diff --git a/.github/actions/run-tests/action.yml b/.github/actions/run-tests/action.yml
index bb48e9e4c..9ade249ac 100644
--- a/.github/actions/run-tests/action.yml
+++ b/.github/actions/run-tests/action.yml
@@ -1,6 +1,6 @@
 # This code is part of a Qiskit project.
 #
-# (C) Copyright IBM 2021, 2023.
+# (C) Copyright IBM 2021, 2024.
 #
 # This code is licensed under the Apache License, Version 2.0. You may
 # obtain a copy of this license in the LICENSE.txt file in the root directory
@@ -36,7 +36,7 @@ runs:
         if [ "${{ inputs.event-name }}" == "schedule" ] || [ "${{ inputs.run-slow }}" == "true" ]; then
           export QISKIT_TESTS="run_slow"
         fi
-        if [ "${{ inputs.os }}" == "ubuntu-latest" ] && [ "${{ inputs.python-version }}" == "3.8" ]; then
+        if [ "${{ inputs.os }}" == "ubuntu-latest" ] && [ "${{ inputs.python-version }}" == "3.9" ]; then
           export PYTHON="coverage3 run --source qiskit_machine_learning --parallel-mode"
         fi
         stestr --test-path test run 2> >(tee /dev/stderr out.txt > /dev/null)
diff --git a/.github/workflows/deploy-code.yml b/.github/workflows/deploy-code.yml
index ad80409ba..163e75b87 100644
--- a/.github/workflows/deploy-code.yml
+++ b/.github/workflows/deploy-code.yml
@@ -1,6 +1,6 @@
 # This code is part of a Qiskit project.
 #
-# (C) Copyright IBM 2021, 2023.
+# (C) Copyright IBM 2021, 2024.
 #
 # This code is licensed under the Apache License, Version 2.0. You may
 # obtain a copy of this license in the LICENSE.txt file in the root directory
@@ -25,7 +25,7 @@ jobs:
       id-token: write
     strategy:
       matrix:
-        python-version: [3.8]
+        python-version: [3.9]
     steps:
       - uses: actions/checkout@v4
       - uses: actions/setup-python@v5
diff --git a/.github/workflows/deploy-docs.yml b/.github/workflows/deploy-docs.yml
index 9e01421ee..b26b9f8da 100644
--- a/.github/workflows/deploy-docs.yml
+++ b/.github/workflows/deploy-docs.yml
@@ -1,6 +1,6 @@
 # This code is part of a Qiskit project.
 #
-# (C) Copyright IBM 2021, 2023.
+# (C) Copyright IBM 2021, 2024.
 #
 # This code is licensed under the Apache License, Version 2.0. You may
 # obtain a copy of this license in the LICENSE.txt file in the root directory
@@ -25,7 +25,7 @@ jobs:
     runs-on: ubuntu-latest
     strategy:
       matrix:
-        python-version: [3.8]
+        python-version: [3.9]
     steps:
       - uses: actions/checkout@v4
         with:
diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
index 828f48b76..2bdd419ad 100644
--- a/.github/workflows/main.yml
+++ b/.github/workflows/main.yml
@@ -35,7 +35,7 @@ jobs:
     strategy:
       matrix:
         os: [ubuntu-latest]
-        python-version: [3.8]
+        python-version: [3.9]
     steps:
       - name: Print Concurrency Group
         env:
@@ -112,14 +112,14 @@ jobs:
       fail-fast: false
       matrix:
         os: [ubuntu-latest]
-        python-version: [3.8, 3.9, '3.10', 3.11, 3.12]
+        python-version: [3.9, '3.10', 3.11, 3.12]
         include:
           - os: macos-latest
-            python-version: 3.8
+            python-version: 3.9
           - os: macos-latest
             python-version: 3.12
           - os: windows-latest
-            python-version: 3.8
+            python-version: 3.9
           - os: windows-latest
             python-version: 3.12
           # macos-14 is an Arm64 image
@@ -165,7 +165,7 @@ jobs:
         run: |
           coverage3 combine
           mv .coverage ./ci-artifact-data/ml.dat
-        if: ${{ matrix.os == 'ubuntu-latest' && matrix.python-version == 3.8 }}
