry.Exporter.InMemory/OpenTelemetry.Exporter.InMemory.csproj
+++ b/src/OpenTelemetry.Exporter.InMemory/OpenTelemetry.Exporter.InMemory.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk">
 
   <PropertyGroup>
-    <TargetFrameworks>$(DefaultTargetFrameworks)</TargetFrameworks>
+    <TargetFrameworks>$(TargetFrameworksForLibraries)</TargetFrameworks>
     <Description>In-memory exporter for OpenTelemetry .NET</Description>
     <PackageTags>$(PackageTags)</PackageTags>
     <MinVerTagPrefix>core-</MinVerTagPrefix>
diff --git a/src/OpenTelemetry.Exporter.OpenTelemetryProtocol/OpenTelemetry.Exporter.OpenTelemetryProtocol.csproj b/src/OpenTelemetry.Exporter.OpenTelemetryProtocol/OpenTelemetry.Exporter.OpenTelemetryProtocol.csproj
index ecd759f4ea6..54a0f27217b 100644
--- a/src/OpenTelemetry.Exporter.OpenTelemetryProtocol/OpenTelemetry.Exporter.OpenTelemetryProtocol.csproj
+++ b/src/OpenTelemetry.Exporter.OpenTelemetryProtocol/OpenTelemetry.Exporter.OpenTelemetryProtocol.csproj
@@ -1,6 +1,6 @@
 <Project Sdk="Microsoft.NET.Sdk">
   <PropertyGroup>
-    <TargetFrameworks>$(DefaultTargetFrameworks);netstandard2.1</TargetFrameworks>
+    <TargetFrameworks>$(TargetFrameworksForLibrariesExtended)</TargetFrameworks>
     <Description>OpenTelemetry protocol exporter for OpenTelemetry .NET</Description>
     <PackageTags>$(PackageTags);OTLP</PackageTags>
     <MinVerTagPrefix>core-</MinVerTagPrefix>
diff --git a/src/OpenTelemetry.Exporter.Prometheus.AspNetCore/OpenTelemetry.Exporter.Prometheus.AspNetCore.csproj b/src/OpenTelemetry.Exporter.Prometheus.AspNetCore/OpenTelemetry.Exporter.Prometheus.AspNetCore.csproj
index 9471eeda251..7806fffbd6b 100644
--- a/src/OpenTelemetry.Exporter.Prometheus.AspNetCore/OpenTelemetry.Exporter.Prometheus.AspNetCore.csproj
+++ b/src/OpenTelemetry.Exporter.Prometheus.AspNetCore/OpenTelemetry.Exporter.Prometheus.AspNetCore.csproj
@@ -2,7 +2,7 @@
 
   <PropertyGroup>
     <!-- OmniSharp/VS Code requires TargetFrameworks to be in descending order for IntelliSense and analysis. -->
-    <TargetFrameworks>net6.0</TargetFrameworks>
+    <TargetFrameworks>$(TargetFrameworksForPrometheusAspNetCore)</TargetFrameworks>
     <Description>ASP.NET Core middleware for hosting OpenTelemetry .NET Prometheus Exporter</Description>
     <PackageTags>$(PackageTags);prometheus;metrics</PackageTags>
     <MinVerTagPrefix>core-</MinVerTagPrefix>
diff --git a/src/OpenTelemetry.Exporter.Prometheus.HttpListener/OpenTelemetry.Exporter.Prometheus.HttpListener.csproj b/src/OpenTelemetry.Exporter.Prometheus.HttpListener/OpenTelemetry.Exporter.Prometheus.HttpListener.csproj
index 08e4db4cd66..5b88efbd6a8 100644
--- a/src/OpenTelemetry.Exporter.Prometheus.HttpListener/OpenTelemetry.Exporter.Prometheus.HttpListener.csproj
+++ b/src/OpenTelemetry.Exporter.Prometheus.HttpListener/OpenTelemetry.Exporter.Prometheus.HttpListener.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk">
 
   <PropertyGroup>
-    <TargetFrameworks>$(DefaultTargetFrameworks)</TargetFrameworks>
+    <TargetFrameworks>$(TargetFrameworksForLibraries)</TargetFrameworks>
     <Description>Stand-alone HttpListener for hosting OpenTelemetry .NET Prometheus Exporter</Description>
     <PackageTags>$(PackageTags);prometheus;metrics</PackageTags>
     <MinVerTagPrefix>core-</MinVerTagPrefix>
diff --git a/src/OpenTelemetry.Exporter.Zipkin/OpenTelemetry.Exporter.Zipkin.csproj b/src/OpenTelemetry.Exporter.Zipkin/OpenTelemetry.Exporter.Zipkin.csproj
index 0d60a5dbf66..82019e09793 100644
--- a/src/OpenTelemetry.Exporter.Zipkin/OpenTelemetry.Exporter.Zipkin.csproj
+++ b/src/OpenTelemetry.Exporter.Zipkin/OpenTelemetry.Exporter.Zipkin.csproj
@@ -1,6 +1,6 @@
 <Project Sdk="Microsoft.NET.Sdk">
   <PropertyGroup>
-    <TargetFrameworks>$(DefaultTargetFrameworks)</TargetFrameworks>
+    <TargetFrameworks>$(TargetFrameworksForLibraries)</TargetFrameworks>
     <Description>Zipkin exporter for OpenTelemetry .NET</Description>
     <PackageTags>$(PackageTags);Zipkin;distributed-tracing</PackageTags>
     <MinVerTagPrefix>core-</MinVerTagPrefix>
diff --git a/src/OpenTelemetry.Extensions.Hosting/OpenTelemetry.Extensions.Hosting.csproj b/src/OpenTelemetry.Extensions.Hosting/OpenTelemetry.Extensions.Hosting.csproj
index eb210ce5160..0d589aae7da 100644
--- a/src/OpenTelemetry.Extensions.Hosting/OpenTelemetry.Extensions.Hosting.csproj
+++ b/src/OpenTelemetry.Extensions.Hosting/OpenTelemetry.Extensions.Hosting.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk">
 
