diff --git a/packages/python/plotly/plotly/express/_core.py b/packages/python/plotly/plotly/express/_core.py
index f4aa02cdc2..f5c3acb9c9 100644
--- a/packages/python/plotly/plotly/express/_core.py
+++ b/packages/python/plotly/plotly/express/_core.py
@@ -1955,10 +1955,37 @@ def make_figure(args, constructor, trace_patch=None, layout_patch=None):
     trace_specs, grouped_mappings, sizeref, show_colorbar = infer_config(
         args, constructor, trace_patch, layout_patch
     )
-    grouper = [x.grouper or one_group for x in grouped_mappings] or [one_group]
-    grouped = args["data_frame"].groupby(grouper, sort=False)
+    grouper_ = [x.grouper or one_group for x in grouped_mappings] or [one_group]
+
+    all_same_group = True  # variable indicating if grouping can be avoided
+    for g in grouper_:
+        if g is not one_group:
+            arr = args["data_frame"][g].values
+            all_same_group &= (arr[0] == arr).all(axis=0)
+        if not all_same_group:
+            break  # early stopping if not all the same
+
+    if all_same_group:
+        # Do not perform an expensive groupby operation when there are either
+        # no groups to group by, or when the group has only one (i.e., the same) value
+        grouper = [g for g in grouper_ if g is not one_group]
+        assert len(grouper) <= 1
+        # -> create orders, sorted_group_names equivalent to those of get_ordings
+        orders = {g: [args["data_frame"][g].iloc[0]] for g in grouper}
+        sorted_group_names = [tuple(args["data_frame"][g].iloc[0] for g in orders)]
+        if len(sorted_group_names):  # check for length to support also empty plots
+            assert len(sorted_group_names) == 1  # should be only for 1 variable
+            sorted_group_names = list(sorted_group_names[0])  # convert [tuple] to list
+            for idx in range(len(grouper_)):
+                # insert "" in the list when no grouping was used
+                if grouper_[idx] is one_group:
+                    sorted_group_names.insert(idx, "")
+            sorted_group_names = [tuple(sorted_group_names)]  # convert list to [tuple]
+    else:
+        grouper = grouper_
+        grouped = args["data_frame"].groupby(grouper, sort=False)
 
-    orders, sorted_group_names = get_orderings(args, grouper, grouped)
+        orders, sorted_group_names = get_orderings(args, grouper, grouped)
 
     col_labels = []
     row_labels = []
@@ -1988,7 +2015,13 @@ def make_figure(args, constructor, trace_patch=None, layout_patch=None):
     trace_name_labels = None
     facet_col_wrap = args.get("facet_col_wrap", 0)
     for group_name in sorted_group_names:
-        group = grouped.get_group(group_name if len(group_name) > 1 else group_name[0])
+        if all_same_group:
+            # No expensive get_group operation when all data from the same group
+            group = args["data_frame"]
+        else:
+            group = grouped.get_group(
+                group_name if len(group_name) > 1 else group_name[0]
+            )
         mapping_labels = OrderedDict()
         trace_name_labels = OrderedDict()
         frame_name = ""