+        if: ${{ matrix.os == 'ubuntu-latest' && matrix.python-version == 3.9 }}
         shell: bash
       - uses: actions/upload-artifact@v4
         with:
@@ -188,7 +188,7 @@ jobs:
       fail-fast: false
       matrix:
         os: [ubuntu-latest]
-        python-version: [3.8, 3.12]
+        python-version: [3.9, 3.12]
     steps:
       - uses: actions/checkout@v4
         with:
@@ -251,29 +251,25 @@ jobs:
 #          cd docs/_build/html
 #          mkdir artifacts
 #          tar -zcvf artifacts/tutorials.tar.gz --exclude=./artifacts .
-#        if: ${{ matrix.python-version == 3.8 && !startsWith(github.ref, 'refs/heads/stable') && !startsWith(github.base_ref, 'stable/') }}
+#        if: ${{ matrix.python-version == 3.9 && !startsWith(github.ref, 'refs/heads/stable') && !startsWith(github.base_ref, 'stable/') }}
 #        shell: bash
 #      - name: Run upload stable tutorials
 #        uses: actions/upload-artifact@v4
 #        with:
 #          name: tutorials-stable${{ matrix.python-version }}
 #          path: docs/_build/html/artifacts/tutorials.tar.gz
-#        if: ${{ matrix.python-version == 3.8 && !startsWith(github.ref, 'refs/heads/stable') && !startsWith(github.base_ref, 'stable/') }}
+#        if: ${{ matrix.python-version == 3.9 && !startsWith(github.ref, 'refs/heads/stable') && !startsWith(github.base_ref, 'stable/') }}
   Deprecation_Messages_and_Coverage:
     needs: [Checks, MachineLearning, Tutorials]
     runs-on: ubuntu-latest
     strategy:
       matrix:
-        python-version: [3.8]
+        python-version: [3.9]
     steps:
       - uses: actions/checkout@v4
       - uses: actions/setup-python@v5
         with:
           python-version: ${{ matrix.python-version }}
-      - uses: actions/download-artifact@v4
-        with:
-          name: ubuntu-latest-3.8
-          path: /tmp/u38
       - uses: actions/download-artifact@v4
         with:
           name: ubuntu-latest-3.9
@@ -292,16 +288,16 @@ jobs:
           path: /tmp/u312
       - uses: actions/download-artifact@v4
         with:
-          name: macos-latest-3.8
-          path: /tmp/m38
+          name: macos-latest-3.9
+          path: /tmp/m39
       - uses: actions/download-artifact@v4
         with:
           name: macos-latest-3.12
           path: /tmp/m312
       - uses: actions/download-artifact@v4
         with:
-          name: windows-latest-3.8
-          path: /tmp/w38
+          name: windows-latest-3.9
+          path: /tmp/w39
       - uses: actions/download-artifact@v4
         with:
           name: windows-latest-3.12
@@ -319,10 +315,10 @@ jobs:
         shell: bash
       - name: Combined Deprecation Messages
         run: |
-          sort -f -u /tmp/u38/ml.dep /tmp/u39/ml.dep /tmp/u310/ml.dep /tmp/u311/ml.dep /tmp/u312/ml.dep /tmp/m38/ml.dep /tmp/m312/ml.dep /tmp/w38/ml.dep /tmp/w312/ml.dep /tmp/a310/ml.dep /tmp/a312/ml.dep || true
+          sort -f -u /tmp/u39/ml.dep /tmp/u310/ml.dep /tmp/u311/ml.dep /tmp/u312/ml.dep /tmp/m39/ml.dep /tmp/m312/ml.dep /tmp/w39/ml.dep /tmp/w312/ml.dep /tmp/a310/ml.dep /tmp/a312/ml.dep || true
         shell: bash
       - name: Coverage combine
-        run: coverage3 combine /tmp/u38/ml.dat
+        run: coverage3 combine /tmp/u39/ml.dat
         shell: bash
       - name: Upload to Coveralls
         env:
diff --git a/.mergify.yml b/.mergify.yml
index d9a318886..ca27e5964 100644
--- a/.mergify.yml
+++ b/.mergify.yml
@@ -1,12 +1,12 @@
 queue_rules:
   - name: automerge
     conditions:
-      - check-success=Deprecation_Messages_and_Coverage (3.8)
+      - check-success=Deprecation_Messages_and_Coverage (3.9)
 
