diff --git a/news/9444.bugfix.rst b/news/9444.bugfix.rst
new file mode 100644
index 00000000000..4cba93e42ff
--- /dev/null
+++ b/news/9444.bugfix.rst
@@ -0,0 +1 @@
+Permit ``pip uninstall -r`` to accept requirements files containing ``--install-option`` or ``--global-option``.
diff --git a/src/pip/_internal/cli/cmdoptions.py b/src/pip/_internal/cli/cmdoptions.py
index b4f0f83c679..cd3101a9734 100644
--- a/src/pip/_internal/cli/cmdoptions.py
+++ b/src/pip/_internal/cli/cmdoptions.py
@@ -73,8 +73,9 @@ def getname(n: str) -> Optional[Any]:
         return getattr(check_options, n, None)
 
     names = ["build_options", "global_options", "install_options"]
-    if any(map(getname, names)):
-        control = options.format_control
+
+    control = getattr(options, "format_control", None)
+    if control and any(map(getname, names)):
         control.disallow_binaries()
         warnings.warn(
             "Disabling all use of wheels due to the use of --build-option "
diff --git a/tests/functional/test_uninstall.py b/tests/functional/test_uninstall.py
index 57bb527da1f..0d6c801b937 100644
--- a/tests/functional/test_uninstall.py
+++ b/tests/functional/test_uninstall.py
@@ -444,6 +444,35 @@ def test_uninstall_from_reqs_file(script, tmpdir):
     )
 
 
+def test_uninstall_per_setup_options(script):
+    """
+    Check that uninstall works with per-setup options are specified
+    """
+    pkg_name = 'pkga'
+    pkga_path = create_test_package_with_setup(
+        script,
+        name=pkg_name, version='1.0',
+    )
+    script.scratch_path.joinpath("test-req.txt").write_text(
+        textwrap.dedent(f"""
+            {pkg_name} --install-option="-v"
+        """)
+    )
+
+    result = script.pip('install', pkga_path)
+    result2 = script.pip('uninstall', '-r', 'test-req.txt', '-y')
+    assert_all_changes(
+        result,
+        result2,
+        [
+            script.venv / 'build',
+            script.venv / 'src',
+            script.scratch / 'test-req.txt',
+            script.site_packages / 'easy-install.pth',
+        ],
+    )
+
+
 def test_uninstallpathset_no_paths(caplog):
     """
     Test UninstallPathSet logs notification when there are no paths to