   <PropertyGroup>
-    <TargetFrameworks>$(DefaultTargetFrameworks)</TargetFrameworks>
+    <TargetFrameworks>$(TargetFrameworksForLibraries)</TargetFrameworks>
     <Description>Contains extensions to start OpenTelemetry in applications using Microsoft.Extensions.Hosting</Description>
     <RootNamespace>OpenTelemetry</RootNamespace>
     <MinVerTagPrefix>core-</MinVerTagPrefix>
diff --git a/src/OpenTelemetry.Extensions.Propagators/OpenTelemetry.Extensions.Propagators.csproj b/src/OpenTelemetry.Extensions.Propagators/OpenTelemetry.Extensions.Propagators.csproj
index 5e5f996440f..c099b609a25 100644
--- a/src/OpenTelemetry.Extensions.Propagators/OpenTelemetry.Extensions.Propagators.csproj
+++ b/src/OpenTelemetry.Extensions.Propagators/OpenTelemetry.Extensions.Propagators.csproj
@@ -1,6 +1,6 @@
 <Project Sdk="Microsoft.NET.Sdk">
   <PropertyGroup>
-    <TargetFrameworks>$(DefaultTargetFrameworks)</TargetFrameworks>
+    <TargetFrameworks>$(TargetFrameworksForLibraries)</TargetFrameworks>
     <Description>OpenTelemetry Extensions Propagators</Description>
     <PackageTags>$(PackageTags);distributed-tracing;AspNet;AspNetCore;B3</PackageTags>
     <MinVerTagPrefix>core-</MinVerTagPrefix>
diff --git a/src/OpenTelemetry.Instrumentation.AspNetCore/OpenTelemetry.Instrumentation.AspNetCore.csproj b/src/OpenTelemetry.Instrumentation.AspNetCore/OpenTelemetry.Instrumentation.AspNetCore.csproj
index b9ae2e4bf44..109de100083 100644
--- a/src/OpenTelemetry.Instrumentation.AspNetCore/OpenTelemetry.Instrumentation.AspNetCore.csproj
+++ b/src/OpenTelemetry.Instrumentation.AspNetCore/OpenTelemetry.Instrumentation.AspNetCore.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk">
   <PropertyGroup>
     <!-- OmniSharp/VS Code requires TargetFrameworks to be in descending order for IntelliSense and analysis. -->
-    <TargetFrameworks>net7.0;net6.0;netstandard2.1;netstandard2.0</TargetFrameworks>
+    <TargetFrameworks>$(TargetFrameworksForAspNetCoreInstrumentation)</TargetFrameworks>
     <Description>ASP.NET Core instrumentation for OpenTelemetry .NET</Description>
     <PackageTags>$(PackageTags);distributed-tracing;AspNetCore</PackageTags>
     <IncludeDiagnosticSourceInstrumentationHelpers>true</IncludeDiagnosticSourceInstrumentationHelpers>
diff --git a/src/OpenTelemetry.Instrumentation.GrpcNetClient/OpenTelemetry.Instrumentation.GrpcNetClient.csproj b/src/OpenTelemetry.Instrumentation.GrpcNetClient/OpenTelemetry.Instrumentation.GrpcNetClient.csproj
index ff59e02f645..268f230f60e 100644
--- a/src/OpenTelemetry.Instrumentation.GrpcNetClient/OpenTelemetry.Instrumentation.GrpcNetClient.csproj
+++ b/src/OpenTelemetry.Instrumentation.GrpcNetClient/OpenTelemetry.Instrumentation.GrpcNetClient.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk">
   <PropertyGroup>
     <!-- OmniSharp/VS Code requires TargetFrameworks to be in descending order for IntelliSense and analysis. -->
-    <TargetFrameworks>net6.0;netstandard2.1;netstandard2.0</TargetFrameworks>
+    <TargetFrameworks>$(TargetFrameworksForGrpcNetClientInstrumentation)</TargetFrameworks>
     <Description>gRPC for .NET client instrumentation for OpenTelemetry .NET</Description>
     <PackageTags>$(PackageTags);distributed-tracing</PackageTags>
     <IncludeDiagnosticSourceInstrumentationHelpers>true</IncludeDiagnosticSourceInstrumentationHelpers>
diff --git a/src/OpenTelemetry.Instrumentation.Http/OpenTelemetry.Instrumentation.Http.csproj b/src/OpenTelemetry.Instrumentation.Http/OpenTelemetry.Instrumentation.Http.csproj
index 8e7f24897b6..929203cbd7c 100644
--- a/src/OpenTelemetry.Instrumentation.Http/OpenTelemetry.Instrumentation.Http.csproj
+++ b/src/OpenTelemetry.Instrumentation.Http/OpenTelemetry.Instrumentation.Http.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk">
 
   <PropertyGroup>
-    <TargetFrameworks>$(DefaultTargetFrameworks)</TargetFrameworks>
+    <TargetFrameworks>$(TargetFrameworksForLibraries)</TargetFrameworks>
     <Description>Http instrumentation for OpenTelemetry .NET</Description>
     <PackageTags>$(PackageTags);distributed-tracing</PackageTags>
     <IncludeDiagnosticSourceInstrumentationHelpers>true</IncludeDiagnosticSourceInstrumentationHelpers>
diff --git a/src/OpenTelemetry.Instrumentation.SqlClient/OpenTelemetry.Instrumentation.SqlClient.csproj b/src/OpenTelemetry.Instrumentation.SqlClient/OpenTelemetry.Instrumentation.SqlClient.csproj
index 35e071a8f36..9f3d57184d3 100644
--- a/src/OpenTelemetry.Instrumentation.SqlClient/OpenTelemetry.Instrumentation.SqlClient.csproj
+++ b/src/OpenTelemetry.Instrumentation.SqlClient/OpenTelemetry.Instrumentation.SqlClient.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk">
 
   <PropertyGroup>
-    <TargetFrameworks>$(DefaultTargetFrameworks)</TargetFrameworks>
+    <TargetFrameworks>$(TargetFrameworksForLibraries)</TargetFrameworks>
     <Description>SqlClient instrumentation for OpenTelemetry .NET</Description>
     <PackageTags>$(PackageTags);distributed-tracing</PackageTags>
     <IncludeDiagnosticSourceInstrumentationHelpers>true</IncludeDiagnosticSourceInstrumentationHelpers>
diff --git a/src/OpenTelemetry.SemanticConventions/OpenTelemetry.SemanticConventions.csproj b/src/OpenTelemetry.SemanticConventions/OpenTelemetry.SemanticConventions.csproj
index ae1c5812fab..493987b395a 100644
--- a/src/OpenTelemetry.SemanticConventions/OpenTelemetry.SemanticConventions.csproj
+++ b/src/OpenTelemetry.SemanticConventions/OpenTelemetry.SemanticConventions.csproj
@@ -1,7 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk">
 
   <PropertyGroup>
-    <TargetFrameworks>$(DefaultTargetFrameworks)</TargetFrameworks>
+    <TargetFrameworks>$(TargetFrameworksForLibraries)</TargetFrameworks>
     <Description>OpenTelemetry Semantic Conventions</Description>
     <PackageTags>$(PackageTags);semantic-conventions</PackageTags>
   </PropertyGroup>
diff --git a/src/OpenTelemetry.Shims.OpenTracing/OpenTelemetry.Shims.OpenTracing.csproj b/src/OpenTelemetry.Shims.OpenTracing/OpenTelemetry.Shims.OpenTracing.csproj
index fb7dbe60a45..35295220a1f 100644
--- a/src/OpenTelemetry.Shims.OpenTracing/OpenTelemetry.Shims.OpenTracing.csproj
+++ b/src/OpenTelemetry.Shims.OpenTracing/OpenTelemetry.Shims.OpenTracing.csproj
@@ -1,6 +1,6 @@
 <Project Sdk="Microsoft.NET.Sdk">
   <PropertyGroup>
-    <TargetFrameworks>$(DefaultTargetFrameworks)</TargetFrameworks>
+    <TargetFrameworks>$(TargetFrameworksForLibraries)</TargetFrameworks>
     <Description>OpenTracing shim for OpenTelemetry .NET</Description>
     <PackageTags>$(PackageTags);distributed-tracing;OpenTracing</PackageTags>
     <IsPackable>true</IsPackable>
diff --git a/src/OpenTelemetry/OpenTelemetry.csproj b/src/OpenTelemetry/OpenTelemetry.csproj
index c7194e17c9f..45faafaec91 100644
--- a/src/OpenTelemetry/OpenTelemetry.csproj
+++ b/src/OpenTelemetry/OpenTelemetry.csproj
@@ -1,6 +1,6 @@
 <Project Sdk="Microsoft.NET.Sdk">
   <PropertyGroup>
-    <TargetFrameworks>$(DefaultTargetFrameworks);netstandard2.1</TargetFrameworks>
+    <TargetFrameworks>$(TargetFrameworksForLibrariesExtended)</TargetFrameworks>
     <Description>OpenTelemetry .NET SDK</Description>
     <MinVerTagPrefix>core-</MinVerTagPrefix>
   </PropertyGroup>