 pull_request_rules:
   - name: automatic merge on CI success and review
     conditions:
-      - check-success=Deprecation_Messages_and_Coverage (3.8)
+      - check-success=Deprecation_Messages_and_Coverage (3.9)
       - "#approved-reviews-by>=1"
       - label=automerge
       - label!=on hold
diff --git a/.pylintdict b/.pylintdict
index 0f90a5135..93892d47d 100644
--- a/.pylintdict
+++ b/.pylintdict
@@ -137,6 +137,7 @@ elif
 endian
 entangler
 enum
+eol
 eps
 estimatorqnn
 et
@@ -352,6 +353,7 @@ o'brien
 objval
 observables
 oct
+october
 olson
 onboarding
 onodera
diff --git a/constraints.txt b/constraints.txt
index cfe92e0b9..4cf890b52 100644
--- a/constraints.txt
+++ b/constraints.txt
@@ -1,4 +1,3 @@
 numpy>=1.20,<2.0
-ipython<8.13;python_version<'3.9'
 nbconvert<7.14  # workaround https://github.com/jupyter/nbconvert/issues/2092
 
diff --git a/pyproject.toml b/pyproject.toml
index 6155f6ff3..dd917cc01 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -4,7 +4,8 @@ build-backend = "setuptools.build_meta"
 
 [tool.black]
 line-length = 100
-target-version = ['py38', 'py39', 'py310', 'py311']
+
+target-version = ['py39', 'py310', 'py311', 'py312']
 
 [tool.pylint.main]
 extension-pkg-allow-list = [
@@ -12,7 +13,7 @@ extension-pkg-allow-list = [
     "rustworkx",
 ]
 load-plugins = ["pylint.extensions.docparams", "pylint.extensions.docstyle"]
-py-version = "3.8"  # update it when bumping minimum supported python version
+py-version = "3.9"  # update it when bumping minimum supported python version
 
 [tool.pylint.basic]
 good-names = ["a", "b", "i", "j", "k", "d", "n", "m", "ex", "v", "w", "x", "y", "z", "Run", "_", "logger", "q", "c", "r", "qr", "cr", "qc", "nd", "pi", "op", "b", "ar", "br", "p", "cp", "ax", "dt", "__unittest", "iSwapGate", "mu"]
diff --git a/releasenotes/notes/py38_end_of_support-fa1fdea6ea02b502.yaml b/releasenotes/notes/py38_end_of_support-fa1fdea6ea02b502.yaml
new file mode 100644
index 000000000..f039fa74e
--- /dev/null
+++ b/releasenotes/notes/py38_end_of_support-fa1fdea6ea02b502.yaml
@@ -0,0 +1,6 @@
+---
+upgrade:
+  - |
+    Removed support for using Qiskit Machine Learning with Python 3.8 to reflect
+    the EOL of Python 3.8 in October 2024 (PEP 569). To continue using Qiskit Machine Learning, you
+    must upgrade to a Python: 3.9 or above if you are using older versions of Python.
diff --git a/setup.py b/setup.py
index 0d654e889..d7caaa4be 100644
--- a/setup.py
+++ b/setup.py
@@ -57,7 +57,6 @@
         "Operating System :: MacOS",
         "Operating System :: POSIX :: Linux",
         "Programming Language :: Python :: 3 :: Only",
-        "Programming Language :: Python :: 3.8",
         "Programming Language :: Python :: 3.9",
         "Programming Language :: Python :: 3.10",
         "Programming Language :: Python :: 3.11",
@@ -68,7 +67,7 @@
     packages=setuptools.find_packages(include=['qiskit_machine_learning','qiskit_machine_learning.*']),
     install_requires=REQUIREMENTS,
     include_package_data=True,
-    python_requires=">=3.8",
+    python_requires=">=3.9",
     extras_require={
         'torch': ["torch"],
         'sparse': ["sparse"],
diff --git a/tox.ini b/tox.ini
index 0f06e2637..f8f98c294 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,7 +1,7 @@
 [tox]
 # Sets this min.version because of differences with env_tmp_dir env.
 minversion = 4.0.2
-envlist = py38, py39, py310, py311, py312, lint, gpu, gpu-amd
+envlist = py39, py310, py311, py312, lint, gpu, gpu-amd
 skipsdist = True
 
 [testenv]