diff --git a/mypy/semanal.py b/mypy/semanal.py
index 782985e3fbab..aff2b02869f6 100644
--- a/mypy/semanal.py
+++ b/mypy/semanal.py
@@ -5904,9 +5904,8 @@ def analyze_type_application_args(self, expr: IndexExpr) -> list[Type] | None:
 
         if has_param_spec and num_args == 1 and types:
             first_arg = get_proper_type(types[0])
-            if not (
-                len(types) == 1 and isinstance(first_arg, (Parameters, ParamSpecType, AnyType))
-            ):
+            single_any = len(types) == 1 and isinstance(first_arg, AnyType)
+            if not (single_any or any(isinstance(t, (Parameters, ParamSpecType)) for t in types)):
                 types = [Parameters(types, [ARG_POS] * len(types), [None] * len(types))]
 
         return types
diff --git a/test-data/unit/check-parameter-specification.test b/test-data/unit/check-parameter-specification.test
index c2afb61586a8..654f36775172 100644
--- a/test-data/unit/check-parameter-specification.test
+++ b/test-data/unit/check-parameter-specification.test
@@ -1836,6 +1836,15 @@ c: C[int, [int, str], str]  # E: Nested parameter specifications are not allowed
 reveal_type(c)  # N: Revealed type is "__main__.C[Any]"
 [builtins fixtures/paramspec.pyi]
 
+[case testParamSpecInheritNoCrashOnNested]
+from typing import Generic
+from typing_extensions import ParamSpec
+
+P = ParamSpec("P")
+class C(Generic[P]): ...
+class D(C[int, [int, str], str]): ... # E: Nested parameter specifications are not allowed
+[builtins fixtures/paramspec.pyi]
+
 [case testParamSpecConcatenateSelfType]
 from typing import Callable
 from typing_extensions import ParamSpec, Concatenate