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bielefeld_pub_1591048.xml
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bielefeld_pub_1591048.xml
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<titleInfo>
<title>Mechanisms of after-hyperpolarization following activation of fly visual motion-sensitive neurons</title>
</titleInfo>
<name type="personal">
<namePart type="given">Rafael</namePart>
<namePart type="family">Kurtz</namePart>
<role>
<roleTerm type="code" authority="marcrelator">aut</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Ulrich</namePart>
<namePart type="family">Beckers</namePart>
<role>
<roleTerm type="code" authority="marcrelator">aut</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Benjamin</namePart>
<namePart type="family">Hundsdoerfer</namePart>
<role>
<roleTerm type="code" authority="marcrelator">aut</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Martin</namePart>
<namePart type="family">Egelhaaf</namePart>
<nameIdentifier type="orcid" typeURI="http://orcid.org">0000-0002-9336-4270</nameIdentifier>
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<roleTerm type="code" authority="marcrelator">aut</roleTerm>
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<typeOfResource>text</typeOfResource>
<genre authority="dini">article</genre>
<originInfo>
<dateIssued encoding="w3cdtf">2009</dateIssued>
</originInfo>
<language>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
</language>
<abstract lang="eng">In many neurons, strong excitatory stimulation causes an after-hyperpolarization (AHP) at stimulus offset, which might give rise to activity-dependent adaptation. Graded-potential visual motion-sensitive neurons of the fly Calliphora vicina respond with depolarization and hyperpolarization during motion in their preferred direction and their anti-preferred direction, respectively. A prominent after-response, opposite in sign to the response during motion, is selectively expressed after stimulation with preferred-direction motion. Previous findings suggested that this AHP is generated in the motion-sensitive neurons themselves rather than in presynaptic processing layers. However, it remained unknown whether the AHP is caused by membrane depolarization itself or by another process, e.g. a signaling cascade triggered by activity of excitatory input channels. Here we showed by current injections and voltage clamp that the AHP and a corresponding current are generated directly by depolarization. To test whether the generation of an AHP is linked to depolarization via a Ca(2+)-dependent mechanism, we used photoactivation of a high-affinity Ca(2+) buffer. In accordance with previous findings the AHP was insensitive to manipulation of cytosolic Ca(2+). We propose that membrane depolarization presents a more direction-selective mechanism for the control of AHP than other potential control parameters.</abstract>
<subject>
<topic>invertebrate</topic>
<topic>calcium</topic>
<topic>voltage clamp</topic>
<topic>adaptation</topic>
<topic>vision</topic>
</subject>
<classification authority="ddc">570</classification>
<relatedItem type="host">
<titleInfo>
<title>European Journal of Neuroscience</title>
</titleInfo>
<part>
<detail type="volume">
<number>30</number>
</detail>
<detail type="issue">
<number>4</number>
</detail>
<extent unit="page">
<start>567</start>
<end>577</end>
</extent>
</part>
</relatedItem>
<identifier type="issn">0953-816X</identifier>
<identifier type="eIssn">1460-9568</identifier>
<identifier type="MEDLINE">19674090</identifier>
<identifier type="ISI">000269263500005</identifier>
<identifier type="urn">urn:nbn:de:0070-pub-15910483</identifier>
<identifier type="doi">10.1111/j.1460-9568.2009.06854.x</identifier>
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