diff --git a/cdc/kv/client.go b/cdc/kv/client.go
index ef242276ea5..ed9ef4de9dc 100644
--- a/cdc/kv/client.go
+++ b/cdc/kv/client.go
@@ -611,12 +611,7 @@ MainLoop:
 			}
 
 			state := newRegionFeedState(sri, requestID)
-			hasOld := pendingRegions.insert(requestID, state)
-			if hasOld {
-				log.Error("region is already pending for the first response while trying to send another request."+
-					"region merge may have happened which is not supported yet",
-					zap.Uint64("regionID", sri.verID.GetID()), zap.Uint64("requestID", requestID))
-			}
+			pendingRegions.insert(requestID, state)
 
 			stream, ok := streams[rpcCtx.Addr]
 			// Establish the stream if it has not been connected yet.
@@ -624,10 +619,12 @@ MainLoop:
 				stream, err = s.client.newStream(ctx, rpcCtx.Addr)
 				if err != nil {
 					// if get stream failed, maybe the store is down permanently, we should try to relocate the active store
-					log.Warn("get grpc stream client failed", zap.Error(err))
+					log.Warn("get grpc stream client failed",
+						zap.Uint64("regionID", sri.verID.GetID()), zap.Uint64("requestID", requestID), zap.Error(err))
 					bo := tikv.NewBackoffer(ctx, tikvRequestMaxBackoff)
 					s.client.regionCache.OnSendFail(bo, rpcCtx, needReloadRegion(sri.failStoreIDs, rpcCtx), err)
-					// Retry connecting and sending the request.
+					// Delete the pendingRegion info from `pendingRegions` and retry connecting and sending the request.
+					pendingRegions.take(requestID)
 					continue
 				}
 				streams[rpcCtx.Addr] = stream
@@ -647,6 +644,7 @@ MainLoop:
 				log.Error("send request to stream failed",
 					zap.String("addr", rpcCtx.Addr),
 					zap.Uint64("storeID", getStoreID(rpcCtx)),
+					zap.Uint64("regionID", sri.verID.GetID()),
 					zap.Uint64("requestID", requestID),
 					zap.Error(err))
 				err1 := stream.CloseSend()
@@ -656,6 +654,11 @@ MainLoop:
 				// Delete the stream from the map so that the next time the store is accessed, the stream will be
 				// re-established.
 				delete(streams, rpcCtx.Addr)
+				// Delete `pendingRegions` from `storePendingRegions` so that the next time a region of this store is
+				// requested, it will create a new one. So if the `receiveFromStream` goroutine tries to stop all
+				// pending regions, the new pending regions that are requested after reconnecting won't be stopped
+				// incorrectly.
+				delete(storePendingRegions, rpcCtx.Addr)
 
 				// Remove the region from pendingRegions. If it's already removed, it should be already retried by
 				// `receiveFromStream`, so no need to retry here.
@@ -968,7 +971,7 @@ func (s *eventFeedSession) receiveFromStream(
 						zap.Uint64("regionID", event.RegionId),
 						zap.Uint64("requestID", event.RequestId),
 						zap.String("addr", addr))
-					return errors.Errorf("received event regionID %v, requestID %v from %v but neither pending"+
+					return errors.Errorf("received event regionID %v, requestID %v from %v but neither pending "+
 						"region nor running region was found", event.RegionId, event.RequestId, addr)
